LOCUS       NM_001370129            3851 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens zinc finger protein 479 (ZNF479), transcript variant
            2, mRNA.
ACCESSION   NM_001370129 XM_017012777
VERSION     NM_001370129.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3851)
  AUTHORS   Jin,X.S., Ji,T.T., Shi,Z.C., Zhang,Q.Q., Ye,F.P., Yu,W.L. and
            Li,R.Z.
  TITLE     Knockdown of ZNF479 inhibits proliferation and glycolysis of
            gastric cancer cells through regulating beta-catenin/c-Myc
            signaling pathway
  JOURNAL   Kaohsiung J Med Sci 37 (9), 759-767 (2021)
   PUBMED   34042257
  REMARK    GeneRIF: Knockdown of ZNF479 inhibits proliferation and glycolysis
            of gastric cancer cells through regulating beta-catenin/c-Myc
            signaling pathway.
REFERENCE   2  (bases 1 to 3851)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3851)
  AUTHORS   Wu,Y.J., Ko,B.S., Liang,S.M., Lu,Y.J., Jan,Y.J., Jiang,S.S.,
            Shyue,S.K., Chen,L. and Liou,J.Y.
  TITLE     ZNF479 downregulates metallothionein-1 expression by regulating
            ASH2L and DNMT1 in hepatocellular carcinoma
  JOURNAL   Cell Death Dis 10 (6), 408 (2019)
   PUBMED   31138789
  REMARK    GeneRIF: ZNF479 regulates metallothionein-1 expression by
            modulating ASH2L in hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3851)
  AUTHORS   Mark,C., Looman,C., Abrink,M. and Hellman,L.
  TITLE     Molecular cloning and preliminary functional analysis of two novel
            human KRAB zinc finger proteins, HKr18 and HKr19
  JOURNAL   DNA Cell Biol 20 (5), 275-286 (2001)
   PUBMED   11410164
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC099654.5, AC125231.2 and AC122133.4.
            
            On Oct 26, 2020 this sequence version replaced NM_001370129.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319636.10/ ENSP00000324518.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC099654.5         5026-5176           c
            152-278             AC125231.2         3720-3846           c
            279-374             AC125231.2         3146-3241           c
            375-3851            AC122133.4         183907-187383       c
FEATURES             Location/Qualifiers
     source          1..3851
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..3851
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /note="zinc finger protein 479"
                     /db_xref="GeneID:90827"
                     /db_xref="HGNC:HGNC:23258"
                     /db_xref="MIM:617444"
     exon            1..151
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..1687
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /note="KRAB zinc finger protein KR19; zinc finger protein
                     Kr19"
                     /codon_start=1
                     /product="zinc finger protein 479"
                     /protein_id="NP_001357058.1"
                     /db_xref="CCDS:CCDS43590.1"
                     /db_xref="GeneID:90827"
