LOCUS       NM_001001668            7194 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens zinc finger protein 470 (ZNF470), mRNA.
ACCESSION   NM_001001668 XM_371198
VERSION     NM_001001668.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7194)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   2  (bases 1 to 7194)
  AUTHORS   Hering,T.M., Kazmi,N.H., Huynh,T.D., Kollar,J., Xu,L., Hunyady,A.B.
            and Johnstone,B.
  TITLE     Characterization and chondrocyte differentiation stage-specific
            expression of KRAB zinc-finger protein gene ZNF470
  JOURNAL   Exp Cell Res 299 (1), 137-147 (2004)
   PUBMED   15302581
REFERENCE   3  (bases 1 to 7194)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007228.1, DA412738.1, AY484591.1, AK129686.1 and AA977233.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001001668.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.65333.1,
                                           SRR1803616.88333.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330619.13/ ENSP00000333223.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AC007228.1         20342-20394
            54-541              DA412738.1         1-488
            542-795             AY484591.1         5-258
            796-796             AC007228.1         27274-27274
            797-1981            AY484591.1         260-1444
            1982-1982           AC007228.1         30555-30555
            1983-3077           AK129686.1         694-1788
            3078-6807           AC007228.1         31651-35380
            6808-7194           AA977233.1         9-395               c
FEATURES             Location/Qualifiers
     source          1..7194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..7194
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /note="zinc finger protein 470"
                     /db_xref="GeneID:388566"
                     /db_xref="HGNC:HGNC:22220"
                     /db_xref="MIM:620441"
     exon            1..571
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            572..697
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..789
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             730..2883
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /note="chondrogenesis zinc finger protein 1"
                     /codon_start=1
                     /product="zinc finger protein 470"
                     /protein_id="NP_001001668.3"
                     /db_xref="CCDS:CCDS33122.1"
                     /db_xref="GeneID:388566"
                     /db_xref="HGNC:HGNC:22220"
                     /db_xref="MIM:620441"
                     /translation="MKSQEEVEVAGIKLCKAMSLGSVTFTDVAIDFSQDEWEWLNLAQ
                     RSLYKKVMLENYRNLVSVGLCISKPDVISLLEQEKDPWVIKGGMNRGLCPDLECVWVT
                     KSLSLNQDIYEEKLPPAIIMERLKSYDLECSTLGKNWKCEDLFERELVNQKTHFRQET
                     ITHIDTLIEKRDHSNKSGTVFHLNTLSYIKQIFPMEERIFNFHTDKKSLKTHSVVKKH
                     KQDRGEKKLLKCNDCEKIFSKISTLTLHQRIHTGEKPYECIECGKAFSQSAHLAQHQR
                     IHTGEKPFECTECGKAFSQNAHLVQHQRVHTGEKPYQCKQCNKAFSQLAHLAQHQRVH
                     TGEKPYECIECGKAFSDCSSLAHHRRIHTGKRPYECIDCGKAFRQNASLIRHRRYYHT
                     GEKPFDCIDCGKAFTDHIGLIQHKRTHTGERPYKCNVCGKAFSHGSSLTVHQRIHTGE
