LOCUS       NM_021646               5824 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 500 (ZNF500), transcript variant
            1, mRNA.
ACCESSION   NM_021646 XM_085507
VERSION     NM_021646.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5824)
  AUTHORS   Ma,X., Fan,M., Yang,K., Wang,Y., Hu,R., Guan,M., Hou,Y., Ying,J.,
            Deng,N., Li,Q., Jiang,G., Zhang,Y. and Zhang,X.
  TITLE     ZNF500 abolishes breast cancer proliferation and sensitizes
            chemotherapy by stabilizing P53 via competing with MDM2
  JOURNAL   Cancer Sci 114 (11), 4237-4251 (2023)
   PUBMED   37700392
  REMARK    GeneRIF: ZNF500 abolishes breast cancer proliferation and
            sensitizes chemotherapy by stabilizing P53 via competing with MDM2.
REFERENCE   2  (bases 1 to 5824)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5824)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK291792.1, AC020663.1, AB011129.1 and BM678198.1.
            
            On May 17, 2019 this sequence version replaced NM_021646.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291792.1, SRR1660809.110408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000219478.11/ ENSP00000219478.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-615               AK291792.1         1-615
            616-616             AC020663.1         58368-58368         c
            617-1677            AB011129.1         413-1473
            1678-1963           AK291792.1         1678-1963
            1964-5165           AC020663.1         41659-44860         c
            5166-5672           BM678198.1         14-520              c
            5673-5824           AC020663.1         41000-41151         c
FEATURES             Location/Qualifiers
     source          1..5824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..5824
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /note="zinc finger protein 500"
                     /db_xref="GeneID:26048"
                     /db_xref="HGNC:HGNC:23716"
     exon            1..146
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     exon            147..658
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1687
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein with KRAB and SCAN domains 18"
                     /codon_start=1
                     /product="zinc finger protein 500 isoform 1"
                     /protein_id="NP_067678.1"
                     /db_xref="CCDS:CCDS32383.1"
                     /db_xref="GeneID:26048"
                     /db_xref="HGNC:HGNC:23716"
                     /translation="MATVPGLQPLPTLEQDLEQEEILIVKVEEDFCLEEEPSVETEDP
                     SPETFRQLFRLFCYQEVAGPREALSRLWELCCRWLRPELRTKEQILELLVLEQFLTVL
                     PGEIQARVREQQPESGEEAVVLVEGLQRKPRKHRQRGSELLSDDEVPLGIGGQFLKHQ
                     AEAQPEDLSLEEEARFSSQQPPAQLSHRPQRGPLLWPERGPPAPRHQEMASASPFLSA
                     WSQVPVNLEDVAVYLSGEEPRCMDPAQRDAPLENEGPGIQLEDGGDGREDAPLRMEWY
                     RVLSARCQGPGHPLPGQRPAPVRGLVRPDQPRGGPPPGRRASHGADKPYTCPECGKGF
                     SKTSHLTKHQRTHTGERPYKCLVCGKGFSDRSNFSTHQRVHTGEKPYPCPECGKRFSQ
                     SSSLVIHRRTHSGERPYACTQCGKRFNNSSHFSAHRRTHTGEKPYTCPACGRGFRRGT
                     DLHKHQRTHMGAGSLPTLQPVAPGGPGAKA"
     exon            659..842
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     exon            843..907
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1004
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..5824
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3723..3728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /note="hexamer: AATAAA"
     polyA_site      3747
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /note="major polyA site"
     polyA_site      4705
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
