LOCUS       NM_152356               2888 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 491 (ZNF491), mRNA.
ACCESSION   NM_152356
VERSION     NM_152356.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008543.9, AA083980.1, DA776617.1 and BC101590.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152356.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.228328.1,
                                           SRR1803611.247391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323169.10/ ENSP00000313443.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC008543.9         175038-175090
            54-62               AA083980.1         16-24
            63-240              DA776617.1         2-179
            241-1746            BC101590.1         1-1506
            1747-2876           AC008543.9         183877-185006
            2877-2888           AC008543.9         185007-185018
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..2888
                     /gene="ZNF491"
                     /note="zinc finger protein 491"
                     /db_xref="GeneID:126069"
                     /db_xref="HGNC:HGNC:23706"
     exon            1..205
                     /gene="ZNF491"
                     /inference="alignment:Splign:2.1.0"
     exon            206..331
                     /gene="ZNF491"
                     /inference="alignment:Splign:2.1.0"
     exon            332..2888
                     /gene="ZNF491"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1652
                     /gene="ZNF491"
                     /codon_start=1
                     /product="zinc finger protein 491"
                     /protein_id="NP_689569.2"
                     /db_xref="CCDS:CCDS12267.1"
                     /db_xref="GeneID:126069"
                     /db_xref="HGNC:HGNC:23706"
                     /translation="MGERLFESAEGSQCGETFTQVPEDMLNKKTLPGVKSCESGTCGE
                     IFMGYSSFNRNIRTDTGHQPHKCQKFLEKPYKHKQRRKALSHSHCFRTHERPHTREKP
                     FDCKECEKSFISPASIRRYMVTHSGDGPYKCKFCGKALDCLSLYLTHERTHTGEKRYE
                     CKQCGKAFSWHSSVRIHERTHTGEKPYECKECGKSFNFSSSFRRHERTHTGEKPYKCK
                     ECGKAFNCPSSFHRHERTHTGEKPYECKLYGKALSRLISFRRHMRMHTGERPHKCKIC
                     GKAFYSPSSFQRHERSHTGEKPYKCKQCGKAFTCSTSFQYHERTHTGEKPDGCKQCGK
                     AFRSAKYIRIHGRTHTGEKPYECKQCGKAFHCVSSFHRHERTHAGEKPYECKHCGKAF
                     TCSIYIRIHERIHTGEKPYQCKECGKAFIRSSYCRKHERTHTINI"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF491"
                     /note="hexamer: ATTAAA"
     polyA_site      2888
                     /gene="ZNF491"
                     /note="major polyA site"
ORIGIN      
        1 aactgtcaat ccggggaagc agaaggccgc actcagagtc tctgcactcc tttgttgctg
       61 gggtccgttg cgttctgcat ccagtccttg ctgctccgag aggccccagg tgcctccgcc
      121 acggctcctg tgacgctgtc acctgcgctg tgacctgctc cggagtcata aagaggacgc
      181 cgggacacca agaagcaggg aaatggaccc agtggccttt gaggatgtgg ctgtgaactt
      241 cacccaggag gagtgggcct tgttgaatcc tttccagaag atctctacag agatgtgatg
      301 caggaaacct tcacgaacct catctgtata gaaattttat gggagagaga ctctttgaga
