LOCUS       NM_145312               2024 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 485 (ZNF485), transcript variant
            2, mRNA.
ACCESSION   NM_145312
VERSION     NM_145312.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2024)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2024)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2024)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074679.1 and BC014161.2.
            
            On Nov 22, 2018 this sequence version replaced NM_145312.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA394799.1, AK074679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361807.8/ ENSP00000354694.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2014              AK074679.1         32-2045
            2015-2024           BC014161.2         2044-2053
FEATURES             Location/Qualifiers
     source          1..2024
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.21"
     gene            1..2024
                     /gene="ZNF485"
                     /note="zinc finger protein 485"
                     /db_xref="GeneID:220992"
                     /db_xref="HGNC:HGNC:23440"
     exon            1..109
                     /gene="ZNF485"
                     /inference="alignment:Splign:2.1.0"
     exon            110..187
                     /gene="ZNF485"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1489
                     /gene="ZNF485"
                     /note="isoform a is encoded by transcript variant 2; Zinc
                     finger protein 93 (Zinc finger protein HTF34)"
                     /codon_start=1
                     /product="zinc finger protein 485 isoform a"
                     /protein_id="NP_660355.2"
                     /db_xref="CCDS:CCDS7205.2"
                     /db_xref="GeneID:220992"
                     /db_xref="HGNC:HGNC:23440"
                     /translation="MAPRAQIQGPLTFGDVAVAFTRIEWRHLDAAQRALYRDVMLENY
                     GNLVSVGLLSSKPKLITQLEQGAEPWTEVREAPSGTHAVEDYWFETKMSALKQSTSEA
                     SVLGERTKSVMMEKGLDWEGRSSTEKNYKCKECGKVFKYNSSFISHQRNHTSEKPHKC
                     KECGIAFMNSSSLLNHHKVHAGKQPYRCIECGKFLKKHSTFINHQRIHSREKPHKCIE
                     CGKTFRKNSILLSHQRIHTGQKPYKCNDCGKAFAQNAALTRHERIHSGEKPFKCNKCG
                     RAFRDNSTVLEHQKIHTGEKPYQCNECGKAFRKSSTLISHQRMHTGEKPYHCSKCGKS
                     FRYSSSFAGHQKTHSGNKPYQCRDCGKAFTKSSTLTGHQRIHTGEKPYHCKKCGKAFR
                     HSSGLVEHQRLHTGEKPYKCNECGKAFPRSSALKQHKKIHNKERAMKCS"
     exon            188..314
                     /gene="ZNF485"
                     /inference="alignment:Splign:2.1.0"
     exon            315..410
                     /gene="ZNF485"
                     /inference="alignment:Splign:2.1.0"
     exon            411..2024
                     /gene="ZNF485"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2002..2007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF485"
                     /note="hexamer: AATAAA"
     polyA_site      2024
                     /gene="ZNF485"
                     /note="major polyA site"
ORIGIN      
        1 gtggtgcgag cgctgcacca gcccctggct ggtggttact gtccgaacgg cgtggtgtgg
       61 tcgctgactc tctgggcgtg cagctccgca gccctgccgg ctcggttcga ttgacttacg
      121 caggattctc agcccttgcc tgggagaaca gttcaggaga cagatggccc caagagccca
      181 gatccaggga ccgctgacat ttggggatgt ggctgtggcc tttacccgga ttgagtggag
      241 acacctggat gctgctcagc gggccctgta cagggatgtg atgctggaga actatgggaa
      301 tctggtgtct gtggggcttc tctcttccaa accaaaacta attactcagt tggagcaagg
      361 ggcagagccc tggactgagg tgcgagaggc tccatcaggc acacatgcag tcgaggatta
      421 ctggtttgaa acaaagatgt cagccctaaa gcaaagcact tctgaagcat ctgttctggg
      481 agagcgaacg aaaagtgtca tgatggaaaa aggcctggac tgggagggca gaagctccac
      541 agagaagaac tataagtgca aggaatgtgg gaaagtcttc aaatacaatt cgtcctttat
      601 tagccaccag agaaatcaca ccagtgagaa accacataaa tgtaaagaat gtgggatcgc
      661 ctttatgaac agttcatccc ttttaaatca ccataaggtt catgcaggca aacagcctta
      721 tagatgtatt gaatgtggga agttcctgaa gaagcactca acgtttatca accatcagag
      781 aattcattct agggagaaac cccacaaatg cattgaatgt ggaaaaactt tcagaaagaa
      841 ctcaatcctt ttaagtcatc agagaattca tactggccag aaaccctaca aatgtaatga
      901 ctgtgggaaa gccttcgctc agaatgcagc tcttactcgt catgaaagaa tacatagtgg
      961 agagaagcct tttaaatgta acaagtgtgg gagagctttc agggataatt caactgtgtt
     1021 ggaacatcag aaaatccata ctggtgagaa gccatatcag tgtaatgaat gtggaaaagc
     1081 ctttaggaag agctcaactc ttattagtca ccaaagaatg catactgggg agaaacccta
     1141 tcactgcagt aaatgtggaa aatctttcag gtatagctca tcctttgctg gtcatcagaa
     1201 aactcacagt ggaaataaac cgtatcagtg tcgtgactgt gggaaggcct ttacaaagag
     1261 ctcaaccctt actggacatc agagaattca tactggagaa aaaccctatc actgtaagaa
     1321 atgtgggaaa gcctttcggc acagctcagg ccttgttgaa catcagagac tccatactgg
     1381 ggaaaaacct tataaatgta atgaatgtgg gaaagctttt ccccgaagtt cagcccttaa
     1441 gcaacataag aaaattcata ataaagaaag agccatgaaa tgtagttagt gtggcaaatt
     1501 gtgcagagta gtttattcct tctgaccatc atagaggaga cattaaataa attatgcatt
     1561 taacagaaat actctgtact tctgagagaa cacatcactt gtgaggatat tcattgtgag
     1621 gttctactag tgaaatattt gaagaaacta aatgtatgtc agtatggaag tagttatagc
     1681 atactgtgtg ctaattgaaa agaatgaggt ggagctgtaa atactgtaca aagccaggca
     1741 tggtggcata tgcctgtagt cccagttact tgggaggctg agacaggatt gcttaagccc
     1801 aggagtttga gtctgtaatg cactatgatt gtgcatgtga atagccactg cactccagcc
     1861 tgggcaacat agcaagactc catctctaag taaaaaaata caacagtaga aatataccca
     1921 tgataatata cccaatatac ccttgttaaa gaagcaagtt tcaggaaatc tatattatat
     1981 gcattcaaaa agacctggac aaataaagac caatcttaac agca
//
