LOCUS       NM_020714               6108 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 490 (ZNF490), mRNA.
ACCESSION   NM_020714
VERSION     NM_020714.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6108)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6108)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6108)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   4  (bases 1 to 6108)
  AUTHORS   Jiang,Y. and Zhang,H.
  TITLE     Propensity score-based nonparametric test revealing genetic
            variants underlying bipolar disorder
  JOURNAL   Genet Epidemiol 35 (2), 125-132 (2011)
   PUBMED   21254220
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010422.7 and AB033024.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020714.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic and transcript sequence to make the sequence consistent
            with the reference genome assembly. The extent of this transcript
            is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB033024.1, BC038586.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311437.11/ ENSP00000311521.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC010422.7         75279-75282
            5-10                AC010422.7         75283-75288
            11-1836             AB033024.1         1-1826
            1837-6102           AC010422.7         105721-109986
            6103-6108           AC010422.7         109987-109992
FEATURES             Location/Qualifiers
     source          1..6108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2-p13.13"
     gene            1..6108
                     /gene="ZNF490"
                     /note="zinc finger protein 490"
                     /db_xref="GeneID:57474"
                     /db_xref="HGNC:HGNC:23705"
                     /db_xref="MIM:620118"
     exon            1..250
                     /gene="ZNF490"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1723
                     /gene="ZNF490"
                     /codon_start=1
                     /product="zinc finger protein 490"
                     /protein_id="NP_065765.1"
                     /db_xref="CCDS:CCDS12272.1"
                     /db_xref="GeneID:57474"
                     /db_xref="HGNC:HGNC:23705"
                     /db_xref="MIM:620118"
                     /translation="MRRNSSLSFQMERPLEEQVQSKWSSSQGRTGTGGSDVLQMQNSE
                     HHGQSIKTQTDSISLEDVAVNFTLEEWALLDPGQRNIYRDVMRATFKNLACIGEKWKD
                     QDIEDEHKNQGRNLRSPMVEALCENKEDCPCGKSTSQIPDLNTNLETPTGLKPCDCSV
                     CGEVFMHQVSLNRHMRSHTEQKPNECHEYGEKPHKCKECGKTFTRSSSIRTHERIHTG
                     EKPYECKECGKAFAFLFSFRNHIRIHTGETPYECKECGKAFRYLTALRRHEKNHTGEK
                     PYKCKQCGKAFIYYQPFLTHERTHTGEKPYECKQCGKAFSCPTYLRSHEKTHTGEKPF
                     VCRECGRAFFSHSSLRKHVKTHTGVQPYTCKKCGEAFKSSSSCEVHERTHFGEKPYEC
                     KQCGKAFNSSSYLQLHERVHTGEKTYECKECGKAFLYSTHFRIHERTHTREKPYECKQ
