LOCUS       NM_001136156            7716 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 507 (ZNF507), transcript variant
            1, mRNA.
ACCESSION   NM_001136156
VERSION     NM_001136156.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7716)
  AUTHORS   Creamer,K.M., Larsen,E.C. and Lawrence,J.B.
  TITLE     ZNF146/OZF and ZNF507 target LINE-1 sequences
  JOURNAL   G3 (Bethesda) 12 (3) (2022)
   PUBMED   35100360
  REMARK    GeneRIF: ZNF146/OZF and ZNF507 target LINE-1 sequences.
REFERENCE   2  (bases 1 to 7716)
  AUTHORS   Kwon,W., Choi,S.K., Kim,D., Kim,H.G., Park,J.K., Han,J.E.,
            Cho,G.J., Yun,S., Yu,W., Han,S.H., Ha,Y.S., Lee,J.N., Kwon,T.G.,
            Cho,D.H., Yi,J.K., Kim,M.O., Ryoo,Z.Y. and Park,S.
  TITLE     ZNF507 affects TGF-beta signaling via TGFBR1 and MAP3K8 activation
            in the progression of prostate cancer to an aggressive state
  JOURNAL   J Exp Clin Cancer Res 40 (1), 291 (2021)
   PUBMED   34537073
  REMARK    GeneRIF: ZNF507 affects TGF-beta signaling via TGFBR1 and MAP3K8
            activation in the progression of prostate cancer to an aggressive
            state.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7716)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB165165.1, AL713775.1, BX640881.1, AC007773.1, BU681879.1 and
            CK820221.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001136156.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.117234.1,
                                           SRR1803611.187557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355898.6/ ENSP00000348162.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               DB165165.1         3-111
            110-433             AL713775.1         1-324
            434-437             DB165165.1         342-345
            438-2840            AL713775.1         327-2729
            2841-4765           BX640881.1         2711-4635
            4766-6014           BX640881.1         4637-5885
            6015-6623           AC007773.1         112831-113439
            6624-7009           BU681879.1         16-401              c
            7010-7705           BX640881.1         6881-7576
            7706-7716           CK820221.1         261-271
FEATURES             Location/Qualifiers
     source          1..7716
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.11"
     gene            1..7716
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="zinc finger protein 507"
                     /db_xref="GeneID:22847"
                     /db_xref="HGNC:HGNC:23783"
                     /db_xref="MIM:620567"
     exon            1..174
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     exon            175..268
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     exon            269..2397
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     CDS             271..3132
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /codon_start=1
                     /product="zinc finger protein 507"
                     /protein_id="NP_001129628.1"
                     /db_xref="CCDS:CCDS32985.1"