                     /db_xref="HGNC:HGNC:23258"
                     /db_xref="MIM:617444"
                     /translation="MAKRPGPPGSREMGLLTFRDIAIEFSLEEWQCLDCAQRNLYRDV
                     MLENYRNLVSLGIAVSKPDLITCLEQNKESQNIKRNEMVAKHPVTRSHFTQDLQPEQG
                     IKDSLQKVIPRTYGKCGHEKLQFKKCCKSVGEYEVHKGGYSEVNQCLSTTQNKIFQTH
                     KYVKVFGKFSNSNRDKTRYTGNKHFKCNKYGKSFCMLSHLNQHQVIHTREKSYKCKEC
                     GKSFNCSSNHTTHKIIHTGEKPYRCEECGKAFSWSANLTRHKRTHTGEKPYTCEECGQ
                     AFRRSSALTNHKRIHTGERPYKCEECGKAFSVSSTLTDHKRIHTGEKPCRCEECGKAF
                     SWSSNLTRHKRIHTREKPYACEECGQAFSLSSNLMRHRRIHTGEKPYTCEECGQDFRR
                     SSALTIHKRIHTGERPYKCEECGKVFSLSSTLTDHKRIHTGERPYKCEECGKAFSLSS
                     TLTDHKRIHTGERPYTCEECGKAFNCSSTLMQHKRIHTGEKPYKCEECEQAFKWHSSL
                     AKHKIIHTGEKPYKCE"
     exon            152..278
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /inference="alignment:Splign:2.1.0"
     exon            279..374
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /inference="alignment:Splign:2.1.0"
     exon            375..3851
                     /gene="ZNF479"
                     /gene_synonym="HKr19; KR19"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctttgtgttt ctctgcgtcc agagctgcag ttctcctctt cactgctctg tgtcctctgc
       61 tcctagaggc caagcctatg tgtccttgtg tcctgcaggt atctgcagat ttatggctaa
      121 aagaccagga ccccctggaa gccgagaaat gggactgttg acattcagag acatagctat
      181 agaattctct ctggaggaat ggcaatgcct ggattgtgct cagcggaatt tatatagaga
      241 tgtgatgtta gagaactaca gaaacctggt ctccctgggt attgctgtct ctaagccaga
      301 cttgatcacc tgtctggagc aaaataaaga gtcccagaat ataaagagaa atgagatggt
      361 agccaaacac ccagttacgc gttcccattt cacccaagac cttcagccag agcagggcat
      421 caaagattca ctccaaaaag taataccaag aacatatgga aaatgtggac atgagaaatt
      481 acaatttaaa aaatgctgta aaagtgtggg tgaatatgag gtgcacaagg gaggttatag
      541 tgaagttaac caatgtttgt caactaccca aaacaaaata tttcagactc ataaatatgt
      601 caaagtcttt ggtaaatttt caaattccaa tagagataaa acaagatata ctggaaataa
      661 acatttcaaa tgtaacaaat atggcaaatc attttgcatg ctttcacacc taaatcaaca
      721 tcaggtaatt catactaggg agaagtccta caaatgcaaa gaatgtggca aatcctttaa
      781 ctgctcctca aaccatacta cacataaaat aattcatact ggagagaaac catatagatg
      841 tgaggaatgt ggcaaagcct ttagctggtc tgcaaacctt actagacata agagaactca
      901 tactggagag aaaccctaca cgtgtgaaga atgtggccaa gcctttaggc gctcctcagc
      961 acttactaac cacaagagaa ttcatactgg agagagaccc tacaaatgtg aagaatgtgg
     1021 caaagccttt agcgtatcct caaccctcac tgaccacaag agaattcata ctggagagaa
     1081 accctgcagg tgtgaggaat gtggcaaagc ctttagctgg tcctcaaacc ttactagaca
     1141 taagagaatt catactagag agaaacccta tgcctgtgaa gaatgtggcc aagcctttag
     1201 cttatcctcg aaccttatga gacataggag aattcatact ggagagaaac cctacacatg
     1261 tgaagaatgt ggccaagact ttaggcgctc ctcagcactt actatccaca agagaattca
     1321 tactggagag agaccctaca aatgtgaaga gtgtggcaaa gtctttagct tatcctcaac
     1381 cctcactgac cacaagagaa ttcatactgg agagagaccc tacaaatgtg aagaatgtgg
