LOCUS       NM_001367624           13770 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens zinc finger protein 469 (ZNF469), mRNA.
ACCESSION   NM_001367624 XM_017023785
VERSION     NM_001367624.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13770)
  AUTHORS   Ariyachet,C., Nokkeaw,A., Boonkaew,B. and Tangkijvanich,P.
  TITLE     ZNF469 is a profibrotic regulator of extracellular matrix in
            hepatic stellate cells
  JOURNAL   J Cell Biochem 125 (7), e30578 (2024)
   PUBMED   38704698
  REMARK    GeneRIF: ZNF469 is a profibrotic regulator of extracellular matrix
            in hepatic stellate cells.
REFERENCE   2  (bases 1 to 13770)
  AUTHORS   Wonneberger,W., Sterner,B., MacLean,U., Claesson,M.,
            Johansson,L.H., Skoog,I., Zetterberg,M. and Zettergren,A.
  TITLE     Genetic variants in the FOXO1 and ZNF469 genes are associated with
            keratoconus in Sweden: a case-control study
  JOURNAL   BMC Ophthalmol 24 (1), 36 (2024)
   PUBMED   38267912
  REMARK    GeneRIF: Genetic variants in the FOXO1 and ZNF469 genes are
            associated with keratoconus in Sweden: a case-control study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13770)
  AUTHORS   Garcia de Oteyza,G., Fernandez Engroba,J. and Charoenrook,V.
  TITLE     New ZNF469 Mutations in Spanish Siblings With Brittle Cornea
            Syndrome
  JOURNAL   Cornea 42 (7), 894-898 (2023)
   PUBMED   37098112
  REMARK    GeneRIF: New ZNF469 Mutations in Spanish Siblings With Brittle
            Cornea Syndrome.
REFERENCE   4  (bases 1 to 13770)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 13770)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   6  (bases 1 to 13770)
  AUTHORS   Vitart,V., Bencic,G., Hayward,C., Skunca Herman,J., Huffman,J.,
            Campbell,S., Bucan,K., Navarro,P., Gunjaca,G., Marin,J., Zgaga,L.,
            Kolcic,I., Polasek,O., Kirin,M., Hastie,N.D., Wilson,J.F.,
            Rudan,I., Campbell,H., Vatavuk,Z., Fleck,B. and Wright,A.
  TITLE     New loci associated with central cornea thickness include COL5A1,
            AKAP13 and AVGR8
  JOURNAL   Hum Mol Genet 19 (21), 4304-4311 (2010)
   PUBMED   20719862
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 13770)
  AUTHORS   Khan,A.O., Aldahmesh,M.A., Mohamed,J.N. and Alkuraya,F.S.
  TITLE     Blue sclera with and without corneal fragility (brittle cornea
            syndrome) in a consanguineous family harboring ZNF469 mutation
            (p.E1392X)
  JOURNAL   Arch Ophthalmol 128 (10), 1376-1379 (2010)
   PUBMED   20938016
  REMARK    GeneRIF: ZNF469 mutation may predispose to childhood blue sclera
            without BCS only in certain individuals, depending on other genetic
            and/or environmental conditions
REFERENCE   8  (bases 1 to 13770)
  AUTHORS   Lu,Y., Dimasi,D.P., Hysi,P.G., Hewitt,A.W., Burdon,K.P., Toh,T.,
            Ruddle,J.B., Li,Y.J., Mitchell,P., Healey,P.R., Montgomery,G.W.,
            Hansell,N., Spector,T.D., Martin,N.G., Young,T.L., Hammond,C.J.,
            Macgregor,S., Craig,J.E. and Mackey,D.A.
  TITLE     Common genetic variants near the Brittle Cornea Syndrome locus
            ZNF469 influence the blinding disease risk factor central corneal
            thickness
  JOURNAL   PLoS Genet 6 (5), e1000947 (2010)
   PUBMED   20485516
  REMARK    GeneRIF: Observational study, meta-analysis, and genome-wide
            association study of gene-disease association. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 13770)
  AUTHORS   Christensen,A.E., Knappskog,P.M., Midtbo,M., Gjesdal,C.G.,
            Mengel-From,J., Morling,N., Rodahl,E. and Boman,H.
  TITLE     Brittle cornea syndrome associated with a missense mutation in the
            zinc-finger 469 gene
  JOURNAL   Invest Ophthalmol Vis Sci 51 (1), 47-52 (2010)
   PUBMED   19661234
  REMARK    GeneRIF: The results confirm that BCS (brittle cornea syndrome) is
            associated with mutations in ZNF469.
REFERENCE   10 (bases 1 to 13770)
  AUTHORS   Abu,A., Frydman,M., Marek,D., Pras,E., Nir,U., Reznik-Wolf,H. and
            Pras,E.
  TITLE     Deleterious mutations in the Zinc-Finger 469 gene cause brittle
            cornea syndrome
  JOURNAL   Am J Hum Genet 82 (5), 1217-1222 (2008)
   PUBMED   18452888
  REMARK    GeneRIF: 30% homology to a number of collagens suggests that ZNF469
            could act as a transcription factor involved in the synthesis
            and/or organization of collagen fibers.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC132804.2, AC135049.2 and
            KF456226.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Aug 29, 2019 this sequence version replaced
            XM_017023785.1, NM_001367624.1.
