LOCUS       NM_001375912            6556 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens zinc finger protein 532 (ZNF532), transcript variant
            19, mRNA.
ACCESSION   NM_001375912 XM_024451198
VERSION     NM_001375912.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6556)
  AUTHORS   Fu,X.L., He,F.T., Li,M.H., Fu,C.Y. and Chen,J.Z.
  TITLE     circZNF532 promotes endothelial-to-mesenchymal transition in
            diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD
  JOURNAL   Endocr J 71 (7), 675-686 (2024)
   PUBMED   38811189
  REMARK    GeneRIF: circZNF532 promotes endothelial-to-mesenchymal transition
            in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
REFERENCE   2  (bases 1 to 6556)
  AUTHORS   Liang,G.H., Luo,Y.N., Wei,R.Z., Yin,J.Y., Qin,Z.L., Lu,L.L. and
            Ma,W.H.
  TITLE     CircZNF532 knockdown protects retinal pigment epithelial cells
            against high glucose-induced apoptosis and pyroptosis by regulating
            the miR-20b-5p/STAT3 axis
  JOURNAL   J Diabetes Investig 13 (5), 781-795 (2022)
   PUBMED   34839589
  REMARK    GeneRIF: CircZNF532 knockdown protects retinal pigment epithelial
            cells against high glucose-induced apoptosis and pyroptosis by
            regulating the miR-20b-5p/STAT3 axis.
REFERENCE   3  (bases 1 to 6556)
  AUTHORS   Chen,M., Zhao,S., Liang,Z., Wang,W., Zhou,P. and Jiang,L.
  TITLE     NUT carcinoma of the parotid gland: report of two cases, one with a
            rare ZNF532-NUTM1 fusion
  JOURNAL   Virchows Arch 480 (4), 887-897 (2022)
   PUBMED   35064291
  REMARK    GeneRIF: NUT carcinoma of the parotid gland: report of two cases,
            one with a rare ZNF532-NUTM1 fusion.
REFERENCE   4  (bases 1 to 6556)
  AUTHORS   Fan,L., Wang,J., Deng,P., Wang,Y., Zhang,A., Yang,M. and Zeng,G.
  TITLE     Foxhead box D1 promotes the partial epithelial-to-mesenchymal
            transition of laryngeal squamous cell carcinoma cells via
            transcriptionally activating the expression of zinc finger protein
            532
  JOURNAL   Bioengineered 13 (2), 3057-3069 (2022)
   PUBMED   35112956
  REMARK    GeneRIF: Foxhead box D1 promotes the partial
            epithelial-to-mesenchymal transition of laryngeal squamous cell
            carcinoma cells via transcriptionally activating the expression of
            zinc finger protein 532.
REFERENCE   5  (bases 1 to 6556)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 6556)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   7  (bases 1 to 6556)
  AUTHORS   Alekseyenko,A.A., Walsh,E.M., Zee,B.M., Pakozdi,T., Hsi,P.,
            Lemieux,M.E., Dal Cin,P., Ince,T.A., Kharchenko,P.V., Kuroda,M.I.
            and French,C.A.
  TITLE     Ectopic protein interactions within BRD4-chromatin complexes drive
            oncogenic megadomain formation in NUT midline carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 114 (21), E4184-E4192 (2017)
   PUBMED   28484033
  REMARK    GeneRIF: The authors discovered ZNF532 associated with BRD4-NUT in
            NMC patient cells. ChIP sequencing revealed the formation of
            ZNF532-NUT-associated hyperacetylated megadomains, distinctly
            localized but otherwise analogous to those found in BRD4-NUT
            patient cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090233.16 and AC040963.6.
