LOCUS       NM_014643               8678 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 516 (ZNF516), mRNA.
ACCESSION   NM_014643 XM_496278 XM_937409
VERSION     NM_014643.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8678)
  AUTHORS   Xie,Z.Q., Chen,F., He,J., Zhong,L., Luo,G. and Fang,M.
  TITLE     MiR-371-5p regulates trophoblast cell proliferation, migration, and
            invasion by directly targeting ZNF516
  JOURNAL   Aging (Albany NY) 16 (10), 8585-8598 (2024)
   PUBMED   38761180
  REMARK    GeneRIF: MiR-371-5p regulates trophoblast cell proliferation,
            migration, and invasion by directly targeting ZNF516.
REFERENCE   2  (bases 1 to 8678)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 8678)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   4  (bases 1 to 8678)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8678)
  AUTHORS   Beck,D.B., Subramanian,T., Vijayalingam,S., Ezekiel,U.R.,
            Donkervoort,S., Yang,M.L., Dubbs,H.A., Ortiz-Gonzalez,X.R.,
            Lakhani,S., Segal,D., Au,M., Graham,J.M. Jr., Verma,S.,
            Waggoner,D., Shinawi,M., Bonnemann,C.G., Chung,W.K. and
            Chinnadurai,G.
  TITLE     A pathogenic CtBP1 missense mutation causes altered cofactor
            binding and transcriptional activity
  JOURNAL   Neurogenetics 20 (3), 129-143 (2019)
   PUBMED   31041561
REFERENCE   6  (bases 1 to 8678)
  AUTHORS   O'Brien,R.P., Phelan,P.J., Conroy,J., O'Kelly,P., Green,A.,
            Keogan,M., O'Neill,D., Jennings,S., Traynor,C., Casey,J.,
            McCormack,M., Conroy,R., Chubb,A., Ennis,S., Shields,D.C.,
            Cavalleri,G.L. and Conlon,P.J.
  TITLE     A genome-wide association study of recipient genotype and
            medium-term kidney allograft function
  JOURNAL   Clin Transplant 27 (3), 379-387 (2013)
   PUBMED   23432519
REFERENCE   7  (bases 1 to 8678)
  AUTHORS   Yang,T.L., Guo,Y., Li,J., Zhang,L., Shen,H., Li,S.M., Li,S.K.,
            Tian,Q., Liu,Y.J., Papasian,C.J. and Deng,H.W.
  TITLE     Gene-gene interaction between RBMS3 and ZNF516 influences bone
            mineral density
  JOURNAL   J Bone Miner Res 28 (4), 828-837 (2013)
   PUBMED   23045156
  REMARK    GeneRIF: one interacting gene pair (RBMS3 versus ZNF516) which,
            even after Bonferroni correction for multiple testing, showed
            consistently significant effects on hip bone mineral density.
REFERENCE   8  (bases 1 to 8678)
  AUTHORS   Shaffer,J.R., Feingold,E., Wang,X., Lee,M., Tcuenco,K., Weeks,D.E.,
            Weyant,R.J., Crout,R., McNeil,D.W. and Marazita,M.L.
  TITLE     GWAS of dental caries patterns in the permanent dentition
  JOURNAL   J Dent Res 92 (1), 38-44 (2013)
   PUBMED   23064961
REFERENCE   9  (bases 1 to 8678)
  AUTHORS   Yashin,A.I., Wu,D., Arbeev,K.G. and Ukraintseva,S.V.
  TITLE     Joint influence of small-effect genetic variants on human longevity
  JOURNAL   Aging (Albany NY) 2 (9), 612-620 (2010)
   PUBMED   20834067
REFERENCE   10 (bases 1 to 8678)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018413.10, D86975.1,
            AC009716.22 and BC108287.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014643.3.
