LOCUS       NM_014717               4973 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 536 (ZNF536), transcript variant
            1, mRNA.
ACCESSION   NM_014717 XM_375593
VERSION     NM_014717.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4973)
  AUTHORS   Zeng,L., Zhang,L., Yin,C., Chen,X., Chen,X., Sun,L. and Sun,J.
  TITLE     Characterization of zinc finger protein 536, a neuroendocrine
            regulator, using pan-cancer analysis
  JOURNAL   Eur J Med Res 29 (1), 273 (2024)
   PUBMED   38720348
  REMARK    GeneRIF: Characterization of zinc finger protein 536, a
            neuroendocrine regulator, using pan-cancer analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4973)
  AUTHORS   Fransen,E., Bonneux,S., Corneveaux,J.J., Schrauwen,I., Di
            Berardino,F., White,C.H., Ohmen,J.D., Van de Heyning,P.,
            Ambrosetti,U., Huentelman,M.J., Van Camp,G. and Friedman,R.A.
  TITLE     Genome-wide association analysis demonstrates the highly polygenic
            character of age-related hearing impairment
  JOURNAL   Eur J Hum Genet 23 (1), 110-115 (2015)
   PUBMED   24939585
REFERENCE   3  (bases 1 to 4973)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
REFERENCE   4  (bases 1 to 4973)
  AUTHORS   Seppala,I., Kleber,M.E., Lyytikainen,L.P., Hernesniemi,J.A.,
            Makela,K.M., Oksala,N., Laaksonen,R., Pilz,S., Tomaschitz,A.,
            Silbernagel,G., Boehm,B.O., Grammer,T.B., Koskinen,T., Juonala,M.,
            Hutri-Kahonen,N., Alfthan,G., Viikari,J.S., Kahonen,M.,
            Raitakari,O.T., Marz,W., Meinitzer,A. and Lehtimaki,T.
  CONSRTM   AtheroRemo Consortium
  TITLE     Genome-wide association study on dimethylarginines reveals novel
            AGXT2 variants associated with heart rate variability but not with
            overall mortality
  JOURNAL   Eur Heart J 35 (8), 524-531 (2014)
   PUBMED   24159190
REFERENCE   5  (bases 1 to 4973)
  AUTHORS   Low,S.K., Chung,S., Takahashi,A., Zembutsu,H., Mushiroda,T.,
            Kubo,M. and Nakamura,Y.
  TITLE     Genome-wide association study of chemotherapeutic agent-induced
            severe neutropenia/leucopenia for patients in Biobank Japan
  JOURNAL   Cancer Sci 104 (8), 1074-1082 (2013)
   PUBMED   23648065
REFERENCE   6  (bases 1 to 4973)
  AUTHORS   Qin,Z., Ren,F., Xu,X., Ren,Y., Li,H., Wang,Y., Zhai,Y. and Chang,Z.
  TITLE     ZNF536, a novel zinc finger protein specifically expressed in the
            brain, negatively regulates neuron differentiation by repressing
            retinoic acid-induced gene transcription
  JOURNAL   Mol Cell Biol 29 (13), 3633-3643 (2009)
   PUBMED   19398580
REFERENCE   7  (bases 1 to 4973)
  AUTHORS   Benjamin,E.J., Dupuis,J., Larson,M.G., Lunetta,K.L., Booth,S.L.,
            Govindaraju,D.R., Kathiresan,S., Keaney,J.F. Jr., Keyes,M.J.,
            Lin,J.P., Meigs,J.B., Robins,S.J., Rong,J., Schnabel,R., Vita,J.A.,
            Wang,T.J., Wilson,P.W., Wolf,P.A. and Vasan,R.S.
  TITLE     Genome-wide association with select biomarker traits in the
            Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S11 (2007)
   PUBMED   17903293
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4973)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   9  (bases 1 to 4973)
  AUTHORS   Dugas,J.C., Tai,Y.C., Speed,T.P., Ngai,J. and Barres,B.A.
  TITLE     Functional genomic analysis of oligodendrocyte differentiation
  JOURNAL   J Neurosci 26 (43), 10967-10983 (2006)
   PUBMED   17065439
  REMARK    GeneRIF: ZFP536 promotes the late phase of oligodendrocyte
            differentiation.
REFERENCE   10 (bases 1 to 4973)
  AUTHORS   Sakai,T., Hino,K., Wada,S. and Maeda,H.
  TITLE     Identification of the DNA binding specificity of the human ZNF219
            protein and its function as a transcriptional repressor
  JOURNAL   DNA Res 10 (4), 155-165 (2003)
   PUBMED   14621294
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC011454.6, HY151164.1 and
            BC146757.1.
            
            On Nov 24, 2018 this sequence version replaced NM_014717.2.
