LOCUS       NM_052852               3895 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 486 (ZNF486), mRNA.
ACCESSION   NM_052852 XM_371152 XM_938180
VERSION     NM_052852.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC027608.1 and AC011447.7.
            
            On Nov 23, 2018 this sequence version replaced NM_052852.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DA784812.1, SRR1803617.272759.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335117.9/ ENSP00000335042.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1493              BC027608.1         6-1498
            1494-3895           AC011447.7         118341-120742
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p12"
     gene            1..3895
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /note="zinc finger protein 486"
                     /db_xref="GeneID:90649"
                     /db_xref="HGNC:HGNC:20807"
     exon            1..147
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1509
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /note="KRAB box only protein 2; KRAB domain only 2; KRAB
                     domain only protein 2"
                     /codon_start=1
                     /product="zinc finger protein 486"
                     /protein_id="NP_443084.2"
                     /db_xref="CCDS:CCDS46029.1"
                     /db_xref="GeneID:90649"
                     /db_xref="HGNC:HGNC:20807"
                     /translation="MPGPLRSLEMESLQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLE
                     NYRHLVFLGIIVSKPDLITCLEQGIKPLTMKRHEMIAKPPVVCSHFAQDLWPEQSIKD
                     SYQKVILRKFEKCGHGNLHFKKGCESVDECKLHKRGYNGLNQCLTTTQSKIFQCGKYV
                     KVFHQFSNSKRHKRRHTEKKPLKYIEGDKAFNQSSTHTTHKKIDTGEKPYKCEECGKA
                     FNRSSHLTTHKITHTREKPYKCEECGKVFKYFSSFTTHKKIHSGEKPYICEECGKAFM
                     YPYTLTTHKIIHTGEQPYKCKECDKAFNHPATLSSHKKIHTGEKPYTCDKCGKAFISS
                     SILSKHEKIHTGEKPYKCEECGKAFTRSSHLTMHKIIHTGEKPYKCEECGKAFTWSAG
                     LHKHRRTHTGEKPYKCEECGKAYTTSSNLTEHKTTHTGEKPYKCKECGKAFNWSSDLN
                     KHKRIHIGQKPRT"
     exon            148..274
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..370
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /inference="alignment:Splign:2.1.0"
     exon            371..3895
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3181..3186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /note="hexamer: ATTAAA"
     polyA_site      3201
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /note="hexamer: AATAAA"
     polyA_site      3895
                     /gene="ZNF486"
                     /gene_synonym="KRBO2"
                     /note="major polyA site"
ORIGIN      
        1 gtctctcgct gcatctggag ctctaggtcg cctcttcgct actctgtgtc ctctgctcct
       61 agaggcccac cctctgtggc cctgtgtcct gtaggtattg ggagatccac agccaagatg
      121 ccgggacccc ttagaagcct agaaatggaa tcattgcaat ttagagatgt ggctgtagaa
      181 ttctctctgg aggagtggca ttgcctggac actgcacagc agaatttata tagggatgtg
      241 atgttagaga actacagaca cctggtcttc cttggtatta ttgtctctaa gccagacctg
      301 atcacctgtc tggagcaagg aataaaacct ctgactatga agagacatga gatgattgcc
      361 aaacccccag ttgtgtgttc tcattttgcc caagaccttt ggccagagca gagcataaaa
      421 gattcttacc aaaaagtgat actgagaaaa tttgaaaaat gtggacatgg caatttacac
      481 tttaaaaaag gctgtgaaag tgtggatgag tgtaagttac acaaaagagg ttataatgga
      541 cttaaccaat gtttgacaac tacccagagc aaaatatttc aatgtggtaa atatgtgaaa
      601 gtctttcatc aattttcaaa ttcaaagaga cataaaagaa gacatactga aaaaaaacct
      661 ttgaaatata tagaaggtga caaagctttt aaccagtcct caacccatac tacacataaa
      721 aaaattgata ctggagagaa accatacaaa tgtgaagaat gtggcaaagc cttcaaccgg
      781 tcctcacacc ttactacaca taagataact catactagag agaaacccta caaatgtgaa
