LOCUS       NM_001099269            3323 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 506 (ZNF506), transcript variant
            1, mRNA.
ACCESSION   NM_001099269 XM_930521 XM_942060
VERSION     NM_001099269.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3323)
  AUTHORS   Wu,Q., Fang,L., Wang,Y. and Yang,P.
  TITLE     Unraveling the role of ZNF506 as a human PBS-pro-targeting protein
            for ERVP repression
  JOURNAL   Nucleic Acids Res 51 (19), 10309-10325 (2023)
   PUBMED   37697430
  REMARK    GeneRIF: Unraveling the role of ZNF506 as a human PBS-pro-targeting
            protein for ERVP repression.
REFERENCE   2  (bases 1 to 3323)
  AUTHORS   Nowsheen,S., Aziz,K., Luo,K., Deng,M., Qin,B., Yuan,J.,
            Jeganathan,K.B., Yu,J., Zhang,H., Ding,W., van Deursen,J.M. and
            Lou,Z.
  TITLE     ZNF506-dependent positive feedback loop regulates H2AX signaling
            after DNA damage
  JOURNAL   Nat Commun 9 (1), 2736 (2018)
   PUBMED   30013081
  REMARK    GeneRIF: ZNF506-dependent positive feedback loop regulates H2AX
            signaling after DNA damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3323)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK095575.1, DA122515.1, AC011477.5 and AI559570.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001099269.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA864018.1, SRR1660805.165666.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMN03267764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540806.7/ ENSP00000440625.1
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AK095575.1         2-53
            53-53               DA122515.1         53-53
            54-1831             AK095575.1         55-1832
            1832-3276           AC011477.5         113070-114514
            3277-3323           AI559570.1         18-64               c
FEATURES             Location/Qualifiers
     source          1..3323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3323
                     /gene="ZNF506"
                     /note="zinc finger protein 506"
                     /db_xref="GeneID:440515"
                     /db_xref="HGNC:HGNC:23780"
     exon            1..150
                     /gene="ZNF506"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1482
                     /gene="ZNF506"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 506 isoform 1"
                     /protein_id="NP_001092739.1"
                     /db_xref="CCDS:CCDS42531.1"
                     /db_xref="GeneID:440515"
                     /db_xref="HGNC:HGNC:23780"
                     /translation="MGPLQFRDVAIEFSLEEWHCLDAAQRNLYRDVMLENYRNLIFLG
                     IVVSKPNLITCLEQGKKPLTMKRHEMIAKPPVMYSHFAQDLWSEQSIKDSFQKVILRR
                     YEKCRHDNLQLKKGCESVDECPVHKRGYNGLKQCLATTQRKIFQCDEYVKFLHKFSNS
                     NKHKIRDTGKKSFKCIEYGKTFNQSSTRTTYKKIDAGEKRYKCEECGKAYKQSSHLTT
                     HKKIHTGEKPYKCEECGKAYKQSCNLTTHKIIHTGEKPYRCRECGKAFNHPATLFSHK
                     KIHTGEKPYKCDKCGKAFISSSTLTKHEIIHTGEKPYKCEECGKAFNRSSNLTKHKRI
                     HTGDVPYKCDECGKTFTWYSSLSKHKRAHTGEKPYKCEECGKAFTAFSTLTEHKIIHT
                     GEKPYKCEECGKAFNWSSALNKHKKIHIRQKPCIVKNVENLLNVPQPLISIR"
     exon            151..277
                     /gene="ZNF506"
                     /inference="alignment:Splign:2.1.0"
     exon            278..373
                     /gene="ZNF506"
                     /inference="alignment:Splign:2.1.0"
     exon            374..3323
                     /gene="ZNF506"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF506"
                     /note="hexamer: AATAAA"
     polyA_site      3323
                     /gene="ZNF506"
                     /note="major polyA site"
ORIGIN      
        1 attgtctctc gctgacgcca gagatccagc tatcgtcttc actgctctgt gccgtcagct
       61 cctagaggcc cagcctctgt ggccctgtga cctgcaggta ttaggagggt cacagctagg
      121 acgccgggac cccctggaag cctagaaatg ggaccattgc aatttagaga tgtggccata