            
            Summary: This gene encodes a zinc-finger protein. Low-percent
            homology to certain collagens suggests that it may function as a
            transcription factor or extra-nuclear regulator factor for the
            synthesis or organization of collagen fibers. Mutations in this
            gene cause brittle cornea syndrome. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151405,
                              SAMEA2157511 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000565624.3/ ENSP00000456500.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               AC132804.2         9984-10279
            297-361             AC135049.2         92725-92789         c
            362-11320           AC135049.2         79293-90251         c
            11321-11633         KF456226.1         1-313
            11634-13770         AC135049.2         76843-78979         c
FEATURES             Location/Qualifiers
     source          1..13770
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.2"
     gene            1..13770
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /note="zinc finger protein 469"
                     /db_xref="GeneID:84627"
                     /db_xref="HGNC:HGNC:23216"
                     /db_xref="MIM:612078"
     exon            1..296
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            297..361
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     exon            362..13770
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /inference="alignment:Splign:2.1.0"
     CDS             488..12349
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /codon_start=1
                     /product="zinc finger protein 469"
                     /protein_id="NP_001354553.1"
                     /db_xref="CCDS:CCDS92205.1"
                     /db_xref="GeneID:84627"
                     /db_xref="HGNC:HGNC:23216"
                     /db_xref="MIM:612078"
                     /translation="MPGERPRGAPPPTMTGDLQPRQVASSPGHPSQPPLEDNTPATRT
                     TKGAREAGGQAQAMELPEAQPRQARDGELKPPSLRGQAPSSTPGKRGSPQTPPGRSPL
                     QAPSRLAGRAEGSPPQRYILGIASSRTKPTLDETPENPQLEAAQLPEVDTPQGPGTGA
                     PLRPGLPRTEAQPAAEELGFHRCFQEPPSSFTSTNYTSPSATPRPPAPGPPQSRGTSP
                     LQPGSYPEYQASGADSWPPAAENSFPGANFGVPPAEPEPIPKGSRPGGSPRGVSFQFP
                     FPALHGASTKPFPADVAGHAFTNGPLVFAFHQPQGAWPEEAVGTGPAYPLPTQPAPSP
                     LPCYQGQPGGLNRHSDLSGALSSPGAAHSAPRPFSDSLHKSLTKILPERPPSAQDGLG
                     STRGPPSSLPQRHFPGQAYRASGVDTSPGPPDTELAAPGPPPARLPQLWDPTAAPYPT
                     PPGGPLAATRSMFFNGQPSPGQRLCLPQSAPLPWPQVLPTARPSPHGMEMLSRLPFPA
                     GGPEWQGGSQGALGTAGKTPGPREKLPAVRSSQGGSPALFTYNGMTDPGAQPLFFGVA
                     QPQVSPHGTPSLPPPRVVGASPSESPLPSPATNTAGSTCSSLSPMSSSPANPSSEESQ
                     LPGPLGPSAFFHPPTHPQETGSPFPSPEPPHSLPTHYQPEPAKAFPFPADGLGAEGAF
                     QCLEETPFPHEGPEVGRGGLQGFPRAPPPYPTHHFSLSSASLDQLDVLLTCRQCDRNY
                     SSLAAFLAHRQFCGLLLARAKDGHQRSPGPPGLPSPPAAPRVPADAHAGLLSHAKTFL
                     LAGDAQAEGKDDPLRTGFLPSLAATPFPLPASDLDMEDDAKLDSLITEALNGMEYQSD
                     NPEIDSSFIDVFADEEPSGPRGPSSGHPLKSKAGVTPESKAPPPLPAATPDPQTPRPG
                     DRGCPARGRPKTRSLGLAPTEADAPSQGRQQRRGKQLKLFRKDLDSGGAAEGSGSGGG
                     GRASGLRPRRNDGLGERPPPRPRRPRTQAPGSRADPAPRVPRAAALPEETRSSRRRRL
                     PPRKDPRKRKARGGAWGKELILKIVQQKNRRHRRLGRRAGRCGSLAAGRPRPGAEDRR
                     LREYDFASESEEDEQPPPRGPGFRGRRGRGEKRKEVELTQGPREDEPQKPRKAARQEA
