LOCUS       NM_032423               3994 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 528 (ZNF528), mRNA.
ACCESSION   NM_032423
VERSION     NM_032423.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3994)
  AUTHORS   Skarp,S., Xia,J.H., Zhang,Q., Loija,M., Costantini,A.,
            Ruddock,L.W., Makitie,O., Wei,G.H. and Mannikko,M.
  TITLE     Exome Sequencing Reveals a Phenotype Modifying Variant in ZNF528 in
            Primary Osteoporosis With a COL1A2 Deletion
  JOURNAL   J Bone Miner Res 35 (12), 2381-2392 (2020)
   PUBMED   32722848
  REMARK    GeneRIF: Exome Sequencing Reveals a Phenotype Modifying Variant in
            ZNF528 in Primary Osteoporosis With a COL1A2 Deletion.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010332.7, AL833325.1 and AL832630.2.
            
            On Nov 22, 2018 this sequence version replaced NM_032423.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL833325.1, SRR1803616.200180.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360465.8/ ENSP00000353652.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC010332.7         44137-44155
            20-2349             AL833325.1         1-2330
            2350-3396           AL833325.1         2333-3379
            3397-3966           AL832630.2         4201-4770
            3967-3994           AL833325.1         3950-3977
FEATURES             Location/Qualifiers
     source          1..3994
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3994
                     /gene="ZNF528"
                     /note="zinc finger protein 528"
                     /db_xref="GeneID:84436"
                     /db_xref="HGNC:HGNC:29384"
                     /db_xref="MIM:615580"
     exon            1..56
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     exon            57..309
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     exon            310..378
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     exon            379..460
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..2332
                     /gene="ZNF528"
                     /codon_start=1
                     /product="zinc finger protein 528"
                     /protein_id="NP_115799.2"
                     /db_xref="CCDS:CCDS33091.1"
                     /db_xref="GeneID:84436"
                     /db_xref="HGNC:HGNC:29384"
                     /db_xref="MIM:615580"
                     /translation="MALTQGPLKFMDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLGICLPDLSVTSMLEQKRDPWTLQSEEKIANDPDGRECIKGVNTERSSKLGSNAGN
                     KPCKNQLGFTFQLHLSDLQLFQAERKISGCKHFEKPVSDNSSVSPLEKISSSVKSHLL
                     NKYRNNFDHAPLLPQEQKAHIREKAYKCNEHGQVFRASASLTNQVIHNADNPYKCSEC
                     GKVFSCSSKLVIHRRMHTGEKPYKCHECGKLFSSNSNLSQHQRIHTGEKPYKCHECDK
                     VFRSSSKLAQHQRIHTGEKPYKCHECDKVFNQIAHLVRHQKIHTGEKPYSCNKCGKVF
                     SRHSYLAEHQTVHTGEKPYKCEECGKAFSVRSSLITHQLIHTGRKPYKCKECDKVFGR
                     KCFLTSHQRIHTRERPYGCSQCGKIFSQKSDLIRHRKTHTDEKPYKCNKCGTAFREFS
                     DLTAHFLIHSGEKPYECKECGKVFRYKSSLTSHHRIHTGEKPYKCNRCGKVFSRSSNL
                     VCHQKIHTGEKPYKCNQCGKVFNQASYLTRHQIIHTGERPYRCSKCGKAFRGCSGLTA
                     HLAIHTEKKSHECKECGKIFTQKSSLTNHHRIHIGEKPYKCTLCSKVFSHNSDLAQHQ
                     RVHS"
     exon            461..587
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     exon            588..716
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     exon            717..3994
                     /gene="ZNF528"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3973..3978
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF528"
                     /note="hexamer: AATAAA"
     polyA_site      3994
                     /gene="ZNF528"
                     /note="major polyA site"
ORIGIN      
        1 agtttccggt agacccggaa gccgattgca gggagaaact gttttcgcag cagtgcgcct
       61 cccttttcca gccaccggtt ctcctgaccc cgagtgtggg gggtgacttc agtctcctga
      121 catccagtgt tctctcgagc cagtttccag cccacagaaa atgagctctt ccggaagtgg
      181 gcatcttatt ccaatcccct ccctgtgaat gtgtggagaa aaagagatgg gaacgaggca
      241 gaggaaatag agaaattttg aaagagaaat gaagaatgag agacccatta acagaaggca
      301 aagtagaagg ttcacaaatt ttaagaaagg gagaataaag tgaaaaaaat ctcagaagga
      361 atccactcaa cagacgagga ttcacttcca aagagacata ttatgcaagg aagcaacttg
      421 gaagaggaaa gaaaagaagt caggaatggc ccttactcag ggacccttga aattcatgga
