LOCUS       NM_001330732            7974 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 518A (ZNF518A), transcript variant
            5, mRNA.
ACCESSION   NM_001330732 XM_017016993
VERSION     NM_001330732.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7974)
  AUTHORS   Maier,V.K., Feeney,C.M., Taylor,J.E., Creech,A.L., Qiao,J.W.,
            Szanto,A., Das,P.P., Chevrier,N., Cifuentes-Rojas,C., Orkin,S.H.,
            Carr,S.A., Jaffe,J.D., Mertins,P. and Lee,J.T.
  TITLE     Functional Proteomic Analysis of Repressive Histone
            Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator
  JOURNAL   Mol Cell Proteomics 14 (6), 1435-1446 (2015)
   PUBMED   25680957
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC021037.6 and FO082045.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001330732.1.
            
            Summary: The protein encoded by this gene is a member of the
            krueppel C2H2-type zinc finger protein family. The encoded protein
            contains five zinc fingers and is likely a nuclear transcriptional
            regulator. Numerous transcript variants encoding two different
            isoforms have been found for this gene. [provided by RefSeq, Aug
            2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.19646.1,
                                           DRR138518.157382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC021037.6         149495-149557       c
            64-148              AC021037.6         146943-147027       c
            149-214             AC021037.6         145965-146030       c
            215-287             AC021037.6         124215-124287       c
            288-411             AC021037.6         123566-123689       c
            412-4505            AC021037.6         119323-123416       c
            4506-4764           FO082045.1         1-259               c
            4765-7974           AC021037.6         115855-119064       c
FEATURES             Location/Qualifiers
     source          1..7974
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..7974
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="zinc finger protein 518A"
                     /db_xref="GeneID:9849"
                     /db_xref="HGNC:HGNC:29009"
                     /db_xref="MIM:617733"
     exon            1..63
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     exon            64..148
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     exon            149..214
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     exon            215..287
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     exon            288..411
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     exon            412..7974
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..4989
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="isoform a is encoded by transcript variant 5; zinc
                     finger protein 518"
                     /codon_start=1
                     /product="zinc finger protein 518A isoform a"
                     /protein_id="NP_001317661.1"
                     /db_xref="CCDS:CCDS73170.1"
                     /db_xref="GeneID:9849"
                     /db_xref="HGNC:HGNC:29009"
                     /db_xref="MIM:617733"
