LOCUS       NM_133464              14694 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 483 (ZNF483), transcript variant
            1, mRNA.
ACCESSION   NM_133464
VERSION     NM_133464.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 14694)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   2  (bases 1 to 14694)
  AUTHORS   Demerath,E.W., Liu,C.T., Franceschini,N., Chen,G., Palmer,J.R.,
            Smith,E.N., Chen,C.T., Ambrosone,C.B., Arnold,A.M., Bandera,E.V.,
            Berenson,G.S., Bernstein,L., Britton,A., Cappola,A.R.,
            Carlson,C.S., Chanock,S.J., Chen,W., Chen,Z., Deming,S.L.,
            Elks,C.E., Evans,M.K., Gajdos,Z., Henderson,B.E., Hu,J.J.,
            Ingles,S., John,E.M., Kerr,K.F., Kolonel,L.N., Le Marchand,L.,
            Lu,X., Millikan,R.C., Musani,S.K., Nock,N.L., North,K., Nyante,S.,
            Press,M.F., Rodriquez-Gil,J.L., Ruiz-Narvaez,E.A., Schork,N.J.,
            Srinivasan,S.R., Woods,N.F., Zheng,W., Ziegler,R.G., Zonderman,A.,
            Heiss,G., Gwen Windham,B., Wellons,M., Murray,S.S., Nalls,M.,
            Pastinen,T., Rajkovic,A., Hirschhorn,J., Adrienne Cupples,L.,
            Kooperberg,C., Murabito,J.M. and Haiman,C.A.
  TITLE     Genome-wide association study of age at menarche in
            African-American women
  JOURNAL   Hum Mol Genet 22 (16), 3329-3346 (2013)
   PUBMED   23599027
REFERENCE   3  (bases 1 to 14694)
  AUTHORS   Cousminer,D.L., Berry,D.J., Timpson,N.J., Ang,W., Thiering,E.,
            Byrne,E.M., Taal,H.R., Huikari,V., Bradfield,J.P., Kerkhof,M.,
            Groen-Blokhuis,M.M., Kreiner-Moller,E., Marinelli,M., Holst,C.,
            Leinonen,J.T., Perry,J.R., Surakka,I., Pietilainen,O., Kettunen,J.,
            Anttila,V., Kaakinen,M., Sovio,U., Pouta,A., Das,S., Lagou,V.,
            Power,C., Prokopenko,I., Evans,D.M., Kemp,J.P., St Pourcain,B.,
            Ring,S., Palotie,A., Kajantie,E., Osmond,C., Lehtimaki,T.,
            Viikari,J.S., Kahonen,M., Warrington,N.M., Lye,S.J., Palmer,L.J.,
            Tiesler,C.M., Flexeder,C., Montgomery,G.W., Medland,S.E.,
            Hofman,A., Hakonarson,H., Guxens,M., Bartels,M., Salomaa,V.,
            Murabito,J.M., Kaprio,J., Sorensen,T.I., Ballester,F., Bisgaard,H.,
            Boomsma,D.I., Koppelman,G.H., Grant,S.F., Jaddoe,V.W., Martin,N.G.,
            Heinrich,J., Pennell,C.E., Raitakari,O.T., Eriksson,J.G.,
            Smith,G.D., Hypponen,E., Jarvelin,M.R., McCarthy,M.I., Ripatti,S.
            and Widen,E.
  CONSRTM   ReproGen Consortium; Early Growth Genetics (EGG) Consortium
  TITLE     Genome-wide association and longitudinal analyses reveal genetic
            loci linking pubertal height growth, pubertal timing and childhood
            adiposity
  JOURNAL   Hum Mol Genet 22 (13), 2735-2747 (2013)
   PUBMED   23449627
REFERENCE   4  (bases 1 to 14694)
  AUTHORS   Elks,C.E., Perry,J.R., Sulem,P., Chasman,D.I., Franceschini,N.,
            He,C., Lunetta,K.L., Visser,J.A., Byrne,E.M., Cousminer,D.L.,
            Gudbjartsson,D.F., Esko,T., Feenstra,B., Hottenga,J.J.,
            Koller,D.L., Kutalik,Z., Lin,P., Mangino,M., Marongiu,M.,
            McArdle,P.F., Smith,A.V., Stolk,L., van Wingerden,S.H., Zhao,J.H.,
            Albrecht,E., Corre,T., Ingelsson,E., Hayward,C., Magnusson,P.K.,
            Smith,E.N., Ulivi,S., Warrington,N.M., Zgaga,L., Alavere,H.,
            Amin,N., Aspelund,T., Bandinelli,S., Barroso,I., Berenson,G.S.,
