LOCUS       NM_213605               3238 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 517 (ZNF517), transcript variant
            1, mRNA.
ACCESSION   NM_213605
VERSION     NM_213605.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3238)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 3238)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 3238)
  AUTHORS   Ota,T., Suzuki,Y., Nishikawa,T., Otsuki,T., Sugiyama,T., Irie,R.,
            Wakamatsu,A., Hayashi,K., Sato,H., Nagai,K., Kimura,K., Makita,H.,
            Sekine,M., Obayashi,M., Nishi,T., Shibahara,T., Tanaka,T.,
            Ishii,S., Yamamoto,J., Saito,K., Kawai,Y., Isono,Y., Nakamura,Y.,
            Nagahari,K., Murakami,K., Yasuda,T., Iwayanagi,T., Wagatsuma,M.,
            Shiratori,A., Sudo,H., Hosoiri,T., Kaku,Y., Kodaira,H., Kondo,H.,
            Sugawara,M., Takahashi,M., Kanda,K., Yokoi,T., Furuya,T.,
            Kikkawa,E., Omura,Y., Abe,K., Kamihara,K., Katsuta,N., Sato,K.,
            Tanikawa,M., Yamazaki,M., Ninomiya,K., Ishibashi,T., Yamashita,H.,
            Murakawa,K., Fujimori,K., Tanai,H., Kimata,M., Watanabe,M.,
            Hiraoka,S., Chiba,Y., Ishida,S., Ono,Y., Takiguchi,S., Watanabe,S.,
            Yosida,M., Hotuta,T., Kusano,J., Kanehori,K., Takahashi-Fujii,A.,
            Hara,H., Tanase,T.O., Nomura,Y., Togiya,S., Komai,F., Hara,R.,
            Takeuchi,K., Arita,M., Imose,N., Musashino,K., Yuuki,H., Oshima,A.,
            Sasaki,N., Aotsuka,S., Yoshikawa,Y., Matsunawa,H., Ichihara,T.,
            Shiohata,N., Sano,S., Moriya,S., Momiyama,H., Satoh,N., Takami,S.,
            Terashima,Y., Suzuki,O., Nakagawa,S., Senoh,A., Mizoguchi,H.,
            Goto,Y., Shimizu,F., Wakebe,H., Hishigaki,H., Watanabe,T.,
            Sugiyama,A., Takemoto,M., Kawakami,B., Yamazaki,M., Watanabe,K.,
            Kumagai,A., Itakura,S., Fukuzumi,Y., Fujimori,Y., Komiyama,M.,
            Tashiro,H., Tanigami,A., Fujiwara,T., Ono,T., Yamada,K., Fujii,Y.,
            Ozaki,K., Hirao,M., Ohmori,Y., Kawabata,A., Hikiji,T., Kobatake,N.,
            Inagaki,H., Ikema,Y., Okamoto,S., Okitani,R., Kawakami,T.,
            Noguchi,S., Itoh,T., Shigeta,K., Senba,T., Matsumura,K.,
            Nakajima,Y., Mizuno,T., Morinaga,M., Sasaki,M., Togashi,T.,
            Oyama,M., Hata,H., Watanabe,M., Komatsu,T., Mizushima-Sugano,J.,
            Satoh,T., Shirai,Y., Takahashi,Y., Nakagawa,K., Okumura,K.,
            Nagase,T., Nomura,N., Kikuchi,H., Masuho,Y., Yamashita,R.,
            Nakai,K., Yada,T., Nakamura,Y., Ohara,O., Isogai,T. and Sugano,S.
  TITLE     Complete sequencing and characterization of 21,243 full-length
            human cDNAs
  JOURNAL   Nat Genet 36 (1), 40-45 (2004)
   PUBMED   14702039
REFERENCE   4  (bases 1 to 3238)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
REFERENCE   5  (bases 1 to 3238)
  AUTHORS   Dias Neto,E., Correa,R.G., Verjovski-Almeida,S., Briones,M.R.,
            Nagai,M.A., da Silva,W. Jr., Zago,M.A., Bordin,S., Costa,F.F.,
            Goldman,G.H., Carvalho,A.F., Matsukuma,A., Baia,G.S., Simpson,D.H.,
            Brunstein,A., de Oliveira,P.S., Bucher,P., Jongeneel,C.V.,
            O'Hare,M.J., Soares,F., Brentani,R.R., Reis,L.F., de Souza,S.J. and
            Simpson,A.J.
