LOCUS       NM_032788               6189 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 514 (ZNF514), transcript variant
            2, mRNA.
ACCESSION   NM_032788
VERSION     NM_032788.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6189)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 6189)
  AUTHORS   Kimura,K., Wakamatsu,A., Suzuki,Y., Ota,T., Nishikawa,T.,
            Yamashita,R., Yamamoto,J., Sekine,M., Tsuritani,K., Wakaguri,H.,
            Ishii,S., Sugiyama,T., Saito,K., Isono,Y., Irie,R., Kushida,N.,
            Yoneyama,T., Otsuka,R., Kanda,K., Yokoi,T., Kondo,H., Wagatsuma,M.,
            Murakawa,K., Ishida,S., Ishibashi,T., Takahashi-Fujii,A.,
            Tanase,T., Nagai,K., Kikuchi,H., Nakai,K., Isogai,T. and Sugano,S.
  TITLE     Diversification of transcriptional modulation: large-scale
            identification and characterization of putative alternative
            promoters of human genes
  JOURNAL   Genome Res 16 (1), 55-65 (2006)
   PUBMED   16344560
REFERENCE   3  (bases 1 to 6189)
  AUTHORS   Hillier,L.W., Graves,T.A., Fulton,R.S., Fulton,L.A., Pepin,K.H.,
            Minx,P., Wagner-McPherson,C., Layman,D., Wylie,K., Sekhon,M.,
            Becker,M.C., Fewell,G.A., Delehaunty,K.D., Miner,T.L., Nash,W.E.,
            Kremitzki,C., Oddy,L., Du,H., Sun,H., Bradshaw-Cordum,H., Ali,J.,
            Carter,J., Cordes,M., Harris,A., Isak,A., van Brunt,A., Nguyen,C.,
            Du,F., Courtney,L., Kalicki,J., Ozersky,P., Abbott,S.,
            Armstrong,J., Belter,E.A., Caruso,L., Cedroni,M., Cotton,M.,
            Davidson,T., Desai,A., Elliott,G., Erb,T., Fronick,C., Gaige,T.,
            Haakenson,W., Haglund,K., Holmes,A., Harkins,R., Kim,K.,
            Kruchowski,S.S., Strong,C.M., Grewal,N., Goyea,E., Hou,S., Levy,A.,
            Martinka,S., Mead,K., McLellan,M.D., Meyer,R., Randall-Maher,J.,
            Tomlinson,C., Dauphin-Kohlberg,S., Kozlowicz-Reilly,A., Shah,N.,
            Swearengen-Shahid,S., Snider,J., Strong,J.T., Thompson,J.,
            Yoakum,M., Leonard,S., Pearman,C., Trani,L., Radionenko,M.,
            Waligorski,J.E., Wang,C., Rock,S.M., Tin-Wollam,A.M., Maupin,R.,
            Latreille,P., Wendl,M.C., Yang,S.P., Pohl,C., Wallis,J.W.,
            Spieth,J., Bieri,T.A., Berkowicz,N., Nelson,J.O., Osborne,J.,
            Ding,L., Meyer,R., Sabo,A., Shotland,Y., Sinha,P., Wohldmann,P.E.,
            Cook,L.L., Hickenbotham,M.T., Eldred,J., Williams,D., Jones,T.A.,
            She,X., Ciccarelli,F.D., Izaurralde,E., Taylor,J., Schmutz,J.,
            Myers,R.M., Cox,D.R., Huang,X., McPherson,J.D., Mardis,E.R.,
            Clifton,S.W., Warren,W.C., Chinwalla,A.T., Eddy,S.R., Marra,M.A.,
            Ovcharenko,I., Furey,T.S., Miller,W., Eichler,E.E., Bork,P.,
            Suyama,M., Torrents,D., Waterston,R.H. and Wilson,R.K.
