LOCUS       NM_020713               5982 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 512B (ZNF512B), mRNA.
ACCESSION   NM_020713
VERSION     NM_020713.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5982)
  AUTHORS   Jiang,H., Yang,B., Wang,F., Li,K., Zhu,Y., Liu,B., Ren,H., Tian,S.,
            Xu,Y., Pang,A. and Yang,X.
  TITLE     Association of Single Nucleotide Polymorphism at rs2275294 in the
            ZNF512B Gene with Prognosis in Amyotrophic Lateral Sclerosis
  JOURNAL   Neuromolecular Med 23 (2), 242-246 (2021)
   PUBMED   33387304
  REMARK    GeneRIF: Association of Single Nucleotide Polymorphism at rs2275294
            in the ZNF512B Gene with Prognosis in Amyotrophic Lateral
            Sclerosis.
REFERENCE   2  (bases 1 to 5982)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5982)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5982)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5982)
  AUTHORS   Ning,P., Yang,X., Yang,B., Zhao,Q., Huang,H., An,R., Chen,Y.,
            Hu,F., Xu,Z. and Xu,Y.
  TITLE     Meta-analysis of the association between ZNF512B polymorphism
            rs2275294 and risk of amyotrophic lateral sclerosis
  JOURNAL   Neurol Sci 39 (7), 1261-1266 (2018)
   PUBMED   29713939
  REMARK    GeneRIF: Five case-control studies involving 2559 patients with
            sporadic amyotrophic lateral sclerosis (ALS) and 5740 controls were
            analyzed. Based on random-effects meta-analysis, the ZNF512B
            polymorphism rs2275294 was associated with increased risk of ALS
            disease in an allele model. The available evidence suggests that
            the ZNF512B polymorphism rs2275294 is associated with ALS risk.
            Review article
REFERENCE   6  (bases 1 to 5982)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   7  (bases 1 to 5982)
  AUTHORS   Tetsuka,S., Morita,M., Iida,A., Uehara,R., Ikegawa,S. and Nakano,I.
  TITLE     ZNF512B gene is a prognostic factor in patients with amyotrophic
            lateral sclerosis
  JOURNAL   J Neurol Sci 324 (1-2), 163-166 (2013)
   PUBMED   23168171
  REMARK    GeneRIF: The objective of our study was to examine whether the new
            single-nucleotide polymorphism in the ZNF512B gene might influence
            the phenotype of amyotrophic lateral sclerosis
REFERENCE   8  (bases 1 to 5982)
  AUTHORS   Iida,A., Takahashi,A., Kubo,M., Saito,S., Hosono,N., Ohnishi,Y.,
            Kiyotani,K., Mushiroda,T., Nakajima,M., Ozaki,K., Tanaka,T.,
            Tsunoda,T., Oshima,S., Sano,M., Kamei,T., Tokuda,T., Aoki,M.,
            Hasegawa,K., Mizoguchi,K., Morita,M., Takahashi,Y., Katsuno,M.,
            Atsuta,N., Watanabe,H., Tanaka,F., Kaji,R., Nakano,I., Kamatani,N.,
            Tsuji,S., Sobue,G., Nakamura,Y. and Ikegawa,S.
  TITLE     A functional variant in ZNF512B is associated with susceptibility
            to amyotrophic lateral sclerosis in Japanese
  JOURNAL   Hum Mol Genet 20 (18), 3684-3692 (2011)
   PUBMED   21665992
  REMARK    GeneRIF: A functional SNP (rs2275294) in ZNF512B was found to be
            significantly associated with amyotrophic lateral sclerosis in
            Japanese.
REFERENCE   9  (bases 1 to 5982)
  AUTHORS   Tili,E., Michaille,J.J., Liu,C.G., Alder,H., Taccioli,C.,
            Volinia,S., Calin,G.A. and Croce,C.M.