     regulatory      4728..4733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
                     /note="hexamer: ATTAAA"
     polyA_site      4751
                     /gene="ZNF500"
                     /gene_synonym="ZKSCAN18; ZSCAN50"
ORIGIN      
        1 acggcctggt ttgcacccct ggtttagggt cttcggcccc ggctctggcg tccctggctg
       61 ccaagcctga ggcccgcagt cctactcccg ccgagacccg ccgctccggt cctgccccga
      121 actgcccacg gccggcagcg cttccaggcc ctgaaaaaaa ctctcttcct gtgtctggcc
      181 agaggtatag agagagacag gttcaactct aaggcctgaa aaggaacaag gcccaccgga
      241 agcaatggcc actgtccctg gcctccagcc cctgccaacc ttggagcagg acctggaaca
      301 ggaagagatc ctgattgtga aggtggagga ggacttctgc ttggaagagg agccctccgt
      361 ggagacggag gaccccagcc ctgagacttt ccgccagctc ttccggctct tctgctacca
      421 ggaggtggct gggccccggg aggccctgag ccgcctctgg gagctgtgct gccgctggct
      481 gcggccggag ctgcgcacca aggagcagat cctggagctg ctggtgctgg agcagttcct
      541 gactgtgctg ccgggggaga tccaggctcg ggtacgcgag cagcagccgg agagcggtga
      601 ggaggccgtg gtccttgtgg aagggctgca gcggaagccc aggaaacaca ggcagcgggg
      661 ctcagagctg ctttctgatg acgaggtgcc cctcgggata gggggacagt tcttaaaaca
      721 ccaggcagag gctcagccag aggatctgtc cctggaggaa gaggctcgat tctccagcca
      781 gcagccccca gcccagctga gccacaggcc acagaggggc ccgctgttgt ggccagagag
      841 aggccctcca gctccccggc atcaggagat ggcgtcagcc tcgcccttcc tttcggcctg
      901 gtcccaggtg cccgtgaact tggaggacgt ggctgtatac ctttctgggg aggagccaag
      961 atgcatggac ccagctcagc gggacgcgcc gctggagaat gaaggacctg ggatccagtt
     1021 ggaggacggc ggtgatggca gggaggatgc cccgttgaga atggagtggt accgagtgct
     1081 ctcggcacga tgccaggggc ctggccaccc gctcccaggt cagaggccag ccccagtcag
     1141 gggcttggtc aggcctgatc agccaagagg cggcccccca ccaggaagac gggcttccca
     1201 tggggctgac aagccgtaca cctgccccga atgtggcaaa ggcttcagca agacgtccca
     1261 cttgaccaag caccagcgca cacacacggg cgagcggcct tacaagtgcc tagtctgtgg
     1321 gaagggcttt agcgaccgct ccaacttcag cacgcaccag agggtgcaca caggcgagaa
     1381 gccctacccg tgccccgagt gtgggaagcg cttcagccag agctccagcc tggtcatcca
     1441 ccgcaggaca cacagcgggg agcggcccta tgcctgcacc cagtgcggga agcgcttcaa
     1501 caacagctcg cacttcagcg cccaccgccg gacgcacaca ggtgagaagc cctacacctg
     1561 cccggcctgt ggccggggct tccgccgggg caccgacctg cacaagcacc agcggaccca
     1621 catgggggca ggctccttgc cgacgctcca gccggtggct cctggaggcc ccggtgccaa
     1681 agcctgatca ccaggcctga aactcccttt ccaggactct catccctggg cacagaattc
     1741 aggaaactgc tagacagcct ggtccgaaag cattgccagc tgcccgtttc ctcccatggc
     1801 ccagtatgag gccagcaggg gacatttggg atgcccaggc cgcagaggaa gctgggcact
     1861 gggtgcagaa caagggcaag gacaggctct gagtgtccag tggcagccag aacaggtgac
     1921 acagagcagg ggcttcagcc acagagacac actcaggagg ccagaagccg acactcaagg
     1981 tgttcgtggg gctggctcct gaagggcctg ggagggtcca tcagctgcct ccagcatcca
     2041 gtggctgctg gcatacagcc tcatccccac gtcccaaccc ctctcctgtg tgtctgtgac
     2101 cctgtgcgct gtctctgtgt gtacccccca cctgctcccc cccccttttt tttttgagac
     2161 ggggccttgc tgtgtccccc aggcgggaat acagtgccat gatcatagct cactgcagcc
     2221 tcgaatccct gggctcaagt gttcctcctg cctcatcctc ctgagtagct ggggttacag
     2281 gtgtgtgccg ccatgcccag tctctttttt ggtagggcca ccactcactg ggtttagggt
     2341 cccccaatac actgtgacct catcttaact aattatatca tcaaaacccg tgtttccaaa
     2401 taaggtcaca ttctgaggtc tgggtgcaca tgaatttgag ggacccctcg tctgctgcag
     2461 ggagccctgc tgtaccccag ccttcccagg acgtggtctc cagcttcttc atcctgccag
     2521 agtttccaaa tggagcccgg ggctctgcag cattccagtc ccctttgcag atccatagct
     2581 gctctgcagg gcggaagaca cctggggcgg gaaagcaccc ctgagttcca tcttcctgac
     2641 atgttgcctg ggatgtgacg ggcctgacat ctccccaggg ccggggccca gggctgcgtt
     2701 tgctcctggc cccttagtgt ctggaatgtg gccttccacg gttgccccac tttgtctttc
     2761 taaggtaaga agccttcacc ttccagcttt tgtctggcct gtgctgcgtg ggagccactg