      841 gaatgtggca aagtctttaa gtacttctct agctttacta cacataagaa aattcatagt
      901 ggagagaaac cctacatttg tgaagaatgt ggcaaagcct ttatgtaccc ctataccctt
      961 actacacata agataatcca tactggagag caaccctaca aatgtaaaga atgtgacaaa
     1021 gcttttaacc atcctgcaac tctttcttca cataagaaaa ttcatactgg agagaaaccg
     1081 tacacgtgtg ataaatgtgg caaagccttt atttcatcct cgatccttag taaacatgag
     1141 aagattcata cgggagagaa accctacaaa tgtgaagaat gtggcaaagc cttcacccgc
     1201 tcctcacacc ttactatgca taagataatt catactggag agaaaccata caaatgtgaa
     1261 gaatgtggca aagcctttac atggtctgca ggcctccata aacataggag aactcatact
     1321 ggagagaaac cctacaaatg tgaagaatgt ggcaaagcgt atactacatc ctcaaatcta
     1381 actgaacata agacaactca tactggagag aaaccttaca aatgtaaaga atgtggcaaa
     1441 gcttttaact ggtcctcaga ccttaataaa cataagagaa ttcatattgg acagaaacca
     1501 agaacgtgac aaaggattat tttattatta ttattttttt gagaggtaat tctgctgttg
     1561 tttcccaggc tggagtgcaa tggcataatt ttggctcacc acaacctcca ccttctgggt
     1621 tcaagtaact ctccttagta gctaggatta cagggctgca ccaccacacc tggctaattt
     1681 tgtattttta gtagagatgg ggtttctcca tgttggtcag gctggtctca atctcctaac
     1741 ctcaggtggt ctgcctgctt tggcctccca aagtgttggg gttacaggca tgagccactg
     1801 tgcctggctg acaaagcttt ttaaggaagt tctcaaccct tattacacat aattcatact
     1861 ggacagaaac cctacaagtg tgaagaatgt ggcaagcctg taacaagttc tcaattcttt
     1921 tatttttatt tgtttattta ttttttgaga tgcagtttca ctcttgtgac ccgggctgta
     1981 gtgcaatggc atgatcttgg cttactgtga cctctgcctc ctgggttcaa gccattctcc
     2041 tgcctcagcc tcccaagtag ctgggattac aggtgccacc accattccca gctaattttt
     2101 gtatttttag tagagatggg cttttgccat atttgccagg ctggtctcaa actcctgacc
     2161 tcaggtgatc cactcgcctc ggcttcctaa agtgctggga tgacaggcat gagcctcaat
     2221 tcccagccat aagctcttaa ttcttaagag acatggcgat aattcatggt gaagaggaac
     2281 tttacaaacc tgaaagatgt gacagtgctt ttcccaacac ctccaacttt tctatgcata
     2341 aaaaaaatta tactacacca tagaaatgta tgaaatgtga caaagccttt atatggttgc
     2401 cacactttat tgtaggtaat tcatacttcc aaaataccta caagtatgaa gaatgtggca
     2461 aaacttttaa tcagtgctta caccgtattt cacaggaaag ctattatcct tgagaaaaat
     2521 tgtacaaata taaagaatat ggaaaagcca ttaatgtcca tcacatctta ctcaacagaa
     2581 gaaggttcat aaaagagcaa ttactgtgac aaaaatcttt cagaaaatat aagcctttaa
     2641 ggtgaagaag agtattgatt ctgaagacaa gcattacaaa tataaagagg tttgtagtac
     2701 ctttgcttgt attacagatc ttattgcccg cgttttgtat tagaaggaaa ccctaaagcg
     2761 gttgccaaac tttgtgcaac atcagggaat gtatattgaa gaagattcct gcaaatgtaa
     2821 tgagtttgga aacacttctt agataaatta tttgtggctg ggcacagtgg ctcatgcctg
     2881 taatcccagc actttgggag gccaaggtgg gaggatcacc tgatgtcggg agtttgagat
     2941 cagactgacc aaaacggaga aacccagtct ctactgaaaa tataaaatta gccatgcatg
     3001 gtggcacatg cctgtaatcc cagctactca ggaggcttga accctggagg cagaggttgt
     3061 ggtgagtcga gatcattgca ctccagcctg ggcaataaga gtgaaactct gtctccagga
     3121 aaaaaaaaaa tttatttgtg tataacttta aaagcagatt tttggaagca ttgtaattac
     3181 attaaaagta tacttgttcc agctgcgtgt ggtggctcat gcctgtaatc ccaacacttt
     3241 gggaggccaa ggcaggtgga tcacgaggtc aggagttcaa gaccatcttg gccaagatgg
     3301 tgaaaccctg tctgtactaa aaatacaaaa attagccatg catggtggcc ggcgcgtata
     3361 atcccagctg cttgggaggc tgaggcagag aattggaatt gcttgaacct gggaggtgga
     3421 ggttgcagtg agccgaggtt gcaccattgt ccagcctggg caacagagca agactccatc
     3481 tcaaaaaaaa aagtgtattt gtttccttaa aaaaattttt ctgaaaagtg ggtaatgaca
     3541 taatacagct ttcaaattac tttatgctgt tattttattc ttattgtatt cacatgtgaa
     3601 agcatgtgat caatttttgc tgcatcagag atattagaga tagtttttta ttaattgggc
     3661 atttatgacc ttttctataa aagtaaggac attaaaatgt aagatgcatg atgaaaatat
     3721 aagtggagag gctctttgta gttaacctat atgaagtaat gtataaggta ggtcagagta
     3781 atacttttct acattatagt gcaagaaata attattgata aaagtatatt aaactaaatt
     3841 cgtatatttt acttattgta cttttatgta ataaaatgca gtgcatttaa aaatt
//