            
            On Nov 6, 2019 this sequence version replaced XM_024451198.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY039256.1, SRR14038191.332376.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000591808.6/ ENSP00000468238.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               AC090233.16        47862-48370
            510-619             AC090233.16        48455-48564
            620-2982            AC090233.16        101256-103618
            2983-3164           AC090233.16        117418-117599
            3165-3341           AC090233.16        122430-122606
            3342-3504           AC090233.16        131052-131214
            3505-3786           AC090233.16        136503-136784
            3787-3899           AC090233.16        162040-162152
            3900-4047           AC090233.16        164455-164602
            4048-4986           AC090233.16        166957-167895
            4987-6556           AC040963.6         106813-108382       c
FEATURES             Location/Qualifiers
     source          1..6556
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..6556
                     /gene="ZNF532"
                     /note="zinc finger protein 532"
                     /db_xref="GeneID:55205"
                     /db_xref="HGNC:HGNC:30940"
                     /db_xref="MIM:619066"
     exon            1..509
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            510..619
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            620..2982
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     CDS             637..4542
                     /gene="ZNF532"
                     /note="isoform a is encoded by transcript variant 19"
                     /codon_start=1
                     /product="zinc finger protein 532 isoform a"
                     /protein_id="NP_001362841.1"
                     /db_xref="CCDS:CCDS11969.1"
                     /db_xref="GeneID:55205"
                     /db_xref="HGNC:HGNC:30940"
                     /db_xref="MIM:619066"
                     /translation="MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQN
                     AHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTGNGLHNGFLTASSLDSY
                     SKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFR
                     SNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPF
                     KVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAA
                     LSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDS
                     PRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKP
                     SEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVAT
                     AFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVP
                     ASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKK
                     VSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDS
                     FALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLIL
                     KPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAM
                     PLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQKTCTICQMLLPNQCSY
                     ASHQRIHQHKSPYTCPECGAICRSVHFQTHVTKNCLHYTRRVGFRCVHCNVVYSDVAA
