LOCUS       NM_001214909            3032 bp    mRNA    linear   PRI 03-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 48 (ZNF48), transcript variant 3,
            mRNA.
ACCESSION   NM_001214909
VERSION     NM_001214909.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3032)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3032)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3032)
  AUTHORS   Lichter,P., Bray,P., Ried,T., Dawid,I.B. and Ward,D.C.
  TITLE     Clustering of C2-H2 zinc finger motif sequences within telomeric
            and fragile site regions of human chromosomes
  JOURNAL   Genomics 13 (4), 999-1007 (1992)
   PUBMED   1505991
REFERENCE   4  (bases 1 to 3032)
  AUTHORS   Bray,P., Lichter,P., Thiesen,H.J., Ward,D.C. and Dawid,I.B.
  TITLE     Characterization and mapping of human genes encoding zinc finger
            proteins
  JOURNAL   Proc Natl Acad Sci U S A 88 (21), 9563-9567 (1991)
   PUBMED   1946370
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU854776.1, CF594347.1, AC116348.3 and CA434624.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 17, 2019 this sequence version replaced NM_001214909.1.
            
            Transcript Variant: This variant (3) has an alternate 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 all encode the same
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2952788.1,
                                           SRR14038197.93401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000613509.2/ ENSP00000480262.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BU854776.1         278-428
            152-367             CF594347.1         157-372
            368-2756            AC116348.3         121630-124018       c
            2757-3032           CA434624.1         18-293              c
FEATURES             Location/Qualifiers
     source          1..3032
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..3032
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="zinc finger protein 48"
                     /db_xref="GeneID:197407"
                     /db_xref="HGNC:HGNC:13114"
     exon            1..159
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /inference="alignment:Splign:2.1.0"
     exon            160..253
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..2031
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="isoform 1 is encoded by transcript variant 3; zinc
                     finger protein 553"
                     /codon_start=1
                     /product="zinc finger protein 48 isoform 1"
                     /protein_id="NP_001201838.1"
                     /db_xref="CCDS:CCDS10679.1"
                     /db_xref="GeneID:197407"
                     /db_xref="HGNC:HGNC:13114"
                     /translation="MERAVEPWGPDLHRPEEREPQRGARTGLGSENVISQPNEFEHTP
                     QEDDLGFKEEDLAPDHEVGNASLKPEGIQNWDDLWVQREGLGKPQPRDRGPRLLGEPR
                     WGQASSDRAAVCGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQR
                     THSGEKPYRARPPAQGPPKIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEK
                     PYKCGICGKGFGDSSARIKHQRTHRGEQPPRPVVPRRQPSRAATAATQGPKAQDKPYI
                     CTDCGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCP
                     ECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLSSTLLRHRLTHMEPQDFSFPGY
                     PLPALIPSPPPPPLGTSPPLTPRSPSHSGEPFGLPGLEPEPGGPQAGEPPPPLAGDKP
                     HKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHRGERARP
                     PPPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHT
                     GEKPYKCAECGKGFGDSSARIKHQRGHLVLTPFGIGDGRARPLKQEAATGLE"
     exon            254..3032
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2300..2305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="hexamer: AATAAA"
     polyA_site      2328
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="major polyA site"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="hexamer: AATAAA"
     polyA_site      2897
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
