LOCUS       NM_145287               6760 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 519 (ZNF519), transcript variant
            1, mRNA.
ACCESSION   NM_145287 XM_940357
VERSION     NM_145287.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6760)
  AUTHORS   Shi,J., Ding,F., Dai,D., Song,X., Wu,X., Yan,D., Han,X., Tao,G. and
            Dai,W.
  TITLE     Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is
            suppressed by hsa-miR-200b-3p
  JOURNAL   Sci Rep 14 (1), 6568 (2024)
   PUBMED   38503887
  REMARK    GeneRIF: Noxa inhibits oncogenesis through ZNF519 in gastric cancer
            and is suppressed by hsa-miR-200b-3p.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6760)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA525188.1, BC024227.1 and AC006557.2.
            
            On Jun 2, 2019 this sequence version replaced NM_145287.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.249771.1,
                                           SRR1660809.211905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590202.3/ ENSP00000464872.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                DA525188.1         56-88
            34-656              BC024227.1         33-655
            657-6760            AC006557.2         47297-53400
FEATURES             Location/Qualifiers
     source          1..6760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..6760
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /note="zinc finger protein 519"
                     /db_xref="GeneID:162655"
                     /db_xref="HGNC:HGNC:30574"
     exon            1..161
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1781
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /codon_start=1
                     /product="zinc finger protein 519"
                     /protein_id="NP_660330.2"
                     /db_xref="CCDS:CCDS32797.1"
                     /db_xref="GeneID:162655"
                     /db_xref="HGNC:HGNC:30574"
                     /translation="MELLTFRDVAIEFSPEEWKCLDPAQQNLYRDVMLENYRNLVSLA
                     VYSYYNQGILPEQGIQDSFKKATLGRYGSCGLENICLWKNWESIGEGEGQKECYNLCS
                     QYLTTSHNKHLTVKGDKEYRIFQKKPQFLSAAPTEPCIPMNKYQHKFLKSVFCNKNQI
                     NFNHDSNISKHHSTHFLENYYNCNECEKVFYQSSKLIFPENIHIQKKPYNSNECGETS
                     DPFSKLTQHQRIYIGESSQRCNKKCIIVFSQSHLKGHKIINTGEKSVKYKERGKAFTR
                     GLHLGHQKIHTGEKPYKCKKCDKAFNKSSHLAQHQRIHTGEKPFKCKECGKAFNRGSY
                     LTQHQRIHTGERAFKCEECGKAFNRGSYLTQHQRIHTGEKPFRCKECGKAFNRSSYVT
                     QHQRMHTGEKPFKCKECGKAFNRASHLTQHQRIHTGEKHFKCKECGKAFNRGSHLTRH
                     QRIHTGEKSFKCEECGKAFIWGSHLTQHQRVHTGEKFFKCKECGKAFTRSSHLTQHQR
                     IHTGEKPFKCKECGKAFNRRSTLTQHQIIHTR"
     exon            162..288
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /inference="alignment:Splign:2.1.0"
     exon            289..6760