                     CGRVFIYFSHLRRHERSHTGVKPCECKQCGKAFTCLNSLKVHKRIHTGERPFQCRQCG
                     KAFSYSKSLHVHERTHSRQKP"
     exon            251..295
                     /gene="ZNF490"
                     /inference="alignment:Splign:2.1.0"
     exon            296..422
                     /gene="ZNF490"
                     /inference="alignment:Splign:2.1.0"
     exon            423..483
                     /gene="ZNF490"
                     /inference="alignment:Splign:2.1.0"
     exon            484..6108
                     /gene="ZNF490"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4230..4235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF490"
                     /note="hexamer: AATAAA"
     polyA_site      4256
                     /gene="ZNF490"
                     /note="major polyA site"
     polyA_site      5357
                     /gene="ZNF490"
                     /note="major polyA site"
     regulatory      6081..6086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF490"
                     /note="hexamer: ATTAAA"
     polyA_site      6108
                     /gene="ZNF490"
                     /note="major polyA site"
ORIGIN      
        1 aggcagatct cgcttccgcc ggtgggacgg aactggtgcc ctccgtggac aattgtgttg
       61 aagcagaaat tgttccggat ctcgggtcgg acacggaagt cttcctgcag tgtttctgga
      121 tgcggggaca gggatgcgca ggaattccag tctcagtttc cagatggagc gacccctcga
      181 ggagcaagtc cagagcaagt ggtcgtctag tcaaggccgc acaggaacag gagggtctga
      241 tgtcctccag atgcagaaca gtgaacacca tggacaaagc atcaagactc aaactgactc
      301 catctccctt gaggatgtgg ctgtgaactt caccctggag gagtgggctt tgctggatcc
      361 tggccagagg aatatctaca gagatgtgat gcgggcaacc ttcaagaacc tggcctgtat
      421 aggggaaaaa tggaaagacc aggatattga agatgaacac aaaaaccagg gaagaaatct
      481 aagaagtcct atggttgaag cactctgtga aaataaagaa gattgtccat gtggaaaaag
      541 cactagccag attcctgatc ttaatacgaa cctggaaact cctactggat taaaaccatg
      601 tgactgcagt gtgtgtgggg aagtcttcat gcatcaggtc tcccttaata ggcacatgag
      661 atctcacact gaacagaaac caaatgagtg tcacgaatat ggagagaagc cacataaatg
      721 caaagaatgt gggaaaacct tcactcgcag ctccagtatt cgaacccatg aaagaattca
      781 cactggagag aaaccctatg aatgtaagga atgtggcaaa gccttcgcat ttctcttttc
      841 ctttcgaaac catataagaa ttcatactgg agagacaccc tatgaatgta aggaatgtgg
      901 gaaggcattc agatatctca ctgctcttcg gcgccatgaa aaaaatcaca ctggagagaa
      961 accctacaaa tgtaaacagt gtggaaaagc ctttatatat taccagcctt ttctaaccca
     1021 cgaaaggact cacactggag agaaacctta tgaatgtaag caatgtggga aagccttcag
     1081 ttgtcccacg tacttacgga gtcatgagaa aactcatact ggagagaaac cttttgtatg
     1141 tagggaatgt gggagagcct tcttttctca ctcaagcctt cgaaaacacg tgaaaaccca
     1201 caccggagtt caaccttata catgtaagaa atgtggggaa gccttcaagt catctagttc
     1261 ctgtgaagtg cacgaaagaa ctcattttgg agaaaaaccc tatgaatgta aacaatgtgg
     1321 taaagccttc aattcttcaa gttaccttca gttgcacgaa agagttcaca ctggcgagaa
     1381 aacttacgaa tgtaaagaat gtggtaaagc ctttctttat tccactcact ttcgaatcca
