LOCUS       NM_053042               6954 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens zinc finger protein 518B (ZNF518B), transcript variant
            1, mRNA.
ACCESSION   NM_053042 XM_114418
VERSION     NM_053042.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6954)
  AUTHORS   Riffo-Campos,A.L., Castillo,J., Vallet-Sanchez,A., Ayala,G.,
            Cervantes,A., Lopez-Rodas,G. and Franco,L.
  TITLE     In silico RNA-seq and experimental analyses reveal the differential
            expression and splicing of EPDR1 and ZNF518B genes in relation to
            KRAS mutations in colorectal cancer cells
  JOURNAL   Oncol Rep 36 (6), 3627-3634 (2016)
   PUBMED   27805251
  REMARK    GeneRIF: ZNF518B exhibits a pattern of isoform abundance dependent
            on KRAS G13D and G12D mutations.
REFERENCE   2  (bases 1 to 6954)
  AUTHORS   Zhang,X.Y., Geng,T.T., Liu,L.J., Yuan,D.Y., Feng,T., Kang,L.L.,
            Jin,T.B. and Chen,C.
  TITLE     SLC2A9 and ZNF518B polymorphisms correlate with gout-related
            metabolic indices in Chinese Tibetan populations
  JOURNAL   Genet Mol Res 14 (3), 9915-9921 (2015)
   PUBMED   26345926
  REMARK    GeneRIF: SLC2A9 and ZNF518B polymorphisms correlate with
            gout-related metabolic indices in Chinese Tibetan populations
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6954)
  AUTHORS   Jin,T.B., Ren,Y., Shi,X., Jiri,M., He,N., Feng,T., Yuan,D. and
            Kang,L.
  TITLE     Genetic variations in the CLNK gene and ZNF518B gene are associated
            with gout in case-control sample sets
  JOURNAL   Rheumatol Int 35 (7), 1141-1147 (2015)
   PUBMED   25591661
  REMARK    GeneRIF: CLNK and ZNF518B SNPs may have potential as diagnostic and
            prognostic marker for Chinese gout patients.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110768.5, BC040874.1, CD656908.1 and AL833306.1.
            
            On Nov 22, 2018 this sequence version replaced NM_053042.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.86079.1,
                                           SRR1803611.273721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326756.4/ ENSP00000317614.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC110768.5         96647-96664         c
            19-294              BC040874.1         1-276
            295-550             CD656908.1         277-532
            551-1551            AL833306.1         69-1069
            1552-6954           AC110768.5         79118-84520         c
FEATURES             Location/Qualifiers
     source          1..6954
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..6954
                     /gene="ZNF518B"
                     /note="zinc finger protein 518B"
                     /db_xref="GeneID:85460"
                     /db_xref="HGNC:HGNC:29365"
