LOCUS       NM_015428               4642 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 473 (ZNF473), transcript variant
            1, mRNA.
ACCESSION   NM_015428
VERSION     NM_015428.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4642)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4642)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4642)
  AUTHORS   de Filippo,C., Key,F.M., Ghirotto,S., Benazzo,A., Meneu,J.R.,
            Weihmann,A., Parra,G., Green,E.D. and Andres,A.M.
  CONSRTM   NISC Comparative Sequence Program
  TITLE     Recent Selection Changes in Human Genes under Long-Term Balancing
            Selection
  JOURNAL   Mol Biol Evol 33 (6), 1435-1447 (2016)
   PUBMED   26831942
REFERENCE   4  (bases 1 to 4642)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4642)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 4642)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
REFERENCE   7  (bases 1 to 4642)
  AUTHORS   Wagner,E.J. and Marzluff,W.F.
  TITLE     ZFP100, a component of the active U7 snRNP limiting for histone
            pre-mRNA processing, is required for entry into S phase
  JOURNAL   Mol Cell Biol 26 (17), 6702-6712 (2006)
   PUBMED   16914750
  REMARK    GeneRIF: ZFP100 is the limiting factor for histone pre-mRNA
            processing in vivo.
REFERENCE   8  (bases 1 to 4642)
  AUTHORS   Wagner,E.J., Ospina,J.K., Hu,Y., Dundr,M., Matera,A.G. and
            Marzluff,W.F.
  TITLE     Conserved zinc fingers mediate multiple functions of ZFP100, a
            U7snRNP associated protein
  JOURNAL   RNA 12 (7), 1206-1218 (2006)
   PUBMED   16714279
REFERENCE   9  (bases 1 to 4642)
  AUTHORS   Pillai,R.S., Grimmler,M., Meister,G., Will,C.L., Luhrmann,R.,
            Fischer,U. and Schumperli,D.
  TITLE     Unique Sm core structure of U7 snRNPs: assembly by a specialized
            SMN complex and the role of a new component, Lsm11, in histone RNA
            processing
  JOURNAL   Genes Dev 17 (18), 2321-2333 (2003)
   PUBMED   12975319
REFERENCE   10 (bases 1 to 4642)
  AUTHORS   Dominski,Z., Erkmann,J.A., Yang,X., Sanchez,R. and Marzluff,W.F.
  TITLE     A novel zinc finger protein is associated with U7 snRNP and
            interacts with the stem-loop binding protein in the histone
            pre-mRNP to stimulate 3'-end processing
  JOURNAL   Genes Dev 16 (1), 58-71 (2002)
   PUBMED   11782445
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB032967.1, BX492803.1,
            AF454744.1 and AL080143.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015428.3.
            
            Summary: This gene encodes a member of the Krueppel C2H2-type
            zinc-finger family of proteins. The encoded protein, a component of
            the U7 snRNP complex, plays a role in histone 3'-end pre-mRNA
            processing and may be required for cell cycle progression to S
            phase. Expression level and methylation status of this gene may be
            correlated with bone mineral density. [provided by RefSeq, Jul
            2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648093.1, SRR1803614.36734.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270617.8/ ENSP00000270617.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AB032967.1         51-84
            35-580              BX492803.1         1-546
            581-2069            AB032967.1         509-1997
            2070-3260           AF454744.1         1953-3143
            3261-4033           AB032967.1         3189-3961
            4034-4642           AL080143.1         2271-2879
FEATURES             Location/Qualifiers
     source          1..4642
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..4642
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="zinc finger protein 473"
                     /db_xref="GeneID:25888"
                     /db_xref="HGNC:HGNC:23239"
                     /db_xref="MIM:617908"
     exon            1..118
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /inference="alignment:Splign:2.1.0"
     exon            119..318
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..2925
