LOCUS       NM_198458               3465 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 497 (ZNF497), transcript variant
            1, mRNA.
ACCESSION   NM_198458 XM_091892
VERSION     NM_198458.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3465)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3465)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126727.1, AC012313.7 and CA438336.1.
            
            On Nov 24, 2018 this sequence version replaced NM_198458.2.
            
            Transcript Variant: This variant (1) is the longer transcript.
            Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK126727.1, DA115261.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2159931, SAMEA2162946
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311044.8/ ENSP00000311183.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-581               AK126727.1         4-584
            582-3331            AC012313.7         12697-15446         c
            3332-3465           CA438336.1         17-150              c
FEATURES             Location/Qualifiers
     source          1..3465
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3465
                     /gene="ZNF497"
                     /note="zinc finger protein 497"
                     /db_xref="GeneID:162968"
                     /db_xref="HGNC:HGNC:23714"
     exon            1..75
                     /gene="ZNF497"
                     /inference="alignment:Splign:2.1.0"
     exon            76..172
                     /gene="ZNF497"
                     /inference="alignment:Splign:2.1.0"
     exon            173..3465
                     /gene="ZNF497"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1683
                     /gene="ZNF497"
                     /note="zinc finger-like protein"
                     /codon_start=1
                     /product="zinc finger protein 497"
                     /protein_id="NP_940860.2"
                     /db_xref="CCDS:CCDS12977.1"
                     /db_xref="GeneID:162968"
                     /db_xref="HGNC:HGNC:23714"
                     /translation="MESPRGWTLQVAPEEGQVLCNVKTATRGLSEGAVSGGWGAWENS
                     TEVPREAGDGQRQQATLGAADEQGGPGRELGPADGGRDGAGPRSEPADRALRPSPLPE
                     EPGCRCGECGKAFSQGSYLLQHRRVHTGEKPYTCPECGKAFAWSSNLSQHQRIHSGEK
                     PYACRECGKAFRAHSQLIHHQETHSGLKPFRCPDCGKSFGRSTTLVQHRRTHTGEKPY
                     ECPECGKAFSWNSNFLEHRRVHTGARPHACRDCGKAFSQSSNLAEHLKIHAGARPHAC
                     PDCGKAFVRVAGLRQHRRTHSSEKPFPCAECGKAFRESSQLLQHQRTHTGERPFECAE
                     CGQAFVMGSYLAEHRRVHTGEKPHACAQCGKAFSQRSNLLSHRRTHSGAKPFACADCG
                     KAFRGSSGLAHHRLSHTGERPFACAECGKAFRGSSELRQHQRLHSGERPFVCAHCSKA
                     FVRKSELLSHRRTHTGERPYACGECGKPFSHRCNLNEHQKRHGGRAAP"
     polyA_site      2174
                     /gene="ZNF497"
     regulatory      3445..3450
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF497"
                     /note="hexamer: AATAAA"
     polyA_site      3465
                     /gene="ZNF497"
                     /note="major polyA site"
ORIGIN      
        1 attccacgcg gctcgagccc gcgtgcgggc ctctttcagg ccgctcctag tggacgcaga
       61 ggcgggccga ggacggtgcc agcccccagg ccccaagagg agctggtccc caggacagag
      121 gagggagagg agcaagaggc tcccctgggc cccttccagg ccccacctcc aggtcacagg
      181 cgcgagatgg agtccccaag agggtggacc ctgcaggtgg ccccagagga aggccaggtc
      241 ctctgcaatg tgaagactgc cacgaggggc ctctctgagg gggctgtgtc tggaggctgg
      301 ggggcctggg aaaactccac ggaggttccg agggaggcag gggacggcca gcggcagcaa
      361 gccacactgg gggcggcgga cgaacaggga ggccccggca gggagctggg ccccgcagac
      421 ggtgggcggg acggggctgg gcccaggagc gagcctgcag accgggcgtt gcgcccttcg
