LOCUS       NM_001008801            4405 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 468 (ZNF468), transcript variant
            2, mRNA.
ACCESSION   NM_001008801
VERSION     NM_001008801.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Zhu,J., Qiu,X., Jin,X., Nie,X., Ou,S., Wu,G., Shen,J. and Zhang,R.
  TITLE     ZNF468-mediated epigenetic upregulation of VEGF-C facilitates
            lymphangiogenesis and lymphatic metastasis in ESCC via PI3K/Akt and
            ERK1/2 signaling pathways
  JOURNAL   Cell Oncol (Dordr) 47 (5), 1927-1942 (2024)
   PUBMED   39141315
  REMARK    GeneRIF: ZNF468-mediated epigenetic upregulation of VEGF-C
            facilitates lymphangiogenesis and lymphatic metastasis in ESCC via
            PI3K/Akt and ERK1/2 signaling pathways.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Bai,G., Mahati,S., Tulahong,A., Eli,M. and Mao,R.
  TITLE     ZNF468 inhibits irradiation-induced G2/M cell cycle arrest and
            apoptosis by facilitating AURKA transcription in Esophageal
            Squamous Cell Carcinoma
  JOURNAL   Biochem Biophys Res Commun 703, 149687 (2024)
   PUBMED   38368674
  REMARK    GeneRIF: ZNF468 inhibits irradiation-induced G2/M cell cycle arrest
            and apoptosis by facilitating AURKA transcription in Esophageal
            Squamous Cell Carcinoma.
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   Sun,L., Gu,S., Li,N., Zheng,D., Sun,Y., Li,D., Ji,C., Ying,K.,
            Xie,Y. and Mao,Y.
  TITLE     A novel zinc finger gene ZNF468 with two co-expressional splice
            variants, ZNF468.1 and ZNF468.2
  JOURNAL   Biochem Genet 43 (5-6), 271-286 (2005)
   PUBMED   16144304
  REMARK    GeneRIF: 2 splice variants ZNF468.1 and ZNF468.2 contain 11
            C2H2-type zinc finger motifs at their C-termini. They are widely
            expressed in normal human tissues, except in heart and brain, and
            they are also co-expressional.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY442330.1, BC037409.1, AK025501.1 and AC008813.6.
            
            On Nov 23, 2018 this sequence version replaced NM_001008801.1.
            
            Transcript Variant: This variant (2) encodes the longer isoform
            (2).
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR936695.1, SRR1803612.67081.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000595646.6/ ENSP00000470381.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2020              AY442330.1         32-2051
            2021-3796           BC037409.1         1655-3430
            3797-3883           AK025501.1         2465-2551
            3884-4405           AC008813.6         23446-23967
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..4405
                     /gene="ZNF468"
                     /note="zinc finger protein 468"
                     /db_xref="GeneID:90333"
                     /db_xref="HGNC:HGNC:33105"
                     /db_xref="MIM:616841"
     exon            1..48
                     /gene="ZNF468"
                     /inference="alignment:Splign:2.1.0"
     exon            49..136
                     /gene="ZNF468"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1690
                     /gene="ZNF468"
                     /note="isoform 2 is encoded by transcript variant 2; zinc
                     finger protein ZNF468"
                     /codon_start=1