                     GGDGAPANPEEPGGSRPGPGRSPQARGPSRSLETGAAAREGGPKCADRPSVAPKDPLQ
                     VPTNTETSEETRPSLDFPQEAKEPETAEESAPDSTEFTEALRSPPAACAGEMGASPGL
                     LIPEQPPPSRHDTGTPKPSGSLANTAPHGSSPTPGVGSLLGGPGGTQAPVSHNSKDPP
                     ARQPGEFLAPVANPSSTACPKPSVLSSKISSFGCDPAGFNRDPLGVPVAKKGPQPYSS
                     PHSELFLGPKDLAGCFLEELHPKPSARDAPPASSSCLCQDGEDAGSLEPQLPRSPPGT
                     AETEPGRAASPPTLESSSLFPDLPVDRFDPPLYGSLSANRDSGLPFACADPPQKTVPS
                     DPPYPSFLLLEEVSPMLPSHFPDLSGGKVLSKTCPPERTVVPGAAPSLPGKGSGCSVA
                     LMSHLSEDELEIQKLVTELESQLQRSKDTRGAPRELAEAESVGRVELGTGTEPPSQRR
                     TCQATVPHEDTFSAADLTRVGESTAHREGAESAVATVEAVQGRPGGTWPCPASFHPGH
                     AALLPCAQEDLVSGAPFSPRGANFHFQPVQKAGASKTGLCQAEGDSRPPQDVCLPEPS
                     KQPGPQLDAGSLAKCSPDQELSFPKNKEAASSQESEDSLRLLPCEQRGGFLPEPGTAD
                     QPHRGAPAPEAFGSPAVHLAPDLAFQGDGAPPLDATWPFGASPSHAAQGHSAGRAGGH
                     LHPTAGRPGFEGNEFAPAGASSLTAPRGREAWLVPVPSPACVSNTHPSRRSQDPALSP
                     PIRQLQLPGPGVAKSKDGILGLQELTPAAQSPPRVNPSGLEGGTVEGGKVACGPAQGS
                     PGGVQVTTLPAVAGHQLGLEADGHWGLLGQAEKTQGQGTANQLQPENGVSPGGTDNHA
                     SVNASPKTALTGPTEGAVLLEKCKGSRAAMSLQEEAEPTPSPPSPNRESLALALTAAH
                     SRSGSEGRTPERASSPGLNKPLLATGDSPAPSVGDLAACAPSPTSAAHMPCSLGPLPR
                     EDPLTSPSRAQGGLGGQLPASPSCRDPPGPQQLLACSPAWAPLEEADGVQATTDTGAE
                     DSPVAPPSLTTSPCDPKEALAGCLLQGEGSPLEDPSSWPPGSVSAVTCTHSGDTPKDS
                     TLRIPEDSRKEKLWESPGRATSPPLAGAVSPSVAVRATGLSSTPTGDEAQAGRGLPGP
                     DPQSRGAPPHTNPDRMPRGHSSYSPSNTARLGHREGQAVTAVPTEPPTLQGAGPDSPA
                     CLEGEMGTSSKEPEDPGTPETGRSGATKMPRVTCPSTGLGLGRTTAPSSTASDFQSDS
                     PQSHRNASHQTPQGDPLGPQDLKQRSRGYKKKPASTENGQWKGQAPHGPVTCEVCAAS
                     FRSGPGLSRHKARKHRPHPGAPAEPSPAALPAQQPLEPLAQKCQPPRKKSHRVSGKER
                     PNHSRGDPSHVTQPPPAQGSKEVLRAPGSPHSQQLHPPSPTEHEVDVKTPASKPRPDQ
                     AREDELHPKQAEKREGRRWRREPTVDSPSHSEGKSNKKRGKLRGRRLREESILPVSAD
                     VISDGRGSRPSPAMASYAASPSHCLSVEGGPEADGEQPPRLATLGPGVMEGAAETDQE
                     ALCAGETGAQKPPGDRMLCPGRMDGAALGEQPTGQKGASARGFWGPRETKALGVCKES
                     GSEPAEDSSRAHSRSEEGVWEENTPPLGPLGFPETSSSPADSTTSSCLQGLPDNPDTQ
                     GGVQGPEGPTPDASGSSAKDPPSLFDDEVSFSQLFPPGGRLTRKRNPHVYGKRCEKPV
                     LPLPTQPSFEEGGDPTLGPARLPTDLSDSSSLCLCHEDPWEDEDPAGLPESFLLDGFL
                     NSRVPGIDPWAPGLSLWALEPSREAGAEKLPSHCPEDDRPEAIPELHMVPAAWRGLEM
                     PAPADDSSSSLGDVSPEPPSLERERCDGGLPGNTHLLPLRATDFEVLSTKFEMQDLCF
                     LGPFEDPVGLPGPSFLDFEGTASSQGPQSRRTEEAAGAGRAQGRGRPAKGRRASYKCK
                     VCFQRFRSLGELDLHKLAHTPAPPPTCYMCVERRFGSRELLRGHLQERHAQSKAGPWA
                     CGMCLKEVADVWMYNEHLREHAVRFARRGQARRSLGDLPGGLEGSSAVAHLLNSITEP
                     APKHHRGKRSAGKAAGSPGDPWGQEGEAKKDSPGERAKPRARSTPSNPDGAATPDSAS
                     ATALADAGSPGPPRTTPSPSPDPWAGGEPLLQATPVHEACKDPSRDCHHCGKRFPKPF
                     KLQRHLAVHSPQRVYLCPRCPRVYPEHGELLAHLGGAHGLLERPELQHTPLYACELCA
                     TVMRIIKKSFACSSCNYTFAKKEQFDRHMNKHLRGGRQPFAFRGVRRPGAPGQKARAL
                     EGTLPSKRRRVAMPGSAPGPGEDRPPPRGSSPILSEGSLPALLHLCSEVAPSTTKGWP
                     ETLERPVDPVTHPIRGCELPSNHQECPPPSLSPFPAALADGRGDCALDGALERPENEA
                     SPGSPGPLLQQALPLGASLPRPGARGQDAEGKRAPLVFSGKRRAPGARGRCAPDHFQE
                     DHLLQKEKEVSSSHMVSEGGPRGAFHKGSATKPAGCQSSSKDRSAASTPSKALKFPVH
                     PRKAVGSLAPGELARGTENGMKPATPKAKPGPSSQGSGSPRPGTKTGGGSQPQPASGQ
