LOCUS       NM_001143938            5203 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 534 (ZNF534), transcript variant
            1, mRNA.
ACCESSION   NM_001143938
VERSION     NM_001143938.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5203)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010332.7 and AB086839.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001143938.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.126847.1,
                                           SRR1803613.77499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000433050.6/ ENSP00000391358.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC010332.7         75436-75532
            98-103              AC010332.7         77696-77701
            104-2147            AB086839.1         1-2044
            2148-5203           AC010332.7         85732-88787
FEATURES             Location/Qualifiers
     source          1..5203
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..5203
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /note="zinc finger protein 534"
                     /db_xref="GeneID:147658"
                     /db_xref="HGNC:HGNC:26337"
     exon            1..97
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /inference="alignment:Splign:2.1.0"
     exon            98..179
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..2150
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /note="isoform 1 is encoded by transcript variant 1; KRAB
                     domain only 3; KRAB domain only protein 3"
                     /codon_start=1
                     /product="zinc finger protein 534 isoform 1"
                     /protein_id="NP_001137410.1"
                     /db_xref="CCDS:CCDS46166.1"
                     /db_xref="GeneID:147658"
                     /db_xref="HGNC:HGNC:26337"
                     /translation="MALTQGQLSFSDVAIEFSQEEWKCLDPGQKALYRDVMLENYRNL
                     VSLGICLPDLSVTSMLEQKRDPWTLQSEVKIINNPDGRECIKGVNTEKSSKLGSSAGN
                     KSLKNQHGLTLQLHLTEWQPFQAVRNIYGCKHVEKSISDNSSVSPVQISFFSVKTHIF
                     NNYRNDFLFSTLLPQEQKVHIREKPYGCNEHGKVFRVSSSLTNRQVIHIADKTYKCSD
                     CGEIFSSNSNFAQHQRIHTGEKPYKYNECGKVFNQNSHLAQHQKIHTGQKPYNNKECG
                     KVFSHHAYLAQHRKIHTGEKPYKCSECGKAFSVCSSLTAHLVIHTGEKPYDCKECGKV
                     FRHKSSLTTHQTVHTGERPYKCNECGKGFSRIAFLARHRKVHTGEKPYKCNECGKVFI
                     GNSRLARHRKIHTGGRRYKCNECGKAFRTCSDLTAHLLIHTGEKPYECIDCGKVFRHK
                     SSLTYHCRIHTGEKPYKCNECGKVFSQNSNLQRHRKIHTGEKLYKCNECGKVFRQNSH
                     LAQHRDIHTGEKPYSCNECGKVFRRNSHLVRHRNVHTGEKPYSCNECGKVFSRNSHLA
                     RHRNIHTGEKPHSCNECGKVFSRNSHLARHRKIHTGEKLYKCNECSKVFSRNSRLAQH
                     RNIHTGVKPYSCNECGKVFSKNSILVQHCSIHTREKP"
     exon            180..306
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /inference="alignment:Splign:2.1.0"
     exon            307..435
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..5203
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5180..5185
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /note="hexamer: AATAAA"
     polyA_site      5203
                     /gene="ZNF534"
                     /gene_synonym="KRBO3"
                     /note="major polyA site"
ORIGIN      