                     LKSHIQGSHCEVFYKCPICPMAFKSAPSTHSHAYTQHPGIKIGEPKIIYKCSMCDTVF
                     TLQTLLYRHFDQHIENQKVSVFKCPDCSLLYAQKQLMMDHIKSMHGTLKSIEGPPNLG
                     INLPLSIKPATQNSANQNKEDTKSMNGKEKLEKKSPSPVKKSMETKKVASPGWTCWEC
                     DCLFMQRDVYISHVRKEHGKQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACS
                     HCPDSRRTFTKRLMLEKHVQLMHGIKDPDLKEMTDATNEEETEIKEDTKVPSPKRKLE
                     EPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHKSDGSSYQ
                     CRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGEDNQQENKPSHEDESPDGAVS
                     DRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK"
     exon            2983..3164
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3341
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3342..3504
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3505..3786
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3787..3899
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3900..4047
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            4048..6556
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4895..4900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF532"
                     /note="hexamer: AATAAA"
     polyA_site      4925
                     /gene="ZNF532"
     regulatory      6532..6537
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF532"
                     /note="hexamer: AATAAA"
     polyA_site      6556
                     /gene="ZNF532"
                     /note="major polyA site"
ORIGIN      
        1 agtaggatag cagcttcctc ccttcatggc agccaaaagc agaggagctt gcaggaaggt
       61 accatcccta cacagtatgt gaatgcacac ttagacacca cacagcactg gtacgtgact
      121 aatggagccc taaaagattc tgggtagaga agatggaaaa aaaggtgcag gtttgcaggg
      181 tctgagatta cttgggcttt tcctgccttt ttcttttgct taagggatgg acaaggagct
      241 gagatttatg acccttatta gagaaaaaaa tgtgccttgc tagggtgggg acacttggtt
      301 gatgcagtct ctctctctct ttctcggtgt ttataacaaa acaaaaccaa aatgaactga
      361 ggggtttgta atggtagttt gtttgttgct ggagaatgct actttgcatg ctttttttct
      421 cttgcagggt atgttctgtc ttgtgctttt tcttttagaa gctactaaag ggtgttgggg
      481 atgcttctga ctattatgaa ggccaaaagg cctgttgact ggggctgctt ttaacccttt
      541 cctatttgct gagaatgcag ccgtgtgaca gtaactgaac attggtctaa agtctttcca
      601 aaaggtcaag gttcacaaga acatctgctc aaattaatga ccatggggga tatgaagacc
      661 ccagactttg atgacctcct ggcagcattt gacatcccag atatggtcga tcctaaagca
      721 gctattgagt ctggacacga tgaccatgaa agccacatga agcagaatgc tcacggagag
      781 gatgactccc acgcaccatc atcttctgat gtgggtgtca gcgttatcgt caagaatgtt
      841 cggaacattg actcttccga gggcggggag aaagacggcc acaaccccac tggcaatggc
      901 ttacataatg ggtttctcac agcatcctcc cttgacagtt acagtaaaga tggagcaaag
      961 tccttgaaag gagatgtgcc tgcctctgag gtgacactga aagactcgac attcagccag
     1021 tttagcccga tctccagtgc tgaagagttt gatgacgacg agaagattga ggtggatgac
     1081 ccccctgaca aggaggacat gcgatcaagc ttcaggtcga atgtgttgac ggggtcggct
     1141 ccccagcagg actacgataa gctgaaggca ctcggagggg aaaactccag caaaactgga
     1201 ctctctacgt caggcaatgt ggagaaaaac aaagctgtta agagagaaac agaagccagt
     1261 tctataaacc tgagtgttta tgaacctttt aaagtcagaa aagcagagga taaattgaag
     1321 gaaagctctg acaaggtgct ggaaaacaga gtcctagatg ggaagctgag ctccgagaag