                     KPYECNICEKAFSHRGSLTLHQRVHTGEKPYECKECGKAFRQSTHLAHHQRIHTGEKP
                     YECKECSKTFSQNAHLAQHQKIHTGEKPYECKECGKAFSQIAHLVQHQRVHTGEKPYE
                     CIECGKAFSDGSYLVQHQRLHSGKRPYECLECGKAFRQRASLICHQRCHTGEKPYECN
                     VCGKAFSHRKSLTLHQRIHTGEKPYECKECSKAFSQVAHLTLHKRIHTGERPYECKEC
                     GKAFRQSVHLAHHQRIHTGESSVILSSALPYHQVL"
     exon            790..916
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1012
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..7194
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7171..7176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /note="hexamer: AATAAA"
     polyA_site      7194
                     /gene="ZNF470"
                     /gene_synonym="CZF-1"
                     /note="major polyA site"
ORIGIN      
        1 acttccggaa aggacccaaa gccgggcgag tgcacgtccc gccggttgct gaggagaagg
       61 gaggtctggg cggggcagcg gccgaggctg gactggggcg cggcgggggc ggtgtcctgg
      121 ttcctgtgtg ggcggcgggc gtgagcgtgc gcgtgtggcc tggtggctgt gagtgcccat
      181 acgtggtgag cgtgcggtgc tgtgctgagg aggggcgagc gcgcgcgggg atggcggccc
      241 ggtgtgtgac tgtccggtgc gtggccgcga atctgcgcct gcgtgcatgg cccggcggcg
      301 tgcggaaggc ggtgtgtgtt ggaatgagtg aagcacttta agtggccaag agcaggaaac
      361 ccggccggag gaggcttacc ccgttctccc ctgtatcgac tgcgtagagc ccagtgtggg
      421 caaagtccta gagcccgggg aagttgcccg ggcggggcag cctcggctga agcatttcct
      481 gtcagcccta tctggaaggg gcagagccca ggacagggct ccatgtccac aggacggcga
      541 ggagcgaaga ccatggggac tgagtacaca gatgaagaca cagaagcata gagaggataa
      601 gtaatcacta gcaagtggaa gaaccgggat tcagatccag aacaggctga ctccagagtc
      661 actggctgtc atgtagtttc ctcaactact gcctcagctc tacaatccca gagtaaagct
      721 cttctccaaa tgaagagcca ggaagaggta gaggtggcag gaattaaact ttgtaaagcc
      781 atgtccctgg gttcagtgac tttcacagat gtggccatag acttttccca agatgaatgg
      841 gagtggctga atcttgctca gagaagtttg tacaagaagg tgatgttaga aaactacagg
      901 aacctagttt cagtgggtct ttgcatttct aaaccagatg tgatctcctt actggagcaa
      961 gagaaagacc cttgggtgat aaaaggaggg atgaacagag gcctgtgccc agacttggag
     1021 tgtgtgtggg tgaccaaatc attatcttta aaccaggata tttatgaaga aaaattaccc
     1081 ccggcaatca taatggaaag acttaaaagc tatgaccttg aatgttcaac attagggaaa
     1141 aactggaaat gtgaagactt gtttgagagg gagcttgtaa accagaagac acattttagg
     1201 caagagacca tcactcatat agatactctt attgaaaaaa gagatcactc taacaaatct
     1261 gggacagttt ttcatctgaa tacattatct tatataaaac agatttttcc catggaagag
     1321 agaatattta attttcatac agataagaaa agcttaaaaa cacattcagt tgtgaaaaaa
     1381 cacaagcaag accgtggaga aaagaaactt ttaaaatgta atgactgtga gaaaatattc
     1441 agcaaaatct caacccttac tcttcaccaa agaattcata caggagagaa accctatgaa
     1501 tgtattgaat gtggaaaggc ctttagccag agtgcccacc ttgctcaaca tcagagaata
     1561 cacacaggag aaaaaccttt tgaatgtact gaatgtggga aagccttcag ccagaatgct
     1621 catcttgttc aacaccagag agttcatact ggagagaaac cttatcagtg taagcagtgt
     1681 aataaagcat tcagccagct tgcacacctt gctcaacatc agagggtcca cactggagag
     1741 aaaccctatg aatgtattga atgtgggaag gcttttagtg attgctcatc cctagctcat
     1801 catcgaagga ttcacactgg gaaaagacct tatgaatgta ttgactgtgg gaaagctttc
     1861 aggcagaatg cttctcttat acgtcatcgg cgatattatc atactggaga gaaacccttt
     1921 gactgtattg attgtgggaa ggctttcact gatcacatag gacttattca gcataagaga