            Bergmann,S., Blackburn,H., Boerwinkle,E., Buring,J.E., Busonero,F.,
            Campbell,H., Chanock,S.J., Chen,W., Cornelis,M.C., Couper,D.,
            Coviello,A.D., d'Adamo,P., de Faire,U., de Geus,E.J., Deloukas,P.,
            Doring,A., Smith,G.D., Easton,D.F., Eiriksdottir,G., Emilsson,V.,
            Eriksson,J., Ferrucci,L., Folsom,A.R., Foroud,T., Garcia,M.,
            Gasparini,P., Geller,F., Gieger,C., Gudnason,V., Hall,P.,
            Hankinson,S.E., Ferreli,L., Heath,A.C., Hernandez,D.G., Hofman,A.,
            Hu,F.B., Illig,T., Jarvelin,M.R., Johnson,A.D., Karasik,D.,
            Khaw,K.T., Kiel,D.P., Kilpelainen,T.O., Kolcic,I., Kraft,P.,
            Launer,L.J., Laven,J.S., Li,S., Liu,J., Levy,D., Martin,N.G.,
            McArdle,W.L., Melbye,M., Mooser,V., Murray,J.C., Murray,S.S.,
            Nalls,M.A., Navarro,P., Nelis,M., Ness,A.R., Northstone,K.,
            Oostra,B.A., Peacock,M., Palmer,L.J., Palotie,A., Pare,G.,
            Parker,A.N., Pedersen,N.L., Peltonen,L., Pennell,C.E., Pharoah,P.,
            Polasek,O., Plump,A.S., Pouta,A., Porcu,E., Rafnar,T., Rice,J.P.,
            Ring,S.M., Rivadeneira,F., Rudan,I., Sala,C., Salomaa,V., Sanna,S.,
            Schlessinger,D., Schork,N.J., Scuteri,A., Segre,A.V.,
            Shuldiner,A.R., Soranzo,N., Sovio,U., Srinivasan,S.R.,
            Strachan,D.P., Tammesoo,M.L., Tikkanen,E., Toniolo,D., Tsui,K.,
            Tryggvadottir,L., Tyrer,J., Uda,M., van Dam,R.M., van Meurs,J.B.,
            Vollenweider,P., Waeber,G., Wareham,N.J., Waterworth,D.M.,
            Weedon,M.N., Wichmann,H.E., Willemsen,G., Wilson,J.F., Wright,A.F.,
            Young,L., Zhai,G., Zhuang,W.V., Bierut,L.J., Boomsma,D.I.,
            Boyd,H.A., Crisponi,L., Demerath,E.W., van Duijn,C.M., Econs,M.J.,
            Harris,T.B., Hunter,D.J., Loos,R.J., Metspalu,A., Montgomery,G.W.,
            Ridker,P.M., Spector,T.D., Streeten,E.A., Stefansson,K.,
            Thorsteinsdottir,U., Uitterlinden,A.G., Widen,E., Murabito,J.M.,
            Ong,K.K. and Murray,A.
  CONSRTM   GIANT Consortium
  TITLE     Thirty new loci for age at menarche identified by a meta-analysis
            of genome-wide association studies
  JOURNAL   Nat Genet 42 (12), 1077-1085 (2010)
   PUBMED   21102462
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL159168.15.
            
            On May 17, 2019 this sequence version replaced NM_133464.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.227475.1, AB075842.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309235.6/ ENSP00000311679.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AL159168.15        96953-97036
            85-624              AL159168.15        99042-99581
            625-713             AL159168.15        102649-102737
            714-840             AL159168.15        105513-105639
            841-933             AL159168.15        106035-106127
            934-14694           AL159168.15        113431-127191
FEATURES             Location/Qualifiers
     source          1..14694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..14694
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /note="zinc finger protein 483"
                     /db_xref="GeneID:158399"
                     /db_xref="HGNC:HGNC:23384"
     exon            1..84
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     exon            85..624
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..2447