     1441 tgaaagaacc catactagag agaaacccta tgaatgcaaa cagtgtggtc gggtcttcat
     1501 ttacttcagt caccttcgaa ggcacgaaag aagtcacact ggagtgaaac catgtgagtg
     1561 taagcagtgt ggcaaagctt tcacttgttt aaattccctg aaagtacaca aaagaattca
     1621 tactggagaa agaccctttc agtgtagaca atgtggtaaa gccttcagtt actcaaagtc
     1681 tttgcacgtg cacgaaagga ctcatagtag acagaagccc taagaaagta aagtgtggta
     1741 atgctgtcag ttgtattagt tccttttgga tgtatgagag tacttacgct ggagagaaat
     1801 tcaaggaatg taaacggtgt gattaagcct tcagttgtcc taattccctt tgaagacgtg
     1861 actcatgcgg caatgaaata tttaacaaat gggggaggaa cttgcactct cctgcgggat
     1921 tgcagatatg tgaatggact ccatggacag aaaagctacg aatgtatgga gtgtaggaaa
     1981 gccttcactt cacgtaatct tttaaagaca cctgagaata tatactggag agaaactata
     2041 aagaaaattc tatatccatc ccatcttttg tggggtttgt tttttgtttt tgtttttgtt
     2101 gagatgtaat tttgctcttg ttgcccaggc tggagtgcag tggtgcgatc gcggctcacc
     2161 gcaacctccg cctcccggat tcaagcaatt ctcctgccgc agcctcccaa gaagctggga
     2221 ttacaggcat gcgccaccac gcctggctaa ttttgtaatt ttagtagaga tggggtttct
     2281 ccatgttggt caggctggtc tcaaactcct gacctcaggt gatctgcctg cctcggcctc
     2341 ccaaagtgct gggattacag gtgtgagcca cagcacccaa cctttttttc cccgccgcac
     2401 cccaagatgg tgtctcactc tgttgcccca ggctggagtg cagtggtgtg atcctggctc
     2461 actgtaacct ctgggttcaa gcaattcttc tgcctcagcc ttccaagtag ctgggattac
     2521 aagtgcccac caccatgccc agctaatttt tatattttta gtagagacag tgtttcacca
     2581 tgttgaccag gctgatctta aactcttgac ctcaaatgat ccacccacct tggcctccca
     2641 aattgttcgt tttacttttt tttttttttt tttttgagct ggagtcttac tctgttgcct
     2701 aggctggagt gaaagtggcg caacctctgc ctcccaggtc aaagcaatcc tgcctcaggc
     2761 cccctagtag ctggcattac aggcacatgc caccacgccc aactaatttt tatattttta
     2821 gtagagacgg ggtttcacca tgttggccag gctggtcttg aactcctgac ctcaggtaat
     2881 ccacctgcct tggcctccca aagtgctggg attacaggcg tgagccacca cacccggccc
     2941 ccagttcttt tttttttttt ttgagacgga gtccttgccc aggctggagt gcagtggcgc
     3001 gatctcagct cactgcaagc tccgcctcct gggttcacgc cattctcctg cctcagcctc
     3061 ccgagtagct gggactacag gcgcccgcca ccacgcccgg ctcatttttt gtatttttag
     3121 tggagacggg gtttcaccgt gttagccagg atagtcttga tctcctgacc tcgtgatccg
     3181 ccctcctcgg cctcccaaag tgctgggatt ataggcgtga gccaccgcgc ccggcctcca
     3241 gttcatttta aaaccatgaa accacccaca ctggagagcc accttcttaa atgtaagcaa
     3301 tatgggaaca tcttcaatga catctgcaac cattgtcgag attcttcgta ggaagaatta
     3361 aaggaatggg gaagaaggac ttgggcccca gcaggccttt tgtggcatcc agtcagaagt
     3421 taggaaacac cctctagggc agtgcctgcc ctcagctctc acacatgact ggagagaagt
     3481 gagaagactc ccagaatctg ccttttaagt ttccatcagt gtcctcgggt cagactgtgg
     3541 gaatgctgta cttctaagac aaaggttcgc atcttacagt ttttccccaa gtgggatctg
     3601 cctatgcaca tcctaattca cagacattgt cagcattgca ttattccagg gctgttttga
     3661 ggtcatctcc agctccattt cccatctcaa acctacactt tggacacttg tttaaacatt
     3721 cacatctgaa tttctctgtg gcaaccgcag gtggctctga ggtgagagac tgaagaagca
