LOCUS       NM_032434               3531 bp    mRNA    linear   PRI 20-AUG-2024
DEFINITION  Homo sapiens zinc finger protein 512 (ZNF512), transcript variant
            1, mRNA.
ACCESSION   NM_032434
VERSION     NM_032434.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3531)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 3531)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3531)
  AUTHORS   Yu,C.J., Wang,L., Mao,S.L., Zhang,Y., Song,L.L., Cai,L.Y. and
            Tao,Y.
  TITLE     The clinical assessment of amyotrophic lateral sclerosis patients'
            prognosis by ZNF512B gene, neck flexor muscle power score and body
            mass index (BMI)
  JOURNAL   BMC Neurol 18 (1), 211 (2018)
   PUBMED   30567526
  REMARK    GeneRIF: risk (C) allele of the SNP (rs2275294) in the ZNF512B
            gene, cervical flexor muscle power and body weight index might have
            clinical potential for amyotrophic lateral sclerosis
            prognostication
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3531)
  AUTHORS   Bao,L., Zhang,Y., Wang,J., Wang,H., Dong,N., Su,X., Xu,M. and
            Wang,X.
  TITLE     Variations of chromosome 2 gene expressions among patients with
            lung cancer or non-cancer
  JOURNAL   Cell Biol Toxicol 32 (5), 419-435 (2016)
   PUBMED   27301951
  REMARK    GeneRIF: MFSD2B, CCL20 and STAT1, or STARD7 and ZNF512 genes may be
            risk or protect factors in prognosis of ADC; HTR2B, DPP4, and
            TGFBRAP1 genes may be risk factors in prognosis of SQC.
REFERENCE   5  (bases 1 to 3531)
  AUTHORS   Weissglas-Volkov,D., Aguilar-Salinas,C.A., Nikkola,E., Deere,K.A.,
            Cruz-Bautista,I., Arellano-Campos,O., Munoz-Hernandez,L.L.,
            Gomez-Munguia,L., Ordonez-Sanchez,M.L., Reddy,P.M., Lusis,A.J.,
            Matikainen,N., Taskinen,M.R., Riba,L., Cantor,R.M.,
            Sinsheimer,J.S., Tusie-Luna,T. and Pajukanta,P.
  TITLE     Genomic study in Mexicans identifies a new locus for triglycerides
            and refines European lipid loci
  JOURNAL   J Med Genet 50 (5), 298-308 (2013)
   PUBMED   23505323
REFERENCE   6  (bases 1 to 3531)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   7  (bases 1 to 3531)
  AUTHORS   Gamsjaeger,R., Liew,C.K., Loughlin,F.E., Crossley,M. and
            Mackay,J.P.
  TITLE     Sticky fingers: zinc-fingers as protein-recognition motifs
  JOURNAL   Trends Biochem Sci 32 (2), 63-70 (2007)
   PUBMED   17210253
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP251717.1, AK057028.1,
            AC074091.6, AK074460.1 and BF593724.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032434.3.
            
            Summary: This gene encodes a protein containing four putative zinc
            finger motifs. Zinc finger motifs may bind to proteins or nucleic
            acids. Zinc finger-containing proteins are involved in a variety of
            processes, including regulation of transcription. Alternative
            splicing results in multiple transcript variants for this gene.
