LOCUS       NM_032453               5186 bp    mRNA    linear   PRI 15-MAR-2022
DEFINITION  Homo sapiens zinc finger protein 527 (ZNF527), mRNA.
ACCESSION   NM_032453 XM_945952
VERSION     NM_032453.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5186)
  AUTHORS   Gulkovskyi,R.V., Chernushyn,S.Y., Kravchenko,S.A. and Livshits,L.A.
  TITLE     ZNF527 GENE rs386809049 ANALYSIS IN POPULATION OF UKRAINE
  JOURNAL   Tsitol Genet 49 (4), 35-39 (2015)
   PUBMED   26419067
  REMARK    GeneRIF: A high polymorphic ZNF527 allele frequency implies that
            rs386809049 polymorphism in ZNF527 gene cannot be the major cause
            of intellectual disability in the Ukrainian population.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008806.4 and DC341389.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032453.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.26349.1,
                                           SRR1803613.111019.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436120.7/ ENSP00000390179.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC008806.4         117891-117948       c
            59-495              DC341389.1         112-548
            496-5184            AC008806.4         95983-100671        c
            5185-5186           AC008806.4         95981-95982         c
FEATURES             Location/Qualifiers
     source          1..5186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..5186
                     /gene="ZNF527"
                     /note="zinc finger protein 527"
                     /db_xref="GeneID:84503"
                     /db_xref="HGNC:HGNC:29385"
     exon            1..128
                     /gene="ZNF527"
                     /inference="alignment:Splign:2.1.0"
     exon            129..202
                     /gene="ZNF527"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1999
                     /gene="ZNF527"
                     /codon_start=1
                     /product="zinc finger protein 527"
                     /protein_id="NP_115829.1"
                     /db_xref="CCDS:CCDS42559.1"
                     /db_xref="GeneID:84503"
                     /db_xref="HGNC:HGNC:29385"
                     /translation="MAVGLCKAMSQGLVTFRDVALDFSQEEWEWLKPSQKDLYRDVML
                     ENYRNLVWLGLSISKPNMISLLEQGKEPWMVERKMSQGHCADWESWCEIEELSPKWFI
                     DEDEISQEMVMERLASHGLECSSFREAWKYKGEFELHQGNAERHFMQVTAVKEISTGK
                     RDNEFSNSGRSIPLKSVFLTQQKVPTIQQVHKFDIYDKLFPQNSVIIEYKRLHAEKES
                     LIGNECEEFNQSTYLSKDIGIPPGEKPYESHDFSKLLSFHSLFTQHQTTHFGKLPHGY
                     DECGDAFSCYSFFTQPQRIHSGEKPYACNDCGKAFSHDFFLSEHQRTHIGEKPYECKE
                     CNKAFRQSAHLAQHQRIHTGEKPFACNECGKAFSRYAFLVEHQRIHTGEKPYECKECN
                     KAFRQSAHLNQHQRIHTGEKPYECNQCGKAFSRRIALTLHQRIHTGEKPFKCSECGKT
                     FGYRSHLNQHQRIHTGEKPYECIKCGKFFRTDSQLNRHHRIHTGERPFECSKCGKAFS
                     DALVLIHHKRSHAGEKPYECNKCGKAFSCGSYLNQHQRIHTGEKPYECSECGKAFHQI
                     LSLRLHQRIHAGEKPYKCNECGNNFSCVSALRRHQRIHNRETL"
     exon            203..329
                     /gene="ZNF527"
                     /inference="alignment:Splign:2.1.0"
     exon            330..425
                     /gene="ZNF527"
                     /inference="alignment:Splign:2.1.0"
     exon            426..5186
                     /gene="ZNF527"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF527"
                     /note="hexamer: AATAAA"
