LOCUS       NM_020813               6266 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 471 (ZNF471), transcript variant
            1, mRNA.
ACCESSION   NM_020813
VERSION     NM_020813.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6266)
  AUTHORS   Liu,Y., Cai,X., Hu,S., Wang,Z., Tian,H. and Wang,H.
  TITLE     Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects
            Proliferation, Invasion, and Docetaxel Sensitivity of Tongue
            Squamous Cell Carcinoma via Regulation of c-Myc
  JOURNAL   Am J Pathol 194 (6), 1106-1125 (2024)
   PUBMED   38749608
  REMARK    GeneRIF: Suppression of N-Glycosylation of Zinc Finger Protein 471
            Affects Proliferation, Invasion, and Docetaxel Sensitivity of
            Tongue Squamous Cell Carcinoma via Regulation of c-Myc.
REFERENCE   2  (bases 1 to 6266)
  AUTHORS   Wang,X., Yao,L., Li,Z., Zhang,J., Ruan,M., Mulati,Y., Gan,Y. and
            Zhang,Q.
  TITLE     ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma
  JOURNAL   Int J Biol Sci 20 (2), 643-663 (2024)
   PUBMED   38169650
  REMARK    GeneRIF: ZNF471 Interacts with BANP to Reduce Tumour Malignancy by
            Inactivating PI3K/AKT/mTOR Signalling but is Frequently Silenced by
            Aberrant Promoter Methylation in Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6266)
  AUTHORS   Tao,C., Luo,J., Tang,J., Zhou,D., Feng,S., Qiu,Z., Putti,T.C.,
            Xiang,T., Tao,Q., Li,L. and Ren,G.
  TITLE     The tumor suppressor Zinc finger protein 471 suppresses breast
            cancer growth and metastasis through inhibiting AKT and
            Wnt/beta-catenin signaling
  JOURNAL   Clin Epigenetics 12 (1), 173 (2020)
   PUBMED   33203470
  REMARK    GeneRIF: The tumor suppressor Zinc finger protein 471 suppresses
            breast cancer growth and metastasis through inhibiting AKT and
            Wnt/beta-catenin signaling.
            Erratum:[Clin Epigenetics. 2022 Jan 31;14(1):17. doi:
            10.1186/s13148-022-01237-3.. PMID: 35101095]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6266)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6266)
  AUTHORS   Cao,L., Wang,S., Zhang,Y., Wong,K.C., Nakatsu,G., Wang,X., Wong,S.,
            Ji,J. and Yu,J.
  TITLE     Zinc-finger protein 471 suppresses gastric cancer through
            transcriptionally repressing downstream oncogenic PLS3 and TFAP2A
  JOURNAL   Oncogene 37 (26), 3601-3616 (2018)
   PUBMED   29610526
  REMARK    GeneRIF: ZNF471 acts as a tumor suppressor in gastric cancer by
            transcriptionally inhibiting downstream targets TFAP2A and PLS3.
            Erratum:[Oncogene. 2022 Jun;41(23):3298-3299. doi:
            10.1038/s41388-022-02216-x.. PMID: 35484334]
REFERENCE   6  (bases 1 to 6266)
  AUTHORS   Bhat,S., Kabekkodu,S.P., Jayaprakash,C., Radhakrishnan,R., Ray,S.
            and Satyamoorthy,K.
  TITLE     Gene promoter-associated CpG island hypermethylation in squamous
            cell carcinoma of the tongue
  JOURNAL   Virchows Arch 470 (4), 445-454 (2017)
   PUBMED   28255813
  REMARK    GeneRIF: This is the first study to report hypermethylation of
            LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue
REFERENCE   7  (bases 1 to 6266)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   8  (bases 1 to 6266)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831845.1, BC125221.1, AC005498.1, BM991696.1 and AI375847.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020813.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.63188.1,
                                           SRR1660809.31498.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308031.10/ ENSP00000309161.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AL831845.1         13-43