            [provided by RefSeq, Sep 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.191555.1,
                                           SRR1660807.121057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355467.6/ ENSP00000347648.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BP251717.1         74-90
            18-142              AK057028.1         1-125
            143-143             AC074091.6         196534-196534       c
            144-2890            AK057028.1         127-2873
            2891-3410           AK074460.1         1946-2465
            3411-3529           BF593724.1         2-120               c
            3530-3531           AC074091.6         157016-157017       c
FEATURES             Location/Qualifiers
     source          1..3531
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..3531
                     /gene="ZNF512"
                     /note="zinc finger protein 512"
                     /db_xref="GeneID:84450"
                     /db_xref="HGNC:HGNC:29380"
                     /db_xref="MIM:620921"
     exon            1..101
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1775
                     /gene="ZNF512"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 512 isoform a"
                     /protein_id="NP_115810.2"
                     /db_xref="CCDS:CCDS1758.1"
                     /db_xref="GeneID:84450"
                     /db_xref="HGNC:HGNC:29380"
                     /db_xref="MIM:620921"
                     /translation="MSSRLGAVPATSGPTTFKQQRSTRIVGAKNSRTQCSIKDNSFQY
                     TIPHDDSLSGSSSASSCEPVSDFPASFRKSTYWMKMRRIKPAATSHVEGSGGVSAKGK
                     RKPRQEEDEDYREFPQKKHKLYGRKQRPKTQPNPKSQARRIRKEPPVYAAGSLEEQWY
                     LEIVDKGSVSCPTCQAVGRKTIEGLKKHMENCKQEMFTCHHCGKQLRSLAGMKYHVMA
                     NHNSLPILKAGDEIDEPSERERLRTVLKRLGKLRCMRESCSSSFTSIMGYLYHVRKCG
                     KGAAELEKMTLKCHHCGKPYRSKAGLAYHLRSEHGPISFFPESGQPECLKEMNLESKS
                     GGRVQRRSAKIAVYHLQELASAELAKEWPKRKVLQDLVPDDRKLKYTRPGLPTFSQEV
                     LHKWKTDIKKYHRIQCPNQGCEAVYSSVSGLKAHLGSCTLGNFVAGKYKCLLCQKEFV
                     SESGVKYHINSVHAEDWFVVNPTTTKSFEKLMKIKQRQQEEEKRRQQHRSRRSLRRRQ
                     QPGIELPETELSLRVGKDQRRNNEELVVSASCKEPEQEPVPAQFQKVKPPKTNHKRGR
                     K"
     exon            102..160
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            161..348
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            349..444
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            445..528
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            529..653
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            654..740
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            741..839
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1007
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1202
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1304
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1367
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1466
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..3531
                     /gene="ZNF512"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3386..3391
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF512"
                     /note="hexamer: AAGAAA"
     regulatory      3390..3395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF512"
                     /note="hexamer: AATAAA"
     polyA_site      3404
                     /gene="ZNF512"
     polyA_site      3408
                     /gene="ZNF512"
                     /note="major polyA site"
     regulatory      3502..3507
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF512"
                     /note="hexamer: AATAAA"
     polyA_site      3531
                     /gene="ZNF512"
ORIGIN      
        1 agaggagagc ggaagtggcg ttggtctggc cggagccctt gggtgaaatt gttaggcgtg
       61 gagagggagt gatgtcttcc agactcggtg ctgtacccgc cacttcggga cccacaacct
      121 ttaagcagca gaggagcacg aggatcgtgg gagctaagaa tagcaggacc cagtgctcca
      181 taaaggataa tagtttccag tacactatcc ctcatgatga ctccttaagt ggttcatcgt