            
            Summary: The protein encoded by this gene is a highly conserved
            zinc finger protein. The encoded protein is most abundant in brain,
            where it negatively regulates neuronal differentiation. [provided
            by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146757.1, AB002388.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355537.4/ ENSP00000347730.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC011454.6         67319-67327
            10-37               HY151164.1         2-29
            38-4973             BC146757.1         1-4936
FEATURES             Location/Qualifiers
     source          1..4973
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q12"
     gene            1..4973
                     /gene="ZNF536"
                     /note="zinc finger protein 536"
                     /db_xref="GeneID:9745"
                     /db_xref="HGNC:HGNC:29025"
                     /db_xref="MIM:618037"
     exon            1..173
                     /gene="ZNF536"
                     /inference="alignment:Splign:2.1.0"
     exon            174..2345
                     /gene="ZNF536"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..4078
                     /gene="ZNF536"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 536 isoform 1"
                     /protein_id="NP_055532.1"
                     /db_xref="CCDS:CCDS32984.1"
                     /db_xref="GeneID:9745"
                     /db_xref="HGNC:HGNC:29025"
                     /db_xref="MIM:618037"
                     /translation="MEEASLCLGVSSAEPEAEPHLSGPVLNGQYAMSQKLHQITSQLS
                     HAFPELHPRPNPEEKPPASLEEKAHVPMSGQPMGSQMALLANQLGREVDTSLNGRVDL
                     QQFLNGQNLGIMSQMSDIEDDARKNRKYPCPLCGKRFRFNSILSLHMRTHTGEKPFKC
                     PYCDHRAAQKGNLKIHLRTHKLGNLGKGRGRVREENRLLHELEERAILRDKQLKGSLL
                     QPRPDLKPPPHAQQAPLAACTLALQANHSVPDVAHPVPSPKPASVQEDAVAPAAGFRC
                     TFCKGKFKKREELDRHIRILHKPYKCTLCDFAASQEEELISHVEKAHITAESAQGQGP
                     NGGGEQSANEFRCEVCGQVFSQAWFLKGHMRKHKDSFEHCCQICGRRFKEPWFLKNHM
                     KVHLNKLSVKNKSPSDPEVPVPMGGMSQEAHANLYSRYLSCLQSGFMTPDKAGLSEPS
                     QLYGKGELPMKEKEALGKLLSPISSMAHGVPEGDKHSLLGCLNLVPPLKSSCIERLQA
                     AAKAAEMDPVNSYQAWQLMARGMAMEHGFLSKEHPLQRNHEDTLANAGVLFDKEKREY
                     VLVGADGSKQKMPADLVHSTKVGSQRDLPSKLDPLESSRDFLSHGLNQTLEYNLQGPG
                     NMKEKPTECPDCGRVFRTYHQVVVHSRVHKRDRKGEEDGLHVGLDERRGSGSDQESQS
                     VSRSTTPGSSNVTEESGVGGGLSQTGSAQEDSPHPSSPSSSDIGEEAGRSAGVQQPAL
                     LRDRSLGSAMKDCPYCGKTFRTSHHLKVHLRIHTGEKPYKCPHCDYAGTQSASLKYHL
                     ERHHRERQNGAGPLSGQPPNQDHKDEMSSKASLFIRPDILRGAFKGLPGIDFRGGPAS
                     QQWTSGVLSSGDHSGQATGMSSEVPSDALKGTDLPSKSTHFSEIGRAYQSIVSNGVNF
                     QGSLQAFMDSFVLSSLKKEKDMKDKALADPPSMKVHGVDGGEEKPSGKSSQRKSEKSQ
                     YEPLDLSVRPDAASLPGSSVTVQDSIAWHGCLFCAFTTSSMELMALHLQANHLGKAKR
                     KDNTIGVTVNCKDQAREASKMALLPSLQSNKDLGLSNMISSLDSASEKMAQGQLKETL
                     GEQKSGAWTGHVDPAFCNFPSDFYKQFGVYPGMVGSGASSSCPNKEPDGKAHSEEDVP
                     ILIPETTSKNTTDDLSDIASSEDMDSSKGENNDEEDVETEPEMMTKPLSALSKDSSSD
                     GGDSLQPTGTSQPVQGLVSPLSQAPEKQWHSQGLLQAQDPLAGLPKPERGPQSLDKPM
                     NMLSVLRAYSSDGLAAFNGLASSTANSGCIKRPDLCGK"
     exon            2346..2498
