LOCUS       NP_660330                540 aa            linear   PRI 28-APR-2025
DEFINITION  zinc finger protein 519 [Homo sapiens].
ACCESSION   NP_660330 XP_945450
VERSION     NP_660330.2
DBSOURCE    REFSEQ: accession NM_145287.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 540)
  AUTHORS   Shi,J., Ding,F., Dai,D., Song,X., Wu,X., Yan,D., Han,X., Tao,G. and
            Dai,W.
  TITLE     Noxa inhibits oncogenesis through ZNF519 in gastric cancer and is
            suppressed by hsa-miR-200b-3p
  JOURNAL   Sci Rep 14 (1), 6568 (2024)
   PUBMED   38503887
  REMARK    GeneRIF: Noxa inhibits oncogenesis through ZNF519 in gastric cancer
            and is suppressed by hsa-miR-200b-3p.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 540)
  AUTHORS   Cronin,S., Tomik,B., Bradley,D.G., Slowik,A. and Hardiman,O.
  TITLE     Screening for replication of genome-wide SNP associations in
            sporadic ALS
  JOURNAL   Eur J Hum Genet 17 (2), 213-218 (2009)
   PUBMED   18987618
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA525188.1, BC024227.1 and AC006557.2.
            
            On Feb 27, 2010 this sequence version replaced NP_660330.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.249771.1,
                                           SRR1660809.211905.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000590202.3/ ENSP00000464872.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..540
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     Protein         1..540
                     /product="zinc finger protein 519"
                     /calculated_mol_wt=62889
     Region          4..>43
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          183..229
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          290..>539
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          294..314
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          322..342
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          350..370
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(355,357,359,361..362,365..366,369,383,385,389..390,
                     393..394,397,411,413,415,417..418,421..422,425)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          378..398
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          402..>454
                     /region_name="SUF4-like"
                     /note="N-terminal domain of Oryza sativa transcription
                     factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana
                     SUF4 (AtSUF4), and similar proteins; cd20908"
                     /db_xref="CDD:411020"
     Site            order(406,409,422,431,434,437,450,454)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:411020"
     Region          406..431
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          406..426
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(411,417,424,430,433,440)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:411020"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:411020"
     Region          434..454
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(439,441,443,445..446,449..450,453,467,469,473..474,
                     477..478,481,495,497,499,501..502,505..506,509)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          462..482
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          490..510
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          518..538
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..540
                     /gene="ZNF519"
                     /gene_synonym="HsT2362"
                     /coded_by="NM_145287.4:159..1781"
                     /db_xref="CCDS:CCDS32797.1"
                     /db_xref="GeneID:162655"
                     /db_xref="HGNC:HGNC:30574"
ORIGIN      
        1 melltfrdva iefspeewkc ldpaqqnlyr dvmlenyrnl vslavysyyn qgilpeqgiq
       61 dsfkkatlgr ygscglenic lwknwesige gegqkecynl csqylttshn khltvkgdke
      121 yrifqkkpqf lsaaptepci pmnkyqhkfl ksvfcnknqi nfnhdsnisk hhsthfleny
      181 yncnecekvf yqssklifpe nihiqkkpyn snecgetsdp fskltqhqri yigessqrcn
      241 kkciivfsqs hlkghkiint geksvkyker gkaftrglhl ghqkihtgek pykckkcdka
      301 fnksshlaqh qrihtgekpf kckecgkafn rgsyltqhqr ihtgerafkc eecgkafnrg
      361 syltqhqrih tgekpfrcke cgkafnrssy vtqhqrmhtg ekpfkckecg kafnrashlt
      421 qhqrihtgek hfkckecgka fnrgshltrh qrihtgeksf kceecgkafi wgshltqhqr
      481 vhtgekffkc kecgkaftrs shltqhqrih tgekpfkcke cgkafnrrst ltqhqiihtr
//