     1981 actcatactg gagagagacc ttacaaatgt aatgtgtgtg ggaaggcttt tagccatggc
     2041 tcatctctga cagtacatca gagaattcat acaggagaga aaccttatga atgcaatatc
     2101 tgtgagaaag ccttcagcca tcgtgggtct cttactcttc atcagagagt tcatactgga
     2161 gagaaaccct atgaatgtaa agaatgtggg aaagctttcc ggcagagcac gcatctggct
     2221 catcatcaga gaattcatac tggagagaaa ccttatgaat gtaaggaatg cagcaaaacc
     2281 ttcagccaga atgcacacct cgcgcaacat cagaaaatac acactgggga gaaaccttat
     2341 gaatgtaagg aatgtggtaa ggccttcagt cagattgcac accttgttca gcaccagaga
     2401 gttcatactg gtgagaagcc ttacgaatgt attgaatgtg ggaaggcctt tagtgatggc
     2461 tcatatcttg ttcaacatca gagactccac agtggcaaaa gaccgtatga atgtcttgaa
     2521 tgtgggaagg cattcaggca gagggcatcc ttgatttgtc atcagagatg tcatactggt
     2581 gagaaacctt atgaatgtaa tgtttgtggg aaagccttta gccatcgtaa atcccttact
     2641 ctgcatcaga gaattcatac aggagagaaa ccttatgagt gtaaggaatg tagcaaagcc
     2701 ttcagccagg ttgcccatct tactctacat aagagaattc atactggaga aaggccctat
     2761 gagtgtaaag aatgtggaaa agccttcagg cagagtgtac atcttgctca tcatcagcga
     2821 attcataccg gagagtcatc agttattctc tcctctgccc tcccatacca ccaagtccta
     2881 tagattcaat ctcgtaaatg cttctagcat ccatctgctt ttttccagca catgtcccat
     2941 catcatagtc caagacgcaa ccatctcatc tggatttctg cagtagcata actgttgccc
     3001 cttttgcttc tatcaactac atgtttaaca ctgtaggcag cctaaccttt taaaaataaa
     3061 aatacataat ttatgttatt ttcccattta aaacacttga tttgaaaaat atattaacta
     3121 atccatttca aggatttagc acacactggc atatagttat tgctaaataa atgctagcca
     3181 ttaaggtaaa ggtttcctta caaactatca tattaagcag caagtaaacc aaacagtaag
     3241 tctaagacta agattttaga gcagacagaa gactactctc ctggtagaga ggaaagatga
     3301 acaaactcag aattgaaaga tttatggtac acaaggtaac atggtggctt atcactccct
     3361 ctgtgacatt gttgatgagc aactctcact ttacctgaca ctgagaagtg agaatcagcc
     3421 aattagaaca aaagctttta gctgggtgcg gtggctcatg cctgtagtcc cagcactttg
     3481 ggaggctgag gcaggcagat tgcttgagct caggagttcg agaccaacct gagcaacatg
     3541 gtgaaaccct gtctctacaa aaaatacaga aattagccag gcgtggtggt gcacacctgt
     3601 agtcctagct actcaggagg ctgaagcagg aggattgctt gagcccagga ggtagaggtt
     3661 gcagtgagtc atgatcacac cactgcaatt ccagctgggc agcagagcca gacactgtct
     3721 caaggaaaaa caaagaacaa aagcatttgg tagaatgtag gactaaccag ggtaggtagt
     3781 agtaaaccaa aagtaacaag ccaaaaaaac ttgaatagat taatagccat gaaacactga
     3841 aaagggtagt tcaatacttt ggcctttata aaagtaccac agacaattcg tgtggtattt
     3901 aaattgttct agcataaaat aaaatgcaat aagaccttcc atcttgttcc atgagattga
     3961 caagacatgc caaaacataa aaatatgtac actgcaatta gtttctgaat gtagatgtta
     4021 caacttaaac ttatttttaa aatatttaaa aataggaagg ctagacatgc ctctgtatag
     4081 aaaatctgat aaaaatattt ctccctaaat tgtaaattca ttgatattcc agtaaaaatt
     4141 tccatatttt tttagttgag aagctgattc tgatcatctg tagaattttg attttaacga
     4201 ggaatgtagt ttacattagg aatgtagtac taatactaat tgaacatttg ctaatgtttc
     4261 acacactatt ttaggtgctg ggggatacag taaggtacaa gatggacaaa aatacgtgct
     4321 cttacagatc tagtagaaca gaaaaaatta aatgcatgct atgtgataag tatatgatat
     4381 gtcccataaa gagaaatgat ataaaaaaga agctagggag tgctggatca ggcaccttac
     4441 tatccccaga acatgttggt attagaggat gagggaagaa ctagaggtaa ctgtgagaca
     4501 caaaaggcat aatgaaaata gtcatgatag tcccaaggca gatattgttt atgatgcttt