                     /translation="MPSEQKQLFCDEKQTTLKKDYDVKNEIVDRSAPKPKISGSIHYA
                     LKNVKIDLPKINIPNEVLLKHEVDKYRKLFQSKQQTARKSISIKTVSCVEECTLLHKS
                     ERAEEEGVKMSAKILNFSCLKCRDNTRYSPNDLQKHFQMWHHGELPSYPCEMCNFSAN
                     DFQVFKQHRRTHRSTLVKCDICNNESVYTLLNLTKHFTSTHCVNGNFQCEKCKFSTQD
                     VGTFVQHIHRHNEIHYKCGKCHHVCFTKGELQKHLHIHSGTFPFTCQYCSYGATRREH
                     LVRHVITLHKEHLYAKEKLEKDKYEKRMAKTSAGLKLILKRYKIGASRKTFWKRKKIN
                     SGSDRSIEKNTQVLKKMNKTQTKSEDQSHVVQEHLSEEKDERLHCENNDKAPESESEK
                     PTPLSTGQGNRAEEGPNASSGFMKTAVLGPTLKNVMMKNNKLAVSPNYNATFMGFKMM
                     DGKQHIVLKLVPIKQNVCSPGSQSGAAKDGTANLQPQTLDTNGFLTGVTTELNDTVYM
                     KAATPFSCSSSILSGKASSEKEMTLISQRNNMLQTMDYEKSVSSLSATSELVTASVNL
                     TTKFETRDNVDFWGNHLTQSHPEVLGTTIKSPDKVNCVAKPNAYNSGDMHNYCINYGN
                     CELPVESSNQGSLPFHNYSKVNNSNKRRRFSGTAVYENPQRESSSSKTVVQQPISESF
                     LSLVRQESSKPDSLLASISLLNDKDGTLKAKSEIEEQYVLEKGQNIDGQNLYSNENQN
                     LECATEKSKWEDFSNVDSPMMPRITSVFSLQSQQASEFLPPEVNQLLQDVLKIKPDVK
                     QDSSNTPNKGLPLHCDQSFQKHEREGKIVESSKDFKVQGIFPVPPGSVGINVPTNDLN
                     LKFGKEKQVSSIPQDVRDSEKMPRISGFGTLLKTQSDAIITQQLVKDKLRATTQNLGS
                     FYMQSPLLNSEQKKTIIVQTSKGFLIPLNITNKPGLPVIPGNALPLVNSQGIPASLFV
                     NKKPGMVLTLNNGKLEGVSAVKTEGAPARGTVTKEPCKTPILKVEPNNNCLTPGLCSS
                     IGSCLSMKSSSENTLPLKGPYILKPTSSVKAVLIPNMLSEQQSTKLNISDSVKQQNEI
                     FPKPPLYTFLPDGKQAVFLKCVMPNKTELLKPKLVQNSTYQNIQPKKPEGTPQRILLK
                     IFNPVLNVTAANNLSVSNSASSLQKDNVPSNQIIGGEQKEPESRDALPFLLDDLMPAN
                     EIVITSTATCPESSEEPICVSDCSESRVLRCKTNCRIERNFNRKKTSKKIFSKTKTHG
                     SKDSETAFVSRNRNCKRKCRDSYQEPPRRKATLHRKCKEKAKPEDVRETFGFSRPRLS
                     KDSIRTLRLFPFSSKQLVKCPRRNQPVVVLNHPDADAPEVVSVMKTIAKFNGHVLKVS
                     LSKRTINALLKPVCYNPPKTTYDDFSKRHKTFKPVSSVKERFVLKLTLKKTSKNNYQI
                     VKTTSENILKAKFNCWFCGRVFDNQDTWAGHGQRHLMEATRDWNMLE"
     regulatory      6467..6472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="hexamer: AATAAA"
     polyA_site      6496
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="major polyA site"
     regulatory      6925..6930
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="hexamer: ATTAAA"
     polyA_site      6957
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="major polyA site"
     regulatory      7003..7008
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="hexamer: AATACA"
     polyA_site      7022
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
     regulatory      7835..7840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="hexamer: AATAAA"
     polyA_site      7855
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
     regulatory      7955..7960
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
                     /note="hexamer: AATAAA"
     polyA_site      7974
                     /gene="ZNF518A"
                     /gene_synonym="ZNF518"
ORIGIN      
        1 aatacccgga tggaagtgta atggccgcca tcagggactc gcaggcaatg ggtactacga
       61 cagatatcat ctcttctttt gatcactgtt cctgattgtg acattgtgca agtgttaaat
      121 tgtgtgcctt ttgttcctga agaaagaggt cctgggatct ttgaaatgct aagattcttg
