LOCUS       NM_001318727            6251 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens zinc finger protein 532 (ZNF532), transcript variant
            3, mRNA.
ACCESSION   NM_001318727 XM_011526061
VERSION     NM_001318727.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6251)
  AUTHORS   Fu,X.L., He,F.T., Li,M.H., Fu,C.Y. and Chen,J.Z.
  TITLE     circZNF532 promotes endothelial-to-mesenchymal transition in
            diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD
  JOURNAL   Endocr J 71 (7), 675-686 (2024)
   PUBMED   38811189
  REMARK    GeneRIF: circZNF532 promotes endothelial-to-mesenchymal transition
            in diabetic retinopathy by recruiting TAF15 to stabilize PIK3CD.
REFERENCE   2  (bases 1 to 6251)
  AUTHORS   Liang,G.H., Luo,Y.N., Wei,R.Z., Yin,J.Y., Qin,Z.L., Lu,L.L. and
            Ma,W.H.
  TITLE     CircZNF532 knockdown protects retinal pigment epithelial cells
            against high glucose-induced apoptosis and pyroptosis by regulating
            the miR-20b-5p/STAT3 axis
  JOURNAL   J Diabetes Investig 13 (5), 781-795 (2022)
   PUBMED   34839589
  REMARK    GeneRIF: CircZNF532 knockdown protects retinal pigment epithelial
            cells against high glucose-induced apoptosis and pyroptosis by
            regulating the miR-20b-5p/STAT3 axis.
REFERENCE   3  (bases 1 to 6251)
  AUTHORS   Chen,M., Zhao,S., Liang,Z., Wang,W., Zhou,P. and Jiang,L.
  TITLE     NUT carcinoma of the parotid gland: report of two cases, one with a
            rare ZNF532-NUTM1 fusion
  JOURNAL   Virchows Arch 480 (4), 887-897 (2022)
   PUBMED   35064291
  REMARK    GeneRIF: NUT carcinoma of the parotid gland: report of two cases,
            one with a rare ZNF532-NUTM1 fusion.
REFERENCE   4  (bases 1 to 6251)
  AUTHORS   Fan,L., Wang,J., Deng,P., Wang,Y., Zhang,A., Yang,M. and Zeng,G.
  TITLE     Foxhead box D1 promotes the partial epithelial-to-mesenchymal
            transition of laryngeal squamous cell carcinoma cells via
            transcriptionally activating the expression of zinc finger protein
            532
  JOURNAL   Bioengineered 13 (2), 3057-3069 (2022)
   PUBMED   35112956
  REMARK    GeneRIF: Foxhead box D1 promotes the partial
            epithelial-to-mesenchymal transition of laryngeal squamous cell
            carcinoma cells via transcriptionally activating the expression of
            zinc finger protein 532.
REFERENCE   5  (bases 1 to 6251)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 6251)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   7  (bases 1 to 6251)
  AUTHORS   Alekseyenko,A.A., Walsh,E.M., Zee,B.M., Pakozdi,T., Hsi,P.,
            Lemieux,M.E., Dal Cin,P., Ince,T.A., Kharchenko,P.V., Kuroda,M.I.
            and French,C.A.
