LOCUS       NM_020855               4246 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 492 (ZNF492), mRNA.
ACCESSION   NM_020855 XM_047550
VERSION     NM_020855.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4246)
  AUTHORS   Kim,Y.J., Jang,W., Piao,X.M., Yoon,H.Y., Byun,Y.J., Kim,J.S.,
            Kim,S.M., Lee,S.K., Seo,S.P., Kang,H.W., Kim,W.T., Yun,S.J.,
            Shon,H.S., Ryu,K.H., Kim,S.W., Ha,Y.S., Yoon,G.S., Lee,S.C.,
            Kwon,T.G. and Kim,W.J.
  TITLE     ZNF492 and GPR149 methylation patterns as prognostic markers for
            clear cell renal cell carcinoma: Array-based DNA methylation
            profiling
  JOURNAL   Oncol Rep 42 (1), 453-460 (2019)
   PUBMED   31115548
  REMARK    GeneRIF: Data revealed that hypermethylation of ZNF492 and GPR149
            was significantly associated with shorter timetoprogression of
            patients with clear cell renal cell carcinoma (ccRCC).
            Hypermethylation of ZNF492 and GPR149 may be independent predictors
            of tumor progression. Similarly, the methylation status of these
            two genes was significantly associated with poor outcomes in the
            independent external validation cohort.
REFERENCE   2  (bases 1 to 4246)
  AUTHORS   Figueiredo,J.C., Hsu,L., Hutter,C.M., Lin,Y., Campbell,P.T.,
            Baron,J.A., Berndt,S.I., Jiao,S., Casey,G., Fortini,B., Chan,A.T.,
            Cotterchio,M., Lemire,M., Gallinger,S., Harrison,T.A., Le
            Marchand,L., Newcomb,P.A., Slattery,M.L., Caan,B.J., Carlson,C.S.,
            Zanke,B.W., Rosse,S.A., Brenner,H., Giovannucci,E.L., Wu,K.,
            Chang-Claude,J., Chanock,S.J., Curtis,K.R., Duggan,D., Gong,J.,
            Haile,R.W., Hayes,R.B., Hoffmeister,M., Hopper,J.L., Jenkins,M.A.,
            Kolonel,L.N., Qu,C., Rudolph,A., Schoen,R.E., Schumacher,F.R.,
            Seminara,D., Stelling,D.L., Thibodeau,S.N., Thornquist,M.,
            Warnick,G.S., Henderson,B.E., Ulrich,C.M., Gauderman,W.J.,
            Potter,J.D., White,E. and Peters,U.
  CONSRTM   CCFR; GECCO
  TITLE     Genome-wide diet-gene interaction analyses for risk of colorectal
            cancer
  JOURNAL   PLoS Genet 10 (4), e1004228 (2014)
   PUBMED   24743840
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4246)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   4  (bases 1 to 4246)
  AUTHORS   Lu,Z., Poliakov,E. and Redmond,T.M.
  TITLE     Identification of a KRAB-zinc finger protein binding to the Rpe65
            gene promoter
  JOURNAL   Curr Eye Res 31 (5), 457-466 (2006)
   PUBMED   16714237
  REMARK    GeneRIF: This KRAB-zinc finger protein serves as a moderate
            transcriptional factor for Rpe65 gene upregulation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP871882.1, AB040906.1 and AC011467.7.