  TITLE     Generation and annotation of the DNA sequences of human chromosomes
            2 and 4
  JOURNAL   Nature 434 (7034), 724-731 (2005)
   PUBMED   15815621
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092835.4, DA757737.1, AK027363.1, BC068498.1 and AI694922.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032788.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate splice site in the 5' coding region that results in
            use of a downstream start codon compared to variant 1. It encodes
            isoform 2, which has a shorter N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.157358.1, AK027363.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2150385, SAMN03267767
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295208.7/ ENSP00000295208.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC092835.4         78091-78353         c
            264-330             DA757737.1         1-67
            331-3065            AK027363.1         1-2735
            3066-3066           BC068498.1         3011-3011
            3067-3534           AK027363.1         2737-3204
            3535-5842           AC092835.4         63852-66159         c
            5843-6189           AI694922.1         10-356              c
FEATURES             Location/Qualifiers
     source          1..6189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q11.1"
     gene            1..6189
                     /gene="ZNF514"
                     /note="zinc finger protein 514"
                     /db_xref="GeneID:84874"
                     /db_xref="HGNC:HGNC:25894"
     exon            1..609
                     /gene="ZNF514"
                     /inference="alignment:Splign:2.1.0"
     exon            610..698
                     /gene="ZNF514"
                     /inference="alignment:Splign:2.1.0"
     exon            699..825
                     /gene="ZNF514"
                     /inference="alignment:Splign:2.1.0"
     CDS             705..1907
                     /gene="ZNF514"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="zinc finger protein 514 isoform 2"
                     /protein_id="NP_116177.1"
                     /db_xref="CCDS:CCDS2011.1"
                     /db_xref="GeneID:84874"
                     /db_xref="HGNC:HGNC:25894"
                     /translation="MTFEDVAVEFSQWEWGQLNPAQKDLYREVMLENFRNLAILGLLV
                     SKPYVICQLEEGGEPFMVEREISTGAHSDWKRRSKSKESMPSWGISKEELFQVVSVEK
                     HIQDVLQFSKLKAACGCDGQLEMQQIKQERHLKQMSTIHKSATTLSRDYKWNGFGRSL
                     GLRSVLVNQHSILMGEGSYKCDTEFRQTLGGNNSQRTHPEKKSCKCNECGKSFHFQSE
                     LRRHQRCHTGEKPYECSDCGRAFGHISSLIKHQRTHTGEKPYECSECGRAFSQSSSLV
                     LHYRFHTGEKPYKCNECGRAFGHTSSLIKHQRTHTGEKPYECRECGRTFSQSSSLIVH
                     YRFHTGEKPYKCNKCGRAFSQSSSLTQHYRFHTGEKPYKCNECGRAFAHTASLIKHQR
                     SHAGKKTL"
     exon            826..921
                     /gene="ZNF514"
                     /inference="alignment:Splign:2.1.0"
     exon            922..6189
                     /gene="ZNF514"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3837..3842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF514"
                     /note="hexamer: AATAAA"
     polyA_site      3861
                     /gene="ZNF514"
     regulatory      6163..6168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF514"
                     /note="hexamer: ATTAAA"
     polyA_site      6189
                     /gene="ZNF514"
                     /note="major polyA site"
ORIGIN      
        1 agcttcgccg cgccagcacc ccgccaccgg cgctggctct gaagggcccc ggcggcggcc
       61 gcgtctgcgc aagctcggga cggcctcggg aggcggggct ggcgcggggc ggacgcgggg
      121 gctggcgcgg ggcggacgcg ggggctggcg cggggcggac gcgggggctg gcgcggggtg