      241 ctgcatcttc gtgtgaacca gtgagtgatt ttccagcatc tttccgaaaa tctacctact
      301 ggatgaagat gagaagaatc aagccagctg ctacttctca tgtcgaaggg tcaggtggag
      361 tatcagccaa ggggaaaagg aaacccaggc aggaagaaga tgaagactat cgagaatttc
      421 ctcagaagaa gcataagctt tatgggagga agcaacggcc taaaactcag cccaatccca
      481 aatcccaggc ccgtcgtatt cggaaggaac caccagttta tgcagcaggc agtttggagg
      541 agcaatggta cttagaaatc gttgataaag gcagtgtctc ctgccctacc tgccaggcag
      601 tggggaggaa gaccatagag ggtttaaaga aacacatgga aaactgcaag caggaaatgt
      661 ttacttgtca tcattgtggg aaacaacttc gttcactggc agggatgaag tatcatgtca
      721 tggcaaatca taatagtttg cccattttga aagccggaga tgaaatagat gagccaagtg
      781 agagggaaag gctccgaaca gttctaaaga gactgggaaa gctcaggtgc atgcgtgaga
      841 gttgctccag tagcttcacc agcatcatgg gatatctcta ccatgtcaga aaatgtggca
      901 aaggggctgc agagctggaa aagatgaccc tgaaatgtca ccactgtgga aaaccatata
      961 ggtcgaaggc tggacttgca tatcacctga ggtcagagca tgggcctata tccttctttc
     1021 cagagtcagg acagccagag tgcttaaagg agatgaacct agagtcaaag agtgggggcc
     1081 gagttcagag acgttctgcc aagatagctg tataccacct acaggagctg gcctctgctg
     1141 aactggccaa ggaatggccc aagaggaagg tgcttcagga cctggtacct gatgatcgaa
     1201 agttaaaata tactcgtcca gggctcccta ccttcagcca ggaagtacta cataaatgga
     1261 agacagatat caagaaatat catcgtattc agtgtcctaa ccagggctgt gaggctgtct
     1321 acagcagtgt atctggcctt aaagctcacc tgggctcttg tacattggga aactttgtgg
     1381 ctggaaaata caaatgtctt ctatgtcaga aagaatttgt gtcagagagt ggtgtcaagt
     1441 atcacatcaa ctccgtccat gctgaggact ggttcgttgt aaacccaaca acaaccaaaa
     1501 gctttgaaaa gctgatgaag ataaagcagc ggcagcaaga agaagaaaag cggaggcagc
     1561 agcacaggag cagaaggtct ctaagaaggc ggcagcagcc tggcattgag cttcccgaga
     1621 cagagctgag tcttagagta gggaaggatc agaggaggaa taatgaggaa ctggtagtgt
     1681 cagcctcctg taaggaacca gagcaggagc cagtgccagc acagttccag aaagtaaagc
     1741 ccccaaagac taatcataaa cgaggaagga aataggcagt cagtgtaaaa gtgctcctag
     1801 gaaagcagat gtgatgctgt tgtcacgggg acctgtgctg ggaggactga gtgaagattc
     1861 tttcagctgt ttgtgtaagg ctgtgacttt ctcagctcct tcctcctgtg taaatttcac
     1921 tgtcttccct tcttacattt tgattccccc ctcccctttt agtaggtttt cctgctattc
     1981 ctcgtcaagt cctcttgttt ttttatcttg cccaaagagc tccctctcaa ggccaactat
     2041 aggctcctct tgccctgtac aaaactaaga aacctctttg gttgtccttt ccttcctggg
     2101 gtatagaatg ttcttggaag ctccattgat ttagtagctg ctccatcatc tagcttgtga
     2161 aaccattcca aactaatttt ttaaaaccat aactgatttg tcattttgta tttgtgatat
     2221 aacaagtcta gaagttagaa ctgttgtcat tcacataata agattactct gtctccttgg
     2281 gaaaaaaact ttatggaggc tgtttgtcct ctcaatatgg ttttaagatt gaaagtaaga
     2341 aaacggattt aggatgaaaa ctctagaact accctatgct gtttatactg ggaaatgctt
     2401 tgtaccaagt agcagtgact agacccacag acatgaaaag caaccttagg agtaaagtga
     2461 cccaaacatt aaaatgacag gaaagagaaa gtagaagcag caataaatac tgccccaact
     2521 ttcctggagc ccgaggcctc atccatagct atgatcactt gccctctgaa gcttattttt
     2581 gcttctttgg ttttaagaat tgagaaatat cacattgccc ctgatgtttt gacagtctcc
     2641 tagtgctcct ggtagtgcca ctaagggaaa accaaggtgc gcattccttc tccctggact
     2701 ttaccttact tgttagtcta cgccccactg tttccaccca tccccttagc caacctctgt
     2761 ctttttgaat tttctgagaa tattgtccta tcctctttta tatatggagt tctctcctct
     2821 ttatatcctg agactttgac accagatgta gatatttatc tggagctgga aagaaaaatt
     2881 ctttttctgt acctcatgcc tatctggtaa tgtttaatgg gttatttctc tttgagggtg
     2941 gctttctctg gaacattggt tagagcagct ttgttgtcgt gtttctggat tctcttcccc
     3001 attttgcgta aatattggtc ttatatattc ttgcctattt tgtggcatat gccacataaa
     3061 aaatgaacct gatatagaca agtactacct tttcaaattc tgaaaggcta ttaccacttt
     3121 aactctttgt gctcctccaa atagctttaa aatgtgggct tttgtgaaga ccactttcaa
     3181 acaagggagc actgaaacct gaattggata ctgccagaat aggtagtttt gaaacaagtt
     3241 aaggacatgg tatatgcact ctgcattttc attggcagtg tgcccttaaa gccctttcag
     3301 tagatgaggg ttgtcaggga ggagaaatga agaagctatg ttaatttctg gtgagtaaga
     3361 cctggggaat gtttggcaat gacaaaagaa ataaatgact ctcagaaaga tgtttccagt
     3421 gttctttgac gccgacctgc tgcatgactc cttgacactg tatgggggta agaagatggc
     3481 tagagatggg ggtgagtttg aaataaattc cacatgcagt tgtctcagta a
//