      181 gataccacag tatcataaaa ttcctctaaa tgcaatgaag gaactgagac acagaggttg
      241 agacttgtct aaagtaacat gaccagtaag tgcttgaatt aatgcagatg aggaaactga
      301 ggtccagaga agttgaagtt ttcccaaggt cacacagcag agctggaact agagcttgca
      361 tttcctgact tccagattag tgttattttt acttcaaact attacttctt ggtgagttat
      421 tgtgggaaaa atcctgtata ttgaagatgt ctctacacag tatcgtttcc tgtttaaatt
      481 acagataact tcaagagttt tcagaaaaaa agaaattggg acttttttgg ttaaatcatg
      541 ccatctgaac agaaacagtt attttgtgat gaaaaacaaa ctactttaaa aaaagattat
      601 gatgtgaaaa atgagatagt tgataggtcg gcacctaaac caaaaatttc aggaagtatt
      661 cattatgcac taaaaaatgt gaaaattgat ttgccaaaaa taaatattcc aaatgaagtc
      721 ctattgaaac atgaagttga caaatacaga aaattatttc agagtaaaca gcagactgca
      781 agaaaatcta tcagtataaa gactgtaagc tgtgtagagg agtgtacatt gcttcataag
      841 tctgagagag ctgaagaaga gggtgtaaaa atgtctgcaa aaatactcaa tttcagctgt
      901 ttaaaatgcc gagacaacac tcgatatagc ccaaatgatt tgcagaaaca ctttcaaatg
      961 tggcaccatg gcgaattacc ttcatatcct tgtgaaatgt gcaacttttc agcaaatgac
     1021 tttcaggtat ttaaacaaca cagacgaacc catagaagca ctttagtaaa atgtgacatt
     1081 tgtaacaatg agagtgtata tactttactg aacttgacaa agcatttcac atccacacat
     1141 tgtgttaatg gtaattttca atgtgaaaag tgtaagttct ccacccagga tgttggcaca
     1201 tttgttcagc acattcatag acataatgaa attcattata agtgtggtaa atgtcatcat
     1261 gtatgtttta ccaaaggaga gcttcagaag caccttcata ttcattctgg tacttttccc
     1321 ttcacttgtc aatattgtag ctatggtgcc accaggagag aacaccttgt aagacatgtt
     1381 ataactttgc acaaagaaca tttatatgca aaagaaaaac tggaaaaaga caaatatgaa
     1441 aaaagaatgg caaagacttc tgcaggactt aagctaatac tgaaaagata taaaataggt
     1501 gcatcaagga agacgttctg gaaacgtaag aaaattaaca gtggaagtga cagaagtata
     1561 gaaaagaaca ctcaagtgct taagaaaatg aacaaaacac agactaaatc tgaagaccag
     1621 agccatgttg ttcaagagca tttaagtgaa gaaaaggatg aaagactaca ctgtgagaat
     1681 aatgataaag cccctgaatc agagtcagag aagccaactc ctctgtccac tgggcaaggt
     1741 aatagagctg aagagggacc aaacgctagt tcaggtttca tgaagactgc tgtactagga
     1801 cctacactga aaaatgtaat gatgaaaaat aataaactag cagtttcccc taactataat
     1861 gctacgttta tgggcttcaa gatgatggat ggaaaacagc atattgtatt aaaattggtg
     1921 cctatcaaac aaaatgtatg ttcaccaggc tcacagtcag gtgctgcaaa ggacggtact
     1981 gctaatttgc agccccagac tttggacact aatggatttt taacaggagt aacaactgag
     2041 ttaaatgaca cagtttatat gaaagcagct actccatttt catgttcatc ttctatactt
     2101 tcagggaaag caagttcaga aaaagaaatg actttgatat ctcaaaggaa taatatgctt
     2161 caaacaatgg attatgagaa aagtgtatct tctttgtcag caacatcaga attggttaca
     2221 gcatcagtga atttgaccac aaaatttgaa acaagagata atgttgactt ctggggaaat
     2281 catctcactc agagtcaccc cgaggtatta ggtaccacca ttaaaagtcc agataaagtc
     2341 aactgtgttg ccaaaccaaa tgcatacaac agtggagata tgcataatta ttgcattaat
     2401 tatggcaact gtgagttacc tgttgaatcc tccaaccaag gatcattacc ttttcataat
     2461 tactcaaaag tgaataattc taataaacgt cgtaggtttt caggaacagc agtgtatgaa
     2521 aaccctcaaa gagaatcttc atccagcaaa acagttgtcc aacaaccaat tagtgaatca
     2581 tttttatcac tagtgaggca ggagagctca aaaccagata gcctattagc atctattagc
     2641 cttttaaatg ataaagatgg aactttaaaa gcaaaatctg aaattgaaga acagtatgtt
     2701 ttagaaaaag gacaaaacat tgatggacaa aacctgtaca gtaatgaaaa tcaaaattta