      181 gcgggcgggg gctggcgcgg ggtggcgggc gggggctggc gcggggtggc gggcgggggc
      241 tggcgcgggg tggcgggcgg ggcctggtcc tgtgagcgtt cggagactgc gggcgcgcag
      301 acctgtactg ggcccgcgcc ccggcccctt acagagctgg gtgtgtccct ccgagtgccc
      361 cccgctaggg actgtgcagg ccggagctag gcagggacag cggggcgaac cgggctgata
      421 gagtcggtcc ctgctcctgt gaggctctca ccgaatccct gctgtttccg ggcagctgaa
      481 gagcgctggg ccctcgcgtc gcgggcgtgg ctgtggccgt gtctcctggt agtctgagcc
      541 cactgtgcgt gtggatccac gtgggagctg ggttccagag cctggtcctg aggaggagcc
      601 gagccggggc ttccccttct cagaatcctg ctcttcctcc agagagattc ccaggagaag
      661 agggaacaac caattcattc ctgaaagcca ggcctcggga cctgatgaca tttgaagatg
      721 tggctgtgga attcagccag tgggagtggg ggcagctgaa ccctgctcag aaggacctct
      781 acagggaggt gatgctggag aacttcagga acttggccat tctgggcctt ctagtatcca
      841 aaccatatgt gatctgccag ttggaggaag ggggtgagcc cttcatggtg gagagagaaa
      901 tctcaacagg agcccactca gactggaaga gaaggtctaa atccaaggaa tcaatgccaa
      961 gttggggaat ttccaaagaa gaattattcc aggtagtatc agtggaaaaa cacattcaag
     1021 atgtgctgca gttctcgaag ttgaaagcag cctgcggttg tgatggccag ttagagatgc
     1081 agcagataaa acaggagaga cacctgaaac aaatgtcaac cattcacaaa tctgccacca
     1141 cccttagcag agattataaa tggaatggat ttgggagaag cttaggttta agatcagtcc
     1201 ttgttaacca acacagcatt ctcatgggag aaggatctta taaatgtgat acagaattca
     1261 ggcagacttt agggggaaac aactctcaga gaacccaccc agaaaagaaa tcttgtaaat
     1321 gtaatgagtg tgggaagtcc tttcacttcc agtcagaact taggcgccat cagcgatgtc
     1381 acactggaga aaagccgtat gaatgcagtg actgtggaag agcctttggt catatttcat
     1441 cccttattaa acatcaaaga actcatactg gagaaaagcc ctatgaatgc agtgaatgtg
     1501 ggagagcctt cagccagagt tcgtctcttg ttctgcacta tagatttcac actggagaga
     1561 aaccctacaa atgtaatgaa tgtggacgag cctttggtca cacttcatcc cttattaagc
     1621 atcagaggac tcatactgga gaaaagccct atgaatgccg ggaatgtggg agaaccttca
     1681 gccagagctc atcactcatt gtgcattaca gatttcatac tggagagaaa ccttacaaat
     1741 gtaataaatg tgggagagcc ttcagccaga gttcatctct cactcaacat tacagatttc
     1801 acactggaga gaaaccctac aaatgtaatg agtgtggaag ggcctttgct catactgcat
     1861 cccttattaa acatcagaga agtcatgctg gaaaaaaaac cctataaatt cagtgaatat
     1921 agaagggctt tcagctggag tgcagacatc actggaactt aaagaattca tatcagagag
     1981 agatcctaaa ggtgtaatgt atgtgggaag accacatctt gttccacatc aggcaataat
     2041 tactaaagag aatccctgtc aatgtcaaga gggggtgggc ttcccctctc ttaccaaaca
     2101 tgggagaatc catactagtg agaaaccacg tgaatgtaat gaatgtggga acgctttgat
     2161 cagaggatgc atattattca gcatcagaca gccgacactg gggaggagcc ttatcaatgc
     2221 agtgagtgtg gcaagccttc agttacatac tgattcttta agaaaatcag ataacttgta
     2281 ctggagagaa atcctacaag tgtggtaagt atggaaaaat cttcagttgt atctcttcct
     2341 ttactaagca tcaagaacac atactagaga gaggccctat gaaagcagga aatagaggaa
     2401 ggccttcagt cagggctcat cccttattaa gcatcagaaa attcatacct gagaaaaacc
     2461 tgtgaatgtg ggtaatgtgg gagagccttc agccaaacct cattgcttta taaacccctt
     2521 agaactctcc ctactagctg gaaactctgg tgacgtgatg aatgtgggaa gggctttggt
     2581 ggatgttcca ccaaaacacg ttagagaatt tgtacattag agaatttgtg ctagagcaac
     2641 tcttcaaatt tagtgaaact gggaaaaccc attagtagag ttcaagcttc agtattcatc
     2701 tcaaagagaa accttgggaa catgatgaat gtgaggaaag ttcctttcca acttgagatg
     2761 tataaaacta gagctgaaaa gaagctgaga aatcaccttg tctggtgatt ttctgcctgg
     2821 tggggccatt tgtataacga cacttgtgca ttgcctcctc atgctgttac tgacggggca
     2881 gggtgtcatg catgggtgca gaggatggag gctgagaaag gtagacagct acccatgatc
     2941 tagcccagtc gtattttaga gctaataaaa ctgatgttca gaaagtgaca tgccttggcc
     3001 tatagtccta actgggctgg gcctctttcc tgtggttcac agctgtagta tggagattaa
     3061 tagactggat ctttgcagta caacacctct atgcacttct ttctctgtag cacatgttac
     3121 ctttctttgt gaggcaatgg agtggtctag gattgagcaa aaagcaattt ttgttacatc