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /note="isoform a is encoded by transcript variant 1; zinc
                     finger protein HIT-10; zinc finger protein with KRAB and
                     SCAN domains 16"
                     /codon_start=1
                     /product="zinc finger protein 483 isoform a"
                     /protein_id="NP_597721.2"
                     /db_xref="CCDS:CCDS35106.1"
                     /db_xref="GeneID:158399"
                     /db_xref="HGNC:HGNC:23384"
                     /translation="MQAVVPLNKMTAISPEPQTLASTEQNEVPRVVTSGEQEAILRGN
                     AADAESFRQRFRWFCYSEVAGPRKALSQLWELCNQWLRPDIHTKEQILELLVFEQFLT
                     ILPGEIRIWVKSQHPESSEEVVTLIEDLTQMLEEKDPVSQDSTVSQEENSKEDKMVTV
                     CPNTESCESITLKDVAVNFSRGEWKKLEPFQKELYKEVLLENLRNLEFLDFPVSKLEL
                     ISQLKWVELPWLLEEVSKSSRLDESALDKIIERCLRDDDHGLMEESQQYCGSSEEDHG
                     NQGNSKGRVAQNKTLGSGSRGKKFDPDKSPFGHNFKETSDLIKHLRVYLRKKSRRYNE
                     SKKPFSFHSDLVLNRKEKTAGEKSRKSNDGGKVLSHSSALTEHQKRQKIHLGDRSQKC
                     SKCGIIFIRRSTLSRRKTPMCEKCRKDSCQEAALNKDEGNESGEKTHKCSKCGKAFGY
                     SASLTKHRRIHTGEKPYMCNECGKAFSDSSSLTPHHRTHSGEKPFKCDDCGKGFTLSA
                     HLIKHQRIHTGEKPYKCKDCGRPFSDSSSLIQHQRIHTGEKPYTCSNCGKSFSHSSSL
                     SKHQRIHTGEKPYKCGECGKAFRQNSCLTRHQRIHTGEKPYLCNDCGMTFSHFTSVIY
                     HQRLHSGEKPYKCNQCEKAFPTHSLLSRHQRIHTGVKPYKCKECGKSFSQSSSLNEHH
                     RIHTGEKPYECNYCGATFSRSSILVEHLKIHTGRREYECNECEKTFKSNSGLIRHRGF
                     HSAE"
     exon            625..713
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     exon            714..840
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     exon            841..933
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     exon            934..14694
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12984..12989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /note="hexamer: AATAAA"
     polyA_site      13007
                     /gene="ZNF483"
                     /gene_synonym="ZKSCAN16; ZSCAN48"
                     /note="major polyA site"
ORIGIN      
        1 aggcttgcgc gcgcactcgc tgcgggacaa gcttctggaa gctctttgcg gtggcgttgg
       61 tgctgtttgc ggatgctgat gcagtttctg caggactgta aactggattc ctggaacctt
      121 tgatattcct ggctgtgtat agtgcctgtt ggtggactgt actgatactc aactagagtg
      181 tgaagggact ggattcctgc ccctgagaca caatgcaagc tgtagtgccc ttgaacaaga
      241 tgacagccat ctcaccagaa cctcaaactc tggcctcgac tgaacaaaat gaggtcccaa
      301 gagtggttac ttctggggaa caagaagcta ttttaagagg aaatgctgct gatgcagagt
      361 ctttcagaca gaggtttagg tggttttgtt actcagaagt agctggaccc aggaaagctc
      421 tgagtcaact ctgggagctc tgcaatcagt ggctgagacc agacattcac acgaaagaac
      481 agattttaga gcttctggtg tttgagcagt tcctgaccat tttgcctggg gagatcagga
      541 tttgggtaaa gtcacaacat cctgagagta gtgaggaagt ggtgacccta atagaagatt
      601 tgacccagat gcttgaagaa aaagatccag tctctcaaga ttctactgtt tcccaagagg
      661 agaactcaaa agaggataaa atggtcactg tttgtcccaa tactgagtcc tgtgaatcta
      721 taacattgaa ggatgtagct gtgaactttt caagaggaga gtggaagaag ctggagcctt
      781 ttcaaaagga gctatataag gaagtgctac tggaaaacct caggaaccta gaatttctgg
      841 actttccagt ttcaaaatta gagttgattt cccagctaaa gtgggttgaa ttgccatggc
      901 tgctggaaga agtctcaaaa agctcccgac tagatgaatc agctttagat aaaataatag
      961 aaaggtgcct cagggatgat gatcatggct tgatggaaga atcccagcaa tattgtggca
