LOCUS       NM_153034               3516 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens zinc finger protein 488 (ZNF488), transcript variant
            2, mRNA.
ACCESSION   NM_153034
VERSION     NM_153034.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3516)
  AUTHORS   Weng,K., Li,L. and Zhou,H.
  TITLE     Transcription factor ZNF488 accelerates cervical cancer progression
            through regulating the MEK/ERK signaling pathway
  JOURNAL   Histol Histopathol 38 (12), 1381-1390 (2023)
   PUBMED   36537752
  REMARK    GeneRIF: Transcription factor ZNF488 accelerates cervical cancer
            progression through regulating the MEK/ERK signaling pathway.
REFERENCE   2  (bases 1 to 3516)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 3516)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3516)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3516)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731561.12 and BC051323.1.
            
            On Nov 23, 2018 this sequence version replaced NM_153034.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. All six variants encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.160620.1,
                                           SRR1803613.71942.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585316.3/ ENSP00000462269.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL731561.12        77662-77681
            21-3516             BC051323.1         1-3496
FEATURES             Location/Qualifiers
     source          1..3516
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.22"
     gene            1..3516
                     /gene="ZNF488"
                     /note="zinc finger protein 488"
                     /db_xref="GeneID:118738"
                     /db_xref="HGNC:HGNC:23535"
     exon            1..74
                     /gene="ZNF488"
                     /inference="alignment:Splign:2.1.0"
     exon            75..3516
                     /gene="ZNF488"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1205
                     /gene="ZNF488"
                     /codon_start=1
                     /product="zinc finger protein 488"
                     /protein_id="NP_694579.1"
                     /db_xref="CCDS:CCDS73120.1"
                     /db_xref="GeneID:118738"
                     /db_xref="HGNC:HGNC:23535"
                     /translation="MPEWPPCLSVAPALVITMAAGKGAPLSPSAENRWRLSEPELGRG
                     CKPVLLEKTNRLGPEAAVGRAGRDVGSAELALLVAPGKPRPGKPLPPKTRGEQRQSAF
                     TELPRMKDRQVDAQAQEREHDDPTGQPGAPQLTQNIPRGPAGSKVFSVWPSGARSEQR
                     SAFSKPTKRPAERPELTSVFPAGESADALGELSGLLNTTDLACWGRLSTPKLLVGDLW
                     NLQALPQNAPLCSTFLGAPTLWLEHTQAQVPPPSSSSTTSWALLPPTLTSLGLSTQNW
                     CAKCNLSFRLTSDLVFHMRSHHKKEHAGPDPHSQKRREEALACPVCQEHFRERHHLSR
                     HMTSHS"
     regulatory      3497..3502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF488"
                     /note="hexamer: AATAAA"
     polyA_site      3516
                     /gene="ZNF488"
                     /note="major polyA site"
ORIGIN      
        1 acgcgcagtg ctcttggccg ggaggaggct gtgctgcacc agcacctctt gctccacatc
       61 tccagagagc ccagggccct gtggccgagt gtgtccagcc cagtgtcatg gggagcttcc
      121 atatctcatg gctccttgct gggccaagcc ctccagaacc ccaaaccccc aaagactgat
      181 gaatgccaga gtggccacct tgcttatctg tggccccggc cctggtgatc accatggcag
      241 ctgggaaggg agccccgttg agcccatcgg ctgaaaacag atggcgactt agcgaacctg
      301 agctgggccg gggctgcaag ccagtgctgc tcgagaagac gaaccgcctg ggccctgagg
      361 ctgctgtggg cagggcgggc cgggatgtgg gcagtgcgga gctggcactg ttggtagccc
      421 caggcaagcc ccgacctggc aagccgctgc ccccgaagac acgtggagag cagaggcaga
      481 gcgccttcac ggagctgccg aggatgaagg accggcaggt ggatgctcag gcccaggaga