            
            Summary: Zinc-finger proteins bind nucleic acids and play important
            roles in various cellular functions, including cell proliferation,
            differentiation, and apoptosis. This gene encodes a zinc-finger
            protein, and belongs to the krueppel C2H2-type zinc-finger protein
            family. It may be involved in transcriptional regulation. [provided
            by RefSeq, Sep 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86975.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000443185.7/ ENSP00000394757.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC018413.10        73050-73101         c
            53-141              D86975.1           1-89
            142-213             AC009716.22        21935-22006
            214-2180            AC009716.22        41823-43789
            2181-2721           D86975.1           2129-2669
            2722-3629           BC108287.1         524-1431
            3630-5711           D86975.1           3578-5659
            5712-8678           AC009716.22        124387-127353
FEATURES             Location/Qualifiers
     source          1..8678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..8678
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /note="zinc finger protein 516"
                     /db_xref="GeneID:9658"
                     /db_xref="HGNC:HGNC:28990"
                     /db_xref="MIM:615114"
     exon            1..99
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     exon            100..213
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     exon            214..2180
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     CDS             371..3862
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /codon_start=1
                     /product="zinc finger protein 516"
                     /protein_id="NP_055458.1"
                     /db_xref="CCDS:CCDS74234.1"
                     /db_xref="GeneID:9658"
                     /db_xref="HGNC:HGNC:28990"
                     /db_xref="MIM:615114"
                     /translation="MDRNREAEMELRRGPSPTRAGRGHEVDGDKATCHTCCICGKSFP
                     FQSSLSQHMRKHTGEKPYKCPYCDHRASQKGNLKIHIRSHRTGTLIQGHEPEAGEAPL
                     GEMRASEGLDACASPTKSASACNRLLNGASQADGARVLNGASQADSGRVLLRSSKKGA
                     EGSACAPGEAKAAVQCSFCKSQFERKKDLELHVHQAHKPFKCRLCSYATLREESLLSH
                     IERDHITAQGPGSGEACVENGKPELSPGEFPCEVCGQAFSQTWFLKAHMKKHRGSFDH
                     GCHICGRRFKEPWFLKNHMKAHGPKTGSKNRPKSELDPIATINNVVQEEVIVAGLSLY
                     EVCAKCGNLFTNLDSLNAHNAIHRRVEASRTRAPAEEGAEGPSDTKQFFLQCLNLRPS
                     AAGDSCPGTQAGRRVAELDPVNSYQAWQLATRGKVAEPAEYLKYGAWDEALAGDVAFD
                     KDRREYVLVSQEKRKREQDAPAAQGPPRKRASGPGDPAPAGHLDPRSAARPNRRAAAT
                     TGQGKSSECFECGKIFRTYHQMVLHSRVHRRARRERDSDGDRAARARCGSLSEGDSAS
                     QPSSPGSACAAADSPGSGLADEAAEDSGEEGAPEPAPGGQPRRCCFSEEVTSTELSSG
                     DQSHKMGDNASERDTGESKAGIAASVSILENSSRETSRRQEQHRFSMDLKMPAFHPKQ
                     EVPVPGDGVEFPSSTGAEGQTGHPAEKLSDLHNKEHSGGGKRALAPDLMPLDLSARST