  TITLE     Ectopic protein interactions within BRD4-chromatin complexes drive
            oncogenic megadomain formation in NUT midline carcinoma
  JOURNAL   Proc Natl Acad Sci U S A 114 (21), E4184-E4192 (2017)
   PUBMED   28484033
  REMARK    GeneRIF: The authors discovered ZNF532 associated with BRD4-NUT in
            NMC patient cells. ChIP sequencing revealed the formation of
            ZNF532-NUT-associated hyperacetylated megadomains, distinctly
            localized but otherwise analogous to those found in BRD4-NUT
            patient cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090233.16, DA108216.1, AB046849.2, AK001559.1, DB299524.1 and
            AA807005.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001318727.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. Variants 1-9 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046849.2, SRR18074969.1534588.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-79                AC090233.16        46468-46546
            80-133              DA108216.1         1-54
            134-4314            AB046849.2         15-4195
            4315-5723           AK001559.1         1946-3354
            5724-6250           DB299524.1         1-527               c
            6251-6251           AA807005.1         29-29               c
FEATURES             Location/Qualifiers
     source          1..6251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.32"
     gene            1..6251
                     /gene="ZNF532"
                     /note="zinc finger protein 532"
                     /db_xref="GeneID:55205"
                     /db_xref="HGNC:HGNC:30940"
                     /db_xref="MIM:619066"
     exon            1..204
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            205..314
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            315..2677
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     CDS             332..4237
                     /gene="ZNF532"
                     /note="isoform a is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 532 isoform a"
                     /protein_id="NP_001305656.1"
                     /db_xref="CCDS:CCDS11969.1"
                     /db_xref="GeneID:55205"
                     /db_xref="HGNC:HGNC:30940"
                     /db_xref="MIM:619066"
                     /translation="MTMGDMKTPDFDDLLAAFDIPDMVDPKAAIESGHDDHESHMKQN
                     AHGEDDSHAPSSSDVGVSVIVKNVRNIDSSEGGEKDGHNPTGNGLHNGFLTASSLDSY
                     SKDGAKSLKGDVPASEVTLKDSTFSQFSPISSAEEFDDDEKIEVDDPPDKEDMRSSFR
                     SNVLTGSAPQQDYDKLKALGGENSSKTGLSTSGNVEKNKAVKRETEASSINLSVYEPF
                     KVRKAEDKLKESSDKVLENRVLDGKLSSEKNDTSLPSVAPSKTKSSSKLSSCIAAIAA
                     LSAKKAASDSCKEPVANSRESSPLPKEVNDSPRAADKSPESQNLIDGTKKPSLKQPDS
                     PRSISSENSSKGSPSSPAGSTPAIPKVRIKTIKTSSGEIKRTVTRVLPEVDLDSGKKP
                     SEQTASVMASVTSLLSSPASAAVLSSPPRAPLQSAVVTNAVSPAELTPKQVTIKPVAT
                     AFLPVSAVKTAGSQVINLKLANNTTVKATVISAASVQSASSAIIKAANAIQQQTVVVP
                     ASSLANAKLVPKTVHLANLNLLPQGAQATSELRQVLTKPQQQIKQAIINAAASQPPKK
                     VSRVQVVSSLQSSVVEAFNKVLSSVNPVPVYIPNLSPPANAGITLPTRGYKCLECGDS
