LOCUS       NM_144684               4746 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 480 (ZNF480), transcript variant
            1, mRNA.
ACCESSION   NM_144684
VERSION     NM_144684.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4746)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4746)
  AUTHORS   Jouan,L., Girard,S.L., Dobrzeniecka,S., Ambalavanan,A., Krebs,M.O.,
            Joober,R., Gauthier,J., Dion,P.A. and Rouleau,G.A.
  TITLE     Investigation of rare variants in LRP1, KPNA1, ALS2CL and ZNF480
            genes in schizophrenia patients reflects genetic heterogeneity of
            the disease
  JOURNAL   Behav Brain Funct 9, 9 (2013)
   PUBMED   23425335
  REMARK    GeneRIF: This supports the notion that de novo mutations in ZNF480
            are extremely rare in schizophrenia
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4746)
  AUTHORS   Yi,Z., Li,Y., Ma,W., Li,D., Zhu,C., Luo,J., Wang,Y., Huang,X.,
            Yuan,W., Liu,M. and Wu,X.
  TITLE     A novel KRAB zinc-finger protein, ZNF480, expresses in human heart
            and activates transcriptional activities of AP-1 and SRE
  JOURNAL   Biochem Biophys Res Commun 320 (2), 409-415 (2004)
   PUBMED   15219843
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA501214.1, AK303271.1, AY512662.1, AK096442.1, AL832560.1 and
            AC010320.10.
            
            On Nov 23, 2018 this sequence version replaced NM_144684.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018783.1, SRR1803612.48997.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595962.6/ ENSP00000471754.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                DA501214.1         1-10
            11-85               AK303271.1         2-76
            86-805              AY512662.1         55-774
            806-806             AK096442.1         542-542
            807-4210            AL832560.1         657-4060
            4211-4211           AC010320.10        168814-168814
            4212-4746           AL832560.1         4062-4596
FEATURES             Location/Qualifiers
     source          1..4746
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4746
                     /gene="ZNF480"
                     /note="zinc finger protein 480"
                     /db_xref="GeneID:147657"
                     /db_xref="HGNC:HGNC:23305"
                     /db_xref="MIM:613910"
     exon            1..55
                     /gene="ZNF480"
                     /inference="alignment:Splign:2.1.0"
     exon            56..146
                     /gene="ZNF480"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1682
                     /gene="ZNF480"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 480 isoform 1"
                     /protein_id="NP_653285.2"
                     /db_xref="CCDS:CCDS12850.2"
                     /db_xref="GeneID:147657"
                     /db_xref="HGNC:HGNC:23305"
                     /db_xref="MIM:613910"
                     /translation="MLCDEKAQKRRKRKAKESGMALPQGHLTFRDVAIEFSQAEWKCL
                     DPAQRALYKDVMLENYRNLVSLGISLPDLNINSMLEQRREPWSGESEVKIAKNSDGRE
                     CIKGVNTGSSYALGSNAEDKPIKKQLGVSFHLHLSELELFPDERVINGCNQVENFINH
                     SSSVSCLQEMSSSVKTPIFNRNDFDDSSFLPQEQKVHLREKPYECNEHSKVFRVSSSL
                     TKHQVIHTVEKPYKCNSCGKVFSRNSHLAEHCRIHTGEKPYKCNVCGKVFSYNSNFAR
                     HQRIHTREKPYECNECGKVFSNNSYLARHQRIHAEEKPYKCNECGKGFSHKSSLANHW