  TITLE     GAM/ZFp/ZNF512B is central to a gene sensor circuitry involving
            cell-cycle regulators, TGF{beta} effectors, Drosha and microRNAs
            with opposite oncogenic potentials
  JOURNAL   Nucleic Acids Res 38 (21), 7673-7688 (2010)
   PUBMED   20639536
  REMARK    GeneRIF: Evidence that GAM/ZFp/ZNF512B may potentially maintain
            homeostasis by affecting the levels of regulators such as E2F1 and
            Ras, by modulating miR-17-92 miRNAs, by interacting with Drosha,
            and by interfering with TGFbeta signaling.
REFERENCE   10 (bases 1 to 5982)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118506.27, BC125129.1, BC125128.1, AL834525.1 and AW453003.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020713.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.3336191.1,
                                           SRR14038197.2130902.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369888.6/ ENSP00000358904.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                AL118506.27        110809-110878       c
            71-1432             BC125129.1         1-1362
            1433-1696           BC125128.1         1364-1627
            1697-3042           BC125129.1         1627-2972
            3043-5977           AL834525.1         1653-4587
            5978-5982           AW453003.1         17-21               c
FEATURES             Location/Qualifiers
     source          1..5982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..5982
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /note="zinc finger protein 512B"
                     /db_xref="GeneID:57473"
                     /db_xref="HGNC:HGNC:29212"
                     /db_xref="MIM:617886"
     exon            1..117
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            118..240
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2798
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /codon_start=1
                     /product="zinc finger protein 512B"
                     /protein_id="NP_065764.1"
                     /db_xref="CCDS:CCDS13548.1"
                     /db_xref="GeneID:57473"
                     /db_xref="HGNC:HGNC:29212"
                     /db_xref="MIM:617886"
                     /translation="MTDPFCVGGRRLPGSSKSGPGKDGSRKEVRLPMLHDPPKMGMPV
                     VRGGQTVPGQAPLCFDPGSPASDKTEGKKKGRPKAENQALRDIPLSLMNDWKDEFKAH
                     SRVKCPNSGCWLEFPSIYGLKYHYQRCQGGAISDRLAFPCPFCEAAFTSKTQLEKHRI
                     WNHMDRPLPASKPGPISRPVTISRPVGVSKPIGVSKPVTIGKPVGVSKPIGISKPVSV
                     GRPMPVTKAIPVTRPVPVTKPVTVSRPMPVTKAMPVTKPITVTKSVPVTKPVPVTKPI
                     TVTKLVTVTKPVPVTKPVTVSRPIVVSKPVTVSRPIAISRHTPPCKMVLLTRSENKAP
                     RATGRNSGKKRAADSLDTCPIPPKQARPENGEYGPSSMGQSSAFQLSADTSSGSLSPG
                     SRPSGGMEALKAAGPASPPEEDPERTKHRRKQKTPKKFTGEQPSISGTFGLKGLVKAE
                     DKARVHRSKKQEGPGPEDARKKVPAAPITVSKEAPAPVAHPAPGGPEEQWQRAIHERG
                     EAVCPTCNVVTRKTLVGLKKHMEVCQKLQDALKCQHCRKQFKSKAGLNYHTMAEHSAK