                     /db_xref="MIM:617734"
     exon            1..110
                     /gene="ZNF518B"
                     /inference="alignment:Splign:2.1.0"
     exon            111..294
                     /gene="ZNF518B"
                     /inference="alignment:Splign:2.1.0"
     exon            295..6954
                     /gene="ZNF518B"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..3730
                     /gene="ZNF518B"
                     /codon_start=1
                     /product="zinc finger protein 518B"
                     /protein_id="NP_444270.2"
                     /db_xref="CCDS:CCDS33960.1"
                     /db_xref="GeneID:85460"
                     /db_xref="HGNC:HGNC:29365"
                     /db_xref="MIM:617734"
                     /translation="MKDIGQQLYTTHLNGGHNSLTMSPKQPDANGAPRPNRQEAQTLL
                     YQGSEAEAAMMTIATCAKCKSVHKISLQDLQKGTGKDGMYVCFQCSLGAAPPNFHFVS
                     NNSSATHVGNKTENFSSSVNSKFKVRNFKPGKYYCDKCRFSTKDPLQYKKHTLQHEEI
                     KFICSHCSYISYTKGEFQRHLVKHTGIFPYQCEYCDYGAIRNDYIVKHTKRVHERAGA
                     KRPVKAVAKLEPKRTGTSKQNPELLKASNPRTTFQNKWSDQLSGFSLHANKDKMHNIM
                     LLPEPKEYQKDVVCIPNKMTLSEPNEVNLFENKNVEVEVLSPAKEPVQPGMPLTVVAP
                     AELVVPANCLAQLIDVKVVNGTQQLVLKLFPLEENNCLEAGRDNGGNSERMVKEKGSN
                     EQEKVLSAEKTKSLTVDGNVGKLVGIDSFQPSVQKQLKNVKWVRSYDFIMPNSSVHNN
                     GKSFINSETIEDFQKKNNLYPHRTAFPSVALKGHSLASVFKNSVLRSLGAASNPFPYK
                     AAVCFAESGRNLHSSSQQLLPFAASPATCSFSGEKGLLPVSENDLESTSKVNIPVKVV
                     SSNRKQEDNQTEEHKAVSTVGQISSQHKSEYLHINITGEDRSQQPGDKPLELKNSERT
                     NNTNDGPVISSVFSLSSGSENVPEGIKWNSSTSKIKSIELLRRKIAQLIESCGKPSSL
                     ASNSAHRRSVGQASKGTSKATSEGIQEINVSLTGLGHSTGTLQKPPNDGGITGNRQLT
                     HQQIYPHFADGSNRKTKSRVARKAHVATPVLIPKGAVLRVLNSSENAHIIEATCEAPV
                     SIPCSERQLIKPVPFCPVRQADSDLQPLRSERGPIDMSPNIETPLRPKLRKESAVCST
                     IHRKTGLLYGQQGSSELNKQGRLLSRSLSISRNKTKQVHLSRKKNKIQAEPSRCLKDP
                     SIFQVARQLRLIAAKPDQLIKCPRRNQPVIVLNHPDVDSPEVTNVMKVINKYKGNVLK
                     VVLSERTRCQLGIRRHHVRLTYQNAEEASQIKRQMMLKMKLKKVHKNNYQVVDSLPDD
                     SSQCVFKCWFCGRLYEDQEEWMSHGQRHLIEATRDWDVLSSKGK"
     regulatory      6922..6927
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518B"
                     /note="hexamer: AATAAA"
     polyA_site      6954
                     /gene="ZNF518B"
                     /note="major polyA site"
ORIGIN      
        1 gggctccgcc ccccgggtag ggacctacag cgggcgcggc gccggcggtc tgcggccggc
       61 ggtgtagacg ccccttcgcc gggacctggc acccgaatcc ggcctgccgg gcctctttgt
      121 gcagcgcctt gctgacgccc agggttctga tgtagaagcc tacaccaggg cctgaggttg
      181 tgaaactcat ggcagtccac gcctgagaag agaaggcctg aaagagaagg aagagcccat