        1 agacccggaa gtcgagatca tggagtgaac gtttcgcgcg ctttttcctg tagacccggc
       61 acccgactgc gcggaaagac tgtctaagcc gccactcgat tcactttcaa agagacatat
      121 tatgcaagga agcaactcgg aagaggaaag aaaggaagtc aggaatggcc cttactcagg
      181 ggcaattgtc attcagcgat gtggccatag aattctctca ggaggagtgg aaatgcctgg
      241 accctgggca gaaagcttta tacagggacg tgatgttaga gaactacagg aacctggtct
      301 ccctaggaat ctgtcttcct gacctgagtg ttacctccat gttggagcaa aagagagatc
      361 cctggactct gcagagtgaa gtgaaaataa taaacaatcc agatggcagg gagtgcatca
      421 aaggtgtgaa cacagagaag agttctaaat tgggaagcag tgcaggaaac aagtcactta
      481 aaaatcaaca tggattaact cttcagttac atctgactga atggcagcca tttcaagctg
      541 taaggaatat ttatggatgt aagcatgttg agaaatctat cagtgacaat tcttcagttt
      601 caccagttca aataagtttt ttcagtgtca aaacccatat ttttaataac tacagaaatg
      661 attttctttt ttctacatta ctcccacaag aacagaaagt acacattagg gaaaagcctt
      721 atggatgtaa tgagcatggg aaagtcttca gagtgtcttc aagccttact aaccgtcaag
      781 taatccacat tgcagataaa acttacaaat gtagtgactg tggcgagatc tttagtagca
      841 attcaaactt tgcacaacat caacgaatcc atactggaga gaagccttac aaatataatg
      901 aatgtggcaa agtcttcaat cagaattcac accttgcaca acatcagaaa attcatactg
      961 gacagaaacc ttacaataac aaagaatgtg ggaaagtctt tagtcaccat gcctaccttg
     1021 cacagcatag gaaaattcat actggagaga agccttacaa atgtagtgaa tgtggcaaag
     1081 catttagtgt gtgttccagt cttactgctc atcttgtaat ccatactgga gagaaacctt
     1141 atgattgtaa ggaatgtggc aaggtcttca ggcataagtc ttccctaacc actcatcaga
     1201 cagttcatac tggagagaga ccatacaaat gtaatgaatg tggcaagggg tttagtcgaa
     1261 ttgcattcct tgcaaggcat cggaaagttc atactggaga gaaaccttac aaatgtaatg
     1321 agtgtggcaa ggtctttatt ggcaattcac gccttgcacg acataggaaa attcatactg
     1381 gggggaggcg ttacaaatgt aatgaatgtg gcaaagcatt tagaacgtgt tcagatctca
     1441 ctgcccatct tctaatccat actggagaga aaccttacga atgtatagac tgtggcaagg
     1501 tcttcaggca caagtcttcc ctaacctatc actgtagaat tcatactgga gagaagcctt
     1561 acaaatgtaa cgaatgtggc aaggtcttca gtcagaattc aaaccttcaa cgacatagga
     1621 aaattcatac tggagagaag ctttacaaat gtaatgaatg tggcaaggtc ttccgtcaga
     1681 attcacacct tgcacaacat agggatattc atactggaga gaagccttac agttgtaatg
     1741 aatgtggcaa ggtcttccgt cggaattcac accttgtgcg acataggaat gttcatactg
     1801 gagaaaagcc ttacagttgt aatgaatgtg gcaaggtctt cagtcggaat tcacaccttg
     1861 cgcgacatag gaatattcat actggagaga agcctcacag ttgtaatgaa tgtggcaagg
     1921 tcttcagtcg gaattcacac cttgcgcgac ataggaaaat tcatactgga gagaagcttt
     1981 acaaatgtaa tgaatgtagc aaggtcttca gtcggaattc acgccttgca caacatagga
     2041 atattcatac tggagtgaag ccttacagtt gtaatgaatg tggcaaggtc tttagtaaaa
     2101 attccatcct agtacaacat tgcagtattc ataccagaga gaagccttaa aaatttagtg
     2161 aagctggcag ggcgcagtgg ctcacgtctg taatcccagc actttgggag tccgaggcag
     2221 gtggatcatg aggtcaggag attgagacca tcctggctaa cacggtgaaa ccccatctct
     2281 actaaaaata caaaaaaaaa aaaaaaaaaa aaattagctg ggtgtggtgg caggcacctg
     2341 tagtcccagc tactcaggag gctgaggcag gaggatggca tgaacctggg aggcagagcc
     2401 tccagtgagc cgagtgagcc actgcactcc agcctaggtg acagagtgaa actccatctc
     2461 aaaaaaagaa aaaaaaaaaa tgagtgaagc tgccaagcat ggtggctcac gcctttaatc
     2521 ccagtacttt gggaggccaa ggtggccaga tcacctgagg ttagaagttc gagaccagcc