     2761 gagtgtgcga ctgaaaaatc taaatgggaa gacttttcta atgtcgattc acctatgatg
     2821 cctagaatca catctgtttt ctctctccag agccaacagg catcagaatt tctgccacct
     2881 gaagtaaacc aattgcttca ggatgtattg aaaataaaac ctgatgtaaa acaagactct
     2941 agtaacactc caaataaagg cttgccactt cattgtgacc agtcatttca aaaacacgag
     3001 agagaaggca aaattgttga atcttcgaaa gatttcaaag tgcaaggcat cttcccagtt
     3061 ccacctggca gtgtgggtat taatgtgcct acaaatgatt tgaatttgaa atttggaaaa
     3121 gaaaaacaag tgtcatcaat accacaagat gtgagagatt cagagaagat gcctagaatt
     3181 tcaggttttg gcacattact taagactcag tcagatgcga taataacaca gcagcttgta
     3241 aaagacaaac tacgagccac cacacaaaat ttaggttctt tttatatgca gagtccactt
     3301 ttaaattcag aacaaaaaaa aactataatt gttcagactt caaaaggatt cttaatacca
     3361 ttgaacatta ctaacaagcc tgggctacca gttattcctg gaaatgcact tccattggtt
     3421 aattcacaag gtatccctgc ttctcttttt gtaaacaaga aacctgggat ggttttaaca
     3481 cttaataatg ggaaacttga aggtgtttcc gctgtcaaaa ccgagggtgc cccagctcgt
     3541 ggaactgtga ctaaggagcc ttgcaaaaca cctattttga aggtagaacc aaacaataat
     3601 tgtcttacac ctggactttg ttccagcatt ggcagttgtt tgagcatgaa aagtagctca
     3661 gaaaatactt tgccattaaa aggcccttac attttgaaac caacgagttc tgtgaaagct
     3721 gttcttattc ctaacatgct atctgagcaa cagagcacta agttgaatat ctccgattca
     3781 gtaaaacagc agaatgagat ttttccaaaa ccacctcttt ataccttctt gcctgatggc
     3841 aaacaagctg tttttttaaa gtgtgtgatg ccaaataaaa ctgagctgct taagcccaaa
     3901 ttagtccaaa atagtactta tcaaaatata cagccaaaga aacctgaagg aacaccacaa
     3961 agaatattgc tgaaaatttt taaccctgtt ttaaatgtga ctgctgctaa taatctgtca
     4021 gtaagcaact ctgcatcctc attgcaaaaa gacaacgtac catctaatca gattatagga
     4081 ggagagcaga aagagccaga atctagagat gccttaccct tcttactaga tgacttaatg
     4141 ccagcaaatg aaattgtgat aacttctact gcaacatgcc cagaatcttc tgaggaacca
     4201 atatgtgtca gtgactgttc agagtccagg gtattaaggt gtaaaacaaa ttgtagaatt
     4261 gagaggaact tcaatagaaa aaagacttcc aaaaaaattt tttcaaaaac aaaaactcat
     4321 ggaagtaaag actctgaaac tgcctttgta tctagaaaca gaaactgtaa acgaaagtgt
     4381 agggatagtt accaagaacc tccaagaaga aaagcaacat tgcatagaaa gtgtaaagaa
     4441 aaggcaaaac ctgaagatgt ccgtgaaaca tttggattta gcagacctag gctttcaaaa
     4501 gattccatca gaactttgcg gcttttccct tttagttcta aacagcttgt gaaatgtcct
     4561 aggagaaacc aaccagttgt agttttgaat catcctgacg cagatgcacc agaagtagta
     4621 agtgtaatga aaactattgc taaatttaat ggacatgtac ttaaggtttc attgtcaaaa
     4681 agaactataa atgctttact gaaaccagtt tgttataacc ctcctaaaac aacttatgat
     4741 gatttttcca agaggcacaa aacatttaaa cctgttagtt ctgtgaaaga aagatttgtg
     4801 ctaaaattaa cactcaaaaa gacaagcaaa aacaattacc agattgtgaa gactacctct
     4861 gaaaatattt tgaaggctaa atttaactgt tggttttgtg gtagagtatt tgacaatcag
     4921 gatacttggg ctggtcatgg gcagagacat ttaatggaag ctactcggga ttggaacatg
     4981 ttagaatagt ttaccataat taccaaggaa aagaaaagta aaattacctt agaagaaaac
     5041 aacgggttca gttaccataa tgcagacatt ttctacttca gtatagtacc tgaaatcgaa
     5101 cattttaaaa gttgattgta tttctgtgga agagtaaaag ttgtatgtat gatatttgaa
     5161 aatgctatcc ctgcactcaa aagttttgaa agaaactaat cacagcacag aagtaccttg
     5221 atttaatttt ttaaacgtgt tctcgggaag ttagggctaa agaaaatttt gataaaacaa
     5281 ttttcccact ttagttcttt agtgactctt agtagagggt aatggctgac acccccattc
     5341 cctctcttct tccaccagcc ttatgcatct aagtgtagct cctctggaga tggagagctc