  TITLE     Shotgun sequencing of the human transcriptome with ORF expressed
            sequence tags
  JOURNAL   Proc Natl Acad Sci U S A 97 (7), 3491-3496 (2000)
   PUBMED   10737800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF235103.5 and KC877379.1.
            
            On Jul 1, 2020 this sequence version replaced NM_213605.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853564.26896.1,
                                           SRR14038191.330735.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359971.4/ ENSP00000353058.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AF235103.5         101877-101901
            26-43               KC877379.1         1-18                c
            44-103              AF235103.5         105852-105911
            104-230             AF235103.5         106605-106731
            231-344             AF235103.5         107089-107202
            345-3238            AF235103.5         110155-113048
FEATURES             Location/Qualifiers
     source          1..3238
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..3238
                     /gene="ZNF517"
                     /note="zinc finger protein 517"
                     /db_xref="GeneID:340385"
                     /db_xref="HGNC:HGNC:27984"
     exon            1..25
                     /gene="ZNF517"
                     /inference="alignment:Splign:2.1.0"
     exon            26..103
                     /gene="ZNF517"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..1549
                     /gene="ZNF517"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 517 isoform 1"
                     /protein_id="NP_998770.2"
                     /db_xref="CCDS:CCDS6434.1"
                     /db_xref="GeneID:340385"
                     /db_xref="HGNC:HGNC:27984"
                     /translation="MAMALPMPGPQEAVVFEDVAVYFTRIEWSCLAPDQQALYRDVML
                     ENYGNLASLGFLVAKPALISLLEQGEEPGALILQVAEQSVAKASLCTDSRMEAGIMES
                     PLQRKLSRQAGLPGTVWGCLPWGHPVGGHPAPPHPHGGPEDGSDKPTHPRAREHSASP
                     RVLQEDLGRPVGSSAPRYRCVCGKAFRYNSLLLRHQIIHTGAKPFQCTECGKAFKQSS
                     ILLRHQLIHTEEKPFQCGECGKAFRQSTQLAAHHRVHTRERPYACGECGKAFSRSSRL
                     LQHQKFHTGEKPFACTECGKAFCRRFTLNEHGRIHSGERPYRCLRCGQRFIRGSSLLK
                     HHRLHAQEGAQDGGVGQGALLGAAQRPQAGDPPHECPVCGRPFRHNSLLLLHLRLHTG
                     EKPFECAECGKAFGRKSNLTLHQKIHTKEKPFACTECGKAFRRSYTLNEHYRLHSGER
                     PYRCRACGRACSRLSTLIQHQKVHGREPGEDTEGRRAPCWAS"
     exon            104..230
                     /gene="ZNF517"
                     /inference="alignment:Splign:2.1.0"
     exon            231..344
                     /gene="ZNF517"
                     /inference="alignment:Splign:2.1.0"
     exon            345..3238
                     /gene="ZNF517"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3212..3217
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF517"
                     /note="hexamer: AATAAA"
     polyA_site      3238
                     /gene="ZNF517"
                     /note="major polyA site"
ORIGIN      
        1 ccccgcgctg tctcggcggc ccaggaattc actgtctgta gcatctgctc ctccacagag
       61 ggaccctgga atggcgatgg cactcccgat gcctggacct caggaggcgg ttgtgttcga
      121 ggatgtggct gtgtacttca caaggataga gtggagttgc ctggcccccg accagcaggc
      181 actctacagg gacgtgatgc tggagaacta tgggaacctg gcctcactag gctttcttgt
      241 tgccaaacca gcactgatct ccctattgga gcaaggagag gagccggggg ccttgattct
      301 gcaggtggct gaacagagcg tggccaaagc cagcctgtgc acagattcca ggatggaggc