     2581 tgaccaacat ggagaaaccc catctctact aaaaatacaa aattagctga ctgaggtggc
     2641 aggcacttgt gatcccagct actcaggagg ctgaggcagg agaattgctt gaacctggga
     2701 ggcagaggtt gtgatgagcc gagattgcaa cattgcactc cagcttgggc aagaggagca
     2761 aaactctttc tttaaaaaca aaacaaaaaa agttatgaag cctcacaaaa gtaataaata
     2821 tggcaaagaa tttcatatga aatcatgcct ctctacccat ctattaatcc atactggaag
     2881 gaaaccatag aaatataaag aatacaagaa ggtcttcagg cacatgtttt ccctaacctc
     2941 tcatcaagag aattcacact ggtgattgac tttaaacata taacaagtgt ggcaacgtat
     3001 tcacttaaaa tacacacctt gtaaactatc acagaatcca tactggagag aaaccttaca
     3061 aatgaatgac agcatcttca aataaaatgc acatctggca caacattgga aaattcatac
     3121 tgtagatacc ttttaaatgt agcaaatatg gcaaagtcaa agtcacaatt cacatcttgc
     3181 acatcaaata attcatactg gaggctgggt gcggtggctc acgcctgtaa tcccagcact
     3241 ttgggaggct gaggcagacg gatcagttga ggtcaggagt ttgagaccag cctgaccaat
     3301 gtgttgaaac cccatcacta ctaaaaataa aaaaaatagc tgggtgtggt ggtgggtgtc
     3361 tgtaatccca gctactcagg aggctgaggc aggagaatca cttaaaccca ggagatggag
     3421 gttgcagtga gccaagaatg cgctactaca ctccagcctg tgtgacagtg agattctgtc
     3481 tcaaaaaaaa aaaaaagaat tcatactgga aggaagcgtt acaaatgtaa tgaatgcggc
     3541 agagcattga gaaggtgttc aggtcttaac tgttcatttt gtaatccata gtggagataa
     3601 gtcttttttt tttttttccc ccgaaacaag agtctcgctc tgatgcccag gctggagtgc
     3661 agtggtgtaa tctcagctca ctgcaaccgc cacctcctag gttcaagcaa ttctcctgcc
     3721 tctacctccc gagtagctag gactacaagc acatgatgcc atcatgcctg gctaattttt
     3781 tgtattttta gtagagacgg ggtttcacca tgttagccag gctggtctcg atctcctgac
     3841 cttgtgatcc atctgccttg gcctcccaaa gtgctgggat tacaggcatg agctgctgca
     3901 cccagcttga gaaatcatat gaatatatgg aatgtactcc aggcatggtg gctcacacct
     3961 ataatcccag ccctttggga ggccaaggtg agaggattgc ttgaacccag gagtttgaga
     4021 ccaacctggg taacataagg acaactccat ctctacaaat aataaaaaat tagccaggtg
     4081 tgttggtata tgcatgtatt cccagctact tgggaggctg aggcagaagg atcatttgag
     4141 cctaggagct tgaggctgca gtgagtcatg tttgcagtac tgcactccag cctgggtgac
     4201 agagtgagac cctatctaca aatataaaca aacaatgtga aacgtcttca gtcacaagta
     4261 ttccctaaca aatcactata gaattcatac tgcagagaag ccttacaaat gcagcgaatg
     4321 tgacaaagca tttagataat gttcaggctt tactgcccat cttgtaatcc atactgcaga
     4381 caaaccttac aactgtaatg aatgtggcaa ggtctcaaat tgaaattcac atcttgcgaa
     4441 tcaccacata gagagaaacc ttacaaatac aaatcaccac atagagagaa accttacaaa
     4501 tacaaatcac cacataatgg agagaaacct tacaaatgca acatatgtgg taaaatgttt
     4561 tagtcacaat tcacaccttg gacagcatca gataatttat tcatgaaaga gtccttacaa
     4621 gctgtgtacg gaaagctcgt catgagtttt agcattaatg aacatcagag gttccatact
     4681 aaggagaaat catataaatg taatgtatgt ggcacaggct ttcctgaggc ctgccaaatc
     4741 actagaaatc aaaatatact tttggataaa acgacacaga tggattgtat atgctgagga
     4801 tatccaagga ccattactat agaacatgaa aaggatttaa ttattgtttt cttttttcct
     4861 aaaagtgttg ggaacaggcc accaaaactg gccataaaca aaatctctgt aggactgtga
     4921 catgttcttg atgggcatga cacccatgct gaaggtcgtt ggtttaccag aatgatggca
     4981 aagaacacct ggcccaccca gggcagaaaa accgcttaag gcgttccaga accacaaata
     5041 atagcatgtg cattctgtgc cttaaggaca tgttcatgct gcagataact aaccagagcc
     5101 catccctttg tttcccataa ggaatgcttt tatgtaatct ataatcaata gaaacaatgc
     5161 ttatcactgg cttgctctca ataaatatgt gggtcaaact ctg
//