                     RDDPSNKETASSLQAALVVHPCPYCSHKTYYPEVLWMHKRIWHRVSCNSVAPPWIQPN
                     GYKSIRSNLVFLSRSGRTGPPPALGGKECQPLLLARFTRTQVPGGMPGSKSGSSPLGV
                     VTKAASMPKNKESHSGGPCALWAPGPDGYRQTKPCHGQEPHGAATQGPLAKPRQEASS
                     KPVPAPGGGGFSRSATPTPTVIARAGAQPSANSKPVEKFGVPPAGAGFAPTNKHSAPD
                     SLKAKFSAQPQGPPPAKGEGGAPPLPPREPPSKAAQELRTLATCAAGSRGDAALQAQP
                     GVAGAPPVLHSIKQEPVAEGHEKRLDILNIFKTYIPKDFATLYQGWGVSGPGLEHRGT
                     LRTQARPGEFVCIECGKSFHQPGHLRAHMRAHSVVFESDGPRGSEVHTTSADAPKQGR
                     DHSNTGTVQTVPLRKGT"
     exon            2181..3629
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3734
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..3802
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..8678
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6064..6069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /note="hexamer: AAGAAA"
     polyA_site      6082
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
     regulatory      8147..8152
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /note="hexamer: AATAAA"
     polyA_site      8170
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /note="major polyA site"
     regulatory      8655..8660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
                     /note="hexamer: AATAAA"
     polyA_site      8678
                     /gene="ZNF516"
                     /gene_synonym="HsT287"
ORIGIN      
        1 agtgcagcgc tcggctccgc gccgcgggcg ctcggcttca ccttcagatg cgcggggcgt
       61 gcgcgtcctc ctccccaggc ccgccgcctc cctgccaaga atctgagaga ggccgagtgg
      121 agttcggtcc ttctctgaac acttttagct gagagtacca gcatccaact gggagcgttg
      181 tcattgcatt tccacattcc caggaaagcc caggtgctgg ctgccagctg ctgcgccccc
      241 catgtagaag gtgcacctcc tgggagcagg cacgtctttt ggctcttctg accatggaga
      301 gataggacgg tccctgcagc ccgcgcgaca gaaagctgtg ccgccaccac cggccgcgcc
      361 cgtccttcgg atggatcgca acagagaggc cgagatggag ctgaggcgag gccccagccc
      421 caccagggcc ggccggggcc acgaggtgga tggggacaag gctacctgcc acacctgctg
      481 catctgcggc aagagcttcc ccttccagag ctcgctttcg cagcacatgc gcaagcacac
      541 gggcgagaag ccctacaagt gtccctactg cgaccaccgg gcttcccaga agggcaacct
      601 gaagattcac atccggagcc accgcacggg gactctgatt cagggacacg agccggaggc
      661 gggcgaggcg ccgctgggtg agatgcgcgc ctccgagggc ctggacgcct gcgccagccc
      721 caccaagagc gcctcggcct gcaaccggct gctgaacggg gcctcgcagg ccgacggcgc
      781 cagggtcctg aacggggcct cgcaggccga cagcggcaga gtcctgctgc ggagcagcaa
      841 gaagggggca gaggggtccg catgcgcccc gggggaggcc aaggcagcgg tccagtgctc
      901 cttctgcaag agccagttcg agcgtaagaa ggacctggag ctgcacgtgc accaggcgca
      961 caagccgttc aagtgcaggc tgtgcagcta cgcgacgctg cgggaggagt cgctgctgag
     1021 ccacatcgag agggaccaca tcaccgcgca ggggcccggc agcggcgagg cctgcgtgga
     1081 gaacggcaag cccgagctga gccccgggga gttcccgtgc gaggtgtgtg gccaggcctt
     1141 cagccagacc tggttcctga aggcgcacat gaagaagcac cggggctcct tcgaccacgg
     1201 ctgccacatc tgcggccgta ggttcaagga gccctggttc ctcaagaacc acatgaaggc