     polyA_site      2892
                     /gene="ZNF527"
                     /note="major polyA site"
     regulatory      4995..5000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF527"
                     /note="hexamer: ACTAAA"
     polyA_site      5021
                     /gene="ZNF527"
                     /note="major polyA site"
     polyA_site      5186
                     /gene="ZNF527"
ORIGIN      
        1 agatctcgca gagctcagag tcctgcatgc ctcagtcctc gcctcgctcc tcctcgcgga
       61 ggattctggg aggtgacgtc gcgggtctcg gtcgcggggc ccgtttgcag agcccgcggc
      121 gccgggagga ctttgttctt cttcagaaga gaaaactgaa gaaggaggaa tggctgtggg
      181 gctttgtaaa gccatgtccc aggggttggt gaccttcaga gatgtggcgc tagacttttc
      241 ccaagaagag tgggaatggc tgaagccatc tcagaaggat ttatacagag atgtcatgtt
      301 ggagaactac aggaacttgg tatggcttgg actctccatt tctaagccca acatgatctc
      361 cttactggag caagggaagg aaccgtggat ggtggagaga aagatgtcac agggtcactg
      421 tgcagactgg gagtcttggt gtgaaattga ggaattatct ccaaaatggt tcattgatga
      481 agatgaaata tcccaggaga tggtaatgga aaggctagca agtcatggcc ttgaatgctc
      541 cagtttcaga gaagcctgga aatataaggg tgaatttgag ctacatcagg gaaatgcgga
      601 gaggcatttc atgcaagtga cagctgttaa ggaaatctct actgggaaaa gagacaatga
      661 atttagtaat tctgggagaa gcatacccct gaaatcagta tttttaacac aacagaaagt
      721 tcctaccata cagcaagtac ataaatttga tatttatgat aaactcttcc cccaaaattc
      781 agtcataatt gaatataaaa gactccatgc tgagaaggaa tctttgatag gtaatgaatg
      841 tgaagaattc aaccagagta cgtaccttag taaagatata ggaattcctc ctggggagaa
      901 accttatgaa agtcatgatt tttcaaagct cttaagtttc cactcattat ttactcaaca
      961 tcagaccact cattttggaa aattacccca tggatacgat gaatgtggtg atgcctttag
     1021 ctgttactca ttctttactc aacctcagag aattcacagt ggagaaaaac catatgcatg
     1081 caatgactgt ggaaaagcct ttagccacga cttctttctc agtgaacatc aaagaactca
     1141 tattggggag aaaccttatg aatgtaagga atgtaacaaa gctttcagac agagtgctca
     1201 ccttgctcaa catcagagga tccacactgg agagaaaccg tttgcgtgca atgaatgtgg
     1261 gaaggccttt agccgttatg ccttccttgt tgaacatcag agaattcaca caggtgagaa
     1321 accatatgaa tgtaaagaat gtaataaagc cttcagacag agtgctcacc ttaatcaaca
     1381 tcagaggatt cacactggag agaaacccta tgaatgtaat cagtgtggaa aagccttcag
     1441 cagacgcata gcccttactc tacatcaaag aattcacaca ggagagaaac ccttcaaatg
     1501 tagtgaatgt gggaagacct ttggctatcg ctcacacctg aatcaacatc agagaattca
     1561 taccggagaa aagccctatg aatgcatcaa atgtgggaag ttttttagga ctgactcaca
     1621 acttaatcga catcatagaa ttcacactgg agagagacca tttgaatgca gtaaatgtgg
     1681 gaaagccttc agtgatgctt tagttctaat tcaccataag agaagtcatg caggagagaa
     1741 accctatgaa tgtaacaaat gtggaaaggc cttcagttgt ggctcatatc ttaatcaaca
     1801 tcaaagaatt catactggag agaaacccta tgaatgtagt gaatgtggga aggcttttca
     1861 tcagatcttg tccctaagac tacaccagag aattcacgct ggagaaaaac cttataaatg
     1921 taacgaatgt gggaataatt ttagctgtgt ctcagccctt agacgacatc agagaattca
     1981 taatagagaa acgctctgat tataacaagt ataggaaaga aaacatgtgg ttaccactca
     2041 atccttatta aatattagtg agttcttttt ggttagtaat tctttgaatg tagttcatat
     2101 ttcagttcat gagtatccgt tatttgaagt agctcagtag tagacatctg ttactttttt
     2161 ttttttcaga cagagtctcg ctctgttgcc caggctggag tgcagtggtg taatcttggc
     2221 tcactgcagc ctctgcctcc tgggttcaag caatcctcct gcctcagcct cctgagtagc
     2281 tgggattaca ggtgcctgcc accatacctg gctaattttt gtatttttag tagagacggg
     2341 gtttcaccac attggtcagg ctgatctcga actcctgact ttaggtgatc cacacgcctc
     2401 agactcccaa agtgctggga ttatgggcgt gagccaccgc gcctggccac atctgttact