            32-2830             BC125221.1         1-2799
            2831-5642           AC005498.1         6812-9623
            5643-6207           BM991696.1         72-636              c
            6208-6266           AI375847.1         12-70               c
FEATURES             Location/Qualifiers
     source          1..6266
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..6266
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="zinc finger protein 471"
                     /db_xref="GeneID:57573"
                     /db_xref="HGNC:HGNC:23226"
                     /db_xref="MIM:620162"
     exon            1..66
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /inference="alignment:Splign:2.1.0"
     exon            67..154
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..2002
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="isoform 1 is encoded by transcript variant 1;
                     EZFIT-related protein 1"
                     /codon_start=1
                     /product="zinc finger protein 471 isoform 1"
                     /protein_id="NP_065864.2"
                     /db_xref="CCDS:CCDS12945.1"
                     /db_xref="GeneID:57573"
                     /db_xref="HGNC:HGNC:23226"
                     /db_xref="MIM:620162"
                     /translation="MNVEVVKVMPQDLVTFKDVAIDFSQEEWQWMNPAQKRLYRSMML
                     ENYQSLVSLGLCISKPYVISLLEQGREPWEMTSEMTRSPFSDWESIYVTQELPLKQFM
                     YDDACMEGITSYGLECSTFEENWKWEDLFEKQMGSHEMFSKKEIITHKETITKETEFK
                     YTKFGKCIHLENIEESIYNHTSDKKSFSKNSMVIKHKKVYVGKKLFKCNECDKTFTHS
                     SSLTVHFRIHTGEKPYACEECGKAFKQRQHLAQHHRTHTGEKLFECKECRKAFKQSEH
                     LIQHQRIHTGEKPYKCKECRKAFRQPAHLAQHQRIHTGEKPYECKECGKAFSDGSSFA
                     RHQRCHTGKRPYECIECGKAFRYNTSFIRHWRSYHTGEKPFNCIDCGKAFSVHIGLIL
                     HRRIHTGEKPYKCGVCGKTFSSGSSRTVHQRIHTGEKPYECDICGKDFSHHASLTQHQ
                     RVHSGEKPYECKECGKAFRQNVHLVSHLRIHTGEKPYECKECGKAFRISSQLATHQRI
                     HTGEKPYECIECGNAFKQRSHLAQHQKTHTGEKPYECNECGKAFSQTSNLTQHQRIHT
                     GEKPYKCTECGKAFSDSSSCAQHQRLHTGQRPYQCFECGKAFRRKLSLICHQRSHTGE
                     EP"
     exon            155..281
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /inference="alignment:Splign:2.1.0"
     exon            282..377
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /inference="alignment:Splign:2.1.0"
     exon            378..6266
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4933..4938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="hexamer: AGTAAA"
     polyA_site      4955
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="major polyA site"
     regulatory      5357..5362
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="hexamer: AATAAA"
     polyA_site      5386
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
     regulatory      6251..6256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="hexamer: TATAAA"
     polyA_site      6266
                     /gene="ZNF471"
                     /gene_synonym="ERP1; Z1971; Zfp78"
                     /note="major polyA site"
ORIGIN      
        1 ggggttccag cgtcgactca cggagtcctt cggatgagag cgtctgggtg ccagacgagg
       61 ccggggcctt gccctcccaa gacactgttc ttcaagagaa agaccagaag agaaggcaaa
      121 aatgaatgtt gaagtagtaa aagtcatgcc ccaggactta gtgacattca aggatgtggc
      181 aatagatttt tcccaggaag aatggcaatg gatgaaccct gctcagaagc gtttatacag
      241 gagtatgatg ttggagaact atcagagcct ggtatcactt ggtctttgca tttctaagcc
      301 atatgtgatc tccttattgg agcaagggag agagccttgg gagatgacga gtgagatgac
      361 aagaagccca ttctcagatt gggaatctat atatgtgaca caggaattac ctctgaagca