      241 gggacttgcc acggttttga cttacatctg caactccaag gctacaggca ggaatgttac
      301 ctggaatgtc agagagctga aagcagtcat attttgggat catgcaccta ctgcggcagt
      361 atataaagaa agataattaa gtatgcaccc aagaagtagc tgcgccccta cccatcacaa
      421 actgtataga aggatatctc ctaaggattt tatcatgtga aaactttctg aattttagtt
      481 ggctcttttt agaaatgcag ataagatgaa ggatattgga cagcagctat acactacaca
      541 cttgaacggc ggacataatt ccttgaccat gtcacccaaa cagcctgatg ctaatggagc
      601 acctcggcca aatagacaag aagcacaaac ccttttgtat caaggctcag aggcagaggc
      661 tgccatgatg accattgcta catgtgcaaa gtgcaaaagt gttcacaaga tctctcttca
      721 agatttgcag aagggtacag ggaaggacgg tatgtatgtc tgcttccagt gcagcctcgg
      781 tgcagctcct cccaattttc attttgtgag caataattcc agtgcgactc atgttggaaa
      841 taaaactgaa aacttctcaa gttctgtcaa tagcaaattt aaggtaagga actttaagcc
      901 aggcaaatac tattgtgata aatgtcgatt ctctacaaag gacccgctgc agtacaaaaa
      961 gcacaccctt caacacgagg agattaaatt catttgttct cactgcagct acatttcgta
     1021 tacgaaagga gagtttcaga ggcatttggt gaaacacaca ggcatatttc cttatcagtg
     1081 tgagtattgt gactatggtg ctattagaaa tgattatatt gtcaaacaca cgaagagagt
     1141 acatgaaagg gcaggtgcga aacggccagt caaagctgtt gccaagctgg agccaaaaag
     1201 aaccggaact tcaaaacaaa acccagagct tctaaaagct tccaatccac ggactacatt
     1261 tcaaaataag tggtcagacc aactgtcagg tttctctctc catgcaaata aagacaaaat
     1321 gcacaatatc atgttgttac ctgaaccaaa ggaataccaa aaagatgtag tttgtattcc
     1381 aaataaaatg accctgtctg agccaaatga agtcaaccta tttgagaaca aaaatgttga
     1441 agtagaagtg ttatcccctg caaaagaacc tgttcagcca ggtatgccat tgacagttgt
     1501 tgcaccagca gaactagttg tccctgcaaa ctgtttagcc cagttgatag atgtgaaggt
     1561 tgtcaatggt acacagcagc ttgttctgaa actgtttccg ctggaagaaa ataattgcct
     1621 tgaagctggg agggataatg gaggtaattc tgaacgtatg gtgaaagaga agggttcaaa
     1681 tgaacaagaa aaagtacttt ctgcagaaaa aacaaagtca ctgacagttg acgggaatgt
     1741 tggaaaactc gtaggcattg atagttttca accttcagtt cagaaacagc ttaaaaatgt
     1801 gaaatgggta aggtcttatg attttattat gccaaattct agtgtgcaca acaatggaaa
     1861 atccttcatt aattcggaaa caattgagga ttttcagaaa aaaaataatt tgtatccaca
     1921 tagaactgct tttccttccg ttgccttaaa aggtcattct ctagcatctg tatttaaaaa
     1981 cagtgtttta cgtagtcttg gagctgcatc aaaccctttt ccatataaag ctgctgtttg
     2041 ttttgctgaa agtggaagaa atttacacag tagctcacag cagttactcc catttgctgc
     2101 atcacctgca acctgttcct tctctggaga aaagggctta ttgcctgtaa gtgaaaatga
     2161 cttggaatct acaagtaaag tcaatattcc tgtaaaagtg gtttcctcta ataggaagca
     2221 ggaagataac cagacagagg aacacaaggc agtttcaact gtaggccaga tttcctctca
     2281 acataagagt gagtatttac atataaacat aactggagaa gatagatctc aacagcctgg
     2341 ggataagcct ttggaattaa agaattctga aaggactaac aacactaatg atggcccagt
     2401 catctcatca gtattttctc tgagctctgg atctgaaaat gtccccgagg gcattaagtg