                     PSDAEASEGGEQEERERLRKVLKQMGRLRCPQEGCGAAFSSLMGYQYHQRRCGKPPCE
                     VDSPSFPCTHCGKTYRSKAGHDYHVRSEHTAPPPEEPTDKSPEAEDPLGVERTPSGRV
                     RRTSAQVAVFHLQEIAEDELARDWTKRRMKDDLVPETARLNYTRPGLPTLNPQLLEAW
                     KNEVKEKGHVNCPNDCCEAIYSSVSGLKAHLASCSKGAHLAGKYRCLLCPKEFSSESG
                     VKYHILKTHAENWFRTSADPPPKHRSQDSLVPKKEKKKNLAGGKKRGRKPKERTPEEP
                     VAKLPPRRDDWPPGCRDKGARGSTGRKVGVSKAPEK"
     exon            241..383
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            384..512
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            513..1153
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1380
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1452
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1599
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1724
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1817
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1916
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2087
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..2282
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2384
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2447
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2546
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..5982
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4308
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /note="major polyA site"
     regulatory      5957..5962
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /note="hexamer: AATAAA"
     polyA_site      5982
                     /gene="ZNF512B"
                     /gene_synonym="GM632"
                     /note="major polyA site"
ORIGIN      
        1 agcgcgcatg tgcgcagcgc ggcgcgcagc ctgcgccgcc cggacccagc gccccgcgcc
       61 ccgcgccccc cgccccggcc cggcccggcc cggccgcagc cccgctgggc gccgcagaga
      121 tgacggatcc tttctgcgtt ggaggccgtc ggctcccggg gtccagcaag agtggtcccg
      181 ggaaggatgg cagccgaaag gaggtccgac ttccaatgct gcatgaccca ccgaagatgg
      241 ggatgccggt ggtccgtggt ggacagacag tgcccggcca ggcccctctc tgctttgacc
      301 cgggaagtcc agccagtgac aagacagaag ggaagaaaaa ggggcggcca aaagccgaga
      361 accaggccct ccgagacatt cctctctccc tgatgaacga ctggaaggat gagttcaagg
      421 cacactcgag ggtgaagtgt ccaaactcag ggtgctggct ggagttcccc agcatctacg
      481 ggctcaagta ccattaccag cggtgccaag ggggtgccat ctcagatcgc ctggccttcc
      541 cctgcccctt ctgcgaggcc gcattcacct ctaagaccca gctggagaaa caccggatct
      601 ggaaccacat ggaccgaccc ctgcctgcct ccaagcctgg gcccatcagc aggccggtca
      661 ccatcagccg gcctgttggg gtcagcaagc ccatcggagt gagcaaacct gtcactattg
      721 gcaaacctgt gggtgtcagc aaacccattg gcatcagcaa gccagtctcg gtcggcagac
      781 ccatgccagt caccaaggcc atcccggtca ctaggcccgt gccagtcacc aaacctgtca
      841 cagtcagcag gcccatgccc gtcaccaagg ccatgccggt caccaaaccc atcacagtca
      901 ccaagtctgt gccggtcacc aaacccgtac ctgtcaccaa acccattacg gtaacaaagc
      961 ttgtgacagt tacgaaaccc gtgccggtca ccaagccagt gacagtcagc aggcccattg
     1021 tggtcagcaa gccggtgaca gtcagcaggc ccattgctat cagcagacac acaccgccct