                     LQSETATTPAKPSFPSRSPAPERLPARAQAKSCTKGPREAGEQGPHGSLGPKEKGESS
                     TKRKKGQVPGPARSESVGSFGRAPSAPDKPPRTPRKQATPSRVLPTKPKPNSQNKPRP
                     PPSEQRKAEPGHTQRKDRLGKAFPQGRPLLRPPKRGTAVHGAEPAEPHTHRTAEAQSD
                     LLSQLFGQRLTGFKIPLKKDASE"
     regulatory      13743..13748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /note="hexamer: AATATA"
     polyA_site      13770
                     /gene="ZNF469"
                     /gene_synonym="BCS; BCS1; Zfp469"
                     /note="major polyA site"
ORIGIN      
        1 agaccccgcg gccgccggcc ggcgtccggc cttcccagca cccggcccag ggctggagct
       61 ggctgcaggg ctggcccgcg gcgacctggg cagggtggcg gctgctccct ctcctcccac
      121 cccgccccga ggcgcagcgc gcggcagagc ggctcggtgc ccggcgggcg ggcggcccgg
      181 gcgggcctgc ggtcgggatg aggacggcgc ctccgctgca gagcgctggg gcggcgcggg
      241 ccgggagctc gttggcggcg gccggcgtgg cgggcggagc gggcctcgga gcggagccaa
      301 gaaattctca ttcctcagga agttgtgcgg cgacccagct gaggggcccc cgactcccca
      361 ggctccactc aggaccatga gcgcaggctt ccctggggcc catcgagggc tgaggatggc
      421 cgtccagccc actccccagg gcccccctcg gacagctgcg tcgtcctagc gccaggacgg
      481 aggggccatg cctggggagc gcccccgagg agcgccgccc cccaccatga ctggagacct
      541 gcagccccgc caagttgcca gcagcccggg gcacccctcc cagccgccac tggaggacaa
      601 caccccagct accaggacca ccaagggtgc cagggaggct ggcggccagg cccaggccat
      661 ggagctcccc gaggcccagc caaggcaggc cagggacggg gagctcaagc ccccatccct
      721 gagaggccag gccccgagca gcacccctgg gaagaggggc agcccccaga ccccaccggg
      781 gagaagcccc ttgcaggctc cctcaaggct ggcgggcagg gcagagggca gccccccaca
      841 gcgctacatt ctgggcatcg ccagctcgag gaccaagccc accctggacg agacaccaga
      901 gaacccacag ctggaggctg cccagctccc tgaggtggac accccccagg gccctgggac
      961 tggagctcca ctcaggccgg gcctcccaag gactgaggcc caacccgccg ccgaagagct
     1021 tggcttccac aggtgcttcc aggagccacc ctccagcttt acctccacca actatacctc
     1081 accaagcgcc acccccaggc ccccagcccc ggggcccccc cagagcaggg gcaccagccc
     1141 cctccagccc ggttcctatc ccgaatacca ggccagtggg gccgactcct ggcctcccgc
     1201 tgctgagaat agcttcccag gtgctaattt cggggttccc cccgccgagc cggaacctat
     1261 tcccaaaggc agcaggcccg gcggcagccc caggggagtt tccttccagt tccccttccc
     1321 ggcactgcat ggggccagca caaaaccctt ccctgcggat gtggctgggc acgcattcac
     1381 caatgggcca ctggtgtttg ccttccatca gccccaggga gcgtggccgg aggaggccgt
     1441 gggcacgggc cctgcctacc cgctgcccac ccagcctgcg ccctcacccc tgccctgcta
     1501 ccagggccag ccaggtggcc tgaaccgcca cagcgacctc agtggtgccc tctcttcccc
     1561 tggagctgct cactcggccc cgagaccctt ctctgacagt ttacacaaga gcctgaccaa
     1621 aatccttccc gaaagaccac cttcagccca ggatgggctg gggagcacga gagggccccc
     1681 tagctcccta ccccagaggc actttccagg gcaggcgtac agagccagtg gggtggacac
     1741 cagcccgggg cctccggaca ccgagctggc cgccccaggg cccccacccg ccaggctgcc
     1801 ccagctgtgg gaccccacag cagcccctta ccccacacct cctgggggcc ccctggctgc
     1861 caccaggagt atgttcttta acggccagcc cagcccaggc cagcggctct gcctccccca
     1921 gagtgccccc ctgccttggc cccaagtgct cccgaccgcc cggccaagtc cccacggaat
     1981 ggagatgctg agccggctgc ctttccccgc ggggggcccc gagtggcagg ggggcagcca
     2041 aggagccctg ggcactgctg gcaagacacc gggacccaga gagaagctgc cagccgtgag
     2101 aagcagccag ggcggctccc cagcactgtt cacctacaac ggaatgacag accctggggc
     2161 tcagcccctg ttcttcgggg tggcccagcc ccaggtttca ccccacggga cacccagcct
     2221 gcccccaccg agggtagtgg gagcctcccc cagcgagtcc ccactgccgt caccggccac
     2281 caacacggcc ggcagcacct gctcttccct gtcgccgatg tccagcagcc cagccaaccc
     2341 cagctcagag gaaagccagc tccccggccc cctcgggccc tcggccttct tccacccacc
