LOCUS       NM_001076678            5023 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 493 (ZNF493), transcript variant
            3, mRNA.
ACCESSION   NM_001076678
VERSION     NM_001076678.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5023)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX648842.1 and AC010615.9.
            
            On Jun 2, 2019 this sequence version replaced NM_001076678.2.
            
            Transcript Variant: This variant (3) represents the longest
            transcript and encodes the longest isoform (3).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648842.1, SRR1660803.31545.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392288.7/ ENSP00000376110.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-778               BX648842.1         5-782
            779-5023            AC010615.9         78999-83243
FEATURES             Location/Qualifiers
     source          1..5023
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..5023
                     /gene="ZNF493"
                     /note="zinc finger protein 493"
                     /db_xref="GeneID:284443"
                     /db_xref="HGNC:HGNC:23708"
     exon            1..135
                     /gene="ZNF493"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2430
                     /gene="ZNF493"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /codon_start=1
                     /product="zinc finger protein 493 isoform 3"
                     /protein_id="NP_001070146.1"
                     /db_xref="CCDS:CCDS42536.1"
                     /db_xref="GeneID:284443"
                     /db_xref="HGNC:HGNC:23708"
                     /translation="MPGPPESLDMGPLTFRDVAIEFSLEEWQCLDTAQQDLYRKVMLE
                     NYRNLVFLGIAVSKPDLVTCLEQGKDPWNMKGHSTVVKPPVICSHFAEDFCPGPGIKD
                     SFQKVILREYVKCGHKDLQLRKGCKSMNECNVHKEGYNELNQYLTTTQSKIFQCDKYV
                     KVFHKLLNSNRHNTKHTGKKPFKCKKCGKSFCMLLHLCQHKRIHIRENSYRCEECGKA
                     FIWFSTLTRHRRVHTGEKSYKYECGKSFNQDSNLTTHKRIHTGQKPYKCEECGTSFYQ
                     FSYLTRHKLIHTREKPYKCEQYGKTFNQSSTLTGHKIIHNGEKPYKCEECGKAFSIFS
                     TPTKHKIIHTEEKSHRCEEYCKAYKESSHLTTHKRIHTGEKPYKCEECGKAFSIFSTL
                     TKHKIIHTEEKSHRCEECGKAYKESSHLTTHKRIHTGEKPYKCEECGKTFSVFSILTK
                     HKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIHTEEKPYKCEECGKAFNQSSTLSIHK
                     IIHTGEKPYKCEECGKAFKRSSTLTIHKMIHTGEKPYKCEECGKAFNRSSHLTTHKRI
                     HTGHKPYKCKECGKSFSVFSTLTKHKIIHTDKKPYKCEECGKAFNRSSILSIHKKIHT
                     GEKPYKCEECGKAFKRSSHLAGHKQIHSVQKPYKCEECGKAFSIFSTLTKHKIIHTEE
                     KPYKCEKCGKTFYRFSNLNTHKIIHTGEKPCKCEECGKAFNHSSNLIKHKLIHTGDKP
                     YKCEACGKAFRRSSHLSRHKIIHIGIHTEETVQK"
     exon            136..262
                     /gene="ZNF493"
                     /inference="alignment:Splign:2.1.0"
     exon            263..358
                     /gene="ZNF493"
                     /inference="alignment:Splign:2.1.0"
     exon            359..5023
                     /gene="ZNF493"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4412..4417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF493"
                     /note="hexamer: ATTACA"
     polyA_site      4435
                     /gene="ZNF493"