     4561 gagtgttgga ggaagggagg attgatggtt taacagagat catggcagtt atgttcactc
     4621 atataaatgt tgatttagaa gctggtggaa gggtattttt tgagtgacag ctttattgag
     4681 acaaagcaat tctggagaac acccatatcc ttctctctgt atccatcagc agaagtgaag
     4741 agggagcccc aaagttccac ttaaagtgta caacttatgg cttttagttc attcacggag
     4801 ttgtgcaacc atcaccacca tcaattttag aacattttca tcacctcaaa gaggaatccc
     4861 ttgtcctttt gtagttatgg ccatccctgg aagagtactt tttttttttt ttcaactgaa
     4921 gcacccagag ctcttgggtt ccctcttaac tgctttctgt ggaagtatag agggccatgt
     4981 gagggaagcc gttatccaga gtacatgact gctagaaaat ggagtttggg gctccctctt
     5041 cacttctgct gatagaagca taatggctag gggatgggta gtctcaccag agaatgtgga
     5101 gctttcagac tctccttata tatgataaaa aggatttttc attgtagtgg ggaaaaggtg
     5161 gtttgatcaa atggcattgg gaaacttagc tcactggaaa aacagatctg tacctttcac
     5221 actaatgaaa tgcctgagat attaaaggtc taaatgtaaa attaaagtac atgaaaaaca
     5281 gaataatata tatgtaccct cggtttgaaa tagactttaa gcactaatgc ataaccccaa
     5341 agctgacatt aggcttttat atggtggaaa acatcatagt caatagataa atgagagact
     5401 gacacaaagt gtttgcaaca gatataataa aggactgtaa ttcgtgatat tcaaagtact
     5461 attacaaacc aataataatc tgcaacttag aaaaatggac taatgtccca ttcacaaaag
     5521 atgcaataaa agcagttaat gaaaattatc caatatcact agaaatcaag aaatgcaaat
     5581 taaagtgatt atctactttt tccccaaaag actgactaat cgagtgataa cattcagtat
     5641 tggtgaatgt gtggaaacaa gggaattcca ttgttgatta catatctatt gctttatgta
     5701 tatacccttt gaattaatat tccttggaaa ccaacatata caaaggtaga taaatgtatt
     5761 agtggcaaaa aaattaatgg taaactatta aaacaacaag tgtccatcag ggtaataaat
     5821 aaattaatta tggtatatat ccattcaata ggaattatgc agctgttgaa aaaaaatcaa
     5881 tgtgtgtagt catagaaaga tagctgtgct atactaaatg aaaaattgca gacctgtatt
     5941 gtagtatagg cccataattg tgatatcaaa aataaaaatc aaaatatata ttatagtagg
     6001 catttgtttt tctctgccca gtttcccttg cctcctcctt ttggctgcac tatctcatct
     6061 tttccttttg agtaactggc cataccctac catatgtttt tgatggacgt ggccaataaa
     6121 attgtctctg aatttcaaaa ggcatttgga tctgtgtcat ccaatggcaa ctccctaaaa
     6181 gctgatgcag ttattctttt gattggtcct tggaaccacc ctggtttttg tactttccaa
     6241 gtctgtgatt cctcaaacta cccattgtct ttccggtact tgatttttgc ctcctgttgg
     6301 tcagttgctt gcaagtaaag aaacaatcat acagaatttg gtacgaagat tgggtaatgg
     6361 gcattagaat ctttggaaaa atcaggtatt gggagttgct ttttggatga gatggggcga
     6421 ataagactta tattctagac tggaaagcat ctcatggtgt gcgatgagca aacgcctgat
     6481 tattcattat agtcacctgg gatgaataga ggtctagggt tctggataat gataatttaa
     6541 ggaggatgga gaatgctgaa tccaaaaggt atatgtaata ctggtatcta actgcttgga
     6601 ataacttaaa gtttagctct tgaatttcta gcattaaggc aaaaaaaatt cacctaaggg
     6661 attttgtatg atattgttga aagatgtctt acattgttta aagtcatagg gttaagatgg
     6721 ctcataacca aatttagaga ctatttttat gcattgttaa agtggaatgc tggttaaatt
     6781 ttatacttta ttcacaagag tcactgtgaa ttgaattgtg aattcagttc tgaattgtgt
     6841 tcccaccagc accaccaaat gctggcctct accaccacca aatttacttg ttgaagtcct
     6901 aaaccccaac atgactgtat ttggacataa ggcctttaag aaactaaggt taagttaggc
     6961 cataagagtg aggccctaat cccataggac tagtgtcctt ataagaggaa gagacaccag
     7021 aggtttgtct ctccacatgt gcacagagga aatgctgtgt aaggacacaa caagaatgct
     7081 gccatctgca agccaggagg agagacctca ccaggaacca gccctgccag caccttgatc
     7141 ttggactttt aatctccagg actgtgagaa aataaatgtt ggttgtttaa gcca
//