     2401 cactcacccc caggagacgg gcagcccctt cccgtccccg gagccccccc actccctccc
     2461 cacccactac cagccagagc cagccaaggc cttccctttt cccgcagatg ggctgggagc
     2521 cgagggtgcc ttccagtgcc tggaggagac cccattcccc cacgagggcc ccgaggtggg
     2581 tcggggaggg ctgcagggct tcccccgtgc gccgcctccg taccccacac accacttctc
     2641 cctcagcagc gccagcctgg accagctgga cgtgctgctg acctgcaggc agtgtgaccg
     2701 caactacagc agcctggcgg ccttcctggc ccaccggcag ttctgtggcc tgctcctggc
     2761 cagggccaag gatggccacc agcggtctcc aggcccccct gggctcccct cgccccccgc
     2821 tgcccccaga gtccctgccg acgcacacgc gggcttgctc agccacgcga agaccttcct
     2881 gttagctggg gacgcccagg ccgagggcaa agacgacccc ctgaggacag gcttcctgcc
     2941 cagcctggcc gccaccccct tcccgctccc tgcctcggac ctggacatgg aggatgacgc
     3001 caagctggac agcctcatca cagaggcgct caacggcatg gagtaccagt cggacaaccc
     3061 ggagatcgac agcagcttca tcgacgtctt cgcggacgag gagccttccg gccccagagg
     3121 tcccagctcc ggacaccccc ttaagagcaa ggcgggggtg actccagaga gcaaagctcc
     3181 gcccccgctc ccagcagcca cgccggaccc ccaaaccccc cgccctgggg acaggggctg
     3241 cccagcccga ggcaggccca aaacgcgttc cctgggtctg gcccccaccg aggcggatgc
     3301 gcccagccag ggcaggcagc agaggagggg gaagcagttg aagctgttcc ggaaggatct
     3361 ggactcgggc ggcgcagcag aggggtcggg gtcgggcggc ggcggcagag cctccggcct
     3421 gaggccccgg aggaacgacg gtctcgggga gcggccccca ccccgtcccc ggcgccctag
     3481 aacgcaggcc cccgggagcc gcgcagaccc cgcgccccgg gtcccgagag ccgccgccct
     3541 ccccgaggag acccgcagct cccggcgccg ccggctgccc cccaggaagg accccaggaa
     3601 gaggaaggct cggggcggcg cctggggcaa ggagctcatt ctgaagatcg tgcagcagaa
     3661 gaacaggcgc caccggcggc tggggcggcg ggcgggcagg tgcggctccc tggcggcggg
     3721 gaggccccgg cccggagctg aggaccgcag gctccgcgag tacgacttcg cctcggagtc
     3781 cgaggaggac gagcagcctc cgccgcgggg ccccggcttc agaggccggc ggggccgagg
     3841 cgagaagagg aaggaagtgg agctgaccca gggtcccaga gaggatgagc cacagaaacc
     3901 ccggaaggcg gcgaggcagg aagccggcgg ggacggagcc cccgcgaacc ccgaggagcc
     3961 gggcgggtct cgcccgggcc ccggcaggag ccctcaggcc cgtggcccgt ctcgaagcct
     4021 ggagacggga gcggccgcca gggagggagg ccccaagtgt gctgatcgcc cctcagtggc
     4081 ccccaaggat cccctgcagg tccccaccaa caccgagacc tcagaggaaa cccgcccgtc
     4141 gctggacttt ccccaggagg ccaaggagcc tgaaactgcc gaagagtcag ccccggacag
     4201 cacagaattc acagaggctt tgcgttctcc tccagccgcc tgtgcgggag aaatgggagc
     4261 aagccccggt ctcctgatac cagagcagcc gccgcccagc agacatgaca ccggcacccc
     4321 caagccgtcg ggaagcctcg ccaacacggc gccccacgga agctcgccaa cgccaggtgt
     4381 gggcagcctg ctgggtggtc ctgggggcac acaggcccca gtctcccaca acagcaagga
     4441 cccccctgcc cgccagcctg gagaatttct ggcacccgtg gctaacccct caagtaccgc
     4501 ctgccccaaa cccagtgttc tgtcttcaaa gatctccagt tttggctgtg accctgctgg
     4561 ttttaacaga gaccccttgg gggttccagt tgccaaaaag gggcctcagc cctacagcag
     4621 cccccacagt gagttgttcc tcggacccaa agacctggct ggctgtttcc tggaagaact
     4681 gcaccccaag ccctcagcca gggatgcccc gccggccagc agctcctgcc tttgccagga
     4741 cggcgaggat gccggttccc tcgagccaca gctgccaagg agcccacctg gcaccgctga
     4801 gacggagcca ggcagggctg catcgccacc gaccttggag tcctcatccc tcttcccaga
     4861 cctgccggtg gacagattcg acccacccct ctatggcagc ctgtctgcga acagggactc
     4921 cggtctgccg ttcgcatgtg ccgaccctcc ccagaagacg gtgccgtcag atccaccgta
     4981 cccctctttt ttgctgcttg aggaagtatc cccgatgctg cctagccatt ttcctgatct
     5041 ctcgggggga aaggtgctca gtaagacgtg tccccctgaa cggacagtgg ttcccggcgc
     5101 cgccccatct ttgcctggga aggggagtgg atgtagcgtt gctcttatga gtcacctgtc
     5161 cgaggatgaa ctggagatcc agaaattggt caccgaatta gaaagtcagc tgcaaaggag
     5221 caaagacaca cgtggggccc cgagagagct tgcagaagct gagtcggtgg gcagggtgga