     regulatory      3010..3015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="hexamer: AATAAA"
     polyA_site      3032
                     /gene="ZNF48"
                     /gene_synonym="ZNF553"
                     /note="major polyA site"
ORIGIN      
        1 ccccgccccc ggtggccgcc cccgggacgc ctgggtccga gcccgctccc ggcttggcgc
       61 ggagcctgca tcccggagcc gctggcggct cgggcgcctg caccccgctg aggagctccg
      121 gagggcgccg gggtggcgga gccggaggcg gccggcaagg gcggcgtgcc ggcgatggag
      181 cgcgcggtag agccttgggg cccagatctc caccgcccgg aggagaggga gccacagaga
      241 ggcgcccgca caggtctagg gagtgagaac gtgatttctc agccgaatga gtttgaacat
      301 accccacagg aagatgactt ggggttcaag gaagaagatt tggctccaga tcatgaagta
      361 ggaaatgcct ctctcaaacc tgaaggcatc cagaactggg atgacttatg ggtccagaga
      421 gagggtctag gaaagcctca gcctcgggac agaggccccc ggctcctggg tgaaccacgc
      481 tggggccagg ctagtagtga tcgggccgct gtgtgtggtg agtgtggcaa aagcttcagg
      541 cagatgtcag atctggtgaa acaccagcgg acccacacag gggagaaacc ctacaagtgt
      601 ggggtctgtg gcaagggctt tggggatagc tctgcccgga tcaaacacca gcggactcat
      661 agtggggaga agccctatag agcccggcca ccagcccagg gtcccccaaa gattcctcgg
      721 tcccggatcc ctgctggtga gcgccccact atctgtggtg aatgtggcaa gagcttccgg
      781 cagagttctg acctggtgaa acaccagcgg acacacactg gtgagaagcc ctacaagtgt
      841 ggcatatgtg gcaagggctt tggcgacagt tccgcccgca tcaagcacca gcggacacac
      901 cggggggagc agcccccccg accagtggtg ccccgacggc agccatctcg ggcagccacg
      961 gcagctaccc agggaccgaa ggcccaggac aagccatata tctgcactga ttgcggcaag
     1021 aggtttgtgc tcagctgcag cctcctgagt caccagcgta gtcacttggg gcccaagccc
     1081 tttggctgtg atgtgtgtgg aaaggagttt gcccggggat ccgacctggt gaagcacctg
     1141 cgggtgcaca cgggtgagaa gccctacctc tgcccagagt gcggcaaagg tttcgcggac
     1201 agctccgccc gagtcaaaca cctccgcacc cacagtggcg agaggcccca tgcctgcccg
     1261 gaatgcgacc gtaccttcag cctcagctcc acccttcttc gccaccgcct cactcacatg
     1321 gagccccagg acttcagctt cccaggctat cccctacccg ctctgatccc cagcccaccc
     1381 ccacctcctc tgggcaccag ccccccgctg acacctcgaa gtccctcaca ctcgggtgag
     1441 ccttttggcc tgcctggctt ggagccagag cctgggggcc cacaggctgg ggagccaccc
     1501 ccaccactgg cgggcgacaa gccccacaag tgccctgagt gtggcaaggg cttccgccga
     1561 agctctgacc tggtgaaaca ccatcgtgtg cacacagggg agaaacccta cctctgtcct
     1621 gaatgcggca agggttttgc tgacagctca gcccgagtca agcacctccg cacccaccgt
     1681 ggtgaacggg cccggccacc accaccatcc actctgctgc ggccacataa cccacctggc
     1741 ccagtaccca tggcccctcg accccgagtt cgggcccagc cttctggacc cagccagccc
     1801 cacgtgtgtg gcttctgtgg gaaggagttc ccccggagct cagatctggt caaacacagg
     1861 cgtacacaca cgggggagaa gccatacaag tgtgcagagt gtggcaaggg ttttggtgac
     1921 agttctgccc gcatcaagca ccagcgtggg cacctggtcc tgacgccctt tgggataggg
     1981 gatggtaggg caaggcccct caagcaggag gcagcaacag gactggaatg acgcggtcca
     2041 gggagggcgg aggcccagga gaccaaaggg aggggctctg ccgcttagca gagaagaaag
     2101 ggcctgggag gtggtgggag ggagaaggaa gggaagaaag gggaggaaga atagatagaa
     2161 atagggattg gagacagtaa ccttgaagct caggaaactg tcctggctgg gctgagtcag
     2221 gaccttgcca ggacgggctg tacccctggc ttctagaaga ctgcctagca cacagtaggc
     2281 attcaatact tgttgaataa ataaactggc tttcacctaa ggactcaacc ctaaattcct
     2341 gctgcctcat ctgttaagaa ctgacacttt ccccttgctg ggcaggtagt acacacctgt
     2401 aatcccagca gtttgggagg ctgaggtggg agaatcactt gagcccaaaa gtttgaggct
     2461 gcagtgagct gattgcacca ctgatgcctc ccaaccttgc tctgggagac caatgcctga
     2521 accagggttt gtttaccttc tgagctgcag agatggggct tctggaattt aaggtaacag
     2581 gatgaggcag gggtatcttg atcatccgga tggggcaaat actgctgtgt ggcatggtgg
     2641 tacccacccc tatggagggg cactcttgga cagagcccag acctttgtgc cctggaggga
     2701 gccaacccac cctgacacgg agacactggc agaatagacc agagacagaa ggtgctctca
     2761 tggtatccag cctggatgcc aagcccaagt cctggtggat agcagaggcc agctgtttgg
     2821 gaaaagggca ggatgctctg aggcctggca gccacatttc catgtgtctt tttaccaata
     2881 aacggcttct cttctgaggc ttggacagtg tgtgtgtaca cacaggcatg aaaaaggtgg
     2941 agaggggtct ctgcgcgcaa aactcagact gtaaattttg tgtgcttccc ttgctctctg
     3001 agcccattaa ataaagaggt tgtcttggcg ta
//