                     /product="zinc finger protein 468 isoform 2"
                     /protein_id="NP_001008801.1"
                     /db_xref="CCDS:CCDS33094.1"
                     /db_xref="GeneID:90333"
                     /db_xref="HGNC:HGNC:33105"
                     /db_xref="MIM:616841"
                     /translation="MALPQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNL
                     VSLDISSKCMLKTLSSTGQGNTEVIHTGTLHRQASHHIGEFCFHEIEKDIHGFEFQWK
                     EDETNGHAAPMTEIKELAGSTGQHDQRHAGNKRIKDQLGSSFHLHLPEPHIFQSEGKI
                     GNQVEKSINNASSVSTSQRICCRPKTHISNKYGNNSLHSSLLTQKWEVHMREKSFECI
                     QSFKSFNCSSLLKKHQIIHLEEKQCKCDVCGKVFNQKRYLACHRRCHTGEKPYKCNEC
                     GKTFGHNSSLFIHKALHTGEKPYECEECDKVFSRKSHLERHKRIHTGEKPYKCKVCDE
                     AFAYNSYLAKHTILHTGEKPYTCNECGKVFNRLSTLARHHRLHTGEKPYKCEECDKVF
                     SRKSHLERHRRIHSGEKPYKCEECCKVFSRKSNLERHRRIHTGEKPYKCKVCDKAFQR
                     DSHLAQHQRVHTGEKPYKCNECGKTFGQTSSLIIHRRLHTGEKPYKCNECGKTFSQMS
                     SLVYHHRLHSGEKP"
     exon            137..263
                     /gene="ZNF468"
                     /inference="alignment:Splign:2.1.0"
     exon            264..4405
                     /gene="ZNF468"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF468"
                     /note="hexamer: AATAAA"
     polyA_site      3790
                     /gene="ZNF468"
                     /note="major polyA site"
     regulatory      3857..3862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF468"
                     /note="hexamer: AATAAA"
     polyA_site      3883
                     /gene="ZNF468"
                     /note="major polyA site"
     regulatory      4331..4336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF468"
                     /note="hexamer: AATACA"
     polyA_site      4352
                     /gene="ZNF468"
     regulatory      4380..4385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF468"
                     /note="hexamer: AATAAA"
     polyA_site      4405
                     /gene="ZNF468"
ORIGIN      
        1 agaccaggaa gtggatcccg tggaatgacg gtcacgccgc ggcgggcgga ttgacttcta
       61 aagactgttg gtacgtgaga aagaaaccca gaagaggaag aggaaagcaa aggagtcagg
      121 gatggctctt cctcagggtc tattgacatt cagggacgtg gccatagaat tctctcagga
      181 ggagtggaaa tgcctggacc ctgctcagag gactttatac agggacgtga tgctggagaa
      241 ttataggaac ctcgtctccc tggatatctc ttccaaatgc atgttgaaga cgttgtcgtc
      301 aacagggcaa ggcaatacag aagtgatcca cacagggaca ttgcacagac aagcaagtca
      361 tcacattgga gaattttgtt tccatgaaat tgagaaagac attcatggct tcgagtttca
      421 gtggaaagaa gatgaaacaa atggccatgc agcacccatg acagaaatca aagagttggc
      481 tggtagtaca ggccaacatg atcaaaggca tgctggaaac aagcgtatta aagatcagct
      541 tggatcaagc tttcatttgc atctgcctga accgcacata tttcagtctg aagggaaaat
      601 tggtaatcaa gttgagaagt ctatcaacaa tgcttcctca gtttcaacat cccaaagaat
      661 ttgttgtagg cccaaaaccc atatttctaa taagtatgga aataattccc tccattcttc
      721 attactcaca caaaaatggg aagtacacat gagagaaaaa tcttttgaat gtatacagag
      781 cttcaaatcc tttaattgca gctcactctt aaaaaaacat cagataattc acttagaaga
      841 gaaacaatgt aaatgtgatg tatgtggcaa ggtctttaat cagaagcgat accttgcctg
      901 ccatcgtaga tgtcacactg gtgagaaacc ttacaagtgt aatgagtgtg gcaagacctt
      961 tggtcataat tcatccctct tcattcacaa agcgcttcat actggagaga aaccttatga