                     FALEKSLTQHYDRRSVRIEVTCNHCTKNLVFYNKCSLLSHARGHKEKGVVMQCSHLIL
                     KPVPADQMIVSPSSNTSTSTSTLQSPVGAGTHTVTKIQSGITGTVISAPSSTPITPAM
                     PLDEDPSKLCRHSLKCLECNEVFQDETSLATHFQQAADTSGQKTCTICQMLLPNQCSY
                     ASHQRIHQHKSPYTCPECGAICRSVHFQTHVTKNCLHYTRRVGFRCVHCNVVYSDVAA
                     LKSHIQGSHCEVFYKCPICPMAFKSAPSTHSHAYTQHPGIKIGEPKIIYKCSMCDTVF
                     TLQTLLYRHFDQHIENQKVSVFKCPDCSLLYAQKQLMMDHIKSMHGTLKSIEGPPNLG
                     INLPLSIKPATQNSANQNKEDTKSMNGKEKLEKKSPSPVKKSMETKKVASPGWTCWEC
                     DCLFMQRDVYISHVRKEHGKQMKKHPCRQCDKSFSSSHSLCRHNRIKHKGIRKVYACS
                     HCPDSRRTFTKRLMLEKHVQLMHGIKDPDLKEMTDATNEEETEIKEDTKVPSPKRKLE
                     EPVLEFRPPRGAITQPLKKLKINVFKVHKCAVCGFTTENLLQFHEHIPQHKSDGSSYQ
                     CRECGLCYTSHVSLSRHLFIVHKLKEPQPVSKQNGAGEDNQQENKPSHEDESPDGAVS
                     DRKCKVCAKTFETEAALNTHMRTHGMAFIKSKRMSSAEK"
     exon            2678..2859
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3036
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3037..3199
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3481
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..3594
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3595..3742
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..6251
                     /gene="ZNF532"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF532"
                     /note="hexamer: AATAAA"
     polyA_site      4620
                     /gene="ZNF532"
     regulatory      6227..6232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF532"
                     /note="hexamer: AATAAA"
     polyA_site      6251
                     /gene="ZNF532"
                     /note="major polyA site"
ORIGIN      
        1 gttcgctcgc cgcccgggcc gagccgccgc cgccgccgcc gcccggcccg gcggcgaggc
       61 cgctccaccg cacacgcaca cacagacccc ggcagcggga acgcagatga cacgcccgta
      121 acatggaagc cgccgccgcc gccgctccga cgacagcagc agcagccaca gcagcagccg
      181 ccggcggcgc cgcgctgaac aaaggcctgt tgactggggc tgcttttaac cctttcctat
      241 ttgctgagaa tgcagccgtg tgacagtaac tgaacattgg tctaaagtct ttccaaaagg
      301 tcaaggttca caagaacatc tgctcaaatt aatgaccatg ggggatatga agaccccaga
      361 ctttgatgac ctcctggcag catttgacat cccagatatg gtcgatccta aagcagctat
      421 tgagtctgga cacgatgacc atgaaagcca catgaagcag aatgctcacg gagaggatga
      481 ctcccacgca ccatcatctt ctgatgtggg tgtcagcgtt atcgtcaaga atgttcggaa
      541 cattgactct tccgagggcg gggagaaaga cggccacaac cccactggca atggcttaca
      601 taatgggttt ctcacagcat cctcccttga cagttacagt aaagatggag caaagtcctt
      661 gaaaggagat gtgcctgcct ctgaggtgac actgaaagac tcgacattca gccagtttag
      721 cccgatctcc agtgctgaag agtttgatga cgacgagaag attgaggtgg atgacccccc
      781 tgacaaggag gacatgcgat caagcttcag gtcgaatgtg ttgacggggt cggctcccca
      841 gcaggactac gataagctga aggcactcgg aggggaaaac tccagcaaaa ctggactctc
      901 tacgtcaggc aatgtggaga aaaacaaagc tgttaagaga gaaacagaag ccagttctat
      961 aaacctgagt gtttatgaac cttttaaagt cagaaaagca gaggataaat tgaaggaaag
     1021 ctctgacaag gtgctggaaa acagagtcct agatgggaag ctgagctccg agaagaatga
     1081 caccagcctc cccagcgttg cgccatcaaa gacaaagtcg tcctccaagc tctcgtcctg
