LOCUS       NM_032752               5315 bp    mRNA    linear   PRI 03-MAY-2024
DEFINITION  Homo sapiens zinc finger protein 496 (ZNF496), transcript variant
            1, mRNA.
ACCESSION   NM_032752 XM_005273330
VERSION     NM_032752.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5315)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 5315)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5315)
  AUTHORS   Helleboid,P.Y., Heusel,M., Duc,J., Piot,C., Thorball,C.W.,
            Coluccio,A., Pontis,J., Imbeault,M., Turelli,P., Aebersold,R. and
            Trono,D.
  TITLE     The interactome of KRAB zinc finger proteins reveals the
            evolutionary history of their functional diversification
  JOURNAL   EMBO J 38 (18), e101220 (2019)
   PUBMED   31403225
REFERENCE   4  (bases 1 to 5315)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5315)
  AUTHORS   Wang,J., Zhang,X., Ling,J., Wang,Y., Xu,X., Liu,Y., Jin,C., Ju,J.,
            Yuan,Y., He,F., Zhao,C., Wang,J. and Tian,C.
  TITLE     KRAB-containing zinc finger protein ZNF496 inhibits breast cancer
            cell proliferation by selectively repressing ERalpha activity
  JOURNAL   Biochim Biophys Acta Gene Regul Mech (2018) In press
   PUBMED   30012466
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   6  (bases 1 to 5315)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   7  (bases 1 to 5315)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   8  (bases 1 to 5315)
  AUTHORS   Losson,R. and Nielsen,A.L.
  TITLE     The NIZP1 KRAB and C2HR domains cross-talk for transcriptional
            regulation
  JOURNAL   Biochim Biophys Acta 1799 (5-6), 463-468 (2010)
   PUBMED   20176155
  REMARK    GeneRIF: the Nizp1 KRAB-domain was identified to possess an
            intrinsic transcriptional activation capacity suppressed in cis by
            the presence of the C2HR domain
REFERENCE   9  (bases 1 to 5315)
  AUTHORS   Nielsen,A.L., Jorgensen,P., Lerouge,T., Cervino,M., Chambon,P. and
            Losson,R.
  TITLE     Nizp1, a novel multitype zinc finger protein that interacts with
            the NSD1 histone lysine methyltransferase through a unique C2HR
            motif
  JOURNAL   Mol Cell Biol 24 (12), 5184-5196 (2004)
   PUBMED   15169884
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY023128.1, BC007263.1, BC025794.1, AC104335.2 and BU740940.1.
            
            On Jun 3, 2019 this sequence version replaced NM_032752.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.612427.1,
                                           SRR14038193.2446725.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682384.1/ ENSP00000507236.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                HY023128.1         75-152
            79-2410             BC007263.1         97-2428
            2411-3758           BC025794.1         1739-3086
            3759-5305           AC104335.2         65868-67414         c
            5306-5315           BU740940.1         17-26               c
FEATURES             Location/Qualifiers
     source          1..5315
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q44"
     gene            1..5315
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="zinc finger protein 496"