      481 tgtggccata gagttctctc aggaagagtg gaaatgcctg gaccctgcgc agaggacttt
      541 atacagggac gtgatgttgg agaattatag gaacctggtc tccctgggaa tctgtcttcc
      601 tgacctgagt gttacctcca tgttagagca aaagagagat ccctggactc tgcagagtga
      661 agagaaaata gcaaacgatc cagacggcag ggagtgcatc aaaggtgtga acacagagag
      721 gagctctaaa ttgggaagta atgcaggaaa caagccttgt aaaaatcaac ttggattcac
      781 ttttcagtta catctgagtg atctacagct atttcaagct gaaaggaaaa tttctgggtg
      841 taagcatttt gaaaaacccg tcagtgacaa ttcctcagtt tcaccgcttg aaaaaatttc
      901 ttccagtgtc aaatcccacc ttttaaataa atatagaaat aattttgatc atgctccatt
      961 acttccacaa gaacagaaag cacacattag ggaaaaagct tataaatgta atgagcacgg
     1021 ccaagtcttt agagcatctg caagccttac taaccaagta atccataacg cagataatcc
     1081 ttacaaatgc agtgaatgtg gcaaggtctt tagttgcagt tcaaagcttg tgatacatcg
     1141 aagaatgcat actggagaga agccttacaa atgtcatgaa tgtggcaagc tcttcagtag
     1201 caattcaaac ctttcacaac atcaaagaat tcatactgga gagaagcctt acaaatgtca
     1261 tgaatgtgac aaggtctttc gaagcagttc aaagcttgca caacatcaaa gaattcatac
     1321 tggagagaag ccttacaaat gtcatgaatg tgacaaggtc ttcaatcaaa ttgcacacct
     1381 tgtacgacat caaaaaattc atactggaga gaaaccttac agttgtaata aatgtggcaa
     1441 ggtctttagt cgccattcat atctagcaga acatcaaacg gttcatactg gtgagaaacc
     1501 ttacaaatgt gaagaatgtg gcaaagcatt ttcagtgcgt tccagcctca taacccatca
     1561 gttaattcac actggaagga aaccttacaa atgtaaagaa tgtgacaagg tctttgggcg
     1621 caagtgtttc ctgacctctc atcagagaat tcatactaga gagagacctt atggatgcag
     1681 tcagtgtggc aagatcttta gtcagaaatc agaccttata cgacatcgaa aaactcatac
     1741 tgatgagaag ccttacaaat gtaataaatg tggcacagcg tttagagagt tttcagacct
     1801 tactgcccat tttctaatcc atagtggaga gaaaccttat gaatgtaaag aatgtggcaa
     1861 agtcttcagg tacaagtctt ctctaaccag tcatcataga attcatactg gagagaagcc
     1921 ttacaaatgt aacagatgtg gcaaggtctt cagtcgcagt tcaaacctgg tatgccatca
     1981 gaaaattcat acaggagaaa agccttacaa atgtaatcaa tgtggcaagg tctttaatca
     2041 agcatcatac cttacaagac atcaaataat tcatactgga gagaggcctt acagatgtag
     2101 taaatgtggc aaagcatttc gagggtgttc aggccttact gcccatcttg caatccatac
     2161 tgaaaagaaa tctcatgagt gtaaagaatg tggcaagatc ttcactcaga agtcttccct
     2221 caccaatcac catagaattc acattggaga gaaaccttac aaatgcaccc tgtgcagtaa
     2281 ggtcttcagt cacaattctg accttgcaca gcatcagaga gttcattcat gagagtccct
     2341 acaaactgta tggcaaaacc atcatcatga gttctagcat taatcaacat cagtgagtcc
     2401 atactaagtg gaaatcatat aaatgaaatg tatgtgacac aggctttatc aaggcctgcc
     2461 aaatcactgg acatcaccac atcactgtgg aggatgaaag cacacagatg aattgtgtgt
     2521 acttgggcta ttattcaagg accattgcta tagaacacga taggatttac acaagaagta
     2581 actctgtctc tggttctctg atactaatct atgatattgc atgatgcaga ataatgctaa
     2641 gtcaaaatat gttgaatctc atgacctgat gtatatcaaa ggtgcaacgg cttgtaaatg
     2701 accagtttta ttcaggctat aaagcattca attatttggg gcttatagaa aaggctactt
     2761 tactctttgt gacttcgaaa tcttttcatg tgccttccat acaggccatt cactgtggtc
     2821 cctgggaaag aatcagtagg atgacagggc tgacttcatt agctgaggat tatttctatc
     2881 caatttcctg atgaaggaca ttgccttttg agattaaata ttgtctgatt tagagagcat
     2941 ggaggtgggc agagtaacat aaaactgatg accgtcatca tactgttgca gttagcacac
     3001 tttctcctga cataagtgca cagagcttca gtgtccacca actgaccatg aaatagagta
     3061 tgctgtaatc ttaaggcata ggttattagt gggaagagag taataggttg ctagtgtctg
     3121 attatatggt agaaataatg caaggaaaaa ggtagccacc ttctccattg aacagcagta
     3181 cctgctgttt agcaaagact gatgagaagt agactttttt ttttttggag atagagtctc
     3241 actctgttgc ccaggctgga gtgtagtggt gtgttcttgg ctcactgcac cctccgcctc
     3301 ctgggctcaa gcagtccttc tgccttagcc tcctaagtag ctgagactac agacgtgcgc
     3361 caccacaccc agttcatttt tgtattttta gtagagacag tgtttaccat gttggccagg
     3421 caggtctcca actcctgacc tcaagtgata tgttcacctc agcctcccaa agtgctggga
     3481 ttacaggcat gaaccatggt gcccagcctc atttttgaaa tggaatagag aacagttata
     3541 tcacagttga gagtttaatc aaaatgaccg gatcagcata ttcttttttt agatgagaca
     3601 gagtttcgcc cttgtcaccc aggctgtagt gcggtggcgc gatctcggct cactgcaacc
     3661 tccgcctccc gggttcaagc aattctcctg cctcagcctc ccaagtagct gggattacag
     3721 gcgtgtacca ccatacccag ctaatttttg tatttttagt agagatgggg tttcaccacg
     3781 ttggccacac tggtctcaaa ctcctgacct caggcgatcc atctgcctca gcctgaaagt
     3841 gctaggatta caggcgtgag ccaccacacc tggccagctc agcatattct taagtaggat
     3901 tcacatttaa ttcttggtat tataagttgc aaccatttga tttagaatgt atgcagctct
     3961 catgtttgta gtaataaagt ttcatttttc ctaa
//