     1141 catcgctgcc atcgcggctc tcagcgctaa aaaggcggct tcagactcct gcaaagaacc
     1201 agtggccaat tcgagggaat cctccccgtt accaaaagaa gtaaatgaca gtccgagagc
     1261 cgctgacaag tctcctgaat cccagaatct catcgacggg accaaaaaac catccctgaa
     1321 gcaaccggat agtcccagaa gcatctcaag tgagaacagc agcaaaggat ccccgtcctc
     1381 tcccgcaggg tccacaccag caatccccaa agtccgcata aaaaccatta agacatcttc
     1441 tggggaaatc aagagaacag tgaccagggt attgccagaa gtggatcttg actctggaaa
     1501 gaaaccttcc gagcagacag cgtccgtgat ggcctctgtg acatcccttc tgtcgtctcc
     1561 agcatcagcc gccgtccttt cctctccccc cagggcgcct ctccagtctg cggtcgtgac
     1621 caatgcagtt tcccctgcag agctcacccc caaacaggtc acaatcaagc ctgtggctac
     1681 tgctttcctc ccagtgtctg ctgtgaagac ggcaggatcc caagtcatta atttgaagct
     1741 cgctaacaac accacggtga aagccacggt catatctgct gcctctgtcc agagtgccag
     1801 cagcgccatc attaaagctg ccaacgccat ccagcagcaa actgtcgtgg tgccggcatc
     1861 cagcctggcc aatgccaaac tcgtgccaaa gactgtgcac cttgccaacc ttaacctttt
     1921 gcctcagggt gcccaggcca cctctgaact ccgccaagtg ctaaccaaac ctcagcaaca
     1981 aataaagcag gcaataatca atgcagcagc ctcgcaaccc cccaaaaagg tgtctcgagt
     2041 ccaggtggtg tcgtccttgc agagttctgt ggtggaagct ttcaacaagg tgctgagcag
     2101 tgtcaatcca gtccctgttt acatcccaaa cctcagtcct cccgccaatg cagggatcac
     2161 gttaccgacg cgtgggtaca agtgcttgga gtgtggggac tcctttgcac ttgaaaagag
     2221 tctgacccag cactacgaca gacggagcgt gcgcatcgaa gtaacgtgca accattgtac
     2281 aaagaacctc gttttttaca acaaatgcag cctcctttcc catgcccgtg ggcataagga
     2341 gaaaggggtg gtaatgcaat gctcccactt aattttaaag ccagtcccag cagatcaaat
     2401 gatagtttct ccgtcaagca atacttccac ttcaacttcc actcttcaga gccctgtggg
     2461 agctggcaca cacactgtca caaaaattca gtctggcata actgggacag tcatatcggc
     2521 tccttcaagc actcccatca ccccagccat gcccctagat gaagacccct ccaaactgtg
     2581 tagacatagt ctaaaatgtt tggagtgtaa tgaagtcttc caggacgaga catcactggc
     2641 tacacatttc cagcaggctg cagatacgag tggacaaaag acttgcacta tctgccagat
     2701 gctgcttcct aaccagtgca gttatgcatc acaccagaga atccatcagc acaaatctcc
     2761 ctacacctgc cctgagtgtg gggccatctg caggtcggtg cacttccaga cccacgtcac
     2821 caagaactgt ctgcactaca cgaggagagt tggttttcga tgtgtgcatt gcaatgttgt
     2881 gtactctgat gtggctgctc tgaagtctca cattcaaggt tctcactgtg aagtcttcta
     2941 caagtgtcct atttgtccaa tggcgtttaa gtctgcccca agcacacatt cccacgccta
     3001 cacacagcat cctggcatca agataggaga accaaaaata atatataagt gttccatgtg
     3061 cgacactgtg ttcaccctgc aaaccttgct gtatcgccac tttgaccaac acattgaaaa
     3121 ccagaaggtg tctgttttca agtgtccaga ctgttctctt ttatatgcac agaagcaact
     3181 tatgatggac catatcaagt ctatgcatgg aacattgaaa agtattgaag ggcctccaaa
     3241 cttgggtata aacttgcctt tgagcattaa gcctgcaact caaaattcag caaatcagaa
     3301 caaagaggac accaaatcca tgaatgggaa agagaaattg gaaaagaaat ctccatctcc
     3361 tgtgaaaaaa tcaatggaaa ccaagaaagt ggccagtcct gggtggacgt gttgggagtg
     3421 tgactgcctg ttcatgcaga gagatgtgta catatcccac gtgaggaagg agcacgggaa
     3481 gcaaatgaag aaacacccct gccgccagtg tgacaagtct ttcagctcgt cccacagcct
     3541 gtgccggcac aaccggatca agcacaaagg catcaggaaa gtgtacgcct gctcgcactg
     3601 cccagactcc agacgtacct ttaccaaacg tttgatgctg gagaagcacg tccagctgat
     3661 gcatggcatc aaggaccctg acctgaaaga aatgacagat gccaccaatg aggaggaaac