     regulatory      4909..4914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF493"
                     /note="hexamer: AATAAA"
     polyA_site      4941
                     /gene="ZNF493"
                     /note="major polyA site"
     regulatory      5000..5005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF493"
                     /note="hexamer: AATAAA"
     polyA_site      5023
                     /gene="ZNF493"
ORIGIN      
        1 attgtttctc tctgctgccg gagctccagg tctacccttc actgctctgt gtcctcagcg
       61 tgtgtggctt cgtgacctga agatactggg aaatccatag ctaagatgcc aggaccccct
      121 gaaagcctag acatggggcc gttgacattt agggatgtgg ccatagaatt ctctctggag
      181 gagtggcaat gcctggacac tgctcagcag gatttgtata ggaaagtgat gttagagaac
      241 tacagaaacc tggtcttctt gggtattgct gtctctaagc cagatctggt cacctgtctg
      301 gagcaaggaa aagatccctg gaatatgaag ggacacagta cggtagtcaa acccccagtt
      361 atatgttctc attttgctga agacttttgc ccagggccag gcattaaaga ttcttttcaa
      421 aaagtgatac tgagagaata tgtaaaatgt ggacataagg atttacagtt aagaaaagga
      481 tgtaaaagta tgaatgagtg taatgtgcac aaagaaggtt ataatgaact aaaccagtat
      541 ttgacaacta cccagagcaa aatatttcaa tgtgataaat atgtgaaagt ctttcataaa
      601 cttttaaatt caaatagaca taacacaaaa catactggaa agaaaccttt caaatgtaaa
      661 aaatgtggca aatcattttg catgctttta cacctatgtc agcataaaag aattcatatt
      721 agagagaatt cttaccgatg tgaagaatgt ggcaaagcct ttatctggtt ttcaaccctt
      781 actagacaca ggagagttca tactggagag aaatcctaca aatatgaatg tggcaaatct
      841 tttaaccagg actcaaacct tactacacat aagagaattc atactggaca gaaaccctac
      901 aaatgtgaag aatgtggcac atctttctac caattctcat accttactag gcataagcta
      961 attcatacta gagagaaacc ctataaatgt gaacaatatg gcaaaacttt taaccaatct
     1021 tcaaccctta ctggacataa gataattcat aatggagaaa aaccctataa atgtgaagaa
     1081 tgtggcaaag cctttagtat tttctcaacc cctactaaac ataagataat tcacactgaa
     1141 gagaaatccc acagatgtga agaatattgc aaagcttata aggagtcctc acaccttact
     1201 acacataaaa gaattcatac tggagagaaa ccctacaaat gtgaagaatg tggcaaagcc
     1261 tttagtattt tctcaaccct tactaaacat aagataattc acactgaaga gaaatcccac
     1321 agatgtgaag aatgtggcaa agcttataag gagtcttcac accttactac acataaaaga
     1381 attcatactg gagagaaacc ctacaaatgt gaagaatgtg gcaaaacctt tagtgtattc
     1441 tcaattctta ctaaacataa aataattcat acagaagaga aaccctacaa atgtgaagaa
     1501 tgtggcaaag cttttaaacg atcttcaacc cttactaaac ataggataat tcatactgaa
     1561 gagaaaccct acaaatgtga agaatgtggc aaagctttta accaatcttc aacccttagt
     1621 atacataaaa taattcatac tggagaaaaa ccctacaaat gtgaagaatg tggcaaagct
     1681 tttaaacgat cttcaaccct tactatacat aaaatgattc acactggaga aaaaccctac
     1741 aaatgtgaag aatgtggcaa agcttttaat cggtcctcac accttactac acataagaga
     1801 attcatactg gacacaaacc ctacaaatgt aaagaatgtg gcaaatcctt tagtgtattc
     1861 tcaaccctta ctaaacacaa gataattcat actgataaga aaccctacaa atgtgaagaa
     1921 tgtggcaaag cttttaaccg atcttcaatc cttagtatac ataagaaaat tcatactgga
     1981 gaaaaaccct acaaatgtga agaatgtggc aaagctttta agcggtcctc acacctcgct
     2041 gggcacaagc aaattcatag tgtacaaaaa ccctacaaat gtgaagaatg tggcaaagcc
     2101 tttagtatat tctcaaccct tactaaacat aagataattc atactgaaga gaaaccctac
     2161 aaatgtgaaa aatgtggcaa aactttctac cgattctcaa accttaatac gcataagata
     2221 attcatactg gagagaaacc ttgcaaatgt gaagaatgtg gcaaagcttt taaccattcc
     2281 tcaaacctta ttaaacataa gctaattcat actggagaca aaccctacaa atgtgaagca