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6734..6739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /note="hexamer: AATAAG"
     polyA_site      6760
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /note="major polyA site"
ORIGIN      
        1 tgtctcactt cagccagagc gcggggttag ggcttcattg ccttgtgtcc tctgctccgg
       61 gagacttcgg tgattctgcc actcactccg tcgctctgtg acctgctggc attgaatgat
      121 ttatagctaa gactccagga cacccctgaa gccgagaaat ggaactctta acattcaggg
      181 atgtggccat agaattctct ccagaagagt ggaaatgcct agaccctgcc caacagaatt
      241 tatatagaga tgtgatgttg gagaactaca gaaacctcgt ctccctggct gtgtattctt
      301 attacaacca aggcatttta ccagagcaag gcatacaaga ttcattcaaa aaagcaacac
      361 tgggaagata tgggagctgt ggccttgaaa atatatgctt atggaaaaac tgggaaagta
      421 taggtgaagg tgaaggacaa aaggaatgtt ataatctatg tagccaatat ttgacaacta
      481 gtcataacaa acatttaact gtgaaaggag acaaagaata tagaatattt cagaagaagc
      541 ctcagtttct gtcagctgct cctacagaac catgtattcc tatgaataaa tatcaacata
      601 aatttttgaa atctgtcttt tgtaataaaa atcagataaa ttttaaccat gactcaaata
      661 ttagtaaaca tcatagtact cattttctag aaaactatta caattgtaat gaatgtgaaa
      721 aagtatttta ccaatcctca aagcttattt tccctgaaaa tatccatatt caaaaaaagc
      781 cttacaactc taatgaatgt ggtgaaactt ctgacccatt ctcaaagctt actcaacatc
      841 aaagaattta tattggagag agctcacaaa gatgtaataa aaaatgtata atagtcttta
      901 gtcaatcaca tctaaaggga cataagataa ttaacactgg agaaaaatca gtgaaatata
      961 aagaacgtgg caaagctttt accaggggct tacatcttgg acatcagaaa attcatactg
     1021 gagagaaacc ttacaaatgt aaaaaatgtg acaaagcctt taacaagagt tcacaccttg
     1081 ctcaacatca gagaatccat actggagaga agcctttcaa gtgtaaggaa tgtggcaaag
     1141 cttttaacag aggctcatac cttactcaac atcagagaat ccatactgga gagagagctt
     1201 tcaaatgtga agaatgtggc aaagccttta acagggggtc ataccttact caacaccaga
     1261 gaatccatac cggagagaaa cctttcagat gtaaggaatg tggcaaagcc tttaatagaa
     1321 gctcatacgt tactcagcat cagagaatgc atactggaga gaaacctttc aagtgtaagg
     1381 aatgtggcaa agcttttaac agagcttcac accttactca acatcagaga atccatactg
     1441 gagagaaaca cttcaaatgt aaagaatgtg gcaaagcctt taacaggggc tcacacctta
     1501 ctcgacatca aagaatccat actggagaga agtctttcaa atgtgaagaa tgtggcaaag
     1561 cttttatctg gggctcacac cttactcaac atcagagagt ccatactgga gagaaattct
     1621 tcaaatgtaa agaatgtggc aaagctttta ccaggagctc acaccttact caacatcaga
     1681 gaattcatac tggagagaaa cctttcaaat gtaaagaatg tggcaaagct tttaacagac
     1741 gctcaaccct tactcaacat caaataattc ataccaggta gaaaccctgc aagtgtaaag
     1801 aatgtgctaa aaccctaaac tggtgctcac accttactca acattagaaa atcaatactg
     1861 gatagaaatc ccatatgtgt aatgattttt gaaacatcaa aatgaagatt aaataaaaat
     1921 tagaagtgtc actttagaaa gaactaaggt gctagcactt ccgtaaatta ctctgaatca
     1981 gtgtgtttat tataacaaat aattcaaact caattagata attaaattgt atgtttaaaa
     2041 agagggacga cattgatgga gaggcataat tatattcaat gttcacttat ttttgtaatc