            
            On Nov 23, 2018 this sequence version replaced NM_020855.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BP871882.1, AB040906.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000456783.3/ ENSP00000413660.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               BP871882.1         1-113
            114-2611            AB040906.1         1-2498
            2612-3731           AB040906.1         2500-3619
            3732-3732           AC011467.7         19271-19271         c
            3733-4245           AB040906.1         3621-4133
            4246-4246           AC011467.7         18757-18757         c
FEATURES             Location/Qualifiers
     source          1..4246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..4246
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="zinc finger protein 492"
                     /db_xref="GeneID:57615"
                     /db_xref="HGNC:HGNC:23707"
                     /db_xref="MIM:620124"
     exon            1..151
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /inference="alignment:Splign:2.1.0"
     exon            152..278
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1840
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="zinc finger protein 115 (Y20)"
                     /codon_start=1
                     /product="zinc finger protein 492"
                     /protein_id="NP_065906.1"
                     /db_xref="CCDS:CCDS46032.1"
                     /db_xref="GeneID:57615"
                     /db_xref="HGNC:HGNC:23707"
                     /db_xref="MIM:620124"
                     /translation="MLENYRNLVFVGIAASKPDLITCLEQGKEPWNVKRHEMVAEPPV
                     VCSYFARDLWPKQGKKNYFQKVILRRYKKCGCENLQLRKYCKSMDECKVHKECYNGLN
                     QCLTTTQNKIFQCDKYVKVFHKFSNSNRHTIRHTGKKSFKCKECEKSFCMLSHLAQHK
                     RIHSGEKPYKCKECGKAYNETSNLSTHKRIHTGKKPYKCEECGKAFNRLSHLTTHKII
                     HTGKKPYKCEECGKAFNQSANLTTHKRIHTGEKPYKCEECGRAFSQSSTLTAHKIIHA
                     GEKPYKCEECGKAFSQSSTLTTHKIIHTGEKFYKCEECGKAFSQLSHLTTHKRIHSGE
                     KPYKCEECGKAFKQSSTLTTHKRIHAGEKFYKCEVCSKAFSRFSHLTTHKRIHTGEKP
                     YKCEECGKAFNLSSQLTTHKIIHTGEKPYKCEECGKAFNQSSTLSKHKVIHTGEKPYK
                     YEECGKAFNQSSHLTTHKMIHTGEKPYKCEECGKAFNNSSILNRHKMIHTGEKLYKPE
                     SCNNACDNIAKISKYKRNCAGEK"
     exon            279..374
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /inference="alignment:Splign:2.1.0"
     exon            375..4246
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4176..4181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="hexamer: AATAAA"
     regulatory      4183..4188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="hexamer: ATTATA"
     polyA_site      4196
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="major polyA site"
     polyA_site      4205
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="major polyA site"
     regulatory      4227..4232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="hexamer: AATAAA"
     polyA_site      4246
                     /gene="ZNF492"
                     /gene_synonym="ZNF115"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgtct ctcgctgcag tcggagtatg gtctagtgtt cgctgttctg cgtcctctgg
       61 tcctagaggc ccatcctctg tggccctgtg acctgcaggt attgggagat ccacagctaa
      121 gacgctagga ccccctggaa gcctagaaac gggagtgttg acatttaggg atgtggccat
      181 agaattctct ctggaggagt ggcaatgcct ggacaccgca cagcagaatt tatataggaa
      241 tgtgatgtta gagaactaca gaaacctggt cttcgtgggt attgctgcct ctaagccaga
      301 cctgatcacc tgtctggagc aaggaaaaga accttggaat gtgaagagac atgagatggt
      361 agctgaaccc ccagttgtat gttcttattt tgcccgagac ctttggccaa agcagggcaa
      421 aaaaaattat ttccaaaaag tgatactgag aagatataaa aaatgtggat gtgaaaattt
      481 acagttaaga aaatactgta aaagcatgga tgagtgtaag gtgcacaaag aatgttacaa
      541 tggacttaac cagtgtttga cgactaccca gaacaaaata tttcaatgtg acaaatatgt
      601 gaaagtcttt cataaatttt caaattcaaa cagacatacg ataagacata ctggaaagaa
      661 atctttcaaa tgtaaagaat gtgaaaagtc attttgcatg ctttcacact tagctcaaca
      721 taaaagaatt catagtggag agaaacccta caaatgtaaa gaatgtggga aagcctataa
      781 tgagacctca aacctttcta cacataaaag aattcatact ggaaagaaac cctacaaatg
