LOCUS       NM_031486               4784 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 484 (ZNF484), transcript variant
            1, mRNA.
ACCESSION   NM_031486
VERSION     NM_031486.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4784)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   2  (bases 1 to 4784)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   3  (bases 1 to 4784)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136981.22.
            
            On Nov 22, 2018 this sequence version replaced NM_031486.3.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK309617.1, SRR1660807.125966.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375495.8/ ENSP00000364645.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AL136981.22        147528-147676       c
            150-194             AL136981.22        144653-144697       c
            195-321             AL136981.22        125830-125956       c
            322-414             AL136981.22        125449-125541       c
            415-4784            AL136981.22        113820-118189       c
FEATURES             Location/Qualifiers
     source          1..4784
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.31"
     gene            1..4784
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="zinc finger protein 484"
                     /db_xref="GeneID:83744"
                     /db_xref="HGNC:HGNC:23385"
     exon            1..149
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /inference="alignment:Splign:2.1.0"
     exon            150..194
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..2738
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="isoform a is encoded by transcript variant 1; KRAB
                     box containing C2H2 type zinc finger bA526D8.4"
                     /codon_start=1
                     /product="zinc finger protein 484 isoform a"
                     /protein_id="NP_113674.1"
                     /db_xref="CCDS:CCDS35066.1"
                     /db_xref="GeneID:83744"
                     /db_xref="HGNC:HGNC:23385"
                     /translation="MTKSLESVSFKDVTVDFSRDEWQQLDLAQKSLYREVMLENYFNL
                     ISVGCQVPKPEVIFSLEQEEPCMLDGEIPSQSRPDGDIGFGPLQQRMSEEVSFQSEIN
                     INLFTRDDPYSILEELWKDDEHTRKCGENQNKPLSRVVFINKKTLANDSIFEYKDIGE
                     IVHVNTHLVSSRKRPHNCNSCGKNLEPIITLYNRNNATENSDKTIGDGDIFTHLNSHT
                     EVTACECNQCGKPLHHKQALIQQQKIHTRESLYLFSDYVNVFSPKSHAFAHESICAEE
                     KQHECHECEAVFTQKSQLDGSQRVYAGICTEYEKDFSLKSNRQKTPYEGNYYKCSDYG
                     RAFIQKSDLFRCQRIHSGEKPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECTECGKA
                     FTRKSTLSMHQKIHTGEKPYVCTECGKAFIRKSHFITHERIHTGEKPYECSDCGKSFI
                     KKSQLHVHQRIHTGENPFICSECGKVFTHKTNLIIHQKIHTGERPYICTVCGKAFTDR
                     SNLIKHQKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKST
                     LSMHQRIHRGEKPYVCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLH
                     VHQQIHTGEKPYRCAECGKAFTDRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIH
                     QQSHTGERHYECSECGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNRHRR
                     IHTGEKPYECSDCGKSFIKKSQLHEHHRIHTGEKPYICAECGKAFTIRSNLIKHQKIH
                     TKQKPYKCSDLGKALNWKPQLSMPQKSDNGEVECSMPQLWCGDSEGDQGQLSSI"
     exon            195..321