                     /db_xref="GeneID:22847"
                     /db_xref="HGNC:HGNC:23783"
                     /db_xref="MIM:620567"
                     /translation="MEESSSVAMLVPDIGEQEAILTAESIISPSLEIDEQRKTKPDPL
                     IHVIQKLSKIVENEKSQKCLLIGKKRPRSSAATHSLETQELCEIPAKVIQSPAADTRR
                     AEMSQTNFTPDTLAQNEGKAMSYQCSLCKFLSSSFSVLKDHIKQHGQQNEVILMCSEC
                     HITSRSQEELEAHVVNDHDNDANIHTQSKAQQCVSPSSSLCRKTTERNETIPDIPVSV
                     DNLQTHTVQTASVAEMGRRKWYAYEQYGMYRCLFCSYTCGQQRMLKTHAWKHAGEVDC
                     SYPIFENENEPLGLLDSSAAAAPGGVDAVVIAIGESELSIHNGPSVQVQICSSEQLSS
                     SSPLEQSAERGVHLSQSVTLDPNEEEMLEVISDAEENLIPDSLLTSAQKIISSSPNKK
                     GHVNVIVERLPSAEETLSQKRFLMNTEMEEGKDLSLTEAQIGREGMDDVYRADKCTVD
                     IGGLIIGWSSSEKKDELMNKGLATDENAPPGRRRTNSESLRLHSLAAEALVTMPIRAA
                     ELTRANLGHYGDINLLDPDTSQRQVDSTLAAYSKMMSPLKNSSDGLTSLNQSNSTLVA
                     LPEGRQELSDGQVKTGISMSLLTVIEKLRERTDQNASDDDILKELQDNAQCQPNSDTS
                     LSGNNVVEYIPNAERPYRCRLCHYTSGNKGYIKQHLRVHRQRQPYQCPICEHIADNSK
                     DLESHMIHHCKTRIYQCKQCEESFHYKSQLRNHEREQHSLPDTLSIATSNEPRISSDT
                     ADGKCVQEGNKSSVQKQYRCDVCDYTSTTYVGVRNHRRIHNSDKPYRCSLCGYVCSHP
                     PSLKSHMWKHASDQNYNYEQVNKAINDAISQSGRVLGKSPGKTQLKSSEESADPVTGS
                     SENAVSSSELMSQTPSEVLGTNENEKLSPTSNTSYSLEKISSLAPPSMEYCVLLFCCC
                     ICGFESTSKENLLDHMKEHEGEIVNIILNKDHNTALNTN"
     exon            2398..2515
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     exon            2516..2630
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     exon            2631..2765
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     exon            2766..7716
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3283..3288
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="hexamer: AATAAA"
     polyA_site      3304
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="major polyA site"
     regulatory      3421..3426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="hexamer: AATAAA"
     polyA_site      3451
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
     regulatory      4482..4487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="hexamer: AGTAAA"
     polyA_site      4506
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
     regulatory      6986..6991
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="hexamer: ATTAAA"
     polyA_site      7009
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
     regulatory      7699..7704
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
                     /note="hexamer: AATAAA"
     polyA_site      7716
                     /gene="ZNF507"
                     /gene_synonym="Zfp507"
ORIGIN      
        1 acgtgatccg tccccagcgc cgccattttg gagctccgga tgaggagggg gaaaccgggg
       61 gaaaagaggg aaaagagccg ggagagaggt gggcaaggac gagggcgagg gcacggccgg
      121 gtcctggctg gccaaacgag gctcgcggaa gcagcagccg ccgcctgacc gcagctggat
      181 tttgaagatt gatccaaggg actgtattaa tttcaggaat tgatttgaaa gacactggct
      241 ctgccactta acagccatgt aaccttggat atggaagaaa gtagcagtgt tgccatgttg