                     RIYTGEKPYKCDECGKAFYRIALLVRHQKIHTGEKPYKCNECGKVFIQNSHLAQHWRI
                     HTGEKPYKCNECGKVFNQLSNLARHRRIHTGEKPYKCNECGKAFSEYSGLSAHLVIHT
                     GEKPYKCSECGKAFRHKLSLTNHQRIHTGERPYKCNECGKVFNRIAHLARHRKIHTGE
                     KPYKCNECGKAFSRISYLAQHWTIHMG"
     exon            147..273
                     /gene="ZNF480"
                     /inference="alignment:Splign:2.1.0"
     exon            274..402
                     /gene="ZNF480"
                     /inference="alignment:Splign:2.1.0"
     exon            403..4746
                     /gene="ZNF480"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF480"
                     /note="hexamer: AATAAA"
     polyA_site      4746
                     /gene="ZNF480"
                     /note="major polyA site"
ORIGIN      
        1 agtttcccac aaacccggaa gcggatcgcg tggagtgaag gtcacgccgc ggcgcgattg
       61 acttctaaag agtcatgctg tgtgatgaaa aagcccagaa gagaaggaag aggaaagcaa
      121 aggagtcagg gatggctctt cctcagggac acttaacatt cagggacgtg gccatagaat
      181 tctctcaggc ggagtggaaa tgcctggacc ctgcacagag ggctttatac aaggatgtga
      241 tgttggagaa ctacaggaac ctggtctccc tgggaatctc tcttcctgac ctgaatatta
      301 actccatgtt ggagcaaagg agggagccct ggtctggtga gagtgaagtg aaaatagcaa
      361 aaaattcaga tgggagggag tgcatcaaag gtgtgaacac agggagcagc tatgcattgg
      421 gaagcaatgc agaagacaaa ccaattaaaa aacaacttgg agtatccttt cacttacatc
      481 tgtctgaact ggagctattt ccagatgaaa gggtaataaa tggatgtaat caagttgaaa
      541 actttatcaa ccacagttcc tctgtttcct gtcttcaaga aatgtcttcc agtgtcaaaa
      601 cccccatttt taataggaat gattttgatg attcttcatt tctcccacaa gaacagaaag
      661 tacaccttag agaaaaacct tatgaatgta atgagcatag caaagtcttt agagtatctt
      721 ccagccttac taaacatcaa gtaatccata ctgtagagaa accttacaaa tgtaattcat
      781 gcggcaaggt ctttagtcgc aattcacacc ttgcagaaca ttgtagaatt catactggag
      841 agaaacctta caaatgtaat gtctgtggca aggtttttag ttacaattca aactttgcac
      901 gacatcaaag aattcatacc agagagaagc cgtatgaatg taatgaatgt ggtaaagtct
      961 tcagtaataa ttcttacctt gcacgacatc aaagaattca tgctgaagag aaaccttaca
     1021 aatgtaatga atgtggtaaa ggcttcagtc ataagtcatc tctagcaaat cattggagaa
     1081 tttatactgg agagaagcct tacaaatgtg atgaatgtgg caaggccttc tataggattg
     1141 cgctccttgt acgacatcag aaaattcata ctggagagaa accttacaaa tgtaatgaat
     1201 gtggaaaggt ctttattcaa aattcgcacc tagcacaaca ttggagaatt catacaggag
     1261 agaaacctta caaatgtaat gaatgtggaa aagtatttaa tcaactttca aatcttgcac
     1321 gacatcgaag aattcatact ggagagaagc cttacaaatg taatgaatgt ggtaaagcat
     1381 ttagtgagta ttcaggcctt tcagcccatc ttgtaatcca cactggagag aagccttaca
     1441 aatgtagtga atgtggcaag gcattcagac acaagttatc actaaccaat catcagagaa
     1501 tccatactgg agaaagacct tacaaatgta atgaatgtgg caaggtcttc aatcgaattg
     1561 cacaccttgc acgacatcgg aaaattcata ctggagagaa accttacaaa tgtaatgagt
     1621 gtggcaaggc ctttagtcgc atttcatacc tagcacaaca ttggacaatt catatgggat
     1681 agaaactaca aatgcaacaa atgcgtcaaa gaatttagtg tgcactcaag ccttactacc
     1741 catcttttat tccatactgc aaagaaattt tgcaaatgta aagaatatga caaggtcttc
     1801 aaacacaagt ttttctaata actcattaga gaatttatac tggagagact tcacaattat
     1861 aataaatgtg tggaaaagtc ttcaaaaaaa tttcacacct tgcaaaagga gatctaaaaa
     1921 acacaatcag aaatgacaaa ggggacatta ccaccaaccc cacagaaata cgaaaaaccc
     1981 tcaaagatta ctataaacac ctgtatgcac acaaactaga aaacctagaa aaaattaata