     1081 gcaaaatggt gctgctgacc aggtcggaga acaaagcacc tcgtgccaca gggaggaaca
     1141 gtggtaagaa aagggctgcg gacagcctgg acacctgccc aattccaccc aagcaggcca
     1201 ggccagagaa tggggagtac ggcccctcct ccatgggcca gagctcggcc ttccagctga
     1261 gtgcagacac cagcagtggc tccttgtcgc caggcagcag gccgtcaggg ggcatggagg
     1321 cactgaaggc tgcaggccct gcgtccccgc ctgaggagga cccggagcgc acaaagcaca
     1381 gaaggaaaca gaaaacaccc aaaaagttta caggggagca gccatccatc tcagggacct
     1441 ttgggctcaa aggcctggtc aaagctgagg acaaggcccg agttcaccgc tccaagaagc
     1501 aggaggggcc aggccctgag gacgcccgga agaaggtgcc agctgccccc atcactgtca
     1561 gcaaggaggc accggcccct gtggcccacc cagctccagg tggccctgaa gagcagtggc
     1621 agagggccat ccatgagcgc ggggaagccg tctgccccac ctgcaacgtg gtcacccgga
     1681 agactctcgt ggggcttaag aagcacatgg aggtgtgtca gaagcttcag gatgcactca
     1741 agtgccagca ctgccggaag cagttcaagt ccaaagccgg cctcaactac cacactatgg
     1801 ccgagcacag tgccaagccc tctgacgccg aggcctccga agggggcgag caggaggagc
     1861 gcgagaggct gcgcaaggtg ctgaagcaga tgggacggct gcgctgcccc caggagggtt
     1921 gcggggctgc cttctccagc ctcatgggct accagtacca ccagcggcgc tgcgggaagc
     1981 cgccctgcga ggtggacagc ccctccttcc cctgcaccca ctgtggcaag acgtaccgat
     2041 ccaaggctgg ccacgactac cacgtgcgct cggagcacac ggcccccccc cctgaggagc
     2101 ccacagacaa gtcccctgag gctgaggacc cgctgggtgt ggagcggacc ccaagcgggc
     2161 gtgtccgccg cacgtcggcc caggtggcgg tgttccacct gcaggagata gcggaggacg
     2221 agctggcccg cgactggacc aagcggcgca tgaaggatga ccttgtgccc gagaccgcac
     2281 ggctcaacta cactcgacca gggctcccca cgctgaaccc ccagctgcta gaggcatgga
     2341 agaatgaagt gaaggagaaa ggccacgtca actgtcccaa cgactgctgt gaagccatct
     2401 actccagcgt gtccggactc aaggctcatc tcgccagctg cagtaagggg gcccacctgg
     2461 cagggaagta ccgctgtctg ctgtgtccga aggagttcag ttctgagagt ggcgtcaaat
     2521 accacatcct gaagacccac gcagagaact ggttccgaac atcagcagac ccacctccca
     2581 aacacaggag ccaggactca ttggtgccca agaaggaaaa gaagaaaaat ctggcaggtg
     2641 gaaagaagcg gggccgaaag cccaaggagc ggaccccaga ggagcctgtg gccaagctgc
     2701 ccccgcgccg ggacgactgg cctccaggat gcagagacaa gggggcccgg ggctccaccg
     2761 gccggaaggt gggagtcagc aaggcgcctg aaaagtgagc atggtgcgtg gggcctggcc
     2821 cccatgcagc cgccacaccg ccctctgttc aaggcagggc cagctccggg acctctgtcc
     2881 tccagttctc catcccccac ccccgcctct tcatccgtcc agtggggcag ccagccactc
     2941 tcccttccct gaaggtggcc cttcccctgt taaggctgcc acagggcaca cctgggttgg
     3001 ggctccccaa ggtgtgccca gcagaagtgc aatagccagg agggttgccc ctcctcatgg
     3061 gaatgtgtct ggggtcttgg tgccacaggg gctgcagcgc agagtaggca gatggccttt
     3121 ggccccccgg ctccgcttcc tcaggccctg ccgggtccct tccctggcta ccccaaggct
     3181 caggcatccc tggtgacctg tggttctggg ctggtgaggg cacctgagca acctggcacg
     3241 ggcagccacc atcctggcct cacctccacc caacactgga actccagcac ccccagctac
     3301 ctcccaggac agacccctgt ctgaccactg ccatgctgac ctgacaggct ccggcctgcc
     3361 cttggccacc cacttggtcc ccttgcttct gttttctacc tctccaggcc tgcccactac
     3421 ccccacccct gctcctcctt tgtcagtgcg atccctgctg tgctcaggcc ctgcccccca
     3481 ggcctgtctg taattctccc agcttggggc aagggagggg ttttgcttct tgtacctaca