     2461 ttttgatctg ttctatacct ggcttagccc accctcaatg catatgattc agatgaaact
     2521 gttaatcagg gacagcagtg gactggtcac aggctggcca attatttccc ccaacctagt
     2581 gataagggat tggcaaatgg ccctgtctgg atcaatgaag tcctttgcgg gtattcctat
     2641 gggcagtaag agaggtttta ttctggaact gcaagtttca aggatttaat aagattaaaa
     2701 actcaccagt agcctttttg ccactcatga ggaaagcttt cccaaagaga aatctaacag
     2761 aggaaaatgg agatgagaga cagaaatatg atgatacagc ttgatctcct ggatccagtc
     2821 attcctgaca gctacaccat caccatcctt tttcattttt tgtgatccaa taaatttcct
     2881 ttttttgctt aatttggatt atatttttgc ctcatggaat tagagtgctg attcacacat
     2941 tctatgtttg ctatacataa aagaaagcct taatttttta cgtggcataa ttatttatcc
     3001 tgaggagcaa ccttctgata taacaagttt atgaaagttg aatacacagc cttcataaaa
     3061 ctgagataat tgttacattt tatttgtcga taaaactatt ttagtgtttc ttagtttttt
     3121 tcacattatg gctgaatatt ttaaaattca ccaagtaaaa ttctttaaca ggcttcccct
     3181 taaggagtta aaatcatttg tcacagtgac tcaccatttg cctgtaaaga gagaatggaa
     3241 agctaagaga ataatacttt catttgttta atgaatggct cttcatcttc aaggaattac
     3301 ttgattttct tctttcagta tgggtctaaa catattctgt ggcagaatat aataacaatt
     3361 aaattgtaaa tgaggtcttt tgtgggtggg ctctaaattt ggtttaagac ccagtgcggt
     3421 ggctcacgcc tgtaatccga gcactttggg aggccgaggt gggcagatca cctgaggtca
     3481 ggagttcgag accagcctga ccaacatgga gaaaccccgt ctctactaaa aatacaaaat
     3541 tagccgggtg tggtggtgcg tgcttgtaat cccagctact caggagggtg aggcaggaga
     3601 atcacttgaa cctgggaagt ggaggttaca gtgagcgaag atcgcgccat tgtactccag
     3661 cctgggcaac aagagcgaaa ctccttctca aaaaaaaaaa aaaaaaaaaa ataaataaat
     3721 aaataaataa ataaatttgg tttaagaagt gtatggataa cttctttgca gctagagata
     3781 tcaaacaaag atattgctgg cagaaagaat gagtcatttt taacaaatgg taaaagtaaa
     3841 gcagttaatg cctaaaattt ttagagacta aatcatttcc attattggga gtaatgagga
     3901 agatgaaggt gtagggcaat acgtttcttt tttatctgag tggatatagg gaaataaact
     3961 ggtgatatgg cagctgggcc atcttgaata gtgagaacca gtaagaatat tgggtattgc
     4021 ctgaagagca tctgtaaaaa catatcagaa caaatgaaag aggaaagaat gaaggattta
     4081 tatgtgtgca tagagtgaat atatgtgtgc atagagtgaa atattcaact tatacttatt
     4141 tctaataaaa tctgaaaatt atttttcata aatattcaaa ttccctttaa acagcttaaa
     4201 atacagattt agtgactcag tacttcaaac cttgaataga aacaaatatg attataaaat
     4261 atttccaaac ttatgttaca tctaatctga aacatattaa tattataagc ttaattcatg
     4321 tcatcatttc tttatttttt attatatttc ctggaggtat aaggatattt atttttataa
     4381 tttccaagca ctgagtaata atttatttca gaaagtttca gaaggttaca gtaaacttta
     4441 ccaaacttga agaagaatga ctcagatcag taagaagagt ctgagttact cactaattga
     4501 tttttatttt atttatttat tttttttgag acagggtctc actctgttat ccaggctgga
     4561 atgcggtgac acaatcatgg ctcactgcag cctcaacttc ccaggctcaa gcgaccctcc
     4621 cacctcagcc tcctgagtag ctgggactac aggtgtgctc taccacacct ggctaagttt
     4681 cgcgtttttc tgtagagatg gggtttcgcg agttgcccag gctggtctcc aactcttggc
     4741 ctgaagtgat ttgcccatct cggcttccca aagtgctgag attataggga tgagtcactg
     4801 tgcacagcta ctaattgatt tttgatctat gtatggcacc tgatttcatc ctcgagagtg
     4861 acgtaaacct aagctactgg ttcattctct gtttatatag ttaaacttca cttgtaatgt
     4921 tgataaaatc ttttgtaccc atgtgtttag cttcagtgta ttttacaatc tgatgtttct
     4981 cctcacaatg aagtactaaa ttttgtttct tttcaactgt acaacccatt gtcttgtgat
     5041 atattgacct gatctcttag gattagtgaa aatttatgct ttattaatat ttgattgtta
     5101 ttaggaccat ctagagattt ctgtttatgt gtgtgtatgt gcatctgaag atgtgtattt
     5161 tatttaaatt ttttgtatta agtgcc
//