     5401 tttcatcgta gaactgaagg agtttctcac atttgtgaag atactttgag agaacctggg
     5461 taaagaagtc actctatatc tgctaaatat agttattttg aaggatatta ggctccttga
     5521 aagtacattt aactcactac agttacacct catacaatgc ttgaagagtt tttggcaagt
     5581 aaattttttt tccagttgaa ctctgtcact tgttagagat tgggaacact ctcccaaggt
     5641 gattttcttt ttctaagtga ctgtgtcaaa tgttgcagta gatgggcagc ttcaagagaa
     5701 gaatttaaac tctttgtctc attgaaagtt tggttaaaga acttgaacat atttctaaat
     5761 ttgattatat tctctgatga tccctttgca cagaactatg cttatctcat gtttgtcctc
     5821 cataaacaaa tggccatttt tttcttcttg gttcccatcc ctttaaaaag agtggaacat
     5881 aggagcactt ccaagggagt ggcttttctt gaaaattaaa attgtttacc aaaacagtat
     5941 tttgaagcaa gatcatattt ttgtctgtat tcactttatt atttgaacat gtccaaatta
     6001 ggacaaagca tttctgttag ctgcttctca gtgtgactga caacccaaaa catatataca
     6061 gattgttggc atttgcaaaa ggaagcatca atagtggacc cagaggcagt gcataaaacc
     6121 ttaggataga ttcctaaggg acatgcccaa cagagtttta aaatggatgt tttcatgatg
     6181 acaacagaat catagattta gatttttcac cttgtaagtt tggatcaaat tttgctggtt
     6241 ctttggataa tggagttctt gtgttaacaa attacgtgct atatgatttt ttgttacatt
     6301 gttacaagtg ttaatgacat tttcattaat ggatgaaaac ttcagggctt cttttctgta
     6361 tataacaaat taagtctgta catatttttg taccttttat gtaaattttg cacagaaatt
     6421 tttggcataa gtttattttc tttcagttta gttcagtgca tgcactaata aaactggttg
     6481 tttaatttaa aaggaatata taagacttta cccatgttat tttcttggtt tttatttcag
     6541 atgtagattt tgtttttgag gtaaattcgt tcttcaggga ttgaacacta ttgttagcaa
     6601 gtgcctaaaa aagatgtgaa acagtttaca tatgtcaact gtaacagtag gtcccaaatg
     6661 ggcccattcc cctaatagtt ttatttttaa agaaagccat acatagaatg cttcaagcta
     6721 tcttgctatg cacattatac ttgtactgtt ttgtgcagtt tgtctacttt cttagtgaag
     6781 tattttttgt ataaaatgtt acaattgtgt ttcttaaatt gagcctaaga atggagttaa
     6841 ttggaaatat acagtatata ttaataatgt acatggtgtt taaagaatgg taagcattgt
     6901 taatttctgt aatgaacatt ttcaattaaa tttatcttgt ttgtgtttac acaataattt
     6961 ttttactgtg ctaaaatctg atggaaattt tgttctctag gaaatacaga ttttaaagtg
     7021 tatgtgtttt ttcaatgcta gttaactcta caagatagat aaaagtgtgg gatttttttt
     7081 cttcccaaaa tcatagatga tatattgttt aagaaaggta acatatacca taattttact
     7141 atggttatgc tggcaaggtg agccatagag aggcttatag tcttcagtac cctaacagca
     7201 ataaaattaa aatgctctgt ttgttacata tagatctgtt atgagacatc acctgctgta
     7261 aatagcaagg agagagaagg aactttcctg ctaatattcg cagcactata acattacatt
     7321 tcagaatagc catatcagga aaataatgtc gagatatgta cttcttgcct ttaagtttta
     7381 acagccattt aaagtaagct ttgtgctcca gatattctag ttggaacttt ttctgatttt
     7441 gttaacttaa gttattctga gggaggcaga cctgcttaga gtttcattat tgccattgca
     7501 gaaaatccaa aacaaaagcc tgtatccttt attttttgtg tgtggctttc caaagagggc
     7561 tttccaaaat atgattttca gtagttcgag gttcttatta caattgaaga gttagtttta
     7621 gttttgcagt tgaatttctg tgtgaggaat ttgttttatt ttttctagtt tgtccatctc
     7681 cactgaaatg ggtttcttac tatttggcaa gtacttaaaa aacataattc agttttcaaa
     7741 gaatttatct tgctaagtat tcagtaacac aaattgaaat gtaatagttt ttttaatgga
     7801 aaatattttc attggggggt tagcaaattt tttcaataaa gggtcagata aataagcttc
     7861 gtaggccttc tagtttctgt cctaactact caattctcat aatgcagaaa aaaaccatag
     7921 acaatatgta aatgaattag tgtggctatg ttttaataaa acaatttata aaaa
//