                     /gene="ZNF536"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..4070
                     /gene="ZNF536"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4973
                     /gene="ZNF536"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4946..4951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF536"
                     /note="hexamer: AATAAA"
     polyA_site      4973
                     /gene="ZNF536"
                     /note="major polyA site"
ORIGIN      
        1 gattttgctg aggccagctt tggaacaggg gaggtgagtc tggagaagag agtttccacg
       61 ttgtcatcat aggatctgga ctcaagtgac caaaaccttg cttggatttt tacctgatga
      121 agtttgtctt gaaaagtgaa aatggttcca tttccatttt ccctgttctc aagggatgga
      181 agaagcgagc ctgtgccttg gagtgtcttc ggcggagccg gaagctgagc cccacctgag
      241 tggccccgtc ctcaacggcc agtatgccat gagtcagaag ctgcaccaga tcacctccca
      301 gctcagccat gccttccccg agctccatcc ccggcccaac cccgaggaga agccccccgc
      361 atccctggag gagaaggccc acgtgcccat gagcggccag cccatgggca gtcagatggc
      421 gctcctggcc aaccagctgg gccgggaggt ggacaccagc ctcaacggga gggtggactt
      481 gcagcagttc ctcaacgggc agaacctggg catcatgtcc cagatgagcg acatcgagga
      541 cgacgcccgc aagaaccgca agtacccgtg cccactctgc ggcaagcgct tccgcttcaa
      601 cagcatcctc tccctgcaca tgcgcacgca cacgggcgag aagcccttca agtgcccgta
      661 ctgcgaccac agggcggcgc agaaggggaa cctcaagatt cacctgcgga cccacaagct
      721 gggcaacctg ggcaaggggc gtgggcgtgt gcgcgaggag aaccgcctgc tgcacgagct
      781 ggaggagcgc gccatcctgc gggacaagca gctgaaaggc agcctgctgc agccccggcc
      841 ggacctgaag cccccgccgc acgcccagca ggccccgctg gccgcctgca ccctggccct
      901 gcaggctaac cacagcgttc ccgacgtggc ccacccggtg ccctcgccca agcctgccag
      961 cgtgcaggag gacgcggtgg ccccggcggc gggcttccgc tgtaccttct gcaagggcaa
     1021 gttcaagaag cgcgaggagc tggaccgcca catccgcatc ttgcacaagc cctacaagtg
     1081 cacgttgtgc gacttcgcgg cttcgcagga ggaggagctc atcagccacg tggagaaggc
     1141 acacatcacg gccgagtcgg cccagggcca gggccccaac ggcggtggcg agcagtcggc
     1201 caacgagttc cgctgcgagg tgtgcggtca ggtgttcagc caggcgtggt tcctcaaggg
     1261 tcacatgcgc aagcacaaag actcctttga gcactgctgc cagatctgcg gccggcgctt
     1321 caaggagccc tggttcctca agaaccacat gaaggtccac ctcaacaagc tgtcggtgaa
     1381 gaacaagtcc cccagcgacc ccgaggtgcc tgtgcccatg ggcggcatgt cccaggaggc
     1441 ccacgccaac ctgtactcca ggtacctctc ctgcctgcag agtggcttca tgaccccgga
     1501 caaagccggc ctgagcgagc ccagccagct ctatggcaag ggcgagctgc ccatgaagga
     1561 gaaggaagcg ctggggaagc tgctgtctcc catctccagc atggcccacg gcgtcccgga
     1621 gggggacaag cactccctcc tgggatgcct caatctcgtg ccgccgctga aatccagctg
     1681 catcgagcgg ctgcaggcgg ctgccaaggc tgcggagatg gaccccgtga acagctacca
     1741 ggcttggcag ctcatggcca ggggcatggc catggaacat ggcttcttgt ctaaagagca
     1801 tccgctgcag cgcaaccacg aagacacttt ggcaaacgcc ggggttctgt ttgataagga
     1861 gaagcgggag tacgtgttag tgggagcaga tggctccaag cagaaaatgc ctgctgattt
     1921 ggttcacagc actaaagtgg gcagccagag agacctgcca agtaagctcg accctttaga
     1981 aagcagtcgg gattttttgt cacacgggct gaaccagact ctcgagtata acctgcaggg
     2041 tcctgggaac atgaaggaga agcccaccga gtgccccgac tgcggccggg tgttccgcac
     2101 ttaccaccag gtggtcgtgc actcccgtgt ccacaagcgg gaccgcaagg gcgaggagga
     2161 tgggctgcac gtgggcctgg atgagcggcg tggctcgggc agtgaccagg agtcccagtc
     2221 ggtgagccgc tccaccacgc cgggctcctc taacgtcacc gaggagagcg gggtcggagg