      421 gttcatgtat gatgatgcat gcatggaggg aattactagc tatggacttg agtgttccac
      481 ttttgaagaa aattggaaat gggaagacct ttttgagaag cagatgggaa gtcatgagat
      541 gtttagcaag aaagaaataa tcactcataa agaaaccatc actaaggaaa cagaattcaa
      601 atatactaaa tttgggaaat gtatccatct ggaaaacata gaagagagta tttataatca
      661 cacatcagat aaaaaaagct tctccaaaaa ttctatggta ataaaacaca agaaagtcta
      721 tgtaggaaag aagcttttta aatgtaatga atgtgacaaa accttcaccc atagctcatc
      781 ccttactgtt cattttagaa ttcatactgg tgaaaaacca tatgcatgtg aggaatgtgg
      841 aaaagccttc aagcaaaggc aacaccttgc tcaacatcac agaacacata ctggagagaa
      901 actctttgaa tgtaaagaat gtaggaaagc cttcaaacaa agtgaacacc ttattcagca
      961 tcaaagaatt catactggag aaaaaccata taaatgtaag gaatgcagaa aagccttcag
     1021 acagcctgca caccttgctc agcatcagag aattcatact ggagagaaac cctatgaatg
     1081 taaagaatgt ggcaaagcct tcagtgatgg ctcgtctttt gctcgacatc agagatgtca
     1141 cactggcaaa agaccctatg aatgtattga gtgtgggaag gcttttaggt ataacacatc
     1201 ttttattcgt cactggagga gttatcatac tggagagaag ccttttaatt gcattgattg
     1261 tgggaaagcc ttcagtgttc acataggact tattctgcat aggagaattc atacaggaga
     1321 gaaaccttac aaatgtggtg tgtgtggaaa aaccttcagc tcgggttcat cccgtactgt
     1381 acatcagaga attcatacag gagagaaacc ttatgaatgt gatatatgtg ggaaagattt
     1441 tagccatcat gcatcactca ctcagcatca aagagtacat tctggagaga aaccgtatga
     1501 atgcaaggaa tgtgggaaag cctttaggca gaatgtacac cttgttagtc atttgagaat
     1561 tcatactggt gaaaaaccct atgaatgtaa agaatgtgga aaagctttta gaatcagttc
     1621 acagctggct actcatcaga gaattcatac tggagagaag ccttatgaat gtattgaatg
     1681 tggaaatgct ttcaaacaga gatcacacct tgcccaacat cagaaaactc atacaggaga
     1741 gaaaccttat gagtgtaatg aatgcgggaa agccttcagc caaacttcca atcttactca
     1801 acatcaaaga attcatactg gagagaaacc ctataaatgt actgaatgtg gaaaggcttt
     1861 tagtgatagc tcatcctgtg ctcagcatca aagactccac actggccaaa ggccctatca
     1921 gtgttttgaa tgtgggaagg cgttcagaag aaagttatcc ttaatttgtc atcaaagaag
     1981 tcatactgga gaagaacctt aagaatgtag tgcatgtggc caagccttta gttatcacca
     2041 atcccctact gttaatcaga gatgtcccac tggataaaaa acatataaat gtaagaaatg
     2101 tagaaaaacc ttcagccagg aggctggcaa gatggccgaa taggaacagc tctgatctgc
     2161 agttcccagt gagatcaacg cagaaggtgg gtgctttctg tatttccagc tgaggtacct
     2221 ggctcatctc attgggactg gttagacagt gggtgcagcc cacggagggt gagctgaagc
     2281 agggtggggc gtaacctcac ctgggaagtg caaggagtcg gggatctccc tcccctagcc
     2341 aagggaagcc atgagggact gtgccatgag gaatggtgca ctccggcaca gatactacgc
     2401 ttttcccatg gtcttcgcaa cccacagacc aggagatccc ccttgggtgc ctatgccacc
     2461 aaggccctgg gtttcaagca caaaactggg cggccattcg ggcagacacc gagctagctg
     2521 taggagtttt tttgatagcc cagtggcacc tggaatgcca gtgaaacaga accgcttact
     2581 cccttgttaa gggggctgaa gccggggagc caagtggttc ccatgcccac tgagcccagc
     2641 aagctaagat ccactggctt ggaattctcc ctgccagcac agcagtctga agtcaacctg
     2701 ggatgatcaa gcttggtggg gggaggggcg ccaaccatta ccaaagcttg aataggtggt
     2761 tttcccctca cagcgtaaac aaagccatgg ggaagttcca gctgagcaga gccctccaca
     2821 gctcagcaaa gcctctgtag ccagactgcc tctctagatt cctcctctct gggcagcgca
     2881 tctttgaaaa aagtgcagat aaaaccctca tctccctggg acaaagcacg tgggggaaag
     2941 gggtggctgt gggcacagct tcagcagact taaacattcc tgcctgccag ctctgaagag
     3001 agcagcagtt cttccagcac agcgcttgag ctctgctaag ggacagactg cctcctcaag
     3061 tgggtccctg acccccatgc ctcctgacgg ggagacacct cccagcaggg gtccacagac
     3121 acctcataca ggagagctct ggctggcatc tggtgggtgc ccctctggga caaagcttcc
     3181 agaggaagga acaggcagca atctttgctg ttctgcagcc tccaccggtg atacccaggc
     3241 agatatggtc tggagtggac ctccagcaaa ctccagcaga cctgcagccg aggggcctca
     3301 ctgttagaag gaaaactaac aggaatataa tcaacatcaa caaaggacat ccacacagaa