      481 cctctcccag aggagccggg ctgccggtgc ggggagtgcg gcaaggcgtt cagccagggc
      541 tcttacttgc tgcagcatcg gcgcgtgcac acaggcgaga agccgtacac gtgccccgag
      601 tgcggcaagg ccttcgcctg gagctccaac ctcagccagc accagcgcat ccacagcggc
      661 gagaagccct acgcttgcag ggagtgcggc aaggccttcc gcgcgcactc gcagctcatc
      721 caccaccagg agacacacag cggcctgaag cccttccgct gcccggactg cggcaagtcc
      781 ttcggccgaa gcaccacgct ggtgcagcac cgacgcacgc acacgggcga gaagccctac
      841 gagtgcccgg agtgcggcaa ggccttcagc tggaactcca atttcctgga gcaccggcgc
      901 gtgcacacgg gcgcgcggcc gcacgcctgc cgggactgtg gcaaggcctt cagccagagc
      961 tccaacctgg ccgagcacct gaagatccac gcgggcgcac ggccacacgc ctgtcccgac
     1021 tgcggcaagg ccttcgtgcg tgtggcgggg ctgcggcagc accggcgcac gcacagcagc
     1081 gagaagccct tcccctgcgc cgagtgcgga aaggctttcc gcgagagctc gcagctcctg
     1141 cagcaccagc gcacgcacac tggtgagcgg cccttcgagt gcgccgagtg cggccaggct
     1201 ttcgtcatgg gctcctacct ggcggagcac cggcgcgtgc acacgggcga gaagcctcat
     1261 gcgtgcgccc agtgcggcaa ggccttcagc cagcgctcca acctactgag ccaccggcgc
     1321 acgcactcgg gcgccaagcc cttcgcctgc gccgactgcg gcaaggcctt ccgcggcagt
     1381 tccggcctgg cgcaccaccg gctttcgcac acgggagagc gacccttcgc ctgcgcagaa
     1441 tgcggcaagg ccttccgcgg cagctccgag ctgcgccagc accagcgcct gcactctggc
     1501 gagaggccgt tcgtctgcgc ccactgcagc aaggccttcg tgcgcaagtc ggagctctta
     1561 agccaccggc gcacgcacac gggcgagagg ccctacgctt gcggcgagtg cgggaagcct
     1621 ttcagccacc gttgcaacct caacgagcac cagaagcggc acgggggccg cgctgcgccc
     1681 tgacccgagg acgccctgag cgggaggtcg cggacacacg gcattgcggg gtctcgggcg
     1741 tgagtgcgct gtctgctggc ccagactttt tcgggccgcc ggtgcgggcg ccctcctgct
     1801 gggagtgcag gggcggcctt gggtgtggag aaccctggct gcacagtccc tttgacgata
     1861 gtccaccggc cacccaggcc tgtctgggga catgtaggat gggctcttac cccagggagg
     1921 gcggcaggct ccacttcggc gagaggttcg tccatgcaga ggtgggcaag aactggggtc
     1981 tccgacaggt gtggctattt ctttgagttc tctggcactg tcaaaagcag ccaacccacc
     2041 ccccagtcca catggtcacc actgctgcta ccagctgctc agtgcagtgg ccactgtgtc
     2101 tcctaaggtg ctcgcttcag tcagcacttc atctcaggca accacaggtg acagttaaac
     2161 atgatgaaac cgcatgctat ggctttctag tgtctcatat tctgttggca agaagctcag
     2221 cactgcattc ctgaccgagg tcagaaccag atcaatctca gaatctcacc tgtgtaggtc
     2281 tgtttcatgg gacttttctt ttttggggga gggggcaggg tttcactctg tcacccaggc
     2341 tggagtgcag tggtgcaatc actgtttatt gcagccgcga cttcttaggc tcaggtgatc
     2401 ctcccacctc agcctcccaa gcagctggga tgacagactt gcgtcactac acctggctaa
     2461 ttttaaaatt ttttgtaagg acagtgtctc accatgttgc ctaggcgggt ctcaaaactc
     2521 ctgggctcaa gtgatcctcc tgcctcagcc tcccaaagcg ttgggattat aggcgtgagc
     2581 caccgcacct ggccagggaa ccttctttat accaagtacc acaccagtca gagtcaagtc
     2641 aggaaataga aaccacacta ggtatttcaa acagagggga tataagttag ggactgattg
     2701 tgcaggtttt gcaaggctca gagagcaaaa gtggatgttg cagaatctca gagctggata
     2761 cttgcaggaa gctgctacca cccttagggc tggagaaccc agggaagcta agaggagggt
     2821 gcaacgaggc tggtgttggg actgccaaag gaaacacaga atgacagctc catctctgca
     2881 gacctcagat ttgaccaggc ctctggctgc ctgggcagcc tcattgccaa tgggctgaaa
     2941 ggttctgtca ctgttcagtg gtctgacttc tgagttctgt gcacaccctg agctctgctc
     3001 ctctggcctg gccaccagtc cttgtctgag tgccccaggt ctggttatga cttcaggcct
     3061 cagcacctgg ttgtctcttc tgcaaagaat gcattctccc ccagtccacc cagaacacac
     3121 agcctccatc caggtactgg ctctgagcag gacagagagc atgcagcagg tgctcagcaa
     3181 tatggaaatg ggaccaaaca gagggagtct ccacagctcc ccgtccctca cagcagaagc
     3241 cagagccgct gcagtgccca gctggtcttc atcacgtcta tgagctctgc aatcgctctg
     3301 cagtcgcctc aactcctggt ctcctctgct ccttctcact gcacccgcat ctcccatgtt
     3361 tgcactggct gttccctctg cctggaatgc tccttgccca gttatcccac tgtcttcttt
     3421 gcatctggca cacagtagat gctcaataaa tgcctgtgga atgaa
//