     3781 gagcctgtat catgggacac acaccccttg accacacagc atccactctc ctgcggttac
     3841 cagccctgca ccaaccacca cagtcagaat aatctcaaaa ctgctagtgg agtcacagac
     3901 acactctgcc atgtcttagc tgtaggacac tcagaattct tacctcccct aacttgcttt
     3961 ccctgttttc tggcacattc taccctgaga tattcagcgg catatgcact gatgatgctc
     4021 cggccttctc acgtcagtgc atgtcacatg catcctgctc caggactggt ttcctagcct
     4081 cccgctaaga ctagcactta gctcttcttg gaaaaggacc caccctgcag cgctccagct
     4141 ctgttgtgta tgggaggtgc tggtgtcagg gttcacaagc catggaacta ccttgcttca
     4201 catcacaagg caaggtgaac tcaactccca ataaactgct tgctggagcc tccgaattct
     4261 ccgttttctg aattgcatag gcacgatagg ggtcgggtct gtcctttgtt ggagtcagtc
     4321 cccccttttc ttagcaagtc agtgtgtttt agaagggagg tggcagcatt gagggaaacc
     4381 aggtcaccat ccaccctcgt aacaacagtc tccctgggtg ggtcccagaa gtgatctttg
     4441 tgtcgctcgg gtcggaactc tttaggcctc tggcctccac cctcccccaa cagcagggat
     4501 gggtcaggtg gcagcatcca aaaccacggt gaagatacta gggtccagag gccgactgga
     4561 gcaaggtttg ctggcagatg aggcctcagt ggaagtgacg gctactgtgg agatgcagtg
     4621 gaggacctgg tggctgagcc aggagatgca caccttcgct tctctcacca ggaacattcg
     4681 cttctctcac caggaacatt tatggtagta tgaggggttg gaacattatt actcaaccca
     4741 tttcaggtcc tttcacattc ttgagctgcc atgttgtgct tttgtagaga gatgattatt
     4801 gtactgtggg aggtcaggaa gttcgagatt ccttcactgt cagaatgggc tcaaggagcc
     4861 atcttttgtg ataggtattg gggaactaag gggtatctct gctacaggaa tgggagtgag
     4921 aacattcact ttttgaagga caagtatatg tgggtctatg atgatgtttt tgtaaaaccc
     4981 ttttgtgtat gtgtctgtgt gagtcctaat attcagtaag tattttcctc tgtgtaactc
     5041 cctctaatag gtgtagtcaa caaagctgtg ctaatatctc tgtccccttg atcctggcat
     5101 tctggaagac acgaaagcaa gcaaggatat ataaggcact gtggtggtta ttcccgagga
     5161 gccagagaaa cctggagaag agatcagaac acctggggtc cttctatttg ggagaatctt
     5221 ttagtatctg ggctgttaca cctgtgggtt tgtgaatttg tgtctgtcca cctgtatgta
     5281 cagtgataac gtgtgtgatt tttgtatatt tgtctagagg gctgtgtgta tatatattta
     5341 tatatatttt taaatatgga atgcttttag gttttttttt tttttttttt ttttgagatg
     5401 gattctcact gttgccaggc tggagtgcag tggcacaatc ttggctcact gcaacctcca
     5461 cttctcaggt tcaagcaatt ctcctgcctc agcctcctga gtagctggga ctataggcgc
     5521 gtgccaccac aaccagctaa atttttttgt atttttagta gagatggggt ttcaccatgt
     5581 tgaccaggat ggtctcaatc tcctgacctt gtgatccacc cacctcggtc tccccaaagt
     5641 gctgggatta caggcgtgag ccactctgcc tggctggtta ttttgtttgt ttgttgtttt
     5701 tttgagacac agtctcgctc tgtcaccaag ctggactgca gtggcatgat ctcggctcac
     5761 tgcaatctct gcctcccagg ttcaagcaat tctcctgttt cagcctcctg agtagctggg
     5821 attacaggcg cgtgccacca taccgagcta gtttttttat ttttagtaga gacggggttt
     5881 caccatgttg gccaggatgg tctcgccctc ctgaccttgt gatctgcctg cctcggcctc
     5941 tcaaagtgct gggattagag gcttgagcca ccaggcccgg ctggaatgct tgcattttct
     6001 tgcctgattt ccctgggagc acccccctta acactgaatg gagctggtga gagcaaatat
     6061 ccttgtttct gatattagat attaaaaata tggtttttca ccatcaaa
//