     1261 gcacggcccc aagacgggca gcaagaacag gcccaagagt gagctggacc ccatcgccac
     1321 catcaacaac gtggtccagg aggaggtgat cgtcgccggc ctgagcctct acgaggtctg
     1381 cgccaagtgc gggaacctgt ttacaaacct ggacagcttg aacgcccaca atgccatcca
     1441 ccgcagagtc gaggccagcc gcacgcgcgc cccggccgag gagggggcgg aggggccctc
     1501 ggacaccaag cagttcttcc tccagtgcct gaacctgagg ccgtcggcgg ccggcgactc
     1561 gtgccctggc acgcaggccg gacggcgggt ggctgagctg gacccggtca acagctacca
     1621 ggcctggcag ctggccacgc ggggtaaggt ggccgagccg gccgagtacc tcaagtacgg
     1681 ggcctgggac gaggcgctgg ccggggacgt ggccttcgac aaggacaggc gcgagtacgt
     1741 cctggtgagc caggagaagc gcaagcgtga gcaggatgca ccagccgcgc aggggccccc
     1801 gcggaagcgc gcgagcgggc ctggggaccc cgcgcccgcc ggccacctcg atccccgctc
     1861 ggccgcgcgc cccaaccgca gggccgcagc caccaccggc cagggcaagt cctccgagtg
     1921 cttcgagtgc ggcaagatct tccgcaccta tcatcagatg gtgctgcact cacgcgtgca
     1981 tcgccgcgcg cgccgcgaga gggacagtga cggggacagg gcggcgcggg cccgctgcgg
     2041 atcactcagt gagggtgact cggcctccca gcccagcagc cctggctccg cctgtgccgc
     2101 tgctgactcc ccgggctctg gcctggccga cgaggctgcc gaagacagtg gtgaggaggg
     2161 cgcccctgaa cctgcaccag ggggacagcc gcgccgctgc tgcttttccg aagaggtgac
     2221 ttcgaccgag ctctccagtg gagaccagag tcacaagatg ggagataacg cctcggaaag
     2281 agacaccggc gagtccaagg cagggatcgc agcttctgtg tccatacttg aaaacagtag
     2341 cagagagact tctagaaggc aagagcagca cagattttct atggacttaa agatgccagc
     2401 atttcacccc aagcaggagg tgcccgtccc tggtgatggt gtggagttcc cttccagtac
     2461 gggagcggag ggccagacgg gtcaccctgc agaaaagctg tccgatttgc acaacaagga
     2521 acactctggg ggagggaagc gggcgctggc cccagacctc atgccgctag atttaagtgc
     2581 gaggtcgacg cgggatgacc ccagcaataa ggagacggcc tcctccctgc aggcggcttt
     2641 agtcgttcac ccgtgtcctt actgcagcca caagacctac taccccgagg tcctgtggat
     2701 gcacaaacgc atctggcacc gcgtcagctg caactccgtg gctcccccgt ggattcagcc
     2761 caatggttac aaaagcatca gaagcaattt ggttttcctt tcccggagcg gacgcacggg
     2821 ccccccgcct gccctcggtg gcaaagaatg ccagcctttg ctccttgctc ggttcacccg
     2881 cactcaggtg ccagggggga tgccggggtc caaaagtggc tcttctcccc tgggagtggt
     2941 cacaaaagcc gctagcatgc ctaagaataa ggagagccat tccggaggtc cctgcgctct
     3001 gtgggcgccc ggccctgacg ggtatcgaca gaccaaacct tgtcacggcc aggagccaca
     3061 tggcgcggcc acacaggggc ccctggccaa gcccaggcag gaggctagct ccaaaccggt
     3121 gcctgccccg ggtggcgggg gcttcagcag gagcgccacc cctacgccca ccgtcatcgc
     3181 ccgggctggc gcgcagccct cggccaatag caagcctgtg gagaagtttg gggtcccccc
     3241 agcgggggct ggctttgccc ccacaaataa gcacagtgcc ccggactccc tgaaagccaa
     3301 attcagtgct cagcctcagg gtccacctcc tgcaaagggc gaagggggcg ctcctcctct
     3361 acctccccgc gagcccccct cgaaggcagc ccaggagctg aggactctgg ccacctgtgc
     3421 tgcggggtcc aggggcgacg cggccttgca ggcccagccc ggcgtggctg gggcgccccc
     3481 cgtcctacac tccatcaaac aggagccggt ggccgagggg catgagaagc gcctggacat
     3541 cctcaacatc tttaagacgt acattccaaa ggactttgcg accctctacc agggatgggg
     3601 tgtcagcggc cctgggttgg agcacagagg gacactccgg acgcaggccc ggccaggaga
     3661 gttcgtctgc atcgagtgcg gaaagagctt ccaccagccc ggccacctca gggcccacat
     3721 gcgggcacac tcagtggtgt ttgagtccga tgggcctcgg ggttctgaag ttcataccac
