LOCUS       NM_153219               1185 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 524 (ZNF524), mRNA.
ACCESSION   NM_153219
VERSION     NM_153219.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1185)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 1185)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1185)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 1185)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   5  (bases 1 to 1185)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 1185)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008735.9, HY097571.1, BC067748.1 and BC014666.1.
            
            On Nov 22, 2018 this sequence version replaced NM_153219.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.51860.1,
                                           SRR1163655.518496.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301073.4/ ENSP00000301073.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC008735.9         76008-76059         c
            53-83               HY097571.1         1-31
            84-310              BC067748.1         3-229
            311-1173            AC008735.9         73221-74083         c
            1174-1185           BC014666.1         1065-1076
FEATURES             Location/Qualifiers
     source          1..1185
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..1185
                     /gene="ZNF524"
                     /note="zinc finger protein 524"
                     /db_xref="GeneID:147807"
                     /db_xref="HGNC:HGNC:28322"
     exon            1..121
                     /gene="ZNF524"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1185
                     /gene="ZNF524"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..954
                     /gene="ZNF524"
                     /codon_start=1
                     /product="zinc finger protein 524"
                     /protein_id="NP_694951.1"
                     /db_xref="CCDS:CCDS12929.1"
                     /db_xref="GeneID:147807"
                     /db_xref="HGNC:HGNC:28322"
                     /translation="MDTPSPDPLPSPLPGEEEKPLALSPPVPRGRRGRRPGGATSSNR
                     TLKASLPRKRGRPPKSGQEPPLVQVQGVTAPVGSSGGSDLLLIDDQGVPYTVSEGSAA
                     GPEGSGPRKAPHFCPVCLRAFPYLSDLERHSISHSELKPHQCKVCGKTFKRSSHLRRH
                     CNIHAGLRPFRCPLCPRRFREAGELAHHHRVHSGERPYQCPICRLRFTEANTLRRHAK
                     RKHPEAMGVPLCAPDPGSEPPWDEEGIPATAGAEEEEETEGKGEPA"
     regulatory      1165..1170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF524"
                     /note="hexamer: AATAAA"
     polyA_site      1185
                     /gene="ZNF524"
                     /note="major polyA site"
ORIGIN      
        1 gccgcccccg cctcgccgcc gccgaggggc agggccccct caccccctcc ccttcccacg
       61 cgccggcccc gttgcccccg cgcgcgcgca cactcgcgag ccccggcgac atgcaaatga
      121 gctggctcca gtgcccagac ccaagccccc cactgctcaa tggacacccc cagcccagac
      181 ccgttgcctt cgcctttgcc cggggaggaa gagaaacctc tggccttatc tcctcctgtt
      241 ccccggggcc gccgaggccg tcgtcctggg ggagccacct cctcaaatcg gacactcaag
      301 gcctccctcc ctcgcaagcg gggccgcccc cccaagtcag ggcaggagcc cccactggtg
      361 caggtgcagg gggtgacagc cccagtaggc agcagtggcg ggagcgacct cctcctgatc
      421 gatgatcagg gtgtgcccta tacggtctct gaaggttcag cggctgggcc tgagggctct
      481 ggccccagga aggccccaca cttctgcccg gtgtgcctgc gggccttccc ctacctctcc
      541 gacctggagc gccacagcat ctcgcactca gagctgaagc cgcaccagtg caaggtttgc
      601 ggcaagacct tcaagcgctc cagccacctg cggcggcact gcaacatcca tgccggcctg
      661 cggcccttcc gctgcccgct gtgcccccgc cgcttccgcg aggcgggcga gctggcgcac
      721 caccaccgcg tgcactcggg ggagcgcccg taccagtgcc ccatctgccg gctgcgcttt
      781 acagaggcca acacgctccg gcgccatgcg aagcgcaagc acccggaggc catgggggta
      841 cccctgtgtg caccagatcc agggtctgaa ccgccgtggg acgaggaggg catcccggcc
      901 acagcagggg ccgaggagga ggaggagaca gaggggaaag gggagccggc ctgacccaca
      961 cccccggcca tcgctccctg ggccaggttt agagcaggga gtttggctgg tgctgggcct
     1021 gagccagggg gccgggacac ccttgtttcc ggtggtcttc ccgttgtggg agcaggtgga
     1081 gggtggagac ctaaactttg gggtccagct gccttcagcc cccctccccc agactaacag
     1141 acccttggag gcaggggctg tggaaataaa tctctgcctg ctggc
//