     1021 gctcagagga ggatcacggt aatcagggaa attcaaaagg aagagtcgca caaaacaaaa
     1081 ctcttgggag tggcagtagg ggtaagaaat ttgacccaga taaaagcccc tttggacata
     1141 atttcaaaga aacttcagac ttaattaaac atctgagagt ctacttgagg aagaaatctc
     1201 ggaggtataa tgaaagcaag aaacccttca gttttcattc agaccttgtt ctgaaccgca
     1261 aggagaaaac cgccggagaa aagtcacgga aatctaatga tggtgggaaa gtcctgagtc
     1321 actcttcagc tcttactgaa catcagaaac gtcagaagat tcatttgggg gataggtccc
     1381 aaaaatgcag taagtgtggg ataatcttta ttagaagatc aactctttct aggagaaaaa
     1441 cccctatgtg tgagaaatgt cggaaagatt catgtcaaga agcagcctta aataaagatg
     1501 agggaaatga gagtggagaa aaaactcata aatgtagtaa gtgtggaaaa gcctttggct
     1561 atagcgcctc actcaccaaa catcggagaa ttcacactgg agaaaaaccc tatatgtgta
     1621 atgaatgtgg aaaagctttt agtgatagtt catcgctcac accacatcat agaactcata
     1681 gtggagagaa acccttcaaa tgtgatgact gtgggaaagg tttcacccta agtgctcacc
     1741 tcattaaaca tcagagaatt catactggag aaaaacctta taaatgtaaa gactgtggga
     1801 gaccctttag tgacagttca tctcttattc aacatcagcg aattcatact ggagaaaaac
     1861 cctatacatg tagcaattgt ggaaaatcct tcagtcatag ctcatccctt tccaaacatc
     1921 agagaattca tactggagag aaaccctata aatgtggcga atgtggaaaa gcctttaggc
     1981 agaattcatg ccttacccgg catcagagaa ttcacactgg agaaaaacca tatttgtgta
     2041 atgattgcgg aatgactttt agccatttta cgtctgtgat ttatcatcaa agacttcatt
     2101 caggagaaaa accctacaaa tgtaaccagt gtgagaaagc cttcccaacc cattcactgc
     2161 taagtcgtca tcagagaatt catactggtg taaaacctta taaatgtaaa gaatgtggga
     2221 agtccttcag tcagagttca tctcttaatg agcaccaccg aattcataca ggagagaaac
     2281 cctatgagtg taactattgt ggtgcaacct ttagtcgaag ctcaatcctt gtagaacacc
     2341 taaaaattca taccggaagg agagaatatg aatgtaacga atgtgagaag acatttaaaa
     2401 gtaattcagg cctcattaga catcggggat ttcactctgc agagtaatcc tggaactaca
     2461 ttaaagtggg gggaatttaa ttcaaattgt cagttactga aaccctggga tgtaaactta
     2521 cagtattgat cagtagctgc agctttcgta aattggcagt taggaaaaat atccttttgc
     2581 ccattcatcc ctcttctttt caaggatggc aacgactggt aaacagtaat tagttggtaa
     2641 agtcactgga aagggaagaa tgcaaaatga ttctgaggcc agacgaattg gaaaagctct
     2701 tttcttcagg ggatttctct ctgatttctt ctactaccat gtagtgtgat ggagagaact
     2761 tgactgcagt cacataactt ggattctgtc ccagtttgcc aaccaacttg ctgtatacac
     2821 cttggacaag tcatttgacc tttcagaatt ttattttcgt caccagcaga atgaagggat
     2881 gggattaatg atttttgcct tttttggttt tttagttttt tattggtatc ctgataatct
     2941 ctgaagctgt ggacataagt tatttttttt tatttgtcat tactttcaag tttctctagt
     3001 aaaaaataca ataccactat tcaggatgct ggacttcttt tctttttttt ttcttttttt
     3061 tttttcaatt tttctttttt gggatggagt ctcactatgt tgcccagact ggtcttgaac
     3121 tcctgggctc aagtgatcct tccatctcac tttcctgagt agctgacatt acgggtacac
     3181 tccatcaagc ctggttccta ggatgctgga cttctagctt agtgagaatg cagtatactt
     3241 tttgaaaact tcgtgcagga atccctcaaa tgctgtaact aggaatgggt cagtgaagtt
     3301 caaacgactt ttccttgagg gagtatttta atcggacaag ggaactcttt ttcttttggg
     3361 cattggccaa caggactgag aagccagaga gcttgcacct gagccatctc agccgtgaga
     3421 gtaacagtcc taggaaaata gatgggggct gggggtaagg aaatgtgctg aagacagagc
     3481 tattctggat ggattttggt ttgcaaaaat tctactttaa aacaattttg cctgtagcaa
     3541 gtacattttt ttgcaattgg agtgtaaaca ttctgtgtgg caacagttaa aagctgttat
     3601 aacaatttgc ttgggtgtgt gtgcatgtgt gtgtgtgtgt gtgtgtgtgt atacattgtt
     3661 gccactatct aaaattaggg catttcatac taaaaacaaa gcttgtctta aaaaaaatta
     3721 taagggctaa caacactggg cttttattta tgtaaagcac tcagctggtc ctgggtagca
