LOCUS       NM_001321981            4845 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 530 (ZNF530), transcript variant
            2, mRNA.
ACCESSION   NM_001321981 XM_011526920
VERSION     NM_001321981.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4845)
  AUTHORS   Xu,B., Roos,J.L., Dexheimer,P., Boone,B., Plummer,B., Levy,S.,
            Gogos,J.A. and Karayiorgou,M.
  TITLE     Exome sequencing supports a de novo mutational paradigm for
            schizophrenia
  JOURNAL   Nat Genet 43 (9), 864-868 (2011)
   PUBMED   21822266
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060865.1, AC003682.1 and BX106478.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001321981.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.230947.1,
                                           SRR1660809.124470.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000597700.6/ ENSP00000472024.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               BC060865.1         1-250
            251-302             AC003682.1         89440-89491
            303-601             BC060865.1         251-549
            602-4216            AC003682.1         94567-98181
            4217-4845           BX106478.1         1-629
FEATURES             Location/Qualifiers
     source          1..4845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..4845
                     /gene="ZNF530"
                     /note="zinc finger protein 530"
                     /db_xref="GeneID:348327"
                     /db_xref="HGNC:HGNC:29297"
     exon            1..250
                     /gene="ZNF530"
                     /inference="alignment:Splign:2.1.0"
     exon            251..302
                     /gene="ZNF530"
                     /inference="alignment:Splign:2.1.0"
     exon            303..432
                     /gene="ZNF530"
                     /inference="alignment:Splign:2.1.0"
     CDS             372..2072
                     /gene="ZNF530"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 530 isoform 2"
                     /protein_id="NP_001308910.1"
                     /db_xref="CCDS:CCDS92698.1"
                     /db_xref="GeneID:348327"
                     /db_xref="HGNC:HGNC:29297"
                     /translation="MQRLLYRDVMLENFAVMASLGCWCGAVDEGTPSAESVSVEELSQ
                     GRTPKADTSTDKSHPCEICTPVLRDILQMIELHASPCGQKLYLGGASRDFWMSSNLHQ
                     LQKLDNGEKLFKVDGDQASFMMNCRFHVSGKPFTFGEVGRDFSATSGLLQHQVTPTIE
                     RPHSRIRHLRVPTGRKPLKYTESRKSFREKSVFIQHQRADSGERPYKCSECGKSFSQS
                     SGFLRHRKAHGRTRTHECSECGKSFSRKTHLTQHQRVHTGERPYDCSECGKSFRQVSV
                     LIQHQRVHTGERPYECSECGKSFSHSTNLYRHRSAHTSTRPYECSECGKSFSHSTNLF
                     RHWRVHTGVRPYECSECGKAFSCNIYLIHHQRFHTGERPYVCSECGKSFGQKSVLIQH
                     QRVHTGERPYECSECGKVFSQSSGLFRHRRAHTKTKPYECSECEKSFSCKTDLIRHQT
                     VHTGERPYECSVCGKSFIRKTHLIRHQTVHTNERPYECDECGKSYSQSSALLQHRRVH
                     TGERPYECRECGKSFTRKNHLIQHKTVHTGERPYECSECGKSFSQSSGLLRHRRVHVQ
                     "
     exon            433..4845
                     /gene="ZNF530"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2992..2997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF530"
                     /note="hexamer: GATAAA"
     polyA_site      3021