     2341 tgtggcaaag cttttaggcg gtcttcacat cttagtagac ataagataat tcatattgga
     2401 attcatactg aagagactgt acaaaagtga agaatgtggc aaaggccttt actgctccta
     2461 ttcccttact aaagaatgtg gcaaagcttt tcaccagtac tttaccctta atacacataa
     2521 gataattaat gctggagaga aaccctacaa atgtgaagaa tgtggcaaag atttctattg
     2581 attctcatac cttactaaat ataagataat tcatattgga gagaaattct acagatgtga
     2641 agaatgtggc aaaggcttta attagttctc atcccttact aaacataaga gaattcatac
     2701 catagagaaa tcctacaaat atgaagaatg tgacaaagct tttaaccact tctcaaccct
     2761 gcctacacgt aagataattc atactggaag gaaaccctac aaatatgagg aatgtctcaa
     2821 agctttttac tgattcttat accttactaa acataaaata attcataaag gagataaatt
     2881 atacaaatgt gaagaatgtg gcaaagcttt taacaaatcc tcatccatta gtaaacataa
     2941 gataattcat actggagaga aaacctacaa atgtgaggaa tgtggcaaag cctttagcct
     3001 gtccctccaa tttactgcac ataagataat ttatactgga gagaagccct acaaatgtga
     3061 aaaatgtggc aaacctttta accaatcctc aacccttact acacattaga taattcatgc
     3121 tggagagaaa ccctacaaat gtgaaaaatg tggcaaagct tttaaccaat tttcaaacct
     3181 tactaaacat aagataactc atactggaga aaaatcttac aaatgtgaag aatgtggcaa
     3241 agcctttatc cagtcctcaa ctcctagtaa acataattaa tgatggagag aaaccataca
     3301 actgtgaaga atgtggcaaa gcttttaacc agtcctcaaa ctttattgaa caaaataatt
     3361 catacaggag agaaacccta caaatgtgaa gaatgtgaca aagcctttaa ccagtcctca
     3421 atttttacta aacataagaa aattcatact ggagagaaac cctatgattg tgaaaaatat
     3481 ggcaaaggct ttaactagtc ctcagttctt aacacacata cgataattct tactgcagag
     3541 aaactctaca aaccagtaag atgtgacagt gcttctgaca acatctcaaa cttttctaat
     3601 cataaaagaa atcatattgg tgagaaatcc tagaaatgtg gagaatgtaa caaagtattt
     3661 aaatggttgt cacacttgat tataggtaat attcatattg gaaaaatttc ctacaagtaa
     3721 gaacaatgtg gcaaagtttt taactaatac accttattgc acagaaaatc atttatattt
     3781 gagaaaaatt gtagaaatat agactgtgaa aaagacgtca atatctgctc acatcttact
     3841 aaacaccaga gagttcatgc ttaataaaag catgataagt gcaattactg ccaaaagatc
     3901 tttcagaaaa tattatcctt taaagtgaag gagagtattt atattaaaga tgaacattac
     3961 aaccataaag agggttgaag tacctttact tgtatcagat cttattgtcc acattttgta
     4021 ctacagaaaa actctgaaga ggtcactcaa actttgttca acatcaggga atttatattg
     4081 gagagctgtc ttgcaaatgt aataaatttg ggaaaacaaa ttttcaaaaa ctacagctta
     4141 gaaaacacca gagtttatac gaaaatatat tttcaaaggt gtagtaaaaa taaaaaaaat
     4201 tttaatccaa atttgtctat gtaaatacca gaatttatag tagaaatata tgaggaagcg
     4261 acacttcgaa tattctacta aatgagagtt ctgagtatag aaaataaaac taaagttggt
     4321 agaaaaatta tttgtatata atgttaagag gagtaaaaga ttttttgtag aataataact
     4381 atattcggat tatactttgt ttcttgaaaa aattacagat tttttgaaaa gcaaatgatg
     4441 taactcaact cattattttc tgctgtttct tcattcttat tcacttgtga aagcttgtga
     4501 tcatttgttg ctgcatcaga ggtatgagag attcttcttc attagatggg cattatttat
     4561 gatcttttct atggatgagt aagaatatta aaatgtaaga tgcatggtga aaatctaagt
     4621 ggagaggttc tttgtggtta acttatacta ttgagtgatg cacaaggtag gtgttaagag
     4681 taatattctt ttgcattatg agaaaactag tatattattc atatatttta ctaattgtac
     4741 tttttttatt atactttaag ttttagggta catgtgcaca atgtgcaggt tagttacata
     4801 tgtatacatg tgccatgctg gtgcgctgca cccactaact cgtcatctag cattaggtat
     4861 atctcccaat gctatccgtc ccccctcccc ccaattgtac ttttatataa taaaatgcag
     4921 tacattttaa aaaattttaa attctgtgtg aaggtaactg tttcaacatt tttaacatgg
     4981 taaatattat tgtgcattca ataaagtgtt gttatgccac aaa
//