     3781 gctgccacct tttgatgggg aatcaacttt ctgacttagc tagttctctc atgtatgtca
     3841 cctgactttc ccactgtatg aatgttctat tataacccct accatttgga gaatagatac
     3901 cctaaaatct aaagagactg cactgatagc aagtaaagtt cagggaatga atgtagaatt
     3961 gatacagaaa aaattttcag ttaagttttc ttttgtgaaa ttagacctca gaggaatgga
     4021 atatacgggt attggtggat tattccttat aaatttcatt ggtggagtct gaataataat
     4081 ttccaactga aaaaggaact taaggccctg aatgagtgag gttttggctt caggtcatag
     4141 ggttctggag gaaccccatg gactcaacag tggtctagaa ataagttcct aaagttgaaa
     4201 ttgtgggcac ctcctataaa aagagagcta aaccagaaaa ctcttcactt atggaagtaa
     4261 agcgatcctt aatgctaatc ttagactcag gaacatttac tgtgactaat gtatgtaggt
     4321 gtgaaatgct acctctggga gaaggttttt ggtgcctccc caaccccaag cctgcagttt
     4381 aaatattgcc gtgtgataaa ttggtccgca tagttattgc taagcagacc aacgaatcac
     4441 atcctagcca tgaaaggaat gtttattatg agaatcattc ataatggttt taagtttttt
     4501 tctgaaaaga cagaaaactt gttgtaagtt ttgttttctg aaaaatataa tttatagaaa
     4561 gttgaagaaa taacgtaaaa gtcttcagaa gaggcttgtt ccaagatgat tactcttaga
     4621 ctccctaaca ttcataacaa tgttttatcc cagtatccat tgggaatctg gagtataaac
     4681 ttttttttta aaggaattta ttgaggtaca aattacatat cattaaaacc atttcaagtg
     4741 tacaattcag tgagttttag taaatatgct gagttgtgca accattacca taatccattt
     4801 tttagaacat catcccagca agatccgtta ttccagttta cagttaatct cccgtccaac
     4861 ctctaatccc aggcacccac tactcagtcg actttgtgtc tctagagttg tctttttctg
     4921 tacattttat gttatatgtg atctttctgt gtttttttca ttaatgtgtt ttaagttcat
     4981 ccatgttgta acatactagt actttattcc tttttatcat aaataatatt acattatgtg
     5041 gatgcttcgt gcattcacta gttgaagaac atttgaggtt tttccagttt ttgcctgtta
     5101 ggaataatgc tgctttgaac attggtatgc aagtgttttg aacgttagtg tacaagtctt
     5161 tgtgtggaca tgttttcatt tttcttaggc agatgcctga ggggagttgc taggtcatac
     5221 ggtaaatttt catttaactt ttttaggaaa ctgccaaatt gttttccaaa gtgaccgcat
     5281 tattttacat tctgactagt aatgtgtggg gcttcccatt tctctacagt cttgccagtc
     5341 attgttgtct gttttttaaa aattatgccc atcctagcgt ttgaaatgat attcctttgt
     5401 ggttttaact ttgattttcc tgatggcgaa taatgtcaaa gcatctttta tgtgctcttc
     5461 agccattcat gtatcttagt gaaatgttta ttcagatttt ttgtccattt aaaattggag
     5521 tttgctgata ctgtgttgta gtccttttta ttctggatat aagtccttta tccaatatga
     5581 actttctaaa taccatgtac tagctacaga gagcagccca aactctgttg gataatattt
     5641 atcaaagtct tgatttcagt agttaagtct gtataattgc ctgcaggaca ttcagtctgg
     5701 cccatcaccc aaatatttaa attcactttt ggattaagtc agattatcaa aaggctttaa
     5761 acgtcttttg attcattata ggattgcttt tatgaagagc actgtgacac attttacttt
     5821 aaaatgaagt ccttgcttta aataatgttt cctcttaatg agcgtgtata aatttttttc
     5881 atgtcacagg acaaggcaag gttttggtca ataaagtcat tttatttatt ttagaattat
     5941 tttttaatgt agtaagatac atatagctta aaatgaacca tttaaacact ttttggttat
     6001 acagctcaat agcatttaga tagatgcaca ttttgtgcag tcatcaccac tatccatctc
     6061 cagaactttt tcatcatccc aaactgaaac tctgtactcc ttaaacagta actccccatt
     6121 ttctcctcct caggctcctg gtaaccactg ttctacttcc tgtctgtaca aatttgactg
     6181 ttctaattac ttggtatgaa tggaatcata caatatttgc cctgttgtgt ttggcttatt
     6241 ccacttagca ttatgttttc aaggttcggc cgtgttgtag cacatatcag aatttaattc
     6301 ctttttaagg ctgaataata ttccatttta cttgtatacc acattttgtt tatcctttta
     6361 tctgccagtg aacatttaag ttgtttgcac cattttggct atcaagaata acattgctat
     6421 aatcagtggt gctttctgtt cttttaagta tatgcctaga aatagaattg ctggatctta