     5281 gctcggcaca ggcacagagc caccctccca acggcgcacc tgccaggcca ccgtgcccca
     5341 cgaggacacg ttctcggcag ctgacctcac gcgcgttgga gaatccactg cacatcggga
     5401 gggtgcggaa tcggctgtgg ccaccgtgga agcggttcag gggaggcctg gggggacgtg
     5461 gccctgccca gcctccttcc atccgggaca tgcagccctt ctcccctgtg cccaggaaga
     5521 cctggtttct ggggctcctt tcagccccag gggagccaac ttccattttc agccagtgca
     5581 gaaagccgga gcctccaaga ctggactttg ccaggcagaa ggagacagca ggccccccca
     5641 agatgtctgc ctgcctgagc ccagcaagca gcctggccca cagctggatg ccgggagttt
     5701 agcaaagtgc agccccgacc aggaactttc atttcctaag aataaggagg ccgccagctc
     5761 acaagaaagt gaagactccc tgcggctgct tccctgtgaa cagagaggag ggttcctccc
     5821 agagcccggc acagcagacc agccccaccg aggggcccct gctccagaag cttttggcag
     5881 ccctgctgtc catctggccc ctgacttggc atttcagggt gacggggctc cacctctgga
     5941 tgccacctgg ccttttggtg ccagtcccag ccatgctgcc cagggacatt ctgcaggcag
     6001 agcaggtggg cacctccacc ccacggcagg gaggcctggc tttgagggta atgagtttgc
     6061 accggcgggg gcctcctcac tgactgcccc ccggggcagg gaggcttggt tggtccctgt
     6121 gccaagtccc gcctgtgtat ccaacaccca ccctagcagg aggtcccagg acccagcttt
     6181 gagccccccc atacgtcagc tccagctccc agggcctgga gtggctaaga gtaaagatgg
     6241 catcctgggc ttgcaggagc tgacacctgc tgcccagagc cctccacgag tgaacccctc
     6301 aggtctggaa gggggcactg tggaaggagg gaaggtggcc tgtggccccg cccagggctc
     6361 cccagggggt gtgcaggtga caactctccc tgcagtggcc ggacatcagc tggggctgga
     6421 ggcagatgga cattggggct tgcttggcca agccgagaaa acccagggcc aaggcacagc
     6481 caaccagctt cagccagaga acggggtgag cccagggggc acggacaacc acgcctcagt
     6541 caatgccagt cccaaaacag cgctgaccgg ccccaccgag ggtgcagtcc tgctagagaa
     6601 atgcaaggga agcagggcag ccatgagcct tcaggaggag gccgagccca ccccaagccc
     6661 cccgtcccct aatagggagt ccctggcgct ggccttgaca gcagcccaca gccgaagtgg
     6721 atctgagggc cggactccag agagggcgtc cagccccggc ctgaacaagc cactgctggc
     6781 cacaggggat agcccagcac cctctgtcgg ggacctggcc gcctgcgccc cctcacccac
     6841 ttcagccgcc cacatgccct gcagccttgg gcccctgccc cgtgaagacc cacttacctc
     6901 gccttccagg gcccaaggtg ggctgggggg gcagctgcca gcatctccgt cctgcaggga
     6961 ccctcccggc ccccagcagc tgctggcctg ttctcctgcc tgggcacctc tggaagaggc
     7021 agatggcgtc caagccacga cagatactgg ggctgaggat tccccggtgg ctcccccgtc
     7081 tttgacaaca agcccctgcg atcccaagga agccctggct ggttgccttc tccaggggga
     7141 gggcagcccc ctggaagacc cttcctcctg gcctcctggc tccgtcagtg ctgtaacctg
     7201 cactcacagt ggggacaccc ccaaagacag cactttaaga attccagagg attccagaaa
     7261 agagaagctg tgggagtctc ctggccgagc cacctctcct cctctggcag gggccgtctc
     7321 ccccagcgtg gccgtcaggg ctactggcct gtccagcact cccaccggag atgaggcaca
     7381 ggcaggcagg ggactcccag ggccagaccc ccagagcagg ggagccccgc cccacaccaa
     7441 ccctgacagg atgcccaggg gccactcctc gtattctcca agcaatactg cccgcctcgg
     7501 ccacagggag ggccaggctg tcacagctgt gcccactgag cctcccacgc tacagggtgc
     7561 agggccggac tcccccgcct gcctggaagg tgagatgggg accagcagca aggagccgga
     7621 ggacccaggg acccctgaga ccgggcgctc tggtgctacc aagatgccca gggtcacctg
     7681 cccttccaca ggactgggct tgggaagaac cacagcccca agcagcacag ccagtgactt
     7741 ccagtctgac tccccccaaa gccacagaaa tgcctcccac cagactcccc agggggaccc
     7801 cctcggcccc caagacctca aacagaggtc ccgtggctat aaaaagaagc ctgcatctac
     7861 agagaacggc cagtggaagg gccaagctcc acatgggcct gtgacctgtg aggtctgcgc
     7921 agcctccttc cgctccgggc cgggcctgag ccggcacaag gccaggaagc accggccaca
     7981 cccgggagcc cccgcggagc cgagcccagc ggccttgcct gctcagcagc ctctagagcc
     8041 cctagcccaa aagtgccagc cgcccaggaa gaaaagccac agggtgtctg ggaaggagag