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 100 homolog"
                     /codon_start=1
                     /product="zinc finger protein 473 isoform 1"
                     /protein_id="NP_056243.1"
                     /db_xref="CCDS:CCDS33077.1"
                     /db_xref="GeneID:25888"
                     /db_xref="HGNC:HGNC:23239"
                     /db_xref="MIM:617908"
                     /translation="MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFL
                     LDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEML
                     SKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVS
                     TVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSF
                     SGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQ
                     STYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFH
                     LTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIE
                     HQALHAGEEPYKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHR
                     RIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKM
                     HTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNK
                     CEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQ
                     GKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRV
                     FTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFG
                     LSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQK
                     ANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSS
                     LSRHQRVHNKQQYCL"
     exon            319..445
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /inference="alignment:Splign:2.1.0"
     exon            446..535
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /inference="alignment:Splign:2.1.0"
     exon            536..4642
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="hexamer: AATAAA"
     polyA_site      3041
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="major polyA site"
     regulatory      4622..4627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="hexamer: ATTAAA"
     polyA_site      4642
                     /gene="ZNF473"
                     /gene_synonym="ZFP100; ZN473"
                     /note="major polyA site"
ORIGIN      
        1 agagaagctt ctcgcgcaca ggaagtcgct gcgaggaggc gcgtgtgcgg ggagttgaat
       61 ctcccgctcc cttgaggctg gggttgcgtc tgttgacgcg gccgactaca atcccgaggg
      121 agactcacat tgggacttgt cctcctcctc ctggacattt tgggggctcg tcagcatgga
      181 cagcgagtca gccatgggtg gaagggaggc tttctcacag ctcccttgtg cttcccacag
      241 ccctgccagc cgggaacacg gaggggaagg aggaggagct taaaagaggc tactgaaccc
      301 cagttggcca tggctgagga atttgtgacc ctcaaggatg tcggcatgga cttcaccttg
      361 ggagactggg agcagctcgg gctggaacag ggggacacgt tctgggacac agcgttggac
      421 aattgccagg acctcttcct gctggacccc ccaagaccca acctgacctc ccacccagat
      481 ggcagtgaag atctggagcc tctggcagga ggaagcccag aagcaacaag ccctgatgtg
      541 actgagacca agaactctcc tctgatggag gatttcttcg aagaaggatt ctcccaggag
      601 attatagaga tgttatccaa ggatggcttc tggaactcca atttcggaga agcctgtata
      661 gaggacacct ggttagatag tttgctaggc gatccagaaa gtcttctgag gtctgatatt
      721 gccaccaacg gggaaagtcc cacggaatgc aagagtcatg aattaaagag aggactcagt
      781 cctgtgtcca ccgtttccac gggagaagat tccatggtgc ataatgtttc tgaaaagacc
      841 ctcacaccag ctaagtctaa ggaatatagg ggtgagtttt tctcctactc cgaccacagc
      901 cagcaggatt ctgttcagga aggggagaaa ccatatcaat gtagtgaatg tgggaaaagc
      961 ttcagtggga gttaccgtct tacccagcac tggatcactc atactaggga gaaacccact
     1021 gtccatcaag agtgtgagca aggttttgac cggaatgctt ccctttctgt gtatccgaaa
     1081 actcacacgg gctacaaatt ctatgtgtgt aatgaatatg ggacaacttt tagtcagagt
     1141 acatacctgt ggcatcagaa aactcacact ggagaaaaac catgtaagag tcaagatagt
     1201 gaccacccac ccagtcatga cacacagcct ggtgagcatc agaaaactca cacagatagt
     1261 aagtcctaca actgtaacga atgcggcaag gcttttaccc ggatcttcca ccttactcgg
     1321 caccagaaga tccacactcg gaaacgctat gagtgttcca agtgccaggc gaccttcaac