     6481 tgatgattct atatttaact tcttgaggaa gtgcaactac actattttaa attcccacca
     6541 gctatgtaca agggtttcag tatccccgcc cttgctaaca cttattttct atttcttttt
     6601 tataatagac atcctaatgg gtttgaagtg gcatcttatt ctagttttgt tttgcatttc
     6661 cctagtgatt agtgatgtta actgtctttt tatgtgctta ttgaccattt gtatctcttc
     6721 tttggagaaa tgtttattga agtcctttgc ccatttttta attggttttg ttggcgttgt
     6781 tgtttagttg tagaagttct taatatatcc agaatatata aagaactttt cagataaatg
     6841 atttgcaaat actttcttcc attctgtgtg ggttgccttt tcattctatt cctaatgccc
     6901 tttgaaagaa ggttttaatt ttggtgaagt ttaatttttc tattttttct tttgtttcct
     6961 gtgcttttct ggtcataccc aagaaaccat ggccaaatcc aatgtcatga agcttttctc
     7021 ctattctagg agttttatag tttcaggtct tatgtttaag tcttttaacc attttgattt
     7081 ttatgtatgg taaagggtcc atcttcattc ttttgcatgc gaatatccag ttttcccagc
     7141 cccatctgtt gaagagacta tcctttccac atcatgtatt ctttgcactc ttgtcaaaga
     7201 tcatttgacc atatacatgc atgtttattt ctggctgtct gctctgtttc tttggtctat
     7261 atgtttgtct ttatgccagt accatgctat tttgattact ccagtaatgt tttgtaatca
     7321 ggattacact acgtttcctg tagtatgttt ttgaaatgag gaagtgtgag gcctccagct
     7381 ttgttctttc ccaaattgtt ttggctattt gggggtcctt aagatttcaa atgaatttta
     7441 ggatggtttg tttgtttttg tggaaaatgg catgaagatt gggcttgcat tgaatttgta
     7501 gatcgctttg ggtaatgtgg acatactaac aataacaaac attacagtct gtgaacccca
     7561 ggtgtctttc catgtatttg tgccgtcttt aattttttca gcaatgtgtt acagttgtca
     7621 ttgtacaagt cttttgcctc cttggtcaag tttattcttg agtattttat gtttttgatg
     7681 ctgttgtaaa tgggtctttg ttagtgaagc ataactgagt tttgagtgtt gattttgtat
     7741 cttgcaactt tgctgaattt gtttattagt cataatagtt tcttgtgaaa tttttgggat
     7801 ttttaaatat aagattatgg catctgcaaa tagataattt ttccttcttc ctaatttgga
     7861 tggctttaac ttgccaatgg ctctagctag gacttccagt actgtgttga atacaagtag
     7921 caaaagcagg catctgtgcc ttttcctgaa atgctttcta ttttatatca ttccgtatga
     7981 tgttagctgt ggtcttttca tatttgacct ttattatgtt aaggtaattt ccttttattg
     8041 ataaattctt gtttgaagga cagttttgct gtatatagaa ttctcagttg acagtttttt
     8101 tttttttctt tctgcattaa gagtataaca acgccacagc cttctggctt ccaaggtttt
     8161 tgatgagcaa tcaacagtct cactgaggat ttcttttatg tgatgatttg cttctctctt
     8221 gatgcttttg agattctcct tttgtctttg gatttcagca gcttgattat aacttgtctt
     8281 ggtgtctctg tggggtgagg gtaggagtca attgcagtgc ttgttgccat agttcagaac
     8341 ctgcaccaca aagacccttc cagttctgta gagtggttta ttgctttatt atcagtgcaa
     8401 tagagagtca ctgagtcact ggaggttctc tgtgtgtgtg agtgtataaa taaagattta
     8461 attttgtttt gctcttttgt tttcccctcg gaatagttta tcagatgagg aatttcttga
     8521 tcactgggga gaaatatctt acaattctga aaacacactg tcaaaatgct tttcataaaa
     8581 tgtagcacat tttagggttt ctcccttgtg tggaaatgtt agtgtctata aaggtctgaa
     8641 ctaagaaagc ttctctcaag ccacaacaca tgtgaggttc ctctgctgaa tgaatctttt
     8701 ggtgctcagt aagttgtgat ttccaagcaa agtgtttttc accctgagaa attggtgagg
     8761 tatctttctc tcagagtctt ttttatgaag tctgatgttg agaggttctt ccaggttgga
     8821 gttctcaggt ctgtctccct tgtagattat cagagtgggt cgataatcta caagctttgc
     8881 taaacctacc tgtagctctt ctggggcagc ggtcgtggtg gtggtggcag cggcagcagg
     8941 gttccccatt gattttctaa atgtttgtag tccttttgta aagtggaccc ttgccttcta
     9001 aggtaatggt gaatgataca tattcccttc atttttctgc tttgaagctt caatcttctt
     9061 cattttctct tttgatctgt caacacaatc agaacattta gctctttgag catctttaag
     9121 gcagttgctt taaagtctgt ctagtgagtc aatgtttggt cttcctcatg tccatttttt
     9181 gttggtttat tttgtgcctt tgaatggtca atacttgttt ctttgtatgc atcgtgattg