     8101 accaaatcac tcacggggag accccagcca cgtcacccag ccaccgcctg cccagggctc
     8161 aaaggaggtt ctcagagcac cggggtcccc acacagccag cagctgcacc ctccaagccc
     8221 tactgagcat gaggtagatg tgaagactcc ggcctccaag cccagaccag accaggccag
     8281 ggaagatgag ctgcatccca aacaggcaga aaaaagagaa ggccggaggt ggcgccgaga
     8341 gcccaccgtg gactctccta gccactcaga ggggaagtca aataagaaaa ggggaaagct
     8401 gagagggaga aggctccggg aggagagcat tcttccagtc tctgctgatg tgatttcaga
     8461 tgggcgcggc tccagaccat cccctgcaat ggccagttac gcagcctctc cgagccactg
     8521 cctctctgtg gaaggagggc ctgaggctga cggggagcag ccgcctcgct tggccactct
     8581 gggacctggg gtgatggagg gtgcagcgga gactgaccag gaggctctgt gtgcagggga
     8641 gactggggcc cagaagccac ctggagatcg gatgctgtgt ccagggagga tggatggtgc
     8701 agctctgggg gaacagccaa ctgggcagaa gggagcctcg gcaagggggt tctggggacc
     8761 aagagagacc aaggcgttgg gtgtgtgcaa agagtctggg agcgagcctg cggaggacag
     8821 cagcagggcc cacagccgat cagaggaagg tgtctgggag gagaacacgc cccccttggg
     8881 ccccctgggt tttcccgaga cttccagctc tccggcggac agcaccacca gcagctgcct
     8941 ccagggcctc ccggacaacc cagacaccca gggtggagtc caggggcctg aaggccccac
     9001 tcctgatgcc tctggctcca gtgccaagga tcctccaagc ttgtttgatg atgaggtctc
     9061 tttctcccag ctcttccctc caggcggtcg cttgactaga aagaggaacc cgcatgtcta
     9121 cgggaagcgc tgtgagaagc cggtgctccc gctgccaacc cagcccagct ttgaggaggg
     9181 cggtgacccc acgctgggcc cagcccgcct gcccacggac ctcagcgact ccagctccct
     9241 ctgcctctgc catgaggacc cgtgggagga cgaggatccc gcaggtctgc ccgagtcctt
     9301 cctcctggat gggttcctca atagcagggt gcctggcatt gacccctggg cccccggcct
     9361 cagcctgtgg gccctggagc ccagcaggga agctggtgca gagaagctgc cctcccactg
     9421 ccccgaggac gatcggccgg aggccattcc tgagctgcac atggtcccag cggcttggcg
     9481 aggcctggag atgccggccc ctgccgatga ctcctcctct tctctcggag atgtgagccc
     9541 cgagcccccc agcctggaga gagaacgctg tgacggtggg cttcccggga acacccacct
     9601 gctgccgctc cgtgccacgg actttgaggt gctcagcacc aagtttgaga tgcaagacct
     9661 gtgctttctg ggaccctttg aagaccccgt gggtctcccc ggccccagct tcttagactt
     9721 cgagggcacg gcgagctcac aggggccaca gagccgaagg acagaggagg ctgcaggggc
     9781 agggagggcc caaggcagag gccggccggc caagggcagg cgggcctcct acaagtgcaa
     9841 agtgtgcttc cagcgcttcc gcagcctggg cgagctggac ctgcacaagc tggcccacac
     9901 gcccgcgccg ccgcccacct gctacatgtg cgtggagcgc aggtttggct cgcgggagct
     9961 gctgcggggg cacctgcagg agaggcacgc gcagagcaag gccgggccct gggcgtgcgg
    10021 catgtgcctg aaggaggtgg ccgacgtctg gatgtacaac gagcacctgc gtgagcacgc
    10081 ggtccgcttc gcccgcaggg ggcaggcgcg gaggtccttg ggggacctgc ccggaggcct
    10141 ggagggcagc agcgctgtcg cccaccttct gaacagcatc acggaacccg cgcccaaaca
    10201 ccacaggggc aagcgctccg ccggcaaggc cgccgggagc ccgggagacc cgtgggggca
    10261 agagggagaa gccaagaaag acagcccggg cgagagggcg aaaccccggg cacgcagcac
    10321 ccccagcaac ccagacgggg ccgcgacccc agacagcgcc tctgccaccg ccctggctga
    10381 cgccggcagc ccgggccccc ccaggacgac ccccagcccg tcccccgacc cctgggccgg
    10441 cggggagccc ctcctgcaag ccaccccggt gcacgaggcc tgcaaggacc cctcccgcga
    10501 ctgccaccac tgcgggaagc gcttccccaa gcccttcaag ctgcagcgcc acctggcggt
    10561 gcacagcccg cagcgcgtct acctgtgccc ccggtgcccc cgggtctacc ccgagcacgg
    10621 ggagctgctg gcacacctgg gcggggcgca cgggctgctg gagcggccgg agctgcagca
    10681 cacgccgctg tatgcctgcg agctctgcgc cacggttatg cgcatcatca agaagtcctt
    10741 cgcctgcagc tcctgcaact acaccttcgc caagaaggag cagttcgacc gccacatgaa
    10801 caagcacctc aggggggggc ggcagccctt cgcgttccgc ggcgtgcgga ggccgggagc
    10861 gccgggacag aaggcccggg ccctcgaggg cacactgccc agcaaacggc gcagggtggc