     2101 acagtattca tgattgagaa agtattattg atgtaattaa attcaaatta accttttttt
     2161 tccccactgt ggttgattat tgctgtctct gacatgagag tcccttctac gttaggtagg
     2221 catcattcac atgtctcatt cacatgtcat cattcacatg tctcatgacg tcattcacaa
     2281 gtttcccatg gaagactaag agcattggca tataggatgt atgatgaaat ctaaatggag
     2341 ttgctctttt tgtttgactt acaacactga atataagtca tatatgagtt aggtgttcag
     2401 aatattattg ttctgcatta aagtgtgaga cagaaacact ctgagtttta gatatgaata
     2461 gttttaccaa ctacccatta aaaggtcttg ctagtccatt aatattctaa tgtatcttca
     2521 tagcagcaag ttagaagtcc tgaatgttac tgtgataaca ataaagaaat cacaaatatc
     2581 agagagtggt gcaaataact tctctctggt agaacataga ttattaattc aatcctctaa
     2641 atacttaggc tcagtttaag aaaagagaga acacattttt ttaacatagg tcatggtatc
     2701 agaataagaa tgctttttga atgtttgcag tctgtaattt tgatgattga ggaaactgga
     2761 ttttgaaatg ctttattcag tctgtaaact taattttttt ttaagaataa aatgaaatgt
     2821 cttttaattt gttaacactg ttgcttattg aataatgtct tatcctgaca aaaatgttaa
     2881 cttattccac cttgctcaag attccaggta gtaaatggta atgatatact atcgggtatg
     2941 tctagttcat gctgtcttta gcattttttt acccttagtg gtattaaact ccaaatagtt
     3001 tggagaatgt tgattccata agttattact tgttactcta acaagttccc caaggtgtgt
     3061 tgagtagtta attagccctt agctattttt accaaacatt aggttattaa tttaaaattg
     3121 tttgttttta atgtaggtgt ttactgctat gaatttctct gaacagtttg ctgcatctca
     3181 tgtttcgata tgtcataact tcattttcat ttatctgaaa atattttcca gtttcatttt
     3241 ttctttaaca cattaattag gagtattttt aatttccata tatttgtgag ttccccccat
     3301 tttctgcatt catttatttt taatttcctt ttactaaagt cagggaaaat actttggatt
     3361 attttgatcc tgttaatttt attgacgttt tcctgctgta tggcctagca tatggtctat
     3421 cctggagaat gatttatgtg tacttctaat tttgagtgga aaattctata aatttgagaa
     3481 ttctatcagt tcatatttgt ttacagtgtt caagtgttat gttttcctgt tgatcttccc
     3541 actttttctg cccattattt acattggagt atagaagttt ctatacttct gataaactcc
     3601 aaataatgga tttgattatt taatctattt atagcctgta atattatcag tatagttgaa
     3661 tttgcatcat tttgctttct atttttatgt ctcacgtatt tttctttatt cttcctttac
     3721 tgctttctta ttactttcca tataatcttt taatttatat aattgttcat gtttttgaag
     3781 ttacttcctt gttttctcta gcccttatat accttatcag aatctgcttt atatttatat
     3841 taattccaat gagatataaa atattaccac tatatagctt ttttccccca atttggattg
     3901 aatttttaaa atattgtctt aatttagttt tattgtttta ttaaaaaagc taaacttaac
     3961 aaaattggtt gtatattagt ttaggtgagg ttgttttgta atgagaaaat aatttacaac
     4021 atatagagaa taaattatta ttattttaaa aagtactcta cattttgtat ccttaccatt
     4081 tcctttgata gtttaaaatt gtaattctct aaataagaga tatattcata aatgtgactt
     4141 gtaaatgttg aaatttatat gtttgctttt tctgcattca gtaagggtag tagtttccag
     4201 catctgtgcc tctttaaagt gaaagacagg ggcaggcgta gtggctaatg cctgtaatcc
     4261 cagcacttcg ggaggcccag gtgggtggat cacctgaggt caggagttcg agactagcct
     4321 agccaactta gtaaaaccct ctctctacca aaaatacaaa aaattagctg ggtgtggtgg
     4381 tgggctcctg taatcccagc tacttgggag gctgagacag gaaaatcact taaacctgag