     2821 gtctgtgcac atccacggtg ggtgagtggc caagacaagc agtgtgatag agtccttggt
     2881 gggtttagtc atctcggaag tcgtagggca gctatggaaa ccactgggtt ctggaacgtt
     2941 ccagccaggc agtggttgtt cctcataggt aggtggcctt ggccttcatc ccagcctggg
     3001 atgctccatt gcatttgtca cctagtcact gtatatacgt gcacatttga ccttttggca
     3061 cagcccaggt tccaggtgcg tgacctgccc tttttctcat tcccttaact gacattattt
     3121 agtgtcagag gccgagcaca gtggctccca cctataatcc tagcactttg ggaggccaac
     3181 gcgggtggat tgcttgagcc caggagttca agagcagcct gggcaatata gaaagacctc
     3241 ttccctacca aaaaaaaaaa aaaaaaaaaa aagccaggtg cagtggctca cgcttgtaat
     3301 cccagcactt tgggaggccg aggcaggtgg atcacaaggt caggagatcg agaccatcct
     3361 ggccaacatg gtgaaacccc atctctacta aaaacacaaa aattagctag gcatggtggc
     3421 gtggcacgtg cctgtagtcc cagctactcg ggaagctgag gcaagagaat cacttgaacc
     3481 agggaggcgg aggttgcagt gagccgaggt cgcaccgttg tactccagcc tggtgataga
     3541 acgagactcc acacaaaaaa aaaaaaaatt agccaggcat gatggggtgt gcctgtagtc
     3601 ccagctactt gagaggctga ggctggagga tcacttgagc ccaggaagtt gaggctgcag
     3661 tgagctgtga ttgtgccact gcactcatcc tggaagacag agtgagatcc tgtctcagat
     3721 aaaataaaca attttttttt taagtcattg cttctggccc ctgtgtgctc tgtcctgtgt
     3781 ctgcagaatg gggctgcctg gttgagggac ggcttttacc ttctagacta gctctgggat
     3841 ctctcatggg gcatgaggta cccagctaga tgtggccagg ccacactcca ggagctagca
     3901 aagcacccag cgttgctgac acccatctcc ccagcgcagc ctgagccccc aggcccctct
     3961 ctcatatcca ggcctgtgct ggaggtggcg gcctctgggg gagtgtggtt ggggtctgcc
     4021 cacttccctc cccctgccga ggctgtggcc tcccactggc tgctgcttgg ccccatctca
     4081 tggtcgctgc ctgctgcttg gccccatctc atgggcgtca tcctcagcac tcacgtgatg
     4141 ggagagtttt gtaggagctg tgagtcccag gtgcctgcgt gtgctgtgat gttatctcat
     4201 gcagtccagt gaggggggac tcccattagt ctcctttttt tgttttgttt tgagacacag
     4261 tctcacttca ttacccaggc tggagtgcaa ggcacgatct tggctcacca caacctccac
     4321 ctcccaggtt caagtgattc tcctgcctca gcctcctgag tagctgggat tacaggtgcg
     4381 caccactacg cctggctaat ttttgtattt ttagtagaga tggggtttct ccatgttggt
     4441 caggctggtc ttgaactccc gaccttgtga tccacccacc tcggcctccc aaagtgctgg
     4501 gattacaggc gtgagccacc gcgcccggcc atgattctcc ttctgtgggt ggaggaactg
     4561 ggcactggga gcgtgaaaac cttgcccagg tggcagagcc agctttggac gcaggtctga
     4621 cttcctacct cactcccctt gccttgacag acacagtaat tcagagttga acttggaaca
     4681 gagtttattt tccatcactg taaaacattc tcagtgaggt tactggcatt aaaaaggtgg
     4741 gagaaatgga agaaaatggg gttgaagaaa aaaaaagcct ttgctcttga cagctaggca
     4801 gccacagcgg aggccgccag gctgcgaggg cagcgtatgg gggcagagcc cggttctggc
     4861 ggcacaggcc ccggagtgga gggggcaggg gagggtctct gtaggtggga gagggcctgg
     4921 gggctgggag gcagcctggc cttgtgccct acaggaggga cctcctggga ctttatggaa
     4981 gcctgtcttg cctttgactt gcaatgaaaa tgcccctcat cattgggagt ggggtcgggt
     5041 gggggtcccc agtggccaga tcacgtgggg tccagagagc agacatctgt agccctgatc
     5101 ttggcggcca gtgaccacgg ccaagcaggg cctgtctttt gcctggtaca aggcttgatg
     5161 agaagagacc cctgcccatc ctcagtggcc tggcagccag gggtgaaccc caggggaagc
     5221 tgggacactg tcccaaaggc ccggcgccct actgtgctgc ctgagcccgt ggcaccgtgg
     5281 ggcccaaggt ggtgatgatt tctctgctct tcccacgggg cagacagcag gacacatcct
     5341 ggagacaagg ttggggagac aaacaggtgc ccaggtcagg gctgatcaca gcagttacaa
     5401 aagcatcccg tgaagacggg gctgcaagac ggtgctggca aaggaacagg acccaggaag
     5461 accaggcttg tcctgtggag gggccgggtc ttggcagggg gcaagcagat gtccccagtt
     5521 tttgctggtg atcaacaagt gaggccgctg ctccattcta cacaggacag catttccagg
     5581 ggtttccagt attctgtcta gattcataaa ggtcaaaggc cttgagaatc tatgtgtgcc
     5641 tttctatctt aggtaaagaa gagaaagaga aagcaaattc tcgttactcc tctttcaaaa
     5701 agttcattaa aagccaggct ggcagctcac agtgctataa tcccagcact gtggaaggcc
     5761 taggcaggag gattgagagg agttccagac caacctgggc aacaccgtga gaccccatct
     5821 ctac
//