                     /gene="ZNF530"
                     /note="major polyA site"
     regulatory      4788..4793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF530"
                     /note="hexamer: ATTAAA"
     polyA_site      4810
                     /gene="ZNF530"
                     /note="major polyA site"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF530"
                     /note="hexamer: AATAAA"
     polyA_site      4845
                     /gene="ZNF530"
                     /note="major polyA site"
ORIGIN      
        1 ggaacttccg gcgtcctccc tgtggcgggc actttggctt gtgtcagttc catccgcggg
       61 tgccggatct ggacctaggt gctgacagcg agaaggcgcg aggagagtcg ttttctcagc
      121 tgcacagccg gggcctgacg gtcgccggcg gtggtgacag ctttgctctt gtctccgccc
      181 ggatcgtcca ccgctcccgg cccgctccgc ccagagtccg atggcggcgg cactgagggc
      241 cccgacccag attgccacta gtacttacag gtccgtaaga agcacttgaa gaccctacaa
      301 ggcaggtttt tgtagccttt gaggatgtgg ccatttactt ctcccaggag gagtgggagc
      361 tccttgatga gatgcagagg ctcctgtacc gcgatgtgat gctggagaac tttgcagtta
      421 tggcatccct aggttgctgg tgtggagcag tagatgaggg gacgccttct gcagagagcg
      481 tttctgtgga agaactgtca cagggcagga ctccaaaggc agatacatcc actgataaga
      541 gtcacccctg tgagatttgt accccagtcc tgagagacat tttacaaatg attgagctcc
      601 atgcctcacc ctgtggacag aaattgtact tgggtggagc atcaagagat ttctggatga
      661 gttcaaacct tcaccagctc cagaagcttg ataatggaga gaagctcttt aaagtggatg
      721 gggaccaggc ctcatttatg atgaactgca ggttccatgt gtcaggaaaa cccttcacgt
      781 ttggggaagt cgggagggac ttttcagcca cctcaggact tctccagcat caggtgactc
      841 ccaccattga gagaccacac agcaggatta gacacttgag agttcccact ggacgaaagc
      901 ctctcaaata cactgaatcc aggaaatctt ttagagagaa atctgtattc attcaacacc
      961 aaagagctga ctctggagaa aggccttaca agtgcagtga atgtgggaaa tcctttagtc
     1021 aaagttctgg ctttcttcga cacaggaaag cacacggtag aacaaggact catgaatgta
     1081 gtgaatgtgg gaaatcattt agtcgcaaaa ctcacctaac tcaacaccaa agagttcaca
     1141 ctggagaaag gccttatgac tgcagtgaat gtggcaaatc ctttcgccag gtatctgtcc
     1201 tcattcaaca tcaacgagtt cacactggag aaaggcctta tgagtgcagt gaatgtggga
     1261 aatcttttag ccacagcact aacctctatc gtcacaggag tgcccacact agcacaaggc
     1321 cttatgagtg cagtgaatgt ggaaaatcct ttagccatag cactaacctc tttcgacact
     1381 ggagagttca cactggagta aggccttatg agtgtagtga atgtgggaaa gcatttagtt
     1441 gcaatatcta ccttattcac caccaaagat ttcacactgg agaaagacct tatgtgtgca
     1501 gtgaatgtgg gaaatcattt ggccagaaat ctgtcctcat tcaacaccaa agagttcaca
     1561 ctggagaaag gccttatgag tgcagtgaat gtgggaaagt ttttagccaa agctctggcc
     1621 tctttcgaca cagaagagct cacactaaaa caaagcctta tgagtgcagt gaatgtgaaa
     1681 aatcatttag ttgcaaaact gacctcattc gacaccagac agttcacact ggagaaaggc
     1741 cttatgagtg cagtgtatgt gggaaatctt ttatccgaaa aacccacctc attcgacacc
     1801 agactgttca cactaatgaa aggccttatg agtgcgatga atgtgggaaa tcctatagcc
     1861 aaagctctgc cctccttcag cataggagag ttcacactgg agaaaggcct tatgagtgca
     1921 gagaatgtgg gaaatctttt acccgcaaaa atcacctcat tcaacacaag acagttcaca
     1981 ctggagaaag gccttatgaa tgcagtgaat gtggaaaatc ctttagccaa agctctggcc
     2041 tcttaagaca cagaagagtt catgtgcagt gaatgtggga aattattttg tcactttttt
     2101 tttttttttt gagatggaat tttgctcgtc acccaggctg gagtgcaatt gtgcaatctc
     2161 agctcactgc aacctccgcc tcctgggatc aagtgattct cctgccacag cctcctgagt