     4441 aggtggaggt tgcagtgagc caagatcatg tcactgcact gcagcctggg cagcagagtg
     4501 agactccatc tctaaataag taaattcagc ctgggcaaca tgtgagactc catctctaaa
     4561 taaataaata aatgaatgaa tgaatgatag gatggaatta aaatagtttg aaaacacaaa
     4621 ttaacaaaat ggtgttgaca aagattgttc atttgtggtc taccagggca taaaattctc
     4681 aaaaaacata atcagtagga aacctcttta ttcctgaata ttagagaata ttatatgtct
     4741 taaaattatt catgttgaaa agctctgcct ttcatgcatt taggagaaaa agtagagggc
     4801 aggaggttta tgtagactct ggtctgtgcc tgatttgggg aatggaaaga ctcgacagaa
     4861 gaggccaggt cagccaagca gggctctgtt gcgtgcaaga ttaactgctg gtttgtcttt
     4921 gcagagctcc acacagaaca tcatcaaaga actgatggac acttcatctc cctgggtgag
     4981 gggcaggtgt accatgctgt catggccatt cctgcctcga ttggggtgtg ggtgtagaga
     5041 tggtctctat aaccagggcc cagacatggc tgagaaggcc ttctgccagg actccacctt
     5101 gatgactcac aggactttgt gccttggctt tccctattga gtgacccaca gttttaatcc
     5161 aagggaccct gagtctgttt ccttccttca gccccaccat ttcaccccag cactgttcag
     5221 gtgtacaatc ggctttcaca tatttgtaag aatatctagg aaaattattt atattttact
     5281 ttcacttcat gttatgacca tgagtgtttt tgcatttgct agggctcatt gttttaattg
     5341 gccccccttt atccctctga gtgcggaaat aaatcagccc taaatctgga tgagacctgc
     5401 aggtggactc catcagtgca ggcgtggtgg ggcagcagga ggagcccgtg gtgcccacct
     5461 tccagagctg ccacctcttt tacctcctca tgttccttcc tgtgcaccta gagagagttc
     5521 acccccaccc aacagctcct ggacctgctg cccaaaaggt aagtgctcca tccctccaca
     5581 gcacaagggg gactcagcca cctattatct gtgtcttggg aaagtccctt cacatttgtg
     5641 ggcttcagtt tgcttctttg gaactggggt tctaagaagc ctaacatgat atgattgttt
     5701 caagaactaa atgagataag ctatggaaag tacttcagac ttggccttgt agaaagcact
     5761 gctgagggaa tagattggtt attcatatta taaaactatt taaaactcta gaaaactata
     5821 gtaagatata agattataaa aatatcaaaa ctaagatatt gacagtaata gaattaacct
     5881 actcatctat ttgcatttta ccagattaat tttttcttat gtgtgtgtgt tctgtgcaat
     5941 tttattacat gtgtaggttc acctaccaga agattaactc gttttcctct tataaccaca
     6001 tccgcttccc ttctccccac catacccact ctgattctga ttctttgaaa ccattaattt
     6061 ctatttctgc aaatttgtca ttccaataat gttatataaa tgaaatcata acctgtgcaa
     6121 ccttttgtaa ttggcccttt tccttcagca taattccttg gagattcatc taaattggtt
     6181 tatgttttag tttgttcctt ttgttattgc tgtgggtttt catgtgtgga tgttaccatg
     6241 aaatactgtg tgtaaccctt cactctttca agaacatatt tgttgttttc agtcagtgtg
     6301 tggctattat gaataaaagt gctatgtaca ttcatgtact aggtttcata tgaatacatg
     6361 ttttcattac tctggaaaat atttccagca tacaattcct ggctcatagg gtagttacaa
     6421 gtttaatttt aatagaaact agcactctgt tatccagagt gactatcatt ttacattccc
     6481 atcatcaatg aatttctgtt ttttcaaatc ctcttagcca tactgactga tatgtattga
     6541 tatcacattg ttttaatgta catttttcta aaggataata atgttgaact ttatttaatg
     6601 ttctcatatg acatctgcct attatctctg atgaaatgtt tattcatgtc tgcatgtttt
     6661 ctaattgtat ttgttttctt gcaagttttg agagttctgt ttatattctg gttactagct
     6721 cacataggca ataaataagt tttttttcca caaagaaaaa
//