     3781 ctccgcagac gcccccaaac aagggagaga ccattctaac acaggtaccg tccagacagt
     3841 gcctctgaga aagggaacct aaaggcgtgt ttccgacgca ccccaggtcc ccgtaacggc
     3901 cattagcagt accctcacga tgtcccagca gcctcccacc tgtgacctgg ccgctccatg
     3961 gaagaacagc cggggaactc ctgagcagac acctcacatc ccgagccgct gcgctggagt
     4021 ggaaactgaa ggcagatgcc tctccttgtt aaacgttcag aaataaatga agatgctata
     4081 ttctagaaat acatgtagat actatatacg catttacgtg ctcatcgtcc atagtcccat
     4141 attttcttat aataaacagt agtactggca ggcacagtag gggcacaagg catctgtctt
     4201 attcaagaca agtttgagac actggaaaaa aagatacttg ttgtgtgtgt tggacagagt
     4261 ggcgaggctg agcactgtca caggggcctc ccatgttaag agggactgtg gggatgatgt
     4321 cagaacaaga cgtggtggat ttgaggttga tcgagtatta atactactgc ctctccttgt
     4381 cttagtgggt atttaaaata gtaaataaga gagaggaagg aggtgacgtt caggtgctgt
     4441 gggaagcagg cttggcggag gggtatgatg atgagaccct cattgttcac tggctccatc
     4501 gcactcctcc ctggggccgt gtgcctgttc cattcttccc accattcgaa ctgagcgaat
     4561 ctggcaaagg agacacgtct gtgggaatgc gtagattccg cctcggaaga gagctagcgc
     4621 aacactaaga aaagcaggct tcttgtttat tctcaggacc tttttgtaac agggctacat
     4681 tctgcaaact gcttacaaag gaagactata cgtcttaaca aattatttag ccactgagtc
     4741 ctcccgattc ggacctgttt tagtaatggc agaagaatcc ctgagcaggt tcaggtgccc
     4801 tagatgacta gggtgctgag ctctggcgcc ttctgtcccc actctttgcc tccccgcccc
     4861 ttccctgagc caccccagca agtgggtgtc ttttctccct gggcctggtg acctccacag
     4921 gatgagtgac tttgttcata aagggtgggg atcaccagcc ccttgggtgg gggacggctt
     4981 catatacctc ttcctcagta atgcaaatgc gagtttttgt ggtgggggtt aaggcccata
     5041 acaaaggatc ttaaaccatg cagtgtacgc aattgaaatg gtattccaca gatataaata
     5101 ttttcttttc ccattgccgt gacactatgt gtgatggtaa tatttctgag agtttcagat
     5161 ttttgcacat atgattttat gcattatcaa aagttactgc tgccttgaat gaaaatgttc
     5221 tgtgaaattt tttgcaaaag ctttactagg ttttttttta attgtgaaat tttgtaaagg
     5281 caggaaatgg attaaaacga gcatgctaaa tatatttttc aaaaaagcaa taattttaca
     5341 tgtacagaaa ttatcctaac ctttaatact ggcgagagca acagtttact taatacggta
     5401 atggactagt gcagtttttg tagacagtgg gcttctgata caaagtcttg tttaaacaca
     5461 gacacacaca cacacaaaca cacacacaca ccctaaagtg tgggtttcct gttctaatga
     5521 tttgttgaat attattatat tattattatt attattatta ttattgttat tgttattagt
     5581 aatgtttggt tctggattct acttgttact gagtttaaat tacttgacgg ttcaggttac
     5641 tttgcaacac tttcaaacga tgcaatgtaa ctggctagct tatatatata tatatatata
     5701 tatatatata tatttttttt tttttttact tatttttttc tgatattctt acaccagata
     5761 tgtacgaaaa tgatctgtcc tgttggtgta attaggaatg tccatgcaga tacagttaaa
     5821 caactgtaat tgactgttct gtaaagttat tttgggcaaa gttgcggaga cacattcctc
     5881 tgtccaccta agaaatcaga agactcttct gttgatttat gtttaatcat ttcagtagtt
     5941 tccccacagt gatcatttct gcattttctg gcttttgttt tcttggctga aagtgaatgg
     6001 tgactgttag gaatgtcagg gactagtgac ccagtcctgt ttctctgtgt tttagttatt
     6061 aaaaagaaat tctgtaccca aagtgacacg aaagtgtagt ctacattttt actgtttcag
     6121 aagcggcatg gaaaagtgca gttggccttt ggagctggaa gtgtcttgct ggtgaggctc
     6181 catcctggag gctctggtgg ggagtgggct ggcgctgggg ccctgccggc cgcgtgctgg