      301 gtgccagata ttggggaaca ggaagctata ctgactgctg aaagtatcat cagtccttca
      361 ttggaaattg atgaacaaag aaaaactaaa ccagatccat taatccatgt tatccagaag
      421 ttaagcaaga tagtggaaaa tgaaaagtca caaaaatgtc ttttaattgg gaagaaacgc
      481 ccacgttcaa gtgctgcaac acactctctt gaaacccaag aactttgtga gattccggct
      541 aaagtaatcc agtcacctgc tgctgatact agaagggctg agatgtcaca aacaaatttt
      601 acccctgaca ctcttgccca gaatgaaggg aaggctatgt cttatcagtg tagcctttgt
      661 aagtttctat catcatcctt ttccgtgtta aaagatcata ttaagcaaca tggtcagcaa
      721 aatgaagtga tactgatgtg ctcagagtgc catattacat ctagaagcca ggaggaactt
      781 gaagcccacg tggtgaatga ccatgacaat gatgccaata tccacaccca atccaaagcc
      841 caacagtgcg taagcccctc cagctctttg tgtcggaaaa ccacagaaag aaatgaaacc
      901 attccagata tcccagtaag tgtggacaat ctacagactc atactgtcca aactgcatct
      961 gtggcagaaa tgggtaggag gaaatggtat gcatacgaac agtacggcat gtatcgatgc
     1021 ttgttttgta gttatacttg tggccagcag agaatgttga aaacacacgc ttggaaacat
     1081 gctggggagg ttgattgctc ctatccaatc tttgaaaatg aaaatgaacc cctaggcctg
     1141 ctggattctt cagcagctgc tgcgcctggt ggggtcgatg cagtcgtcat tgctattgga
     1201 gagagtgaac tgagtatcca caatgggcca tcagtgcaag tgcagatttg cagctcagaa
     1261 cagttatcat cttcatctcc tttagaacag agtgcagaaa gaggagtaca cctaagtcag
     1321 tcagttaccc tggaccccaa tgaggaagaa atgctagaag tgatttctga tgcagaggag
     1381 aatctgattc ctgatagcct gcttacatca gcacagaaaa tcatcagcag cagccccaat
     1441 aaaaaagggc atgttaacgt gatagtggag cgattgccaa gtgctgaaga aaccctttca
     1501 cagaagcgct tcctcatgaa cactgaaatg gaagaaggga aggacctgag cctgacagaa
     1561 gctcagattg ggcgcgaagg aatggatgat gtttatcgtg ctgataaatg tactgttgat
     1621 attgggggat tgatcatagg ctggagcagt tcagagaaaa aagacgagtt aatgaataaa
     1681 ggcctggcta ctgatgagaa tgccccacca ggccggagaa ggacaaattc tgagtctctt
     1741 cgattacact cattagctgc agaagccctt gtcacaatgc ctataagagc tgcagagttg
     1801 acaagagcca acctggggca ctatggagat ataaaccttt tagatccaga tactagtcaa
     1861 aggcaagtag atagtacatt ggcagcgtac tcaaaaatga tgtcgccact taaaaactct
     1921 tcagatggat taactagtct taaccaaagc aactccacct tggtagcact cccagagggt
     1981 aggcaggaat tgtcagatgg gcaggttaag acaggcatca gcatgtcctt actcaccgtc
     2041 attgaaaaat tgagagaaag gacagaccaa aacgcttcag acgatgacat tttgaaagag
     2101 ttgcaggaca acgcccagtg ccaacccaac agcgatacaa gtttgtccgg aaacaatgtg
     2161 gtggaataca tcccgaatgc tgaacgaccc taccgttgcc gcctgtgtca ctacacaagt
     2221 ggcaacaagg gctacatcaa gcagcactta cgagtccatc gacagagaca gccttatcag
     2281 tgtcctatct gcgagcacat agcggacaac agcaaagatt tggagagtca catgatccac
     2341 cactgtaaga caagaatata ccagtgcaag cagtgtgaag aatccttcca ttataagagt
     2401 caattgagga accatgagag agaacagcac agtcttccag ataccttgtc aatagcaact
     2461 tctaatgagc caagaatttc cagtgataca gctgatggaa aatgtgtcca ggaagggaat
     2521 aagtcttcag tccagaaaca atatagatgt gatgtgtgtg attatacaag tacaacatat
     2581 gttggtgtca gaaaccacag gcgaatccat aactctgata agccgtacag atgctctctg
     2641 tgtgggtatg tgtgtagcca tcctccttct ttgaagtctc atatgtggaa acatgcaagt
     2701 gaccaaaatt acaactacga acaagtaaac aaggctatta acgacgcgat ttcacaaagt