     3721 agaaataaaa gaagacacta aggtccccag tcccaagcgg aagttggaag aaccagttct
     3781 ggagttcagg cctccccgag gagcaatcac tcaaccactg aaaaagctga aaatcaatgt
     3841 ttttaaggtt cacaagtgtg ccgtgtgtgg cttcaccacc gaaaacctgc tgcaattcca
     3901 cgaacacatc cctcagcaca aatcggatgg ttcttcctac cagtgccggg agtgtggcct
     3961 ctgctacacg tctcacgtct ctctgtccag gcacctcttc atcgtacaca agttaaagga
     4021 acctcagcca gtgtccaagc aaaatggggc tggggaagat aaccaacagg agaacaaacc
     4081 cagccacgag gatgaatccc ctgatggcgc cgtgtcagac agaaagtgca aagtgtgcgc
     4141 aaaaactttt gaaactgaag ctgccttaaa tactcacatg cggacacacg gcatggcctt
     4201 catcaaatcc aaaaggatga gctcagccga gaaatagcca cagatgctcc atgaggaaaa
     4261 tccctgtcca cattggaata aaaaagacat ttttgttaca aagtttgcag tataatagag
     4321 ttaacagtac tgtctaggct gttgcaatat attctctttc aatgtacctt ccttcacctc
     4381 gtcgtatata tcctcgataa gtattaaaac agtatttgag tttaaaagag tttgtatata
     4441 tttaaatgaa taacttttta tactctttgt tacatgtttg tatcagtatt tagtggaaaa
     4501 ccatttgagt tgttttgggt tagaattttt ctttttgtac tgtttcttta aaacagagtt
     4561 cttagtaaca ggggcagttc ctgaattcaa ataaaccatt ttgtatgttt ggattttgaa
     4621 tgggttaact aattacaggc taaaataatg ccttttttag tgtttttaat ttttagaatt
     4681 cactacataa attgtaagta attgtgggtc tcaaaaacac taggaacttt taagtgtctt
     4741 agcacttcct cgatgtgcct gccctgaggg agtgagttca catttgagac aactgcactc
     4801 cagtgtggac gtgcctttgt cttcaggcca tgccgaaggg tgtttaaagc agtcttgcag
     4861 gtcgctcctt tcccagccgt ggataaaaac tgaagctagg aatctaataa ggaatgctga
     4921 tttcctcagt tccattttga ggaatgggga aggctattct aaagaaaaaa atgggatttg
     4981 ttttctcggc agatctgcaa ggctggcttt aagagcacaa ggagggaaag taacgaaagg
     5041 gctggactac tataaaagtt acaaatacgt agttagacca atagatttat atagtcaggt
     5101 ttttgtcatg taatttatta actaactatt acagaaacac agctaagaat atcaagtatt
     5161 tctctggctc ttgacagaaa aaaatcagtt gacttaaccc tttgctgtca aaagagttgg
     5221 cgtttcctgt tctgggtgct actgccaaac gttatggtac ttagagtcgg gatgcacaac
     5281 ttcaaccacc gacttatcaa tgcagccgcc tgtgtattgc aattggccgt taccttaagc
     5341 actgagccac ccgggtttag ttcagccatt tcaagaagta tatttaacgt cggtagttct
     5401 gctttattaa aatgcagcag aggtactctt ctgtcccttc cgtttatagt tctctgagag
     5461 agttctattt tttggttttg ttttgtgttt tcttttgcat tttgtatctt gtatttatcc
     5521 ctgaacatgt tttgtacctt tttttttttt ttttttaaga aaaggaattc ttttgtgtat
     5581 atatagatac ttgcatgata tactgtagtc aatgttcggt tcctcaaaag gtcttgctgc
     5641 tgtcaggtgt tatgcactcc atccatcata actgtatgaa acacatttca tatgtaaata
     5701 aacgtgggac atttggccct tgtgcttctg tgagagaatt attgatggtg ggtctctgac
     5761 atctttgtga agtttgggaa gtaattaatt gcagcgacaa gctacagggt gttgcagaat
     5821 tcttcccact cagaagaatg gcatattcgt tctcattagt aatcagctat tttgtcactt
     5881 tcttgttgac tccatcagta catgggtaca atccgagggt gtgaatttca gcttgaaatt
     5941 ccattgctgt tccttgtttt gtttgtattg ctctaagttg tattcataat agcactttca
     6001 tatgtttctg catttgaacc ttgcaataag cctgtgtggt aggccacata ggtccgaata
     6061 acctagtttt acagttgagg gagctgagct cagattcagt tctttgccga agccctcata
     6121 gctggtaagt ggctttgcat attagaaccc aaatattttg ctctctaaat ctaatgctcg
     6181 ctctatgtgg ttatgtacat attgacaaat attcatttat tcaacaaata aaaagtatgt
     6241 acaaaacatg a
//