      841 cgaagagtgt ggaaaagcct ttaaccggct ctcacacctt actacacata agataattca
      901 tactggaaag aaaccctaca aatgtgagga gtgtggcaaa gcttttaacc aatctgcaaa
      961 ccttactaca cataagagaa ttcatactgg agagaaaccc tacaaatgtg aagaatgtgg
     1021 cagagctttt agccagtcct caacccttac tgcacataag ataattcatg ctggagagaa
     1081 accttacaaa tgtgaagaat gtggcaaagc ttttagccag tcctcaaccc ttactacaca
     1141 taagataatt catactggag agaaattcta caaatgtgaa gaatgtggta aggcctttag
     1201 ccagttatcc caccttacta cacataagag aattcattct ggagagaaac cctacaagtg
     1261 tgaagaatgt ggcaaagctt ttaaacaatc ctcaaccctt actacacata agagaattca
     1321 tgctggagag aaattctaca aatgtgaagt atgtagcaaa gcctttagcc ggttctcaca
     1381 ccttactaca cataagagaa ttcatactgg agagaagccc tacaaatgtg aagaatgtgg
     1441 caaagctttt aacctatcgt cacaacttac tacacataag ataattcata ctggagagaa
     1501 accctacaaa tgtgaagaat gtggcaaagc ttttaaccag tcctcaactc tttctaaaca
     1561 taaggtaatt catactggag agaagcccta caaatatgaa gaatgtggca aagcttttaa
     1621 ccagtcctca caccttacta cacataagat gattcatact ggagagaaac cctacaagtg
     1681 tgaagaatgt ggcaaagcct ttaacaactc ctctattctt aacagacata agatgattca
     1741 tactggagag aaactctaca aacctgaaag ttgtaacaat gcttgtgaca acattgcaaa
     1801 gatttccaaa tataaaagaa attgtgctgg tgagaaataa tagaaatatg aatgtgacaa
     1861 agcctttaaa tggttatcac actggattgt aggtaaggta attcattctg gagaaaactt
     1921 ctacaagtgt gaatgaacag tgtggcaaaa cttacacaat gctcaaacct tattgcacag
     1981 gaaagccttt atacttgaga acaaatgtac aaatataaag aaagtaaaaa agtgattaat
     2041 atctgtgcac atcttattca acatcagagt ttatattaat agcattaaaa gtgcaattac
     2101 tgtcaaaaga gttcaaaaaa taagcattta aagtgctgaa gaggatttat tttgaagaca
     2161 aacattacaa atataaacga agttgtggta actttacttg taacacagat cttgttgtat
     2221 tcattctgta ttagagcaaa ccctgaggca attgctcaaa ctttgttcaa catcagagaa
     2281 tttatatcga agaaaaaccc tgtaaatgta ataaatttag aaaaaaacat ttattcaaaa
     2341 actacaggtt agaaaattcc agagagttca tattaaaata tttttgcata tacagtaaat
     2401 agaaaaaaat atttaattca atggtaagtt tatgtaaata tcagagaatt tatgttagaa
     2461 atatataagg caatgacact tcagacttta cactgaatca gagttctgag tttagaaagt
     2521 aatccaaaac taaacttggc agaaaaatta tttgtttata actttaaaag agtagaagat
     2581 tttttggaga gttacaagta tacttttttt tagaaagatt acagattttt tttaaaagta
     2641 aataactctc aaattacttc atacaaataa tgttgtaatt aactcaaatt acttcgtgtt
     2701 aatgttgtaa ttaactctca aattacttca tgctaaggaa attagttttt ctttttcttc
     2761 ttcttttttt tttttttttt agatggagtc ttgctctatc gcccccccag gctggagtac
     2821 agtggcacga tctcagctca ctgcaacctc cgtctccagg gttcaagtga ttctcctgcc
     2881 tcagcctccc aagtggctgg gattacaggc gcaaaccacc atgcgtggct aaattttgta
     2941 tttttaatag agccagggtt ttgccatgtt ggccaggctg gtctcgaact cgagacttta
     3001 ggtgatccgc ccagcttggc ctcccgcaat gctgcaatta caggtgttag ccactgcgcc
     3061 tgcctgatgt tgtttcttta ttcctattgt attcatatgt gaaagcatgt gaccaaaaga
     3121 tatgaggatt attttttatt aggtgagcat ttatgacctc ttctatgaaa gagtaaggac
     3181 attaaaatgc atgatgaaaa tctaagtaaa gaggttcttt gtgattcact tacagtactg
     3241 agtgatgcat gaggtaggtg ttctgagtaa tattctgcat tatattgaga gacaaatttt
     3301 tagttttagt taaaattaaa aataaattag tatattattt tactaatttt acttttatga
     3361 aaatgcagta catgttaaaa attttagatt atgtgtgaac ttaatttctt aattcaacat
     3421 ttttaacagt ttaaatattg tgcattcaat caagtcacat tattccactt actttaacct
     3481 agtccacctt actcaagggt gtaggtaaaa ggtggtaaca aggccgggca cggtggctca
     3541 cgcctgtaat cccagcactt tgggaggcaa aggtgggtag atcacctgag gtcgggagtt
     3601 caagaccagc ctgaccaaca tggagaaacg ccatctctac taaaaataca aaattagcca
     3661 ggcatggtgg cgcatgcctg taatcccagc tactcgggag gctgaggcag gagaatcact
     3721 tgaacccggg aagcagaggt tgcggtgagc cgagatcatg ccatggcact ccgtcctggg
     3781 tgacaaagtg agactccctc tcaaaaaata aataagtaaa taaaataaat ggtggtaaca
     3841 atacactatt tggtaaaaga atgcactaac atctgtagta ctaatctttt ttccagtggc
     3901 tttaaactgc aaataaggaa tgttgtttct gtaggtaaaa tttttattta ttttttccca
     3961 tttaaattta cttttgttag ttttttcagg catataatat ttatgttata tatggcatat
     4021 tctgataaga ggcatacaat atgtaataat cacattaggg taaatgaggt atccatcacc
     4081 tttagaattt attttttgta ttatgaacag ttcaattgta cagttttagt ttttttaaaa
     4141 tatacgattg ttattgacta cagggttatt tttataataa aaattatata caagtataaa
     4201 atttacacat ttctgagtcc tgaataaata aaaataattt cttgta
//