     2221 acctgagatt acaggcaccc accaccatgc ccagctaatt tttgtatttt taatagaaac
     2281 aaggtttcac catgttggtc aggctggtgt tgaactcctg acctcaggta atccacctgc
     2341 ttcagcctac caaagtgctg ggattacagg cgtgagccac catgtccggc ttgtgttgtg
     2401 acatttaaca caagatttcc caaagaagaa aggccttata tatgctgtga atgtgttttt
     2461 gcttgttagt ttgttttaac ttggtatgac ggcactggag gctagccttt gagaagagcc
     2521 ttctctgatg tgactcatgt atccaaacat ccatggattt cccataaatt tgaggtatgt
     2581 gggaagcatg tgtagctatg ttgtactctc taaacctgcc cagggacctt accagattcg
     2641 tgtcactgcc agtttctgcg gctgaagcct tttcatcact acccgctggg agacccacag
     2701 agtgtgcatc agtcaccacc ccaacatgct cagggaggca gagttcttcc attagttgga
     2761 ggaaagcacg agtagtctaa gctcttaggg gggtttctca tttcctcctg tggctacata
     2821 gtgcatataa ctaccccagt gttggcccca ggacctgatc tgagttctgc tggcagcttc
     2881 cagaggattg ccttttttga ggacattgtt gatctcaggc gatgcttgtg atgaagcatt
     2941 ttttagcttc caccacttac caggaactgc ctgttaactg gcttgtgcaa tgataaaggc
     3001 cttttgttta agtaccttta atcttgtaag ttgtattaat tgttgagtag tttggaaaca
     3061 taataggact ctgtcagctt aaaagggtat ataacatttg tggggattca aattttgttt
     3121 gcctcagagg ggacagtatg ctcacagaat atagattttg ctccattttt ggcctatttc
     3181 gcattgtttc caaggccttc taggagacac tgcagggctt tctggctctg atttttgcct
     3241 gcatgtgggc tcagaggtca ttctgcagag ggggcagttg tggcaacttc cattgtttct
     3301 ggagacaaca caaagttttt cttgttgagt gaggatatca cataatgccc tgcaatgttt
     3361 agaatccctt aatgaggtcc tgtgaaggag ctgtgtccct tgaaacacag aattcagtga
     3421 gctagtgtcc ctagctataa aaccatgggg ctggagcgaa acataattgg taaagaaacg
     3481 ctgggttgaa taatagggaa tggaggagac tgcagcaaat tagatggact gttcctcata
     3541 taaagtttca tccggccggg cgcagtggct cacaccttta atcctagcac tttgggaggc
     3601 tgaggtgggt ggatcacaag gtcgggagtt caataacagc ctggccaagg tggtgaaacc
     3661 ctggaaggct gaggcagata attgcttgaa cttgggaggc agaggttgca gtgagctcag
     3721 atcacaccac tgcactccag cctgggtgac agagcgagac tgcgtctcaa aaaaaaaaaa
     3781 aaaaagatcc attcaggcca gtcacagtgg ctcatgcgtg taatccctac actttccgag
     3841 gccatggcgt gcagatcact tgaggtcagg agtcagagac cagactggcc aacatggtga
     3901 aaccccatct ctactgaaaa tacaaaaatt aaccaggtgc agtggtgcac gtctataatc
     3961 ccagctgctc tgaaggctga cgcaccaaga atagcttgaa cccggaagtg gaggttgcag
     4021 tgagctgaga ccacaccact gcactccagc ccgggtgatg gagtgagact ctgtttccaa
     4081 aaaaaaaaag gctgggcgtg gtggctcacg cctgtaatcc cagcacttta ggaggccgag
     4141 gtgggtggat aacccaaggt caggagttcg agaccagcct ggtcaacatg gcgaaaccct
     4201 gtctctacta aaagtacaaa aattgtaaaa gtaaaaagta aaagtaaaag ctgggtgtgg
     4261 tggcaggcac cagtaatcct agctactcag gagacaggca gaagaatctc ttgaacctgg
     4321 gaggtgagcc gagatcgcac cattgcactt cggcctgggc aacaacagcg aaactctgtc
     4381 tcaaaaaaaa agtatccaca aatgttccag tgactatgac tgcaagatca ctgtgtgcag
     4441 aaatctctag aaatgtgtgt cttgtagctc aagttattac tagagacaac aagggttttg
     4501 tggattcctg tagcctctct ggcctgttta cttcaaggcc attgctgcac agacaaaaaa
     4561 aaaaaaggat gaagtcaaga gagattcggt tgtccttggt gcggcttttg tgatccagta
     4621 gcaatcctct taacgctgat ggaaatggcc ttcattgctc acctgtattt cctgccactg
     4681 aagcaggtct gcctctacgt ggcctgggga gctagatggt agagtcaata gagacttagt
     4741 aaaccagact ttttgaagtg tcaatgacca agattgttat tgcatccatt aaaaaaaaat
     4801 caagttataa ttgatgtgga ataaattata tatatttaaa gtgta
//