     2461 gaatagctca acgtctaaaa taaagtcaat tgaactgttg cgcagaaaga tagctcagtt
     2521 aattgagtcc tgtgggaagc cgtcatcttt ggcttcaaat agtgcacatc gtcgctctgt
     2581 agggcaggca tcaaagggaa cttcaaaagc tacctctgaa ggtattcaag aaatcaacgt
     2641 gtcactcact ggtcttggcc attccacagg tactcttcag aaacctccga atgatggtgg
     2701 tattactggt aatagacagc ttactcatca acaaatatat ccacactttg cagatggcag
     2761 taataggaaa accaaaagca gagtggccag gaaggctcat gttgccacgc cagtgttaat
     2821 ccccaaaggg gctgtgttga gggttcttaa ttcctctgag aatgcccaca tcatagaggc
     2881 tacatgtgaa gcacctgtca gcataccttg cagtgaaaga cagttaataa aaccagttcc
     2941 attttgccct gtgagacagg cggactcaga cttacagcct ttaagaagtg aaagggggcc
     3001 aatagatatg tccccaaata tcgagacacc tctgcggcct aaactgagaa aagagagtgc
     3061 tgtctgtagc accatccata gaaaaactgg cctcttgtat ggacagcaag gaagcagtga
     3121 attaaataag caagggagac tgctttccag aagtctttct ataagtagaa ataaaaccaa
     3181 acaagtacac ttatccagga agaaaaacaa aattcaagct gaacctagcc gctgtctcaa
     3241 ggatccttca atttttcagg ttgcaaggca actaagactg atagcagcta agccagatca
     3301 gttgattaag tgtccccgtc ggaaccagcc agtcattgtg ttaaaccacc ctgatgtgga
     3361 ctcgccagaa gtgaccaatg tgatgaaggt aataaataaa tacaaaggca atgtcctcaa
     3421 agttgtttta tcagagagga ctaggtgtca gctaggcatc agacggcatc atgtacgcct
     3481 gacctaccag aatgcggaag aagccagtca aattaaaagg caaatgatgt tgaaaatgaa
     3541 actcaaaaaa gttcataaaa acaactacca ggtagtggat tccttgcctg atgattcttc
     3601 acagtgtgta tttaagtgct ggttttgtgg gcgactgtat gaagaccagg aagagtggat
     3661 gagtcatggc caacggcatt tgatagaagc aactagagat tgggatgttc tttcctccaa
     3721 gggcaaataa gtaaacagtt actctttaaa gcaagttatc ttttagttta ttctggtttg
     3781 gagtccctcc accaagattc agtagaagaa atacagactg tagaaatgag aggactgcta
     3841 attcttcaga actgtaggaa tattgggagc taggagtctg aacctgaagt atgtgattgg
     3901 accccagaat gtatttgaag gctctgaaat tgtacatgca aattggtaca tatgcatttt
     3961 tctggagaga gcctgtgaaa ctgaacagat tttcagtggg atctgagact tttctttgtt
     4021 tagcaccccg ttttctgagt acatactgat ctttcataat ccattcagag gggcagattg
     4081 agaatgtttt acacatgctc ttcatataaa tgctacagaa aaacctttgt tttggtgtgc
     4141 acatccattt tgtttttgct ttaatttgtg ttctgagtat ttggtgcaca atggaaatta
     4201 tattttctac tttactgtct tcaatttggt tatagagaaa tggccattct tttactccct
     4261 ccctggtttt gtaatactcc cgagtgttcc gtatagcaca aagagttttg cttttactgg
     4321 ccattttaaa gaatgttttc aactgcttgc ctgaatttac tcctttcaca gcaagtgtta
     4381 gaagaaagat aacattttca aatacttagc ttttgctttc tttaaaatac attggtttat
     4441 gacatatggg aagggaacgt acctttttgc aaagacaaaa agagattaca aaaggaaaat
     4501 atctaaaact attttctctt tgcccttacc actcccagaa acataagtga ccaatttaaa
     4561 atgctaggga acaggcttac aacataggta aaactcgcaa acacagttca aggtaggctc
     4621 ataaagttgt gaaaagggtt tcatatgccc tttagttttc atttgggatt catccaaaga
     4681 ccatgggtgg atgctgtctt ctctcttctt gatccctttg attcatggac actagactcc
