LOCUS       NM_001134442            3154 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 502 (ZNF502), transcript variant
            4, mRNA.
ACCESSION   NM_001134442
VERSION     NM_001134442.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3154)
  AUTHORS   Zhang,X., Chen,X., Sun,D., Song,N., Li,M., Zheng,W., Yu,Y., Ding,G.
            and Jiang,Y.
  TITLE     ENAH-202 promotes cancer progression in oral squamous cell
            carcinoma by regulating ZNF502/VIM axis
  JOURNAL   Cancer Med 12 (22), 20892-20905 (2023)
   PUBMED   37902191
  REMARK    GeneRIF: ENAH-202 promotes cancer progression in oral squamous cell
            carcinoma by regulating ZNF502/VIM axis.
REFERENCE   2  (bases 1 to 3154)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3154)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3154)
  AUTHORS   Kipper,S., Hamad,S., Caly,L., Avrahami,D., Bacharach,E., Jans,D.A.,
            Gerber,D. and Bajorek,M.
  TITLE     New host factors important for respiratory syncytial virus (RSV)
            replication revealed by a novel microfluidics screen for
            interactors of matrix (M) protein
  JOURNAL   Mol Cell Proteomics 14 (3), 532-543 (2015)
   PUBMED   25556234
  REMARK    GeneRIF: Results present initial characterization of key proteins
            Cav2 and CFL1 as cellular factors that colocalize with M in viral
            inclusions and filaments and ZNF502 protein which appears to
            interact with RSV M in the nucleus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124045.2 and AC098649.2.
            
            On Feb 27, 2020 this sequence version replaced NM_001134442.2.
            
            Transcript Variant: This variant (4) differs in the 5' UTR,
            compared to variant 5. Variants 1-5 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027761.1, SRR14038196.2286084.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436624.7/ ENSP00000406469.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AC124045.2         54084-54164
            82-195              AC124045.2         61627-61740
            196-2865            AC124045.2         62297-64966
            2866-3154           AC098649.2         1868-2156
FEATURES             Location/Qualifiers
     source          1..3154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..3154
                     /gene="ZNF502"
                     /note="zinc finger protein 502"
                     /db_xref="GeneID:91392"
                     /db_xref="HGNC:HGNC:23718"
     exon            1..81
                     /gene="ZNF502"
                     /inference="alignment:Splign:2.1.0"
     exon            82..195
                     /gene="ZNF502"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1775
                     /gene="ZNF502"
                     /codon_start=1
                     /product="zinc finger protein 502"
                     /protein_id="NP_001127914.1"
                     /db_xref="CCDS:CCDS2719.1"
                     /db_xref="GeneID:91392"
                     /db_xref="HGNC:HGNC:23718"
                     /translation="MLNMQGAEERDIRRETCPGWVNKNKPALEQDVCKIDSSGIVVKR
                     FQEDEYQDSTFEEKYACEGMKENSPREIAESCLFQEGGFGRITFIHKEAPPEIISQGY
                     NFEKSLLLTSSLVTRLRVSTEESLHQWETSNIQTNDISDQSKCPTLCTQKKSWKCNEC
                     GKTFTQSSSLTQHQRTHTGERPYTCEECGKAFSRSSFLVQHQRIHTGVKPYGCEQCGK
                     TFRCRSFLTQHQRIHTGEKPYKCNECGNSFRNHSHLTEHQRIHTGEKPYKCNRCGKAF
                     NQNTHLIHHQRIHTGEKPYICSECGSSFRKHSNLTQHQRIHTGEKPHKCDECGKTFQT
                     KANLSQHQRIHSGEKPYKCKECGKAFCQSPSLIKHQRIHTGEKPYKCKECGKAFTQST
                     PLTKHQRIHTGERPYKCSECGKAFIQSICLIRHQRSHTGEKPYKCNECGKGFNQNTCL
                     TQHMRIHTGEKPYKCKECGKAFAHSSSLTEHHRTHTGEKLYKCSECEKTFRKYAHLSE
                     HYRIHTGEKPYECIECGKFFRHSSVLFRHQKLHSGD"
     exon            196..3154
                     /gene="ZNF502"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF502"
                     /note="hexamer: ATTAAA"
     polyA_site      3154