                     /db_xref="GeneID:84838"
                     /db_xref="HGNC:HGNC:23713"
                     /db_xref="MIM:613911"
     exon            1..78
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            79..294
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            295..410
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            411..837
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     CDS             448..2211
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="isoform 1 is encoded by transcript variant 1; NSD1
                     (nuclear receptor binding SET-domain containing
                     1)-interacting zinc finger protein 1; zinc finger protein
                     with KRAB and SCAN domains 17"
                     /codon_start=1
                     /product="zinc finger protein 496 isoform 1"
                     /protein_id="NP_116141.1"
                     /db_xref="CCDS:CCDS1631.1"
                     /db_xref="GeneID:84838"
                     /db_xref="HGNC:HGNC:23713"
                     /db_xref="MIM:613911"
                     /translation="MPTALCPRVLAPKESEEPRKMRSPPGENPSPQGELPSPESSRRL
                     FRRFRYQEAAGPREALQRLWDLCGGWLRPERHTKEQILELLVLEQFLAILPREIQSWV
                     RAQEPESGEQAVAAVEALEREPGRPWQWLKHCEDPVVIDDGDSPLDQEQEQLPVEPHS
                     DLAKNQDAQPITLAQCLGLPSRPPSQLSGDPVLQDAFLLQEENVRDTQQVTTLQLPPS
                     RVSPFKDMILCFSEEDWSLLDPAQTGFYGEFIIGEDYGVSMPPNDLAAQPDLSQGEEN
                     EPRVPELQDLQGKEVPQVSYLDSPSLQPFQVEERRKREELQVPEFQACPQTVVPQNTY
                     PAGGNPRSLENSLDEEVTIEIVLSSSGDEDSQHGPYCTEELGSPTEKQRSLPASHRSS
                     TEAGGEVQTSKKSYVCPNCGKIFRWRVNFIRHLRSRREQEKPHECSVCGELFSDSEDL
                     DGHLESHEAQKPYRCGACGKSFRLNSHLLSHRRIHLQPDRLQPVEKREQAASEDADKG
                     PKEPLENGKAKLSFQCCECGKAFQRHDHLARHRSHFHLKDKARPFQCRYCVKSFTQNY
                     DLLRHERLHMKRRSKQALNSY"
     exon            838..1021
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1098
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1231
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1339
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1453
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..5315
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4492..4497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="hexamer: AATAAA"
     regulatory      4524..4529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="hexamer: AATAAA"
     polyA_site      4525
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
     polyA_site      4553
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="major polyA site"
     regulatory      5295..5300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
                     /note="hexamer: AATAAA"
     polyA_site      5315
                     /gene="ZNF496"
                     /gene_synonym="NIZP1; ZFP496; ZKSCAN17; ZSCAN49"
ORIGIN      
        1 ctttcctttc ctcggcgtcc ggcgggctcc cgcggcggcc aggcctgcgc cgcccgccaa
       61 cagggacgcg ccgcggcggc gcctccattt gcccccgagc cgagccgtgg ctttccggat
      121 gatcgggaga cgcggtctgg acgggccggg aaaggagccg ggcgcctgcg gagaccccgc