      181 gaattctctc tggaggagtg gcattgcctg gacgctgcac agcggaatct atatagggat
      241 gtgatgttag agaactacag aaacctgatc ttccttggta ttgttgtctc taaaccaaac
      301 ctgatcacct gtctggagca aggaaaaaaa cctttaacta tgaagaggca tgagatgatt
      361 gccaaacccc cagttatgta ttctcatttt gcccaagacc tttggtcaga gcagagcata
      421 aaagattctt tccaaaaagt gatactaaga agatatgaaa aatgtagaca tgacaattta
      481 cagttaaaaa aaggctgtga aagtgtagat gagtgtccag tgcacaaaag aggttataat
      541 ggacttaaac aatgtttggc aactacccag agaaaaatat ttcaatgtga tgaatatgtg
      601 aaattcttgc ataaattttc aaattcaaac aaacataaga taagagatac tggaaaaaaa
      661 tcttttaaat gtatagaata tgggaaaact tttaaccagt cttcaacccg tactacatat
      721 aagaaaattg atgctggaga gaaacgctat aaatgtgaag aatgtggtaa agcctataag
      781 cagtcctcac accttactac acataagaaa attcatactg gagagaaacc ctacaaatgt
      841 gaagaatgtg gcaaagccta taagcagtcc tgtaacctta ctacacataa gataattcat
      901 actggagaga aaccctacag atgtagagaa tgtggcaaag cttttaacca ccctgcaacc
      961 cttttttcac ataagaaaat tcatactgga gagaaaccat acaagtgtga taaatgtggc
     1021 aaagccttta tttcatcctc aacccttact aaacatgaga taattcatac tggagagaaa
     1081 ccctacaaat gtgaggaatg tggcaaagct tttaaccgtt cctcaaacct tactaaacat
     1141 aagagaattc atactggaga tgtaccctac aaatgtgacg aatgtggcaa aacctttacc
     1201 tggtactcaa gcctctctaa acataagaga gctcatactg gagagaaacc ctacaagtgt
     1261 gaagaatgtg gcaaagcctt tactgcattc tcaactctaa ctgaacataa gataattcat
     1321 actggagaga aaccgtacaa atgtgaagaa tgtggcaaag cttttaactg gtcctcagcc
     1381 cttaataaac ataagaaaat tcatattaga cagaaaccct gcatagtgaa gaatgtggaa
     1441 aatcttttaa atgttcctca acccttaata agcataagat aattcatact ggagagaaac
     1501 cgtatgaatg tgatgaatgt gggaaagcct ttaactagcc ctggactctg actaaatatg
     1561 agaatttata tggaacataa accctacaaa tataaagaat gtgacaaagc tttttaagga
     1621 agttctcaac ccttattaca cataatttat actggacaga aaccctacaa gtgtgaagaa
     1681 tatggcaaag cctataacaa cctgtcaact ctttttgttt tttgagatgg agtttcactc
     1741 ttgtcaccca ggctggagtg caatggcacg atctcagctc actgcaactt ctgcctcctg
     1801 gtatcaagcc attctcctgc ctcagcctcc cgagtagctg ggattactgg tgcccaccac
     1861 catgcccagc taatttttgt atttttagta gagatggggt ttcatcatgt ttgccagact
     1921 ggtctccaac tcctgacctc agatggtcca cccacctcgg catcctaaag tgctgagatg
     1981 acaggcatga gccacgacgc ccagccacaa gttctcaatt cttaagagac atggcgataa
     2041 ttcatgctga agaggaactc tacaaacctg aaagatgcaa cagtgctttt accaccacct
     2101 ccaacttttg tatacataaa aataaattat actaatgtga aaccctggaa atgtatgaaa
     2161 tgagacaaag cgtttatatg gttgccacac ttgattgtag gtaagagaat taatgctgcc
     2221 aaaactccta caagtgtgaa gaatgtggca aaacttttga gtgcttacac cttatttcac
     2281 aggaaagctt ttatccttga gaaaaatcgt acagatataa agaatatgga aacgccatta
     2341 acgcccactc acatctcaac agaaggttca tagttaataa aagcaataaa agtgcaatta
     2401 ctgtcaaaaa atctttcaga aaatataagc ctttaaagaa gaatatttat tctgaaatca
     2461 gctattacaa atataagggg gggttgtagt acctttactt gtatcacaga tcttgttgca
     2521 cacattgtgt actagaggaa aacctgaagc agttgctcca gctttattca acaacatgga
     2581 atttatattg gagaagagtc ctgcaaatat aatgaatttg gaaagacttt ttttttcaaa
     2641 atctatagct tagaaaacat cagagagttt atactaaagt atatttttgc agatgtaaat
     2701 atgaaaaaaa tatttaattc aaaattgatt ttacgtaaat atgagaattt acactagaat
     2761 aaggcactga cacttcagac attacactaa atcagagtat tgagtataaa aatgaatcca
     2821 caactaaagc tgtttttgta tataacttta aaagggagat tttctgaagc attgtaattt
     2881 cattgaaagt gtacttgttt cttgaaaaaa atttttgaac agtgaataat gatgtaatac
     2941 aactttcaaa tttctttacg ctgttatttt attcctattg tggtcacatg tgaaagcatg
     3001 tgatcaattg ttgctgcatc agggatatta cagattcttt tttattgggt attatgacct
     3061 tttctataaa agaataagga cattaaaatg taagatgcat gataaaaatg taagtggaga
     3121 ggctctttgt agttaactta tattaagtaa tgtataaggt gggggttctc atttgtataa
     3181 tcctagccta tgacttaatg ttgatgtttt gctttgtctt ttggatggcc taacctacat
     3241 taacatgttg gcagaccatt ttaaaacttt ttttttcaaa aattataatg aattacttta
     3301 ttaataaaga tttttaaaaa gtg
//