     2761 ggcagagttc tggggaaatc ccctggaaag actcaattaa agagcagtga agagagtgca
     2821 gatcccgtca ctggaagttc agaaaatgca gtgtcatctt cagaactgat gtcccagact
     2881 cccagtgaag ttctgggtac caacgagaat gagaaactga gccctacaag taatacctca
     2941 tatagtttag aaaaaatctc cagtctggcc cctcctagca tggagtactg cgttttactc
     3001 ttctgctgtt gtatttgtgg ttttgaatca accagcaaag aaaacctctt ggatcatatg
     3061 aaagagcacg agggtgaaat tgtaaacatc atcctgaata aggaccacaa tacagctcta
     3121 aacacaaatt aggtggaata atgactcgag caggaaagca gtagaagagg attccttcac
     3181 cacagtttca cctttacgct gtcagacaac ttcctgccac agaagaagtc gttgatgtga
     3241 tttttgagga aatgacagat gtgactttgg aaccaaactt gtaataaaag gaattccaaa
     3301 tggacaagca gtaatgatat ttaaatattt tgagtgaggg ggagtgggtc aaagaggaag
     3361 tagaggtgta atcctgtatt aaccctctgt caccccttct tagtgtcgag tgtatttatt
     3421 aataaaagct tattagagtg tagaaatgcc agcaagagtt aagaaagggc ttttcaggaa
     3481 ctattctaaa agtcataaaa gggtcacagt cttaagcaga gcttagtttt cttctcactt
     3541 gtcaaatgca gactgtgagg cctccagtga gaaatgggag gcagttctgg gagggggttt
     3601 tttcagtgtc accaacagag tcaacaagga aacataatta gagggctttg aaatgatcta
     3661 ctgaaatacc taaattgata gaaattaatc atactcaatc taggacatgt tcctttactc
     3721 cttaaaaaag aaaggaaaga tctctaaatt caaagctaga ttgtaaatag gcattcaaga
     3781 agtattgtct taaatttacg atgaatttct tgtgagcaga ggacgaaaca ggtgaattct
     3841 caccagactc aaaccagatc tcaattcgta gtaatgctaa atcgtcttcc gtgttctcag
     3901 aggttctttt cagtgtctgt cagaacttgg catactttct ccatagtacg tagaccttct
     3961 aatactctgc taaatgaaac cacacttgtt atctgaaagt gtgtgaaaga aacaatgtat
     4021 gaaaatttac atttgatcat ccggcattgg aaatagtttg aactatttcc aaaaatccct
     4081 taggggatga ggggtgaaat ttaaaagctc ctgaaaatga gtactgctgt gttgagcttt
     4141 tctttcctgg ggtatattaa tttagttata tttagcagaa gaggaatata accaaatgtg
     4201 actaaaatat agcagaaatt caggttgttt gtaaaaattt taataacaaa tagcatttgg
     4261 caagtctata ggattcttcc tatctggaaa ttctattttg ttagagtgcg ataggacata
     4321 tggaaaacca acacaaagtg ctttagcatt aaaactcacc atcaaataga tgtaatctta
     4381 ttaattacac attttgtatt ttaattattt caaggagtga agaaaacagg gtgtttttgt
     4441 ttttgtagtt ctgattactc atttatgcat tgttttgttt aagtaaattc tgcctacaag
     4501 tgaaaaggtc ggtgcgctct tctgtgcacc atcctcacgg tgctatttcc gaatatctga
     4561 atattgattt ctaacacctg gatgaggctg tgaccgatca acttggaaca ctgtaaaggt
     4621 tttcgaatgg gatacgctgt aggcacgttt taagaagtat tctgttccta aagtccaggt
     4681 atgattggat taatatttat aaaattatta ttaggaatta tttaagtggg gccaggcatc
     4741 ttgcaacatt ttctgatttt tttttctttc tttctaatct cattttggtg atatttaaac
     4801 aaacataaat gattgtaact ttgcagcttt tttatttagg tagctttaat ttatttatga
     4861 aagttaatcc atttctgata cgtggttttt aaaaatatga aatggattta tatatactat
     4921 attcctcaaa tccactgtat gtggacttat attcattttc tccttttttc ggaattgaaa
     4981 cattttaatt tcaaattcaa atagaacatt taaaatgatt tcattattat tacccatact
     5041 gttgccactc atattgtaag tcagtttttt cattgctggt acaatgactc agtatttctt
     5101 tataaaaatc tgttgttctg aaaatcaaca accttagaag gattttgtct tagaaaattt
     5161 ccttggcttt agttttatat catatttaga aaataataat gaaaagcatc cccaaaattt