     9241 tttttgttga cagctagaca tttgaatttt ataatgtggc aactctggaa ataagattat
     9301 tcctttttcc ccagggttta ttttttgttg ttgttttttg tgttgtgtgt tttttgtttt
     9361 cgtttttgtt ttactgtcat aggctgtctc tgtgctaggg atcagcctgt gttgaatgcc
     9421 taaagttgtc tcaattcttt acagagcctg cgtttttccc tgggcgggag caatggcttt
     9481 ctgaattcac ctagatacac agttttttga atgtccagaa aaacaggttt catccctttt
     9541 ttctcctgga agccacttta gccagttggg ggttgggaga atggtagctt gcttctttgt
     9601 ctgctctttc tctgtgatca gaagtagata tctgcaatca gaaccctgat atttggagga
     9661 agtggctatt attgtccacc ctggctgcag caagctgacc cagaaatgtg gggttgtgtc
     9721 tccacagctg cctgccatgg agtgggtggg gatgggtagc tgctacttca ctgaaggctg
     9781 aaatccacca atgttaactg caatttacca ctcagaattt cccctagaag ctacaagtgt
     9841 tcagatggac tcatgtgctc ccaaaataat cactttagga actttctgcc gatgtaatta
     9901 ttatctaggt ggagaggtgg attcctgggc cactctatcc atgtctttga tttttcctgc
     9961 tttcttgaag atttcttcaa ctttatcttc cagctctact attaaatgtt gtgaatgttt
    10021 ttatctctgc tgtcatattt ttatttccaa gtgcattatc tgattctttc ttcctttttt
    10081 ctaattggtt ttgtttcata ggtgaaatat tttttctctg agcatgttaa ttatagtgtc
    10141 tttctgtgtt attctgctcc ctgcattatc cctgtttcct ttgagttgtt ttcacctgtt
    10201 ttctgtctct cacactggag gctttcctga agcctctgat gatctttgac tatttatatt
    10261 taagagcagg gctctaaaaa gctgattgga aggtgtttta ggtacttcag caccatccaa
    10321 cagtaatata atgtgagcca catacataat ttcaaatttt ctagtagcca cttttagaaa
    10381 ataaaacagg taaaattaaa aatgtatttt acttcaccca atatatccat aatattattt
    10441 catcatgtaa tcaatgtaaa aaagtattga gacattttgt tttttgcact atttttgaaa
    10501 tctggtatgt aatgtgttaa tctacacaca aaattttcat ttgtaataca taactcacat
    10561 ttagatttat aaaacgtaga gttgataagt agattcacat agttcttcca aacatacttt
    10621 gttgttgttc taaatatact taattttcca ataactgaat caagtatcca gtttttgttt
    10681 tttttttttt tttttttttt ttgagatgga gtctcactct gttgcccagg ctggagtgca
    10741 gtggcgcaat cttggtccac tgcaacctcc gcctcctggg ttccagcaat tctcctgctt
    10801 cagcctcccc agtagctgag attactggtg cacactgcca cgcctggcta attattttag
    10861 tagaggcggg gtttcactgt gttgcccagg ctgttctcca actcctaagc ccaggcaatc
    10921 tgcctgtctc ggcctcccaa agtgccggga ttacaggtgt gaaccgccac acacaacccc
    10981 aatttttgtt taaaatttgc atccacatta acaaaacttt tattagaaaa attcatttaa
    11041 tatctaggca aaattatatc actttcaaaa ctttttaagt aaattcagta acatatcaat
    11101 tcagtttatt agcatcaaat ttgatgaagc agtgcataaa tggaaacaaa acagtttatc
    11161 aatacaatat atcattcttc agattttgct tattttttgc agccatttat tacatttaaa
    11221 attttgtgca tattgtctca tttgaaaaat gtgagttatt ctgttttatt tgtattatga
    11281 aatgtttcta ttgtaaataa attcttttac ctgtctagcc aggtcacaag tttttcccat
    11341 tttaggagct tcaaatttag cttgttcata tgcagcgtga tattagggag aaaatgtgaa
    11401 tcacagtgct actttttgtc tttgattgaa tatttggtaa gcatttcttt tgtttcaagg
    11461 aaatcttgaa ttggattttc tagtacagga aatccttata aaattctttt gtaagtcatc
    11521 caggtaacat tggtaaagaa acaagatcat tagatacatt gtcttttttt ttcagaagtt
    11581 tcataaactg tcaacattct atagcttttg tgcatatgta ctgaagaatt ataacacatg
    11641 tatccgtgac tcgtttcttg gagtctgctt cagaaaattg aacacaaata ttttcagtat
    11701 gtatcatgca atagaataga gcaatgaggg aaaagttatc ctcttgcttt aaaattccaa
    11761 catggatggt cttttgactt aacttagctg gagttccatc cttgtgatag aaactaactt
    11821 ttctgtctct aactgaaatt ctttgacaga tggaagattg tcaaaaatat ctgccatgag
    11881 tttgagcctt taggcaatga attcacattt cattgccttt acatgaatcg acattgtaaa