      361 tgggatcatg gagtctcctc tgcagagaaa gctctccagg caggcaggac tgccgggcac
      421 cgtgtggggg tgcctcccct gggggcaccc tgtggggggg caccctgcac caccccaccc
      481 gcatggcggt cctgaggacg ggtcagataa acccacccac ccccgggctc gggagcacag
      541 cgcctcccca agggttctgc aggaagacct gggccggcct gtggggagct cagccccccg
      601 ctacaggtgc gtgtgcggca aggcgttcag atacaactcg ctgcttctca ggcaccagat
      661 catccacacc ggcgccaagc ccttccagtg cacagagtgc gggaaggcct tcaagcaaag
      721 ctccatcctg ctgcggcacc agctgatcca cactgaggag aagccgttcc agtgcggcga
      781 gtgcgggaag gccttccggc agagcacgca gctggctgcc caccaccgcg tccacacccg
      841 cgagcggccc tacgcatgcg gcgagtgcgg caaggccttc agccgcagct cccggctgct
      901 gcagcaccag aagttccaca ccggggagaa gcccttcgcg tgcacagagt gcggcaaggc
      961 gttctgccgc aggttcaccc tcaacgagca cggccgcatc cacagcgggg agcggcccta
     1021 ccggtgcctg cggtgtgggc agcgcttcat ccgagggtcc tcgctcctga agcaccaccg
     1081 gctgcacgcg caggagggtg cccaggacgg cggcgtgggg cagggcgccc tgctcggagc
     1141 tgcgcagagg ccccaggcgg gggacccgcc ccacgagtgc ccggtgtgcg ggaggccgtt
     1201 ccgacacaac tccctgctgc tgctgcacct gcgcctacac acgggcgaga agccgttcga
     1261 gtgcgcggag tgcggcaagg ccttcggtcg caagtccaac ctcactctgc accagaagat
     1321 ccacaccaag gagaagccct tcgcgtgcac cgagtgcggc aaggcgttcc gcaggagcta
     1381 cacgctgaac gagcactacc ggctccacag cggcgagagg ccataccggt gccgcgcctg
     1441 cgggagggcc tgcagccggc tgtccaccct catccagcac cagaaggtgc acggccgcga
     1501 gcccggggag gacacagagg gcaggcgggc gccctgttgg gcttcctgat gacggggacg
     1561 acaggccgag gattcacgct ggaagcccac ccaagccggc ggggccctag cgcagaaatt
     1621 cagaaccccc tgtcctgaag gtgaagcaaa gtctaaagaa agggccagct cccatcagga
     1681 gctcggcttc ttgctccagc cgggcactgg ggagggaaag ggcaccaggc agcccgtggt
     1741 gtggcctcag gaaccactat cagccaccat ttcctggggc cttccggaaa tgtccaggag
     1801 cgggcagaag ggagagaggg aggggcagct atgctcagtc cccaaagagc agggcacagg
     1861 gggcgccaca gacgcatatg cagctgagct ccccacaggc cggcccgggt cttcgtgcag
     1921 aaccattggg cacagccagg ccttagcgcc aggctccgtg tggcggtcaa ttccaggtgc
     1981 tgtaaagccg actaacaggg tacagggagc cttagctggc tgccatgtct cctgcctgta
     2041 atcccatcac tttgggaggc tgaggtggga ggtttgctta agcccaggag tttgagacca
     2101 gcttgggcaa catggtgaaa cttctctaca aaaaatttaa aaataagtca ggtatcgtgg
     2161 tctgtgcctg tacgctgtag tcccagctac tcaggaggct gaggtgggag gatgggttga
     2221 gcctgggaag tcaaggctgc agtgagctat gatagcacca cggcactcca acctggttga
     2281 cagagtgaca ccctgtttaa aaaaaaaaag cctagatggc tggtggagct ctatctatct
     2341 atctatctat ctatctcttt ttttgaggca ggatctctct gtcagccagc ctggagtgca
     2401 atggcacaat catggcttac tgcagcctcc agctcccagg ctcaagcgtt tctcccacct
     2461 tagcctcctg agtagctggg actaaggcac acacactgta cttggcagct ggcgaagcat
     2521 tgtttctgag tgtgtgagga tgttttcagt ggactcagtg aagatctgcc ctcagcgtgg
     2581 gcaggcacat ccacttggtt ggggacccag atggaacaca aagggagaag acaagcaaat
     2641 tctcttttct ggagggagac acccatctcc tgcccttgga catcaggact ccaggttctt
     2701 cggcctttgg actcaggctt gccacagagg cctcccaggg ctctcggcca gtcagcctca
     2761 gaatgagagt tacaccactg gcttccttgg ttcaaccacc ttcttacctg gactgagcct
     2821 cacttacagc ttctctaggt ctccagcttg cagacagcct atgggaggac ttctcagcct
     2881 ccataagtgt gtgggccagt tcgcctaata aatcccctct cctggccggg cgcggtagct
     2941 ctcccctgta atctcagcat tttgggaggc agaggtaggt ggatcacctg aggtcaggag
     3001 ttcaagacca gcctggccaa catggtgaga cccccgtctc tactaaaagt acaaaaagta
     3061 gctgggtgtg gtgctgggtg cctgtaatcc cagctactcg ggaggctgaa gcaggagaat
     3121 cacttcaacc tgggaggtag aggttgcagt gagccgagat cgagccactg cactccagcc
     3181 tgggtgacag ggcaagactc tgtctcaaac aaataaaaat cccctctcct aaactcca
//