     4741 ctttgccatt tcttctgaac cggccctcct gtggactagc acaacttcct tgcccactgt
     4801 ttcttccttt ctgtgccttt gagacccctt aaggttttcc ctcatgcgat tactagaaaa
     4861 tggcaggaat caacaaaatg gagacctccc actgtttttg ctaaagttac aggaacacga
     4921 tccctagttt tcattgatag taacgctgtt tctaatttgt cttaaccaca ttcatgctta
     4981 ccctgctgct cagctttctc agggaagcaa ctccaggaac actccttcca ctcccctctc
     5041 taccaacaga tgtcaggact gtcatttatc tacacatttg tgttctttag aaaaaggccc
     5101 accccctgca caagcacagc ctcttgggca gataggtggc tgggtcagtg cttaagacag
     5161 gattctagtc ttcacttgcc tgtgcagctg ggcgctgacc ttccaggtag agcacagatg
     5221 gcacaacccc gaggcagccc caacttgcat ttccctccct ccaggggcta ttcctgtctt
     5281 aggcgatttg tggggtgcag tgaatgaaac taaagagttg ttgcacctga aaaagacacc
     5341 agtgattgtt tattgggtag tcgattggag actttgattt tttttttttt ttttcacatg
     5401 ggaaagtctt agattccagt agatggaatt gcaatccttt gcagtttgtt ctcattacag
     5461 ataatcaaca tttcttttgt ataattcaat acatgatcat caagttaatt ggtaaatttt
     5521 tattgaaatt taaaacttgc atttttatat atgtgtatgt gtacacataa aaatattttt
     5581 taccatatga aaattgcagt agctaatttt ctgatttcct attttataat gatacatggg
     5641 ctggaaaaat gtagaacgtt tttatattct agaaatttat tttggaagta catttttata
     5701 agggtctaat ctcacttttg gaaaatgaaa gcacaggaat gatggggtct ggtttatgtg
     5761 aacaagtgag tagaaacccc tttggatcat tttattactg catttttatt tggtgctttt
     5821 taggaagtag atctttggta ccacttcact acgtagagca ttcgaagttt tatccatgtt
     5881 atatattgta ctcctgtggc atgaaaaata gctcccaaga tatagagagg agaggagtga
     5941 agaaaaggct gtggtttttt tttgttttgt tttgtttgcc acttttttat ctcctattcc
     6001 tcaccacata gtgctttttc ctgaaaagct ggactgagaa ttggccttga atcaggtcag
     6061 agtgttaact gtcaacatga agtattttca cttcgcagca tcaactttca agcataagta
     6121 aaaacacaac ttgcatactt tgatggagct taattgtgtg agtagaatat gtagcaaagc
     6181 tttttaggat tttcagaact agaatacttt ttaaggaatt aaaagtgttt ctggaagtca
     6241 aaaatgggaa agcaaaaagt agctgtcctc cctaaagagc tttagaagat agcttaacct
     6301 gtaggtacat gttatgaaat aaacacattt ctaacaatac aagggagtag gggcagacct
     6361 gtgttgagta tttgtgtggg ttcttaattt tgaaggacct ccaatcacta cattttgtta
     6421 atactgccaa taaaatcatt ttcaacttat tttttaaagt aggttttctt actttggtgg
     6481 accagaagtg agagattgtt atatttagga tataggcaaa tacagtaaaa gttaaaaaaa
     6541 aaaaacctga cccaaagtat actctgatag actatattat attcaatttt gtatccccag
     6601 tcgagaacat cttgtaagcc ttcattaagg gccacctgct gtctgttgaa ctagactgaa
     6661 caaaatatat tttctcacaa gctccatccc tttttcttta ggacatgtta tatataatcc
     6721 atctcagaag ttgaagatgt gatgttgctc ggcctttgga ataattttta aatctgtaaa
     6781 tgtctatatg agcagaaaca aaacattgtg taacatgttt taagcattat tgtaattcct
     6841 gtgttaacag tttgtgtgtc tgctgctctg gttttgaaac atgtttgtat atagatacag
     6901 gagttggcat aaattttgtt aaataaagca acaaaaattt tctttgccct ttga
//