     1381 ttgagaaaac acctcatcca acatcagaaa actcacgctg caaaaactac ctctgagtgt
     1441 caggagtgtg ggaagatttt taggcacagt tcgctgctca ttgaacacca ggctcttcat
     1501 gctggagagg agccttataa gtgtaacgaa cgtgggaaat ccttcaggca taactctacc
     1561 ctaaagatcc atcagagggt tcacagtgga gagaagcctt acaaatgcag tgagtgtggg
     1621 aaggccttcc accggcacac tcaccttaat gaacatcggc gaattcatac aggctacaga
     1681 ccccacaaat gtcaggaatg cgtcaggagt ttcagccggc cctcacatct gatgcgacat
     1741 caggccattc acaccgcaga aaagccctat agctgtgctg aatgcaagga gactttcagc
     1801 gataacaatc gccttgtgca acaccagaaa atgcacactg tcaaaacccc atatgaatgt
     1861 caggagtgcg gagaacgctt catttgcggc tcaaccctga agtgccacga gagtgttcac
     1921 gccagagaaa aacaaggatt ttttgtgagt gggaagatct tggatcagaa cccagaacag
     1981 aaagagaagt gctttaagtg taacaaatgt gagaaaacct ttagctgcag caaataccta
     2041 actcagcacg agaggattca caccagggga gtgaagccct ttgaatgtga ccagtgtggg
     2101 aaagcctttg gccaaagtac tcggctcatt caccatcaaa gaatccactc tagagtgagg
     2161 ctgtataaat ggggtgagca agggaaagcc atcagcagtg cctcccttat caaacttcag
     2221 tccttccaca caaaggagca cccttttaaa tgtaacgaat gcggaaagac cttcagccac
     2281 agtgcacacc tctcaaaaca tcagttaatt cacgctggag agaatccctt taaatgtagt
     2341 aagtgtgaca gagtcttcac ccagagaaac taccttgttc agcatgagcg aactcatgcc
     2401 agaaagaagc cgttggtgtg taacgaatgc gggaaaacgt tccgtcagag ctcatgcctt
     2461 tctaagcatc agagaattca ctcaggtgag aagccctatg tatgtgatta ctgcgggaag
     2521 gccttcggcc tgagtgctga gcttgtccgc caccagagaa ttcacactgg agaaaagcct
     2581 tatgtttgtc aggaatgcgg gaaagccttc acccagagct catgcctttc tattcaccgg
     2641 agagttcaca ctggggagaa gccctacaga tgtggtgaat gtgggaaagc ctttgcccag
     2701 aaagcaaatc taacacagca ccagagaatt cacacagggg agaagcctta ctcctgtaat
     2761 gtgtgtggca aagcttttgt cctcagtgcc catctcaacc agcacctgag agttcacacc
     2821 caggagacac tttatcagtg tcaacgttgc cagaaagcct ttcggtgcca ctcgagcctc
     2881 agccgccatc agcgtgtaca caacaagcag caatactgcc tgtagccatt gggtggcagc
     2941 agagtcccag aatatgagac cgttactcgg atgttgaaag ttggaaacta tcccattgca
     3001 agtttctctc caaataaatg catctaaaga ttgattagaa agtttgtgcg catgtttttc
     3061 attataacaa tgaaaacaca aaagtggaga agctgtacaa cgtcaggatt cagaggtagg
     3121 ctctggagcc agtctacctt gagttaaatc ccacctctgc catctactac ctaagtgacc
     3181 ttgggaaggt cagaaaaatc tctcagggcc tcggtgtcct tatctgtaaa atgggcatca
     3241 cctacctcag agggcttttc tgaggattaa ataaataaat gtgaagcact tagaactgat
     3301 ggccagcaca tgagggctca ccaagtgtaa gccacaaata cacatcagct atagcacaaa
     3361 tatacttgtg ttacaagaaa ggaattagta atctgtgttt actgtagtta atgttcttac
     3421 aatgtatcgc ttttaattta agttttcctt ttttacagtt tttctccagc actttactct
     3481 tcttaagtgc ctggcctttt ttgtcccttt atctctcctg gtttttttct taagccccag
     3541 aaagccaaaa agaacatgta aactcttcac ctcaactagc tacaaccttc cactcctaac
     3601 ctcccaagct tctcacttaa agaggactcc ctatcccaca aacacatgct ccctcttcct
     3661 atgaccttcc tccatttaac agtgttggtt atgcaataag acacccaatt tttcatggga
     3721 gttgacacca aaacacagct ggattccatc aggaaagctg cattgatcag ggtgttaacc
     3781 gcatatgaaa caacccatat ggaagacata cttaggggtc aaacctgtgg tgtgtggaag
     3841 tgaccactgg gatgtcatca ttcaccattt atccaggatg gccgctcacc aggcaatttg
     3901 ctaggctcgg gggcgggtag tatccataca ctatgcacta ctgctctgaa gcttctggaa
     3961 tcagaaatga acccattttc atcgacgatt gctgttagtt gacaagtgac atcttgaaaa
     4021 tgccacattc cctcatgtca caggaagttc tgggatcacc aaggattgtt ggagagtcca
     4081 gtgagatgga accacacaac cagttcccta ccagtgtctt gtcagctctg ggtgtttgtt
     4141 ccctgccact aagtggctca gtcacacctt tgctgaaaca cagtagtctt atgaaaagca
     4201 ctggacacat actttgaata cctttcatat tttaggtgct gaaaatggtg agggagtgag
     4261 tgctctgcac ccttgggctt ttcaactctt gcacctggag ttctgctggt taagtttgtt
     4321 aaacttagtt gaaactggga acctgttggc taaccattgg ggccttacac tgtttttcaa
     4381 atggttgcaa catttaactt ctcgcacatg gttcccgtcc tctggagctc tgtcttgtcg
     4441 gggagatggg catgttgtat accaaaagag tgtacaaagt gttgcagggc tgtgacacaa
     4501 tagggactct atggaaaact ggcagccatt gggtgtgggg gcagtctgta aatcagtcac
     4561 ctgtgttgct gcaggccaag gtagaaacgc cctccgtgtg tgcatatttg ttggttctct
     4621 gattaaagtt ttgagtctaa aa
//