     3541 gggcagcaga agcttgatgc ccttcaacac agctgccagc cctgggggtg tggggcccct
     3601 ggagtgtgct ctcctccagt gttcagcctt ctggcactgc aggcctaggt tggagcagcc
     3661 tcgtggagta gggacggact agttcgggcc ctggggtctt gctggggccc ataggcatgt
     3721 ggggcaggaa gctgggcaga gctggcctgg ctctgagtgg ccactggggg aaaggcagcc
     3781 ttctgtctgc caatctgggt aggcccagtg gccaagctct catgggagcc ccctccccac
     3841 tttttttttt aacctgcccc cattgtttct ggttgtgtgg tcatttgata tgggaactga
     3901 aggccagcca ggggaggggc ttggccaaag tcacagcagg ttgatggcag ctccagagct
     3961 gtctttgccc ctttgtggcc ctgaggacgg ctgggtctat aggtagggca ggggtcaggc
     4021 agggagtcca gggtgcctgg aagaggtggc cacagcctgt ggctccctcc ctggggtcct
     4081 gccttccaac cacggcattg cagggaggat gaggctcaga gggggtaggt ttggagggag
     4141 gccattttcc agggtgggtg ggagtgggct gagggctcgg ccccactgac cctggacgat
     4201 gagaattttg atgtttgccc gtgtgcgtgt gtctcctggg tgtagtggat gccagtcttg
     4261 ttgctgtgac aagtaacaac ctttttttta aattgttttt tatacaaaca ctcgcaatcc
     4321 gacatttggt gctaagggtt tcctggtgca gacggtgggc ctgggggctg ggctggacca
     4381 gggcgtgggt ctctggggtt ggggtccctt gctgctcagg gaggcagtac tgactgggca
     4441 ctgcctctgc ccccagcacc caccctcccc cattccccag ggagaagggg ccccactggg
     4501 cttggcctgc agtagtaggg agacaagttc caggagcact ttggggactg gggttgcaga
     4561 acacttcctg tctctggctt catccttggg ccagaaggct ccaaccctca gcagcccttg
     4621 ccagatgtgc cagggagtgg gtgtggagac ccggactccc cccacccacg cacacctcgg
     4681 cctgatgaga ggatggaggc tggggcagag atgggcgtga cccagcgtca gagggtcggg
     4741 ggaggcattc cttcctgtgt cccagagctt cactggtgga gctggaggag ccggaggtgg
     4801 agggtggggt ctggcagctg ctgctggggc agcctcatga ggggagggga ggggagggga
     4861 ggggagcagg cactgggcgg gggcctaggt gcactttgtc cttgccacca atggcgggag
     4921 gagggtggac ctgaacacct gcagggtgtg gtgcctgccc cagcctctca ggtacttggc
     4981 ccttggggag aagagaagag ggtctggttt ttgctggggg tgagtttccg ggacactccc
     5041 aaagcccaca gataatccct ggtgtgggaa gaggagtcct ggataccttg atgtttagca
     5101 ctttaacccc ctttgtcttt aaggtaggcg tgggggctac tgccagaagt ggctgttggg
     5161 tctgaccccc tcctttctgc cctccctctg ccacatgctg gtccgcagag ccctcctccc
     5221 aaggggtggg gccctgggtg gagctcagca gggtctgccc actccctacg ctggcccaca
     5281 taggcctcca ggagccctca gtgagaggga ccagcatagc tgacccccag agtgtggtgg
     5341 gcgccggccc tgcccgaggc ccagtcgggg ccctttctgc agatctacct ctggctcagc
     5401 gcacgccccc tgccctgaga acaggaaagg gcccggaagg gctgactcac cgggccgacg
     5461 ctcacacgaa aatgggatgc actttatttg ctggtgcaaa ggcaggtgag ggtgcctcct
     5521 gtgtgaccgt tggccctcct gcctggtggc gctgaaggga aggagccagt gagcctgacc
     5581 ccgggagggg ccgtccccgt gtgccgcgtt tggcggggcc ccaggcggct cccccaggcc
     5641 cgggtctggg gccccaggct ttcccctgcc tcgcggccgg gcgtcccgtg ctttgggttt
     5701 cttggtttgg gttttttaat gccagttctc agtacataag tgcattttga aagaggttcc
     5761 agctatcact tgtaaccata tatatataca tatatattct atctacaaag tgtttatttg
     5821 cgagatgttt caacggtgag ttcgggcccc gcccgccttg tgaccatctg tccccggtcc
     5881 tcgtccccgc cccgcgccct ggtcccgagt ggcgtgggga cgggccatca ctgtatgtat
     5941 taaaatgact gtatcaaata aatgtttatt gatttttttc ca
//