     2281 cggcctctcc cagaccggga gtgcccagga ggacagcccg cacccctcct cgccatcctc
     2341 ctcagacatt ggcgaggagg ctgggagatc tgccggcgtc cagcaaccag cgctgcttcg
     2401 cgacagaagc ctgggctcgg ccatgaagga ctgcccgtac tgtgggaaaa ctttccggac
     2461 atcccatcac cttaaggtgc acctgaggat acacacaggt gagaaaccct acaagtgtcc
     2521 gcactgtgac tatgccggca cgcagtcagc atccttaaaa taccacttag agcgacacca
     2581 tcgggagcgg cagaacgggg ctgggccgct gtctgggcaa cccccaaatc aagaccacaa
     2641 ggatgagatg tcaagcaaag cttctctgtt catcaggcca gacatcctga ggggggcctt
     2701 caagggtctc cctggaatcg acttcagagg aggccctgca tctcagcagt ggacatcagg
     2761 ggttctctcc tctggagatc actcggggca ggccacgggc atgtcttcgg aggtcccctc
     2821 agatgctctg aaaggcactg accttccttc caaaagcacc cacttctctg agatcggaag
     2881 agcttatcaa agcattgtga gcaacggtgt gaatttccaa gggtccttgc aagctttcat
     2941 ggacagtttt gtcctcagtt ccttgaagaa ggagaaggac atgaaggaca aagccctggc
     3001 tgacccccct tccatgaaag tccacggagt ggatggtggt gaggagaaac ccagtggcaa
     3061 gtcctcccag aggaagtccg agaaatctca gtatgaaccc ctggacttgt ctgtgcggcc
     3121 agatgccgcc tccctcccgg gctcctcggt aactgtgcag gacagcattg catggcacgg
     3181 ctgcttgttt tgtgctttca caacgtcctc catggagctc atggcccttc atctccaggc
     3241 caaccacctg ggcaaagcga aacgcaaaga taacaccatc ggggtcacag tcaactgcaa
     3301 agaccaagcc cgggaggcga gtaagatggc cctgctgccc tcgttacaat caaacaaaga
     3361 cctgggcctc tccaatatga tcagctctct agactctgct tctgagaaga tggcccaagg
     3421 tcagctcaag gagactctgg gagagcagaa gagcggtgca tggaccggcc acgtggaccc
     3481 tgcattttgt aacttcccat cagacttcta caagcagttt ggtgtttacc caggcatggt
     3541 tggctcaggg gcctccagtt cctgccccaa caaggagcct gatggaaagg cccactctga
     3601 agaggatgtc cccatcctga tccccgaaac cacgagtaag aacactactg atgacctctc
     3661 tgacattgcc tcctcagagg acatggactc ctccaagggg gagaacaacg atgaagagga
     3721 tgttgaaacc gaaccggaaa tgatgaccaa gccactgtct gccctcagca aagacagcag
     3781 cagcgatggc ggggacagcc tgcagcccac aggcacctcc cagcccgtcc agggactggt
     3841 ctcaccttta tcccaagcac cggagaagca gtggcacagc cagggtcttc tccaagccca
     3901 ggaccccttg gcgggcctgc caaagccgga gcgggggccc cagagcctgg acaagccgat
     3961 gaacatgctg tcggtcctca gggcctacag ttctgatggc ttagcagcct ttaacggact
     4021 tgcaagtagc acagcaaatt ctggatgtat caagaggcca gacttgtgtg gtaagtgaca
     4081 ctccctgtcc tagtcggtct atctggactt gcccttgtct gttcgtggtc ctcggtggtt
     4141 atctgcagct tgttaatcgt gtaaagtcaa gagaagaatg tatacacata tgtgtgttga
     4201 ataattacta ttggcatagg tatgtgtata cacacggtgc accaatctac agtatatata
     4261 gcagagaatc agaggctaaa aatattaccc catatgttcc agtattagtc atggattgca
     4321 aaggcttagt aacttgagca ggagagaaaa ctccctcaaa gtcataaatc ctgagtgaca
     4381 actgctgctg gatgacagat cccttcacct gtggacaacc tggctggggg tggggggctg
     4441 ttccaccagc tcacctgagc atgtagaggt gggtcctgca gtggtctcgt gggtattact
     4501 gcttgtgtct gattgtcctg tattttgtaa cactttagaa gaatacagaa aagtgcagta
     4561 attctctttc tccatagtat ttaagcagaa atattgctag tttaatattg tgtcaggtcg
     4621 tcctattaac caggagcaga tgacagtaaa atttcagtga atagcacctt gacatctaca
     4681 acttaaaaat ggtgattgaa gcaaaatatg taaacttgta cggggtgatc gtgtgctttg
     4741 gaacagagta ttgttgaagt aattagaaga tatattaagg tgttcctggt aatgaaggca
     4801 tgtaagttat aataattgta gctttctgaa taagtgtcaa actatatctt taagtgtgct
     4861 gtatgctgag ttacaagtta ggtcatttat gaatggaatg taaaataata ctaaaaatgc
     4921 ttcaataact tatcttggta ttgctaataa aaaaaaaaag ctgtgaaaca tta
//