     1381 aatgacacca gcctccccag cgttgcgcca tcaaagacaa agtcgtcctc caagctctcg
     1441 tcctgcatcg ctgccatcgc ggctctcagc gctaaaaagg cggcttcaga ctcctgcaaa
     1501 gaaccagtgg ccaattcgag ggaatcctcc ccgttaccaa aagaagtaaa tgacagtccg
     1561 agagccgctg acaagtctcc tgaatcccag aatctcatcg acgggaccaa aaaaccatcc
     1621 ctgaagcaac cggatagtcc cagaagcatc tcaagtgaga acagcagcaa aggatccccg
     1681 tcctctcccg cagggtccac accagcaatc cccaaagtcc gcataaaaac cattaagaca
     1741 tcttctgggg aaatcaagag aacagtgacc agggtattgc cagaagtgga tcttgactct
     1801 ggaaagaaac cttccgagca gacagcgtcc gtgatggcct ctgtgacatc ccttctgtcg
     1861 tctccagcat cagccgccgt cctttcctct ccccccaggg cgcctctcca gtctgcggtc
     1921 gtgaccaatg cagtttcccc tgcagagctc acccccaaac aggtcacaat caagcctgtg
     1981 gctactgctt tcctcccagt gtctgctgtg aagacggcag gatcccaagt cattaatttg
     2041 aagctcgcta acaacaccac ggtgaaagcc acggtcatat ctgctgcctc tgtccagagt
     2101 gccagcagcg ccatcattaa agctgccaac gccatccagc agcaaactgt cgtggtgccg
     2161 gcatccagcc tggccaatgc caaactcgtg ccaaagactg tgcaccttgc caaccttaac
     2221 cttttgcctc agggtgccca ggccacctct gaactccgcc aagtgctaac caaacctcag
     2281 caacaaataa agcaggcaat aatcaatgca gcagcctcgc aaccccccaa aaaggtgtct
     2341 cgagtccagg tggtgtcgtc cttgcagagt tctgtggtgg aagctttcaa caaggtgctg
     2401 agcagtgtca atccagtccc tgtttacatc ccaaacctca gtcctcccgc caatgcaggg
     2461 atcacgttac cgacgcgtgg gtacaagtgc ttggagtgtg gggactcctt tgcacttgaa
     2521 aagagtctga cccagcacta cgacagacgg agcgtgcgca tcgaagtaac gtgcaaccat
     2581 tgtacaaaga acctcgtttt ttacaacaaa tgcagcctcc tttcccatgc ccgtgggcat
     2641 aaggagaaag gggtggtaat gcaatgctcc cacttaattt taaagccagt cccagcagat
     2701 caaatgatag tttctccgtc aagcaatact tccacttcaa cttccactct tcagagccct
     2761 gtgggagctg gcacacacac tgtcacaaaa attcagtctg gcataactgg gacagtcata
     2821 tcggctcctt caagcactcc catcacccca gccatgcccc tagatgaaga cccctccaaa
     2881 ctgtgtagac atagtctaaa atgtttggag tgtaatgaag tcttccagga cgagacatca
     2941 ctggctacac atttccagca ggctgcagat acgagtggac aaaagacttg cactatctgc
     3001 cagatgctgc ttcctaacca gtgcagttat gcatcacacc agagaatcca tcagcacaaa
     3061 tctccctaca cctgccctga gtgtggggcc atctgcaggt cggtgcactt ccagacccac
     3121 gtcaccaaga actgtctgca ctacacgagg agagttggtt ttcgatgtgt gcattgcaat
     3181 gttgtgtact ctgatgtggc tgctctgaag tctcacattc aaggttctca ctgtgaagtc
     3241 ttctacaagt gtcctatttg tccaatggcg tttaagtctg ccccaagcac acattcccac
     3301 gcctacacac agcatcctgg catcaagata ggagaaccaa aaataatata taagtgttcc
     3361 atgtgcgaca ctgtgttcac cctgcaaacc ttgctgtatc gccactttga ccaacacatt
     3421 gaaaaccaga aggtgtctgt tttcaagtgt ccagactgtt ctcttttata tgcacagaag
     3481 caacttatga tggaccatat caagtctatg catggaacat tgaaaagtat tgaagggcct
     3541 ccaaacttgg gtataaactt gcctttgagc attaagcctg caactcaaaa ttcagcaaat
     3601 cagaacaaag aggacaccaa atccatgaat gggaaagaga aattggaaaa gaaatctcca
     3661 tctcctgtga aaaaatcaat ggaaaccaag aaagtggcca gtcctgggtg gacgtgttgg
     3721 gagtgtgact gcctgttcat gcagagagat gtgtacatat cccacgtgag gaaggagcac
     3781 gggaagcaaa tgaagaaaca cccctgccgc cagtgtgaca agtctttcag ctcgtcccac
     3841 agcctgtgcc ggcacaaccg gatcaagcac aaaggcatca ggaaagtgta cgcctgctcg
     3901 cactgcccag actccagacg tacctttacc aaacgtttga tgctggagaa gcacgtccag