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /inference="alignment:Splign:2.1.0"
     exon            322..414
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /inference="alignment:Splign:2.1.0"
     exon            415..4784
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="hexamer: AGTAAA"
     polyA_site      2897
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="major polyA site"
     regulatory      4273..4278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="hexamer: AATATA"
     polyA_site      4294
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
     regulatory      4766..4771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
                     /note="hexamer: ATTAAA"
     polyA_site      4784
                     /gene="ZNF484"
                     /gene_synonym="BA526D8.4"
ORIGIN      
        1 atgcgcaaac ccaggcagcg ctgtaagaag tacctctagg cctgggaggc attgagaaaa
       61 aggaagtggg tcctgttctg gttcttgcga ctatagtcac ctcccgaggc aaatgaccac
      121 tgtcctgaga ggacgtgggt gaggggcaga tttctgcccc tttgtccgaa gagccaaaaa
      181 tgaccaagtc cctggaatca gtgtcattca aggacgtaac tgtagacttc agtagggatg
      241 agtggcaaca attagacctt gctcagaaaa gcctgtacag agaagtgatg ctggaaaact
      301 atttcaactt gatctcagtg ggatgtcaag ttcccaaacc agaagtcatc ttcagcttgg
      361 aacaagaaga gccatgtatg ttggatggtg agatccccag tcagagccgt ccagatgggg
      421 acattggttt tggaccttta caacagagga tgtctgaaga agtttctttc cagtctgaga
      481 ttaatattaa tctcttcaca agagatgacc catattccat tttagaagaa ttgtggaaag
      541 acgatgaaca cacaagaaaa tgtggagaaa accagaacaa acctttaagt cgtgttgtct
      601 tcattaacaa gaaaacacta gctaatgaca gcatctttga atataaggac attggggaaa
      661 tagttcatgt aaacacacac ctggtttcct caagaaaaag accccataac tgtaactcgt
      721 gtggaaagaa tttggagcct atcataacct tatataatag aaacaatgca acagaaaatt
      781 ctgataagac tattggagat ggtgatattt tcactcattt gaattctcat acagaagtga
      841 ctgcttgtga atgtaaccaa tgtgggaaac ctctgcatca taagcaagct ctcattcaac
      901 aacagaaaat tcatactaga gagagcctct atttgttttc tgactacgta aatgttttct
      961 ccccgaagtc acatgccttt gcacatgaga gtatttgtgc tgaagaaaag cagcatgaat
     1021 gccatgaatg tgaggcagtc ttcactcaga agtcccagct tgatggcagt cagagggttt
     1081 atgcaggaat atgcactgaa tatgagaagg atttttccct caagtcaaac cgtcagaaaa
     1141 ctccttatga ggggaattac tataaatgca gtgactatgg aagagccttt atccagaagt
     1201 cagatctgtt cagatgccag agaattcatt ctggagaaaa accttatgag tacagtgaat
     1261 gtgagaaaaa cctccctcag aattcaaacc ttaatataca taaaaaaatt catactggag
     1321 ggaaacactt tgaatgtact gaatgtggaa aagctttcac aaggaaatca acactaagta
     1381 tgcatcagaa aatccataca ggagaaaaac cttatgtatg tactgaatgt gggaaggcct
     1441 ttatccggaa gtcacatttt atcacacatg aaagaattca tactggagaa aaaccctatg
     1501 aatgcagtga ctgtgggaaa tcctttatta aaaaatcaca actccatgtg catcagcgaa
     1561 ttcacacagg agagaatccc tttatatgtt cagaatgtgg gaaggtcttc actcacaaga
     1621 caaatctcat tatacaccag aaaattcata caggagaaag accctatata tgtactgtgt
     1681 gtggtaaggc ctttactgac aggtcaaatc tcattaagca ccaaaaaatt catactggag
     1741 agaaacctta taaatgcagc gactgtggaa aatcattcac ctggaagtct cggctcagga
     1801 tacatcagaa gtgtcatact ggagagagac attatgaatg cagtgaatgt gggaaagcat
     1861 tcattcagaa gtcaacatta agtatgcacc agagaattca tagaggggaa aaaccatatg
     1921 tttgcactga atgtggtaag gccttcttcc acaaatccca ttttattaca catgagagaa
     1981 ttcatactgg agagaaaccc tatgaatgca gtatttgtgg gaaatccttc actaagaaat
     2041 cacagctcca cgtacatcag cagattcaca caggagagaa accctatagg tgtgctgaat