     2041 aattccttga aagatataac cccccaagat tgaaccaaga agaaattgca tccctgaaca
     2101 gaccaataat gagttccaaa atttaatcac taattaaaaa tctatcaaac aaaactctgg
     2161 accagacaga tttatagttg aagcctacga gatgtataaa gaaaagctgt taccaatctt
     2221 actgaaactg ttcaaaaaca tggatgcaga gggactcctc cctatctgat tctatgaggc
     2281 cagcatcatt ctaataccaa aacctgacag gcacaatgaa aaaagaaaac ttcaggctgg
     2341 tactcctgac gaatataggt gccaaaatcc tcagcaaaat actagtaaac caaatccatc
     2401 tgcacatcaa aaagctaatc caacattatc aagcaggctt tagtgttggg ctgcaaggtt
     2461 ggttcagtat acacaaatca ataaatgtga tttatcacat acacagaact aaaaacaaaa
     2521 accacatgac catgatcatc tctttagatg cagaaaggtt tttaataaaa ttcaacatcc
     2581 cttcatttta aaaaccctca acaaattaca cattgaggga acatacttca ataagaacca
     2641 tctatgctgg actcacagcc aaattaatac tgaacaagca aaagctggaa gcattcccct
     2701 tgagaactgg aaaatgacag ggatgaccac tctcaccact ccgattcaac atagtactgg
     2761 aagtcctaag cttagtgatc aggcaagata aagatatgaa aggcatatat aaataggaag
     2821 aggggaagtc agtttctctt gcagaagata taattctgta tttagaaaac ctgttgtctc
     2881 tgcccaaagg ctcctagatc tgataaacaa cttcaaaaaa gtttcaggat acaaaatctg
     2941 tgtacaaaaa ttagttgcat ttctatacac cagtaatgtc caagctatga accaaatcaa
     3001 gaatggaatc ccattcacag tagccacaaa aagtataaaa tacctaggaa tacagccaac
     3061 caggtaagtg aaagatttct acaatgagaa ttacaaagca gtgcacaaag aaatcagaaa
     3121 caataaaaat tgaaaaatat ctcatgctca tggataggaa gaatcagtat tgttaaaata
     3181 ctgcccaaag caatttacag agccaatgct atttctatca aactaccaat ggcatttttc
     3241 acagaatcag aagaaaacat tctgaaattt atttggaacc agaaaagccc aacctaaata
     3301 gcaaaagcaa tcctaagcaa aaagagcaat gtttgaggta tcacactacc caactttaaa
     3361 ccatactaca aggctacagc aactaaaaca gcatggtact ggtataaaaa aagacacata
     3421 gatcaatgga ataggtaaga gaacccagaa ataaaggcat atacctacaa ccatgtgatc
     3481 ctcaacaaaa ctgacaagca atgaagtaag aacttcattc aataagtggt gctggcataa
     3541 ctggctagcc atatgcagga tattgaaact ggacccctat ccttcacgat atacaaaaat
     3601 caactcaaga tggattaaag acttaaatat aaaacctaaa agtattaaat tcctagaaga
     3661 aaacccagga aatgccattc tggacataag tgctggaaaa gacttaatga tgaacacccc
     3721 aaagcaattg caacaaaaac aaaaattgac aagtgggacc taattaaact aaataacttc
     3781 tgcacagcaa aagaagctat ttgcagacta cagaatggga gaaaatgttt acaaactgca
     3841 tctgacaaag atctaatcca gaatctataa agaactcaaa caaatcaaca atgagaaaaa
     3901 caaccccatt aaaaactggg caaaggccat gaatagacct ttctcaaaag aatacataca
     3961 tgtggcaata agcatatgaa aaaaatggtt aatatcgcta atcattaagg aaatgcaatc
     4021 aaagccacaa tgagatacca tctcagacct gtctgaatgg gtattatcag aatgggtatt
     4081 attaaaaaat caaaacatag atgctagtga ggctgcagag aaaagcaaat acttatacac
     4141 tgctggtggg aatgtaaatt aattcagcca ttgtggaaag cactgcagcg atttctcaaa
     4201 gacataaaag aacatagcat tcaacccagc atcccattac tgggtgtata cctaaaggaa
     4261 tataatcatt ccaccataaa gacaaacact tgtatgttca ttgcagcact attctcaata
     4321 gcaaagatgt ggaatcaacg taaatgccca tcagcagtag accagataaa gaaaatttgg
     4381 tacatataca ccatggaata ctatgcagcc ataaaaaaga acaagactgt gtcctttaca
     4441 gcaacataga tggagctgag gctcttatcc taagtgaatt aatgcaggaa cagaaaatga
     4501 aatatcccat gttctcactt ataagtggga gctaaacatt gattacacat ggactcaaag
     4561 aagggaacag tagacacggg cttatgggtg gaggttggga agaggatgaa gattgaataa
     4621 ctgcctgttg ggtactatgc tgattacctg gggacaaaat taactgtaca ccaaactcct
     4681 gcaacatgca gttgacccat gtacacatac tccttgaacc taaaataaaa catgaaaaaa
     4741 agcaaa
//