     1441 caaagccttt agcttatcct caaccctcac tgaccacaag agaattcata ctggagagag
     1501 accctacaca tgtgaagaat gtggcaaagc ctttaattgc tcctcaaccc ttatgcaaca
     1561 taagagaatt catactggag agaaacccta caaatgtgaa gaatgtgagc aagcttttaa
     1621 gtggcattca agtcttgcta aacataagat aattcacact ggagagaaac cctacaaatg
     1681 tgaataatat ggcaaagtcc accctcaggc cttataatac ataaaataat ttacactgga
     1741 aaaaaacact acaaatgtag agaatgtggc caagccttta accagttcca aaccttaatt
     1801 gaatgtaaga gaattcatat tggacagaaa ttttataaat gtaaaaaaat gtaacaaagc
     1861 ctttaaccaa ccctcaaacc ttaataaacc taagagaatt tattttaaaa aaattttttt
     1921 gagttggagt ctccctgtgt cacccaggct ggagtgcagt gtcatgatct cagctcactg
     1981 taacctctgc cttccgggtt caagcgattc tcctgcctca gcctcctgag tagctgggat
     2041 tacaggcgtg tgccaccaca ctggctgatt tgtgtatttt tagtagagat agagtttcac
     2101 catgttggcc aggatggtct tgaactcctg acctcaggtg atccaccttt gtcagcctcc
     2161 caaagcctaa gagaacttat attacagaga ccctagaaac ataaaaaaag tgacaaaacc
     2221 tttaagcaca tctcaggcct tacatattat ctgatcattc attctagaga gaaactctac
     2281 aaaagcaaag aatgtggtaa agctgttaac tagtcttgaa cccttattat acataagaga
     2341 attaatactg aagagaaacc ctacaataag gaatatggta atgtctttaa aaagtcctca
     2401 aacctgaata aatgtaagat aattgatatt ggagagaaac cctgcaattg cagaaaaaaa
     2461 tgtggcaaac cctttaactg gttctccatg cttactcact aaaaaatttt atactggaga
     2521 gaaactctgc ttacataaaa atgtgacaga gcatttaagc acacctcaaa cttttctaaa
     2581 aaagagaaat catactggtg agaaactcta gaaatgtgtt aaatgtggca aggactttaa
     2641 atggtagtca cacgttatgg taggtaagat agtttatact gaagaagact cctacaaata
     2701 tgaagaatgt ggcaaaactt ttaacaaatt ctcacacctt atggtacagg aaagcattta
     2761 tactagagaa aaattgtaca aagaatgtga aaaaccatta atatcaggtc acatcttact
     2821 caatatcaga aagtttatac ttaataaagg gattataggt caggtgtgtt ggctcatgcc
     2881 tataattcca gcactttggg agaccaaggt cggtggatca tgaggtcagg agttcaagac
     2941 cagcctggcc aacatggtga aactccatct ctactaaaaa tagaaaaact agctgggtgt
     3001 ggtggcgtgc acttgtaatc ccagctactt ggcaggcaga ggtaggagaa ttgcttgaac
     3061 cggggaggca gaggttgcag tgagctgaga tagagccact acactacagc ctgggtgaca
     3121 gagcaagact ctgtctcaaa aaaaaaatta taaatgtgat tactgtaaaa agaccttttg
     3181 gaaaatatag gcctttaaag taaagaccag ttattctgaa gacaaacata caaacttaaa
     3241 gaggattgct gtacctttac ttccattaca gattttattg tacacatttt atattaaagg
     3301 aaaaatttga agatctgaga agatgctcaa actttgttga acattagaga atttatattg
     3361 gagagaaagt ctaaacatgt aatgaatgtg aaaaacattt tttcaaaacc tccagcttag
     3421 aaaacaccag tttgtactaa atatttttgc agaaccagta aatggggaaa acatattaaa
     3481 tcaaaaatta agtctatata agcatctgag gggtcacagt agaaagaatg aaggcactga
     3541 aacttcatac attacactaa atcagagggt tgagtgtaaa agagatccaa agctaacacc
     3601 atatacatgt taaagaagta gtttttttcg agattcataa ttaccttcga ggtatgcttc
     3661 tttcttctat aaaaaaatag tttctgaaca gcaaataata atgtaactca agtctcagat
     3721 tccgtcatgt tgactcttcc cattgtttgt gaaagtattt gatcagttgt ttcatcagag
     3781 ataggagaga ttgtttttta tcaattgtac gtttatgtaa taaaatgcaa taaatttaaa
     3841 aattttttaa a
//