    10921 catgcccggc agtgcccctg ggcccggcga ggacaggcct cctccccggg gaagcagccc
    10981 catcctgagt gagggctctc tcccggccct gctccacctg tgttcggagg tggctcccag
    11041 caccaccaag ggatggcccg agaccctaga gaggcctgta gaccccgtga cccacccgat
    11101 cagaggttgt gagctgccat ccaaccacca ggagtgtccc ccgccgtctc tgtctccctt
    11161 cccagctgcc ttggctgatg gcagaggaga ctgcgcgctg gacggagccc tggagaggcc
    11221 agagaacgag gcttccccag gcagccccgg gcctcttctc cagcaagctc tccctctggg
    11281 ggcatctctg ccgcggccgg gagccagagg ccaagatgcg gagggaaaga gggctcctct
    11341 cgtgttctca gggaaacgca gggccccggg tgcccgtggc aggtgtgccc ctgaccattt
    11401 ccaggaagac cacctacttc agaaagagaa ggaggtgtcc tcaagccaca tggtgtctga
    11461 gggggggccc cgaggcgcct tccacaaggg cagcgccacc aagcctgcgg gctgccagag
    11521 ctcatcaaag gacaggtcgg cagcatccac ccccagcaaa gcactcaagt tcccagtgca
    11581 cccaaggaag gcggtgggga gcctggcacc cggggagctg gcccgtggca cagagaatgg
    11641 gatgaagccc gccaccccca aagccaaacc cggccccagc tcccagggca gtggaagccc
    11701 tcgccccggc accaagacag gaggtggcag ccagccccag ccagccagcg ggcagctcca
    11761 gagcgagaca gccaccaccc cagccaagcc cagcttcccc agccggagcc ctgcaccaga
    11821 gaggctcccc gctcgagccc aagccaagag ctgcaccaag gggccaaggg aagctggtga
    11881 gcaggggccc cacgggagcc taggtcccaa ggagaaggga gagagcagta cgaagaggaa
    11941 aaagggccag gtcccagggc cagccaggag tgaaagtgtg gggagcttcg ggagagcccc
    12001 ctcagcccct gacaagcccc cccggacccc tcggaagcag gcaactccca gccgcgtgct
    12061 cccgaccaag cccaagccca acagccagaa caaacccagg ccgccaccat cagagcagcg
    12121 gaaggcagag ccgggccaca cacagaggaa ggacagactg ggcaaggcct tcccccaggg
    12181 gagacccctg ctcaggcccc ccaagagggg cacagctgtc cacggtgctg aacctgccga
    12241 gccacacacc caccggacgg ccgaggccca gagtgacctc ctcagccagc tcttcgggca
    12301 gagactaact ggcttcaaaa tccctttaaa gaaagatgct tccgagtaat ttctaggagc
    12361 aagagcctgg gaccggagct gggcgttcct gtctcggcct gcctccttgg ccagctccgg
    12421 ctccctgaga tggtccactc tgtggccact tgacttcttg tgcaactgct caggccttga
    12481 tgtcagagct gaggtggtga tgctttgaac agggcccagg tgggcagcat tccctttctt
    12541 gctggaaggc tgggggtgaa agacggggcc actgcagccc ttttgagacc acacagctgt
    12601 tttcttggta ccaagtactt gaagagacag cagcccatcc cctcagccca cacccctgcg
    12661 ccctgtgggc accgacacca cagaagccaa tgtttggaga tttgcacaac ctcccgttcc
    12721 cccacatgga gaagggaagt aagttgaggc agccgtggga tggtggtagg ttccctctta
    12781 gtcttgctgc tgttgctgga attccaaagt gaccttagaa accacgtggg ggaaggcagt
    12841 gctcactact tagaagggtt gcttctgagc cgcctggtcc cccaagagca caacaggcct
    12901 cctccctctg accacagggt catgcctcct ccctctgacc acagggtcat gccagcctcc
    12961 atttgctctg cgggagaaaa gcccatctct agcacacctt gaccccagga accgggttcc
    13021 cgtatggaac tgggaagaaa ccgcccctgt gccagctccc gcgggccctc ctcgttccct
    13081 cccagcctcc atggccgccc tctagagcct ccctgctgta cggagctctg ggctccgcct
    13141 atttgcaatg ttactctgaa gtttctggtg ctatttttgt gttgtaatgt gaatacaggc
    13201 ttccttgatt ttttttttta atgggggtat tgggtgggac agacggggtc agggaggccc
    13261 caccatggct tgtcgagggc acgggcacct gcatggcggc gctctccctg cctcccctgc
    13321 cgggctgcaa gcctgaggtc tgtgctgcca gacggggatg ctcagggctg gggctgcaga
    13381 gccgctgccc tggccagggc accctcatgc accgacccaa cccaggcctg ggacgcacgt
    13441 gtcctctcac agcgtcgtgc ctgtgaaggt gggtcaaagg gtgagagggc ttccttctca
    13501 cccttctctc cataagtatc ttgaagatcc atggtttgtt ttgctctatt gtttagtttt
    13561 tacttgggtg caatgtgtac gtcaaaagtt tttattttga tatttgaaag agaccaaatc
    13621 aggcccagac cgcctctctg gaaggtgttg taggccattc aaaacgcctc cggagtgtcg
    13681 caaaccaagt gcggaggggc cctgaggttg tactgtaaac atcatagtga cttgtctttt
    13741 caaatatatt cccactattt tcgcagaaaa
//