     3361 accccatctg aaggttacca gcatcaaaga ccaaaggtag ataaattcac gaagatgagg
     3421 agaaaccagt gcaaaaagcc tgaaaattcc aaaaaccaga atgcctcttc tcctccaaag
     3481 gatcacaact ccttgccggc aagggaacaa aactggatag agaatgagtt tgacaaattg
     3541 acagaagtag gcttcagaag gtgggaaata acaaactcct ctgagctaaa ggagcatgtt
     3601 ctaacccaat gcaaggaagc taagaacctt gaaaaaaggt tagaggaatt gctaactaga
     3661 ataaccagtt tagagaagaa cataaatgac ctgatggagc tgaaaaacac agcatgagaa
     3721 cttcgtgaag catacagaag aaaaaccttc agccagattg aatgctttac agggaagaat
     3781 tcatactgca gagcggtctt aacaatgtaa agaatgtgca aatgtcctca gacaagatgc
     3841 acaccttgct cattagtgag ttcatttcag gcagccagct cttcctcacc cactacatca
     3901 ccaagtcctg tggatatatc tgctaaatat ttttggaatt tatccacttc ttttggttcc
     3961 ccagtccaaa acacagtcat ttcacctgga ctatttcaat cattacacag gtgtccaacc
     4021 ttttgtcttc cctgggccac attggaagaa gaaaaattgt cttgtgccac acatacaata
     4081 cactaacatt aacaatagct gatgagctaa gaaaaaaaaa aagtctgtgc atagttttag
     4141 tgatacacca cctccgataa gcaaaaaagt cctcacattc aatgggttgc atacccatga
     4201 attctaaaac ttcatcctct tttgtccctt tcgagttaac attacagcca cagtgacctt
     4261 tcaaaaatgc aaattaagtt actcttaaaa ctctagttaa aatacttgat gtacataaag
     4321 tgcttagcaa aatgaccaac tcatactaag tgcttagtaa atgttagata agtattctcc
     4381 agaattgatg taaattattt ttaaacagtg cattcttgaa agcagtatgg cagtcataaa
     4441 aattttggaa ccaaaacagt atcttttttt aagctaaaaa aaaagtttta aatggtgtct
     4501 ttctatgttg cccagggtgg tctcaaactc ctgtgctcaa gtgaccctcc cacctcattc
     4561 tcaagtggct gcaattacag gcaaccagcc tgacttaaaa cagtatctta aggtagatgg
     4621 tgattagcac atgtagtatg cttaacattt aatattataa taagacatca cagcggctgt
     4681 ctcatgatta aggctgtgtt cccttgttgg tgaggaaatt aattatgact tgataaatag
     4741 aacatgtttt aagaagtggc tatatagctc tggataaaac gaacaaaaga attagaattc
     4801 ctgcggggaa tatatacaag actttattta gtcaagtaaa aaaaaatcac taatgtttaa
     4861 ctgaagaaag agaaattgaa taatatagtt ctatttcaac atgtgggttc acagatttat
     4921 tctaaccttc caagtaaagt tgttccacta gtaaagttgt tctggagtat atttttttta
     4981 aaaaaaacac ttaaaatgtt ccacttcttt catgaggcta agtcaactct gatatcaaac
     5041 caaggggaaa gaaatgaaat tataggtgag tttacttagt tatatacaaa aggaaattat
     5101 tagcctctgc tgatggagaa cagaggctgt gaataaatgg agatccataa catgatccta
     5161 catgaatgtt tcaatattgt aatcctgtaa gttactttta cattgacagt tctgaaattc
     5221 atgttgagtg ttaattaggc aggaatcaga agggaggttt tgtagaaggt cgtatccatg
     5281 ggttttttat atttgaaaag tgttttcgat gtatcattgg gggagattaa atgtctttga
     5341 cagttgtcca actagaaata aagtcagcat cccatttgac tccttacaca gaagttcatt
     5401 ctatactcat tacagatgta agaggttaag atggtagagg agaatgtaga gtatttctgt
     5461 gcctttaggt tcaggaggtc tttgataagc aggacaaggt ccagaagcca tgaagagaga
     5521 atgacaggac tgtgtagaag atttaaacct ttttcatggc gtaagatact gtatgcaaag
     5581 ttaaaaggca tatgacaggc tgagagatat cttaaacata cattagaaag gatatagccc
     5641 ttgaaaaagg gctgttggaa agcagcaagg ataaggtgca cagtcttgca gagcatgtca
     5701 acaaaattta ttggatgaag aaattaaaat ggttaaatag aagaagttct caacctcact
     5761 aatgatcaga taagtgcaga ttgtaaaagt cctcatcccc accaacacaa accagcagaa
     5821 attttatgtg aatgtgaagt ttggataata tccagtattg tcgcaggtgt gagaaaccgt
     5881 attttcaaat attgagaggg taaattagag gaaagccatt ttagagggca atgtggtgtt
     5941 acctgtcagc attttgaata taattaccct ttgccacaat tctacaccta gtcagttatg
     6001 ttctcaaaaa gcacaagtgc agaaatatag atgcataagc aaatgtgttg cagaattgtg
     6061 aaaaatttgg aaaaaatgtt tagtgctatt aaagttatgg gttacttaag ttacagaaaa
     6121 tcagtttagt agatcactgt gtagttacgg aaaatgagat ggatctctac tcaaagatgt
     6181 cttgcagttt atgaactgag atgtaacttc atgactaaca tgatgacatc gttattaact
     6241 acataaactt tataaagctt aaaaaa
//