                     /gene="ZNF502"
                     /note="major polyA site"
ORIGIN      
        1 agaagttaag gctggtgtcc tggccccagt ccacctctgg gagcgcctgc gccgctccgc
       61 ggagagtccg tggatctcac aggttcccag ttttccagac ctgaagtgtt ttccaatcaa
      121 agcgaagaga cgatctgtgg atgttgaata tgcaaggagc tgaagagaga gacattagaa
      181 gagagacttg tccaggctgg gtaaacaaga acaagcctgc tctggagcag gatgtctgta
      241 aaattgactc atcagggata gtagtaaaga ggttccaaga ggatgaatac caagattcta
      301 catttgaaga aaaatatgca tgtgagggca tgaaggaaaa ctctcctagg gagattgctg
      361 aatcatgcct tttccaggaa ggaggttttg ggagaataac tttcatccac aaagaagcac
      421 cccctgaaat tattagtcaa ggatataatt ttgagaaaag cttgcttttg acctcaagcc
      481 ttgttacacg tctcagggtt tctacagaag agagtctgca tcagtgggaa acaagtaata
      541 tacaaaccaa tgatatttca gaccaaagta aatgtccaac tctctgcaca cagaaaaaat
      601 cttggaaatg taatgaatgt ggaaaaacct ttactcagag ctcatccctt acccaacatc
      661 agagaactca tactggagag agaccctaca catgtgagga atgtgggaaa gcctttagtc
      721 gtagttcatt ccttgttcaa catcaaagaa ttcacactgg agtgaaacca tatggatgtg
      781 agcagtgtgg gaaaacattt cgatgtcgat catttcttac tcagcatcaa agaattcaca
      841 ctggagagaa accttataaa tgcaatgaat gtgggaattc cttccgcaat cactcacatc
      901 tcactgaaca ccagagaatt cacactggag agaaacctta taaatgcaat aggtgtggga
      961 aggcattcaa tcagaataca caccttattc atcatcagag aattcacact ggtgagaagc
     1021 cttacatatg cagtgaatgt ggctcttctt ttcgaaaaca ctcaaatctt acgcaacatc
     1081 agagaattca cactggggaa aaaccccata aatgtgacga atgtgggaaa actttccaaa
     1141 caaaggcaaa cctctctcag catcagagaa ttcatagtgg agagaaaccc tataaatgta
     1201 aagaatgtgg caaagccttt tgtcagagcc catctcttat taaacaccag cgaattcata
     1261 ctggagaaaa accatataag tgtaaagaat gtggcaaagc gtttactcag agcaccccac
     1321 tcactaaaca tcagagaata catacagggg agagacccta caaatgcagt gaatgtggta
     1381 aagccttcat tcagagcatt tgccttattc ggcaccagag aagtcacact ggagaaaaac
     1441 cctataaatg caatgaatgt ggaaagggct ttaatcagaa cacctgcctc actcagcata
     1501 tgagaattca tactggagag aagccctata aatgtaaaga atgtgggaaa gcctttgctc
     1561 atagctcatc tcttactgaa catcatagaa ctcacactgg tgagaagctc tataaatgta
     1621 gtgagtgtga gaaaaccttc cgcaagtatg cacaccttag tgaacattac agaattcaca
     1681 ctggtgagaa gccttatgag tgtattgagt gtggaaagtt cttcagacat agttcagtcc
     1741 ttttcagaca tcagaaactt cacagtggtg actaatgctg ccatttaggt tatgacagtt
     1801 tctctagcga ggatgactac gaatctgact gggagtagag gggcaggtag agttcctgga
     1861 gggaaggatg aaggagcctt ggctactgta ctctgagagg aatgtttcca gaaatggagg
     1921 tgggagctta gggaatgcag agcctacttg aggtgggcat ctgggaatac agggtagaaa
     1981 gaaattcctg cttttcagat aaagcctaca cattgccact gtctccccat gtgactctta
     2041 cagcttgagg aggcatttgt tagcacttct gttcacttta ctacatcctg ccccacattc
     2101 tgacttgtca cccattttcg ttggctggca ggttgagatg tttttcttaa acactgcctg
     2161 tcagtgtgaa gtggcacagc tctgatgtag tgctaagtct agcctccaga tttgaggcag
     2221 ccctgaccat gctaccatgg gggaggctcc caacctgtgg aagtggtcct gtgaaaagga
     2281 gacagaaaca agtaagagcc aaaaaaaaaa aaaaaaaaaa tccatatcca ttcattaaaa
     2341 aaatgagata taaagcaaca actgggctga cctctataga tctgccagta aagaaggctt
     2401 tctttcatta tcagggtgaa ggtctttcct gattcttcca agctttgagg tgactcagag
     2461 ctaagaatga aataggagac caagttagaa ttcatgatac tggtttatgg ggaggcagtc
     2521 atacctgttc agagaaccag gaagactcaa tatctatctc agaggaaata tggttaccca
     2581 ggaaagaaat ggtctgctag agtgataaga ctcagaacag gaagcctgca tgtgactgag
     2641 caagtcacct acataaccct gcctgtacta aggtgtacac ctgtctattg taagtttgcc
     2701 taggctgttg gtgtacagag accagaggag agagacacac taggactaac aatgtcctaa
     2761 caaaatggta cttagtttgt tggtctttag gagaaagcat tagtaatgaa agaagaaaga
     2821 attttcactt ggttggacat tggggctctt aagaaagttg acatttgtcg tggaatgact
     2881 ttggaaagac ttctaaaaga atctttttca aatccctgaa aatcaggata gcacattttg
     2941 ctactgactg tgacagtgtt ttattctttt gagagaaatg acatagtttt ccctttattt
     3001 cccaaattcc tttcatgttc ttaactgcta cccagaaatt gagcttcaga agattgagga
     3061 tagcctttga ttggtattta aaataatttc taagctgtga agcttatagc atttttaaag
     3121 tatggctatt aaaaacacta agttgattct ggaa
//