     6241 atccttcctg gcttgcagga gagcaggcgt ggaggacagt cagcttgcgg ggccgcgcag
     6301 ggtgcacaga gtgcaggagg aaggttttca cccagttaaa cagactgggg agccccccca
     6361 agaacgccat cccttgaggc cagctgtggg caggcctgga tgtgtggtcc cttccttcca
     6421 cccatcgtca gtattgtgtt ggtttgttaa tttgttgatt tggtcatagt atttaatatg
     6481 atttgtgttt ccttatttat ttagccaccg ttttgattgc cttttttttt ccgaatggta
     6541 atttctgcat gatacacttc tgtacgttgt cttctgactg ttacagactt tctactacct
     6601 ctcccgatct gctgtttcct tgtttcttaa caggattttt tacagtgttg cgtctaatgt
     6661 aacttagaca ataaagggtt tggttgtcta cactgcagct tctcggtgtc tctcccctgc
     6721 tttccgctcg ctgcttcccg ctctgcccct gctggggcct ggctgcaccc tggcctgcct
     6781 tcctatactc tcctgtttcc tgctcatatc tcttcctcat ttttgcgttc aaataacaca
     6841 cagctaatga gcttctaaaa atcttttcag gttgttcact tgtattcctt aatttgaaga
     6901 atgaatattt aaattctctc aaaagtcaga tattgaggat cttctctggg aaattggcca
     6961 ctgtacctgc ccacctttct gcctggttcc ctggaaggtc ttattgtcat cttagacgga
     7021 cagatttcat tctcagcacc atacagattt ggcttcaaag ccaggtgaat tttgcctttg
     7081 aggctctgaa aagtattaag tgttttaaga ggtcccccaa tatttactta tttatttttt
     7141 aaaccaagaa agacactggt tccctgaaaa gcaggtgctt caggaagtag caattgggag
     7201 ttgcatacag ttacttcgtc agagaaagga gcgcccagta tgacaggccc ccacccctga
     7261 tccggccact gtgcacaggt cgctgagggt gtgagaacac ctctgcaggg gctccggcac
     7321 atgtgggttt catcgtctca cactccttca ggctgcaggg gttgagtgca gaaagggcaa
     7381 gcttcatctc catggtgcct ctccaggctg gcaactctgg tcggcctctg ttctttggac
     7441 agagagggtg taggttacag ggtcagtagg gatgctttct ggatcaaaga aagtgggtgt
     7501 agtgcttagt ctgttgtgtg gaagagggca cctcctgggc tttcgtggct ggagactgtc
     7561 taccaacatt ccttccttca aactagacaa accctcctct gccaccccca gcaaattctc
     7621 agaggtttcc aagctgtaga aaaaggaagg aaggaaggac ggcattcaca tagctttact
     7681 ttctgcttca aaatgtctta agtagcatat gttgttttac tgcttttaac tttggtgagt
     7741 tctaatttca gaacgttttg ttcactgagc aaaaaaacag atgaaacaac cacaggccag
     7801 gacttcaagt gaggaggacg cctttgtttg ccgtggttgg tgggagcaca cgccggagcc
     7861 cggtaacgtg cctgtgggag tgaccaaggg ccacccgccc aagggaaaat gttcattctt
     7921 catcagcttt gctaattctg ctttgaggca gtaaaatgca aaagaccata gaatttgtat
     7981 ttcttttttt aaaatacaat ttataacatt atattttgta ctctttatat tagaatttgt
     8041 aactagattg atgtatttaa ctatttctga aaaagtaatt caatgtttta gttgtgtgat
     8101 aaaaatattt agataaaaca tattcattct attggaattt gaaataaata aaaacatctt
     8161 ggagttctga gatttgtaag acatttttcc ccaatttcag agggtggcgt aaatcgtttg
     8221 acagcccgct ttggtctgtg gttatttatt tttgttggct gaacataaac caaagtgtta
     8281 atgctcttta tttatggaag agttttaggg taattcacaa gatcgttcat ctgaacagat
     8341 gcccagatgg cccgagtggt ttttttccaa ctcttttgtg gactcgagga catacagttt
     8401 tttaatggag acgctgtgtt tttctcattt tctttcacag cacacatgtt atttccccac
     8461 tgaatacacc cactgttctt acccttgcac tgtcacccat acaggacgca cagggatgga
     8521 cgcggacgga attctgactc agccacacct ggaggaaatt attgtgtcaa aaatgtgggg
     8581 acacaagggc tggcactgtg gtttgcaatg gtttactgat gagacagcaa aaatgagaca
     8641 ggaccatcag atgcaataaa gattctaatt taaaaaga
//