     3961 ctgatgcatg gcatcaagga ccctgacctg aaagaaatga cagatgccac caatgaggag
     4021 gaaacagaaa taaaagaaga cactaaggtc cccagtccca agcggaagtt ggaagaacca
     4081 gttctggagt tcaggcctcc ccgaggagca atcactcaac cactgaaaaa gctgaaaatc
     4141 aatgttttta aggttcacaa gtgtgccgtg tgtggcttca ccaccgaaaa cctgctgcaa
     4201 ttccacgaac acatccctca gcacaaatcg gatggttctt cctaccagtg ccgggagtgt
     4261 ggcctctgct acacgtctca cgtctctctg tccaggcacc tcttcatcgt acacaagtta
     4321 aaggaacctc agccagtgtc caagcaaaat ggggctgggg aagataacca acaggagaac
     4381 aaacccagcc acgaggatga atcccctgat ggcgccgtgt cagacagaaa gtgcaaagtg
     4441 tgcgcaaaaa cttttgaaac tgaagctgcc ttaaatactc acatgcggac acacggcatg
     4501 gccttcatca aatccaaaag gatgagctca gccgagaaat agccacagat gctccatgag
     4561 gaaaatccct gtccacattg gaataaaaaa gacatttttg ttacaaagtt tgcagtataa
     4621 tagagttaac agtactgtct aggctgttgc aatatattct ctttcaatgt accttccttc
     4681 acctcgtcgt atatatcctc gataagtatt aaaacagtat ttgagtttaa aagagtttgt
     4741 atatatttaa atgaataact ttttatactc tttgttacat gtttgtatca gtatttagtg
     4801 gaaaaccatt tgagttgttt tgggttagaa tttttctttt tgtactgttt ctttaaaaca
     4861 gagttcttag taacaggggc agttcctgaa ttcaaataaa ccattttgta tgtttggatt
     4921 ttgaatgggt taactaatta caggctaaaa taatgccttt tttagtgttt ttaattttta
     4981 gaattcacta cataaattgt aagtaattgt gggtctcaaa aacactagga acttttaagt
     5041 gtcttagcac ttcctcgatg tgcctgccct gagggagtga gttcacattt gagacaactg
     5101 cactccagtg tggacgtgcc tttgtcttca ggccatgccg aagggtgttt aaagcagtct
     5161 tgcaggtcgc tcctttccca gccgtggata aaaactgaag ctaggaatct aataaggaat
     5221 gctgatttcc tcagttccat tttgaggaat ggggaaggct attctaaaga aaaaaatggg
     5281 atttgttttc tcggcagatc tgcaaggctg gctttaagag cacaaggagg gaaagtaacg
     5341 aaagggctgg actactataa aagttacaaa tacgtagtta gaccaataga tttatatagt
     5401 caggtttttg tcatgtaatt tattaactaa ctattacaga aacacagcta agaatatcaa
     5461 gtatttctct ggctcttgac agaaaaaaat cagttgactt aaccctttgc tgtcaaaaga
     5521 gttggcgttt cctgttctgg gtgctactgc caaacgttat ggtacttaga gtcgggatgc
     5581 acaacttcaa ccaccgactt atcaatgcag ccgcctgtgt attgcaattg gccgttacct
     5641 taagcactga gccacccggg tttagttcag ccatttcaag aagtatattt aacgtcggta
     5701 gttctgcttt attaaaatgc agcagaggta ctcttctgtc ccttccgttt atagttctct
     5761 gagagagttc tattttttgg ttttgttttg tgttttcttt tgcattttgt atcttgtatt
     5821 tatccctgaa catgttttgt accttttttt tttttttttt taagaaaagg aattcttttg
     5881 tgtatatata gatacttgca tgatatactg tagtcaatgt tcggttcctc aaaaggtctt
     5941 gctgctgtca ggtgttatgc actccatcca tcataactgt atgaaacaca tttcatatgt
     6001 aaataaacgt gggacatttg gcccttgtgc ttctgtgaga gaattattga tggtgggtct
     6061 ctgacatctt tgtgaagttt gggaagtaat taattgcagc gacaagctac agggtgttgc
     6121 agaattcttc ccactcagaa gaatggcata ttcgttctca ttagtaatca gctattttgt
     6181 cactttcttg ttgactccat cagtacatgg gtacaatccg agggtgtgaa tttcagcttg
     6241 aaattccatt gctgttcctt gttttgtttg tattgctcta agttgtattc ataatagcac
     6301 tttcatatgt ttctgcattt gaaccttgca ataagcctgt gtggtaggcc acataggtcc
     6361 gaataaccta gttttacagt tgagggagct gagctcagat tcagttcttt gccgaagccc
     6421 tcatagctgg taagtggctt tgcatattag aacccaaata ttttgctctc taaatctaat
     6481 gctcgctcta tgtggttatg tacatattga caaatattca tttattcaac aaataaaaag
     6541 tatgtacaaa acatga
//