      541 gggagcacga tgaccccaca ggccaacctg gtgccccaca gctgacccag aacatcccca
      601 gaggcccagc tggcagcaaa gtcttctctg tgtggcccag cggagcacga agtgagcaaa
      661 gaagcgcctt tagcaaacca accaagcgac cagcagagag gcctgagcta acctcagtct
      721 tccctgcagg ggaatctgca gatgccctgg gggagctgtc tggactcctc aacactacag
      781 acctcgcttg ttggggtcga ctttcaactc ccaagctttt ggttggtgat ttgtggaact
      841 tgcaagcatt gccacagaat gctccactct gtagcacttt tctgggtgcc cctacactgt
      901 ggctggagca tacccaggcc caggtgcccc caccctcatc atcctccacc acttcgtggg
      961 ccctcctgcc acccaccctc acctccctgg gcttgtccac ccagaactgg tgtgcaaagt
     1021 gcaacctgtc ctttcgccta acgtccgacc tggtctttca catgcgatcc caccacaaaa
     1081 aggagcatgc ggggcctgac ccacattctc agaagcggag agaagaggcc cttgcctgcc
     1141 ctgtgtgcca ggagcacttc cgggagcgcc accacctctc ccggcacatg acttctcaca
     1201 gctagcaggt gaccgcagaa tgacctgctg ggtgcagcag ccagcctttg gcagaggggg
     1261 gctccctggg cctgcgttga gggggctgtc atggtccttt gcagagctgc tgcttttggc
     1321 attcatagat aaacagctca ggcataattt gaaaaagcca cacctgcatg atgtgttttg
     1381 aaggaaatga agtcctgaaa taaagtgatg ggctttgcaa atccagggta gaggccctaa
     1441 caggcacaga gagcaggggc aactcctggc acacatcatg ggctttggag gcacacaagc
     1501 ctggattcga atctgggctc tttcacatac tagctgtgac cctggacaaa gagctttaac
     1561 ctgctgagtc cccattttct catctgtgaa atggagatga taacactgtg tcttaggttg
     1621 gcattcaggt cacatgaaag gtgtgtggaa agtggccagc attctgcctg cagaccctga
     1681 gcactgagtc aacaaggttt gtgatgatgt ctgtactagt tagctattgt tattaacaag
     1741 atctccatgg cagacaagct aaagcatctg cctaagtcgt gagtctgtgg gttggctcag
     1801 gttaagctga gcttggctgg gcttggcagc aagtctcaga tttgatcaag tcatattcgt
     1861 tttcttcttc ggctggtggg ctacccagag cgagcacgct tctctcgtgg tcatgccaag
     1921 aacacaggag ggtgagtcta acaagcacac ctcaagcctc tgcttgggtc acattgccaa
     1981 tgtcctctca gcccatacaa gtggcaggac caggcccaat attaaggagt ggaaaagtgt
     2041 aggctgccct tggtgaagct gtgacaaggg agtgaccatc catcccctcc acaggagggt
     2101 gaggaattgg gacaggtaat tccagccaat acctggtcca tagttcttca cattgtgagt
     2161 atatgaatac ggggaaatag aaccccctcc ccaccaccta cacacatgct gttttacctt
     2221 ccaagaatag gacatgtgca aaaactaggc ttccagatcg tgaggctggg gagcattcta
     2281 ggtaccattt attatctact gcgtttcggt cagtagctgt tgtaggtacc cgcatcagcc
     2341 cttgttccta aggatgtgtg gagcccaggc tgtactcttt gacattccac aggtcagtct
     2401 gcgtgaaagc cctttgtggg gagtttccaa gccagtgtcg tttttgcact ggtttccacc
     2461 tcactgtcag atattgttct tttgatatgc agtttccagc cctccaatga gtccccagca
     2521 cagatctcag gcttgtggct gggaataagc ccagctgagc aggtggggat ctcagccagc
     2581 ctcccagact gcacctcttc tattgctctc ctctgtccac cgttccaggc agcagcactc
     2641 ccacctggct gctctgatgt cctcgctccc tccattcctg cctctcacca tgcacgcatc
     2701 cattgtccac acacacacaa ccagataatc ttctgaaagt gtaactcaga tgatgcctcc
     2761 aaccctgtgg ctgcccttca cacttacagg cctaacccca gcaggacctg ccagctgctt
     2821 catgaacaag tccctgcctc atgttaattg caagcactca tttcactctc cctgtgtgcc
     2881 aggcaatagc ataagcactg gaagaataca gatgttatag tgagtcctac aatagccctg
     2941 gaaggcaaga gctgtttcct ttccatttct acaatgagtc aattgcagat gatgctataa
     3001 cacttccagt gtttctgaca cttccctgaa gctatacctg ctaccttcat gggccgagct
     3061 tgcccttatg aggcccacag gtggcagtgg gcagagggga ccccgctata ccacctcgct
     3121 gctgttccac tgtctgctcc cgtgttctga ccacagctct ggtgccgttt ctcaagcctg
     3181 ggcttcattc aacattttct atctagctct tcatggtgct gctcctgcta tggttccaca
     3241 gggcttcttc tcgcaggtca gctccttaga gaggtctccc agattccccg taaagcagcc
     3301 ctgcagcctc tgcctctctc agccgcatca ccctgttgct tccttcacag catgtctcac
     3361 catctgcaac catctttctg tttgtcgtct tgttgatttg ctgcctccac actgtcagct
     3421 ccttgggaac agagattggt ttgtttactg tgcatccctg gtgcccagaa cagggcatgg
     3481 catattgttg gtgcataata aatattgtgg aaataa
//