      181 ctcagcgagt acgcccggcc gggcgggctg ggaggatgag gacggctgcc ctggacttcc
      241 gccgccacag gagggttttc ggccggacgc cgggagggag ctccaggctg tgagctccat
      301 ttgtaaaggt cttaataaca agaacagtga cttcggctcc ggagcttcaa gatagtggcc
      361 tgcttggcct gcccatctcg gatctctcca ggaggaccca gccacccaag ggtcgtcttc
      421 tgctgctgac ccccatcaaa tcccatcatg cccacagccc tgtgcccccg agtcttggct
      481 ccgaaggaaa gtgaggagcc caggaaaatg aggagcccac ctggagagaa ccctagcccc
      541 cagggggagc ttcccagccc cgagtcctct cggcgtctct tccgccgttt ccgctaccag
      601 gaggcggcgg gcccccggga ggccctgcag cgcctctggg acctgtgcgg gggctggctg
      661 cggcctgaga ggcacaccaa ggagcagatt ctggagctgc tggtgctgga gcagttcctg
      721 gccatcctgc cccgggagat ccagagctgg gtgcgggcgc aggagcctga gagcggagag
      781 caggctgtgg ccgcggtgga ggcactggaa cgggagcccg ggagaccctg gcagtggctc
      841 aagcactgtg aagaccctgt ggtgattgat gatggggaca gccctctgga ccaggagcag
      901 gagcagctgc cggtagagcc ccacagcgac cttgcaaaga accaggatgc ccagcccata
      961 accctggcac agtgcctggg gctcccaagc agaccaccaa gccagctcag cggggaccca
     1021 gttctgcaag atgctttcct tcttcaggaa gagaatgtgc gggacacaca gcaggtgacc
     1081 accctccagc tacccccgag tcgggtttct ccattcaagg acatgatttt atgcttctct
     1141 gaagaggatt ggtcccttct agatcctgcc cagactggct tctatggaga gttcatcatt
     1201 ggggaggatt acggggtctc aatgcctcca aacgacctag ctgcccagcc agatctctcc
     1261 cagggagagg agaatgagcc acgcgttcca gagttgcagg atctccaggg caaagaagtg
     1321 ccccaggtct cctacttgga ctctccaagt ctccagccat tccaggtaga agaaagaagg
     1381 aaacgtgagg agctgcaggt gccagagttc caggcctgcc cacagacggt ggtgcctcaa
     1441 aacacctacc cagctggcgg caacccgcga tctctagaga acagcctgga tgaagaagtg
     1501 accatcgaga tcgttctctc cagctctggg gacgaggact cccagcatgg cccgtactgc
     1561 acagaagagc tggggagccc cacagagaag cagcgcagcc tccccgcctc ccaccggagc
     1621 agcaccgagg ccggaggcga ggtgcagacc tccaagaagt cctacgtgtg tccgaactgt
     1681 gggaaaatct tccgctggag ggtcaacttc atccggcatc tgcggagccg cagggagcag
     1741 gagaagccgc acgagtgctc ggtgtgcggg gagctgttca gcgacagcga ggacctggat
     1801 gggcacctag agagccacga ggcccagaag ccttaccggt gtggtgcctg cgggaagagc
     1861 ttccgcctga actcccacct gctctcccac cggcggatac acctgcagcc ggacagactc
     1921 cagccggtgg agaagagaga gcaggcggca tccgaggacg cggacaaggg tcccaaagag
     1981 ccgctggaaa acggcaaggc caaactgagc ttccagtgct gtgagtgtgg gaaggccttc
     2041 cagcggcacg accacctggc tcggcaccgc agccactttc acctgaagga caaagcccgg
     2101 cccttccagt gccggtactg cgtcaagagc ttcacgcaga actatgacct cctccgccac
     2161 gagcgcctgc acatgaagcg ccgttccaag caggctctga actcctactg agcctctccg
     2221 cctggggcgg cctcaccctg gctggtgctg ccccctcacc ttggtactga tcagcgcccc
     2281 cacccaggac ataccttccc caggatagag agcacacctc cctcctgtcc ttgctctcag
     2341 gtagtgagcg ttcgggtggt gccatgggag cactctccct cccccaggta atgaaagagt
     2401 ggccaagtga gtgttctgtt tctgctgtgc caaaaaacgg gggggatgtg ccatcaccag
     2461 gttggacatg ccaggtgttc tgcgtcttag agacccttgg cccatgctcc ccaagctcgg
     2521 ggagtaaaac tgggctatcc cccgtcaggg cggcaccctg gtcaccagcc aaacctcagt
     2581 atactccctc ccctccttcc ctgtctgaac gctaggatct gctcctgaag ctccaggatg
     2641 cctgcacttc cactgagaag ctgctggcgg atgttggact agaggaaaga agaaggcagg
     2701 gtgggactga tgggctcagt ggggagcagg gccaggcaca ctgagccaga catgtcatgt