     2101 gtggaaaggc ttttactgac agatcaaatc tctttacaca ccagaaaatt cacactggag
     2161 agaaacctta taaatgtagt gactgtggga aagccttcac taggaagtca ggtctccata
     2221 tacatcagca atcccatact ggagaaaggc attatgagtg cagtgaatgt gggaaagcct
     2281 ttgcaagaaa atcaacacta attatgcatc agagaattca tacaggagag aaaccctata
     2341 tttgtaatga atgtgggaaa tccttcatcc agaagtcaca cttaaataga cacaggagaa
     2401 ttcatactgg agagaaaccc tatgaatgca gtgactgtgg caagtctttc attaagaaat
     2461 cacaactcca tgagcatcat cgaattcaca caggagagaa accatatata tgtgctgagt
     2521 gtggaaaggc cttcaccatc agatcaaatc ttattaaaca ccagaaaatt catactaaac
     2581 agaaacccta taagtgcagt gacttgggga aagccttaaa ctggaagcca caactcagta
     2641 tgcctcagaa atctgacaat ggggaagtag agtgctccat gccacaatta tggtgtgggg
     2701 actcagaagg tgaccaaggc caactttctt ctatctagtt agaattatga acatctggat
     2761 catatagctg atgtgtagtt acacatatgg ggagacactt ttgagagtgt ttaagcaatg
     2821 tatagtggcc atctttggtt acttgatatt ggtgttgtca agctcctgca aataatagta
     2881 aatgtgcaag gagatgattg gcagtctttc ttgtttcact ttttgggcaa acagttttat
     2941 aaattcatgg ctgttgagtt tttcatgttc tgggtaccac aactattcaa tattgacccg
     3001 caaaaattca taatgagtag tatgatgaga taattttaca ttgtctaagc agcctaagga
     3061 cactgagatc aaggcaaaga gagggcaatt taggtctata atgaaagtga atcagcagtt
     3121 tttgtgaaaa cactaaagac agaaagaaag gactctactt tttttaaaat tttctttggg
     3181 aagtcaccat tatttattgt tatatctgtt ggcgtatgct ggggcagcag ttagccaaga
     3241 ggtctgaaat tgctctttgc ctatttctca aaagtctata ttattacctt agaactggcc
     3301 ctacgatcat ggaacttaga tacagggacc caggtctaga tagcagcact ttagatcctc
     3361 agctttcacc acagaaacct gcactttttt gatgttgttg ttaccaactc ctgtttgaaa
     3421 aataggacaa attaagaaaa tggatatcaa atcctaaaat tttttcccac taattttgtt
     3481 agtacattct ctacatgttc gttacttgct agattaccat gagacacaag catcttgaat
     3541 tttagtttgt gtccttagaa gataaaatgt agttgaacat ttggaagact tctcctttta
     3601 tctcctcaca atctctacaa actaatctta attaattttg tttttcaaat tctctgtatt
     3661 tgaatagact tttttgtctt ttcttctatc aaatactgaa agaactgtgt tgtaatttta
     3721 caaataattg tgaatttgtc tcctttagag ctactaattt ttgctttata tattttgtct
     3781 ttgattttac atacaattta gaattgttgt aatcttcctg gttaattgac acattatcat
     3841 tattagatgt ttctttttat ctctagtaat tttttgcctt aaatgtacta tgtcagatac
     3901 taatatacat atggattaaa agctaatgta aattagtact aacatttctg gacaagggga
     3961 gaagttataa cattataatt tcatttattt gtctcttata tggtattaat tttgtatatt
     4021 tggattctgt acatggtgaa catagccaat cattatttga gtcaatatcc atttaaatta
     4081 acccacatat ttatcatttt aattactttt ttattccttc ctgtccttta agttttcctc
     4141 tagaattatt ttgcttctta ctgaggaaca ccctttagta tttcttttac tgtgagtttg
     4201 gtggtgacaa attgttcttc atttgttggc agtgttttat tttgccttca tttttgaagg
     4261 atacttttac tgaatataga attctaagtt gaaagttgtt ttctattagt attttgatga
     4321 tattttattt tggtttgtct tttattgttt tattgagaag ctttatataa ttacctttgc
     4381 aggcaatctg cttttctgtc tcctttgaaa tttatctatt tgtctttgtt ttttaactgt
     4441 tgcacattga tatgcctagg tgtaattttt ccatgtattt atcctccttg gagtttataa
     4501 tgttttttaa atctgtggtt tagtggtttt ggggtgtgtg tgtgcacgtg tgcgtgtacg
     4561 tgtgtgcaca tgtgcatttg gggaaattcc tagctattat ctattcaaat tatgcatctg
     4621 cctcattctc cttctctgtt tcttttaggg ataaccttat tacccagttc tgttggcctg
     4681 ttttctaatg gttatttttc ttgaattttg ctgatgtcct atctcctcat atggtgattt
     4741 ttatatcact tgccagacaa tatatattaa aattttagag gtaa
//