     5221 caatgatgtg aatttttaaa ttacctttat ttctttaaac taattccatt gattgttact
     5281 taaattttcc acctggaatc atggatttaa aatttcccca cctcatgggg aaaaaactaa
     5341 cccagaagtt caaagccttt aaagtttcat ctgattctgg ccttagaatt gtccttaaaa
     5401 gctttctcct ggccgatagg aggaagcata tatcaaggag gttctttccc ttcccattat
     5461 cattttgtgg caagccttaa gttaacaatg tgtctaccaa gaacaattga gttttctaaa
     5521 agtaataatg aagattatgc aattctaact gtagaagaga tagctattaa aataatcagt
     5581 agcctgggca tagtggctca cacctgtaat cccaatactt tagaaggcca aggctggagg
     5641 actgcttgag tccagaagtt taagaccagc ctgggcaaca cggggagacc ctgtctctac
     5701 aagaaattaa aaattagcca ggcatagttg gcacgtgcct gtagcaccag ctacttggga
     5761 ggttaaggtg ggaggatcac ttgagcctgg gagatagagg cttgcagtga gccgtgatgg
     5821 caccattgca ctccaaccgg ggtgacagat gaggtcctct gtttacctcc ccccccaaaa
     5881 aaaaaattca gtaggaattc cttcatagaa taacatgtta tttattggta ttgacttctt
     5941 attagacaga gctcatagta tttgttttct gctccgaaca cttaaaaaat actaagacgt
     6001 gatagtgaaa atagctttga aaagaaacta catatggcaa aggtggggag gggggaagat
     6061 gatgcattct gatcattata aagaatactt ttcagggctc tatcattttc tccctttctc
     6121 taatcatcca gaatatggcg ggtgtcccag tgttcaacag tatcatgcta atattccatt
     6181 tgatcggtag tccaagttct ttggccagat agtgcaatgt tgtgacaccg accgaagcct
     6241 ttgttctgga tctttcttcc tattgaaggt ggctgctggt ggcttcataa ttttctgttt
     6301 tttttctcac aaagtaaatg gtgggcatcc atgtttacat tgcaccttcc cgtgctgtaa
     6361 ttggcttgac aaagacaagc aggcttctct gttgagactt attgtgtttt tagttttcat
     6421 agacacttat ttaatctttt taaattgtac agcaaggtgc tctaagtaat attcgataaa
     6481 atatatttaa tagaaatttg cgtttgatat tcatgaacat gaatacatgt atttttttaa
     6541 gaaataagta ttgtgtaaca ctatggcatt gcttctatag ccaaagtata aaaatttctg
     6601 gaatactgac atgtaaagac tacagttaat tctgacactg tatcttatta aaataggatg
     6661 atttgcattt tgtaaaatta tcctgcacat caagctgcat gccttaaagc ggaaactcta
     6721 ggactgtgtt catgggagag cagttcatct gttcagaaca gtgaggcaag gtctgtagtg
     6781 cttctttaac tacctttgga aatactgtac aatgttagaa taatttattt tgctttacag
     6841 gagtttgtca tgtattgact ttaatattgt attttggtaa taaatttttt gttaaaaaaa
     6901 acttggctcc aagttctatt aaccacaggt tgtgttcatt cttttcctgg aaatgatgac
     6961 tttattgctt agaaagttgt aaataattaa aagcttccca agagttaaat gaaggttatg
     7021 atgactcttg ataacttgtt aatctgttgc tgactagcat tagactgtta cacgaagata
     7081 aactgaataa gcatttagct ttttaaatca ttttaaaaat taagtctaat tttgaagctt
     7141 ttttccttgc tacccagttc agtttctctt ccaaatgtga cacgcttata tgctttcaat
     7201 tctgatatag tcaaagtgct aaagactagt tctgctattg acgaaggaat tagcattcct
     7261 tagtgaaggc caaaaactac agtgatatgt tcacaccttg atcactctgt cgtctataca
     7321 gacagctatt gacatatttg ttgcattgac gaagctaaca tcatctgact gtatcgtggg
     7381 tctggttatc catttgtgcc ctagaatcct gggtcacctc agttgaaagt gaccaaggcc
     7441 aaatatttcg tcccatgctt cccagggaca acataatcat atcccctgtc tttgaaaaac
     7501 ccaatctgaa actgtgtcac taacctccaa attaaagaat ccgagcatgg aagctctaga
     7561 acgtatggtc cagtgtggca gccactataa tatctaagtg taaaatacat agcagttgca
     7621 aagacttagt acaaaaagaa tggaaatgta ttaacagttt tttatattga ttacatgttg
     7681 aaatgatatt ttggtttaaa taaaatatta aaatta
//