     2761 ctgagcccca gattcgtggc catcaggtag gcaggagcac cccgcagatc caagatgatc
     2821 aggcagccct tttgggctgg cctctgtggc aggggtctgc agagctcctt cttgaggttt
     2881 ggaaacagtc gtcatacctg ttgattttcc tgggggccaa tcactaggga tctggagctc
     2941 accaaaaaca aagcttacat tttaatttgt gttgcacacc taccccataa tgtctttata
     3001 ccccaaagat ccttggtaaa tgcttgtggg ttggaagcgg agttgtcatc gtttaaaagg
     3061 cacttaagtc ccttcttcca atctgtcctg tctaggaatg tggagctctg cccccagtga
     3121 ggggttctcc tgtctgggtg agccaagctc cagaacagaa ccttgcctga caacacactt
     3181 gatagataca ttagcttgga gtgctggtgt gtccaaacac tggctggctt agaacaacag
     3241 gagtgtattc cctgacagtt ctgggaggtg cacgtccaag atcagggtgt cctcagagtt
     3301 ggtgccttcc gagagctgtg agggagaagc ggcttcatgc ctttgctggc agttgccatt
     3361 ccttggtgtg tggaagcgtc acccagtctc tgccttcatc tccacatggc actcttgctg
     3421 tgtgcgtgtc tgtctccaaa cctccctttg tttaaggaca ccagtcatat cggattagag
     3481 cccatcccac cgactccagt ataacctcat ctgtatccgc agcaaccgtt taccaataag
     3541 gtcacattct gaggtactag aggttgggac ttcaacatcg gaatttgaaa gggacagcat
     3601 tcagcccatg actccagata aacgtgaggt atgctatatc attcctaatt tacagatgag
     3661 tcaatacaaa cttgagtgag cttgctcaca attccatcaa aggcagggtt cagacccaag
     3721 tttcagcatt tagggcaggt gtcctctgca tggaagaatc atactcaata gccgtaaacg
     3781 ctgacaaatt ccccttcctc cctgccttct gatgggggct gggcaggcca gctggagctg
     3841 tgtctcctgc tgggattccg gactgagagt gacagcaggt agtgaaacct caagcaattt
     3901 aaaacatggt attgttcctg gaagactggt tatgttggct agggtcagca agagagggca
     3961 tcaaggctgt agtctagcag tgatttaatc tgcaagtcaa accagacggg tattttgtat
     4021 tattcatatg tcacatccta ccaacagaca gtaagtcagg caaggctcct ggtgctcctt
     4081 gtcactcacg taattttcac atcaggaaaa ctctgggctg ggtgcagtgg ctcacacctg
     4141 taatcctagc actttgggaa accaaggtgg gtggattgcc tagctcagtg acaccagcct
     4201 gggccacatg gcaaaacccc gtctgtacca aaaatgcaaa aaattagctg ggtgtggtgt
     4261 tgacgtttgc ggtcccagct actctggagg ctgaggtggg aggattgctt gagtctggga
     4321 ggcagaagtt gcagtaagcc gagatcatgc cactgcacaa gctaggtgac agaatgagac
     4381 tctgtctcaa aaataattaa aaagcctctg ccccaaactc gttaaaagat tttataacca
     4441 caactgctgt ttctgtgtag atgcatctgc atgcccagga gcagtaaatg caataaaatc
     4501 atttggttat actttgaaca caaaataaac ggttgaggct tttactttct aaatagtttg
     4561 tctcttgtat caacatagct ggaaaaggga gaaatccgat ttttaaggcc aagggagggg
     4621 aaaattccaa gtagaagcca ggctctctgt acacgtttac cccacctacc tgtgtgctcc
     4681 tacctgtgct gaggattctc tctgtagctc taaggtcttg ggaaggttat tcaccttcct
     4741 gcttcagacg tctgactcaa gagaagaaca ctgttctact taccagagtg tttttctgtg
     4801 taaaaccaca tcatgaagga gaaagcgaca aagggaatgt gaggggctgg aagccacagg
     4861 gaggctgtct cttgagtccc caccactgat ccagagccaa ccaaggcacc tcaggaaatg
     4921 gaaggccaca ttgcctctgg atttggaaat cctcctgggt aatgtaactg aaacccaggt
     4981 tgatgccatg cagcaggagc agcaggggga acgtgctctc aggagaggtc ggccaaccct
     5041 ccagcccaac acccttcacc acagtggtgg aggaggctgc acccaggaga tctttgtctc
     5101 ccttttggcc actgatacct ttggccttat ctgacaacag ctacccctcg atccttccct
     5161 cccaccccag gggctgggca gctggctgga gctttgtgtc caccttgctc tggaggttga
     5221 gacccccatc tgagcaacat cctctctctt tgttcctctg atcccttggc atcgtcacaa
     5281 acccacaggt gcataataaa aacttgctga gtcaa
//