     3181 tttatgctaa tagatttgga atttttgaaa tgaaatgaaa ccttgtttaa acattaaaat
     3241 tactaaaata ggctgggcgc ggtggctcac gcctgtaacc tcagcacttt gggaggccga
     3301 ggcggacaga tcacgaggtc aggagttcga gaccatcctg gctaacacag tgaaaccctg
     3361 tctctcctaa aaatacaaaa aaattagcca ggcatggtgg cgggcgcctg tagtcccagc
     3421 tacttggaag gctgagacag gagaatggcg tgaatcgggg aggcagagct tgcagtcagc
     3481 cgagatcacg ccactgcact ccagcctggg agacagagtg agactccgtc tcagaaaaaa
     3541 aaaaaaaaaa caactaaaat atgggtatta tgcacaatcc agatctcaaa aacgtgattc
     3601 taagtgaaag aaggcagatg ccagagacca ggtattttct agtaccattt taggaaatgt
     3661 ccagaaatgg cagatcttca gaaacaaagt aactgcaaat gttacaagga atctttttag
     3721 ggtgacgaaa atgttctaaa actagatggt ggtgatggtt gaacgatttg gtaacttcac
     3781 taaaaatcat tgaattgttc actttatatg ggcagatttt atggtaaata tacctcaata
     3841 aaatcatttt tcaaaatcaa atttacacat ataccaacca ttgctaaaca agtattcctg
     3901 ttttgtttgt tacttcaagc catctatgca tttttggtat cactttttat tttctgtaac
     3961 agttacccct acatttactg ggtctcagaa ccttgtcagg ctctgcttta aagttcctac
     4021 catgttggct ctgtaactca ggtggagaag cctagaccag gagctggcgt agaccaaagg
     4081 atacttgcct aataaggatt agcttatact gaggaaaata ctttaagcat ttaaagtcca
     4141 gatgaggaag ttgagcccag aattcaggga accagctcaa agtgggccca tgcagacagg
     4201 ctgggtctaa gagtccacaa ggttggccag ggcaggtagg atgcacagga ggcatctgga
     4261 tctggaagta cttggacagc tgaggtcaag atcacacaga aatttattcc tggacagcca
     4321 aggtttacag gagcagaaat agcaaatatt ttcttgctcc gtctctccct tttttcccag
     4381 tgcccttttc tgtacctacc cagatcactt tatacctaga catctgtcac aattttgtaa
     4441 ctggtcttcg tccaaaatct gtctcctctt ctcatgtatc cttgccatat taaccatact
     4501 taccagtttg aacccagtgt cctgccctcc aaaaatcctt tgcacggcct acaagataaa
     4561 tcctcacccc ccgtgtgtgg tatataatgc cctctttagg ctgctccaac ctcctgctgc
     4621 tcctgacaga agcctccatt gcacacaaat gctctcttgt catccctcag acatgccttt
     4681 ccacatctca gcctgcaaac ctttacctta gctgttctat cagccggggg caccttctct
     4741 acttacctaa agcctacata atcagtcaga aacctgtgta aatttccctt ccttggagag
     4801 gtgttctctt gaaaactgat atgaagtcat atcttaccat ttgtaatcat aaacatattt
     4861 gtttgtgtaa gtttttaaaa atggacaata tctagacttg tggtaaatcg tatcactgtc
     4921 ttgatctatt taaataattt tttatcactt taccactttc ttgtttcctg aaccagatga
     4981 caatggaaaa agtcaaatgg taaaatattt taagagattt attctgagat aaatatgagt
     5041 gacctgtagg cacagttgac cagcatttgc cttaaaacag agaccttaag actaacaaaa
     5101 acagactctt tgtagcaata acaacatgac agtaagtcct gagagaaatc aaagtgtttt
     5161 acgccaaaat agatttaagt ctgataagaa acaagtctga cacagcccca ggagatcctg
     5221 agaacatgtg cccaaggtgg ctcttgtcag gagcagcagc aggttggggc agcctaaaga
     5281 ggacattacc aaacacggga gtgaggattt atcttgtagg aagtgcaaag gatttttgga
     5341 gggcaggaca ctgggttcaa actgacgagt atggttaaca tggcaaaggt acgtgagagg
     5401 aagagacaat tgtgctgtca ggctacagct tggtttcatg catttttaca ttttagggga
     5461 atgtaagaca tcaatacatg taagatttac attggttcga tggagaaagg caggacaact
     5521 tgaagctggt ggggaaggga cagggacaga gggagggcct tctgggttat aggtggattc
     5581 aaagattttc tgattggcag tgggtttatc caaagacctg gaatcaatag aagggaatgt
     5641 ctgggttaag ataaggtgtt gtggagacca aggttcttac tgtgagatga agccagaagg
     5701 tagcaggctt cagagagaat agattgtaaa tgtttcttat cagacttaag agaaatttat
     5761 tttaggataa aatacttaga tttctctcag ggcctgttat ctgtcatgtt atcttattgc
     5821 tacaaagagc ctgtttttgt cagtcttaag gtctctgttt taatgttaat gctggtccac
     5881 tgtgcctgaa ttccaaagag aggaaggtat aatgaggtat gtctgaccac ccattcccat
     5941 catggcctga gctagtgttt caggtttact ttagaatgct cttggccaag tggaagggtc
     6001 gattcagttg gttgtgtgct tagaatttta tttttgactt acatagacta tcagctgctt
     6061 catgtcacat ctcatgcttc tcttatgttg cccagttttc tcagtgcttc cgactgcatg
     6121 tttttgtact atatgaaaag ccttctttct agaagactac caattaaata tttctttaga
     6181 aaaatgtaa
//