      361 gtgcagaagg tagtcagtgt ggagaaactt tcacccaggt tccggaagac atgctgaaca
      421 agaaaactct tcctggagta aaatcatgtg aaagtggtac atgtggagaa atcttcatgg
      481 gatattcatc ctttaatagg aacatcagaa ctgacactgg acaccaacca cataagtgtc
      541 agaaattttt agagaagcca tataaacata aacaacgtag gaaagccttg agccatagcc
      601 actgctttcg aacacatgaa aggcctcaca ctagagagaa accttttgat tgtaaggaat
      661 gtgaaaaatc tttcatttct cctgcaagca ttcgaagata tatggtaacg cacagtggag
      721 atggacctta taaatgtaag ttttgtggga aagccttgga ttgtctcagt ttatacctta
      781 cccatgaacg aactcacact ggagagaaac gatatgaatg taaacaatgt ggtaaagcct
      841 tcagttggca cagttctgtt cgaatccatg aaagaactca cactggggag aagccatatg
      901 aatgtaagga gtgtgggaaa tcattcaatt tttccagttc ctttcgcaga catgaaagga
      961 cacacacagg agagaagccg tacaaatgta aggaatgtgg gaaagccttc aattgtccca
     1021 gttcttttca caggcatgaa aggactcaca caggagaaaa accctatgaa tgtaaactat
     1081 atgggaaagc attatctcgc cttataagct ttcgaagaca catgagaatg cacactggag
     1141 agaggcctca taaatgtaag atatgtggga aagcctttta ctctcccagt tcatttcaaa
     1201 ggcatgaaag aagtcacact ggagagaaac cctacaaatg caagcaatgt gggaaagcct
     1261 tcacttgttc cacttcgttt caatatcatg aaaggactca cactggagag aaacccgatg
     1321 ggtgtaagca atgtgggaaa gccttcagat ctgccaagta cattcgaata catggaagga
     1381 ctcacactgg tgagaaaccc tatgaatgta agcaatgtgg gaaagcattt cattgtgtca
     1441 gctcctttca tagacatgaa aggactcacg ctggagaaaa accttatgaa tgtaagcatt
     1501 gtgggaaagc cttcacttgt tccatatata ttagaataca tgaaagaatt cacactggag
     1561 agaaacctta ccaatgtaag gaatgtggga aagccttcat tcgttccagt tactgtcgaa
     1621 aacatgaaag aactcacact attaatatat gagagaaatg ctatttttta atttttattt
     1681 taatagagac agggtctcac tatcttgtcc aggttggtct tgaactcctg gcctcaagca
     1741 tccctcccag cttgaagtgt caataaagga aggcaataaa atgtagagat ggagttaggt
     1801 gatgccacgc tgggattcac tggtggccta tcttacatat gatttcgaag gcagacatga
     1861 ggaaggcctt agtcacattt tagagccagc caaattcaca tgggctgtgt ggccccctga
     1921 ttctagccca ttttcctgat tctctggctt gtcaatcaag agtatcctcc aaatctcttg
     1981 actttccttt tttcagaggt gtaggtttcc aaagatgtcc ccagaagctc cacattcaag
     2041 ttctatctac agtttggttt ttctttaagt attgtaatgt acataccaga gagataatgc
     2101 agactgtcat gggtggggaa tgttctctga tgctcaactc ccctagtctg cagattgagt
     2161 tggtaggagg tgtgatttgt ttacatgcac ctttgttcct gctggtagtg accttgttct
     2221 tgattcagcc tgacagctac tatgctgcca tcagaaccaa cttgatgaga gctctgctgc
     2281 cctgtgcagt gactggtctc atccaggact ctcatgtgag aaggaacacc ttgctctggt
     2341 caggaaatgt ccagtgtttc ctgttatcca caggagaatg taatgcctca gttcattttc
     2401 agttatcttt gattatatgt gattgacaat gtgtattttt gagggagcaa agatttctgt
     2461 acatatttct taaaaatagt ttattcagct gggtgcagtg gctcatgcct gtaaccccag
     2521 cactttggga ggccgaggtg ggcggatcac gaggtcagga gtttgagact agcctggcca
     2581 acacagtgaa accccatctc tactaaaagt accaaagtta gccgggtgtg gtggtggata
     2641 cctgtaatcc cagctactcg ggaggctgag gcaggagaat ctcctgaacc tgggaggtgg
     2701 aggttgcagt gagccaagat cacgccactg tactccagcc tggacaagag agcaatactc
     2761 tgtctcaaaa aaaaaaaaaa aggtttattc actgtttttc agttgtgtac ttgcaaatgt
     2821 ttttctcttt tttttgtata ctgagaagct ctattaaaat atcccttgtc aacatggatc
     2881 agatcaaa
//