    11941 tttggaggtt ctttgagaca gaatataccc agagttttct ttgggcagtg tcttgtatca
    12001 aacagttcat ctaaggctaa agaaaaatac ttgaaatttt tcaagatttg aattaattgg
    12061 tctttattat taaaatataa atattctatt agcaaaaata tattctgttc atgtatatcc
    12121 aagagcaaaa ttgtttaatg gtttcattga cgttttcagt tttcatgaat gtcttttaag
    12181 gtcttttcct cataattttc taaatacgat aaagtgataa tttcttcatc tctccatcta
    12241 aggttctttg tagatgcatg tgtaagaagc tattttatag cttgccaggt ttacaaactc
    12301 agaccctttt aaaagttgtt taaattgttt tgttagaaat ttcactcgca gttcatatga
    12361 gtaattttgt gtattctttt ttgacttaca ctcactaaat ggttgctaaa aattacatgt
    12421 cttaaatatt gtcttaagta ttatctacta tgtatcttta acacttttga atagaacaaa
    12481 cagcttttcc attttgctct gctgcagtaa attgcaattg ccattcatca ttaaatgtgc
    12541 actatactgt ctctagtctt cttgactatg ccagttgtag taccagcttc tgtatctgca
    12601 ctgaattctg cctcagtaat atgcctttgt ttaaaattta aatatttttt cattttttta
    12661 acctagaaaa taattataat gaaaatatta agtatctcat tttaggattc tgatttacat
    12721 aggtatcact gtaacttgtg ctgtttgcat aggtatactc tatcttgtgc tatctgcata
    12781 aaatatccaa gtaaacacat tgtgatttta catccgtgca tagaaaaaaa aatcatctga
    12841 actcaaatca atctgttgat actgactaga ttggtgacgt gtttatgtgt aacactagtg
    12901 ataatgcacg ttcctgtaca agcattataa tacaacagtg tcctatgcaa tgcagtggtt
    12961 aaagtgaatt gtagttctat caaaataaag atacgtttag tggaaaagta tttgactctg
    13021 cttctgtttt taaaattgtg aaatgtggca ctgtgtggat ttccatttct cactagcctc
    13081 aagtgactac catattaagt tgctctacgc aatcctagcc acagagaacc caacaaattg
    13141 gagtagctta actgaatgaa agtttattcc ccaggggtct ttccagcatt ttgttgcttt
    13201 cccatatttt gtagtcatgc tgtgtggagc acataacttc caacgtccca gaggcaggga
    13261 aaggaagaac tggagcattg tgcagtgttt ttaagcacta gcctagaaac agctgagaac
    13321 cacaggtttc aaactcggtg ccaaggtttc ccattccact ctagagatct cacacaggct
    13381 tcccaggata ttttaaaatc tggagattat cacaactaca actattgaca tcacaaacta
    13441 ctactattat gttattggaa ctaactactt agcaaatgga attgatagtt aatgggtttt
    13501 ttgtttgttt gcctgggagc attgtggaaa aatggccatg gtactacaga tcctgtaact
    13561 aagaaagtca acctctgtct tagaagtcac ttctactctt ccgttgccca gagatcaatc
    13621 atataaccct aacctaactt aaagggaggc ttgaaataca gctttcccct cattgtggtg
    13681 agcacataga ttatttctac cacagtctgt tctttcggtc accaaactct ttcttcccac
    13741 acttaatgca tacagtagcc cccttatcca tgggggatat gctccaagac ctcgagtgga
    13801 tgcctgcaac ctcagatagt accaaaccct gtatgttcta tgttttgtca gtctgataac
    13861 ccaagaaggc tactaagtga ctaacagaca ggtagtgtag atgacatgga tatgctggac
    13921 aaagggataa tttgtgtcct aggaggcacg gagcaggatg gcaagaggtt tcatcaggct
    13981 actcagaaca tactggaatt ttttatttct ggaattttct atttaaaatt ttggggccaa
    14041 gattgagggt aactgaaacc acggaaagtg aaactttgaa taaggggaga ccactgtatt
    14101 ttacccaagg gagacaatcc aaagtctaat ctgctcaggg tctacaactg aagtccaggg
    14161 tctttgagtt agatgctttg agtgtgacct actttttgcc tttgggaccc taaatgtcag
    14221 tgcctgttaa tttttctttg agaagtgtaa tttctccaga ggtctgctct ttaatttccc
    14281 cagagaagga tgttctagtc agcatggggg atataagcct ggctaccatt actggcgagc
    14341 aggcagaggc acgccacatg gtgggatagg agttggagtt catccccttt tattcagact
    14401 tccacttagt atcctgtttt tagtcttcta tcttatttcc atcctcctcc aggcccaggg
    14461 tacccaagtt aatagcctat caagttctat ttggcaaaag ataatgcctc tcatttcctg
    14521 tgggaattgt ggtgaattga taatcacctg gcaaaataag gtaggagtgg cattttgagc
    14581 tcaaactgtt ctgtgcacat tttcaaactc tttagcctct gattttctcc ctacttccag
    14641 aaaacctgat gcctccacct cctaaatctt tccatatttc attagtaccc catc
//