     1021 atgtgaagaa tgtgacaaag ttttcagtcg caaatcacac cttgaaagac ataagaggat
     1081 tcatactgga gagaaaccat acaaatgtaa ggtttgtgat gaggctttcg catataattc
     1141 atatctggca aaacatacta tacttcacac tggagagaaa ccttacacat gtaatgaatg
     1201 tggcaaagtt tttaatcgac tatcaaccct tgcacgccat catagacttc atactggaga
     1261 gaaaccttac aaatgtgaag agtgtgacaa agttttcagt cgcaaatcac accttgaaag
     1321 acataggagg attcatagtg gagagaaacc ttacaaatgt gaagaatgtt gcaaagtttt
     1381 cagtcgcaaa tcaaacctgg aaagacacag gaggattcat actggagaga aaccatacaa
     1441 atgtaaggtt tgtgacaagg ctttccagag ggattcacac ctggcacaac atcagagagt
     1501 tcatactgga gagaaacctt acaagtgtaa tgagtgtggc aagaccttcg gtcagacatc
     1561 atcgcttata atccatcgta ggcttcatac tggagagaaa ccttacaagt gtaatgagtg
     1621 tggcaagacc ttcagtcaga tgtcatccct tgtataccat cataggcttc atagtggaga
     1681 gaagccttaa tagtgtaatg agtgtggcaa gaccttccat cacaattcaa ccctgtaagt
     1741 cataaggcaa ttcatactgg agagaaacct tacaagcata atgaatgtgg caaggttttt
     1801 aatcaaaaag caacctttgc acatcaccat agacttcata ctggagagaa accttacaaa
     1861 tgggaggaat gtgacaaaag ttttcagttg taaatcaaac cttaaaacac ataagaaaat
     1921 tcacattgaa gagaaaccat acagaggtaa ggtttgtgac aaggtttttg catataatgc
     1981 atatctggca aaacatacta gaattcacac tggagagaaa ctcattataa gtgtaatgag
     2041 tgtggcaaga ccgttggtca aaattcacac cttgtaatta aaaggtcaaa attcacacct
     2101 tgtaattcat agtggagaga aaccttacaa gcacaatgaa tgtgacatgg tttttaatca
     2161 acaatcacac cttgcaagtc atcatagact tcatactgca tagaaatctt acaaacgtga
     2221 acaatgtgac aaagttttca ttcacaaatc cagcttcaaa tacataggag aattcacact
     2281 ggagaaaagc catagaaatg taaggtttgt gacaaggctt tcgggaatga ttcacacgtg
     2341 gcaccccata ctagaattca cactggagag aaaccttaca agtgcaatga gtgtggcaaa
     2401 ccctttagtg ggcagtcacc acttattcac catcaagcaa tccatggtat agggaaactt
     2461 gactaatgta atgattgtca caaagttttc agtaatgcta caaccattgc acatcattgg
     2521 agaatccaca gtgaagagat cttacaagtg taataaatgt ggcaaatttt tcagacatcg
     2581 ttcatgcctt gcatttcact ggtgaactca tgctggagag aaaccttata aatgtcatga
     2641 ttgaggcaag gtcttcagtc aagcttcatc ctatgcaaaa cataggagga ttcatacagg
     2701 agagaaacct cacaagtgtg atgattgtgg caaagcgttt acttcacatt cacacctcat
     2761 tagacatcag agaatccatg ctggacagaa atcttacaaa tgtcatcagt gtggaagggt
     2821 cttcagtcca aggtcactcc ttgcagacca tcagacaatt ccttttggag acagttgttt
     2881 caaatgcagt gagtatagca aaccatcaag cattaattga cattagagtc aaatcagcct
     2941 tgacctgagt ttgttgattt aacattgatt tcaagcatta attgccatta aactgtttat
     3001 gttaagagga ttgcactggg ggccatggct catgcctgta attccagcac tttgagaggc
     3061 aaagacaggt aggtcactgg agctcacgag tttgagaaca gcctagccaa cagatgggag
     3121 ctacttttcc cagcctttat tttctttttc ttgttttttt tttgagatgg agtcttgctc
     3181 tgtcgcccag gttggagtgc agtggcacga tctcagctca ctgcaacctc ctcctcccag
     3241 gttcaagcaa ttctcctgcc tcagtctccc aagtagctga cactacagtt gtgtgccacc
     3301 acacctgggt aattttttgt gtttttagta gagactgggt ttcaccgtgt tagccagaat
     3361 ggtctctatc ttctgacttt atgatccacc cgactccacc tcccaaagtg ctgagattac
     3421 aggagtgagc cactgtgcct ggcctgtttt ttgtttcttt aacaaaaagt tatagagact
     3481 tctatgagta ttgtaccgaa tctaaatcac aattgagtat ataatcattg agcgatattc
     3541 atttttccaa tcagtatggg atttatatct atttatacat gtttttaatc attttgatca
     3601 atgtttatag atttcaaggt acaaacctca ctttttatgt ttattcctaa atatttctta
     3661 ctttaagttc tttagcaaat ggaattggtt tttaattttc ttttaaaatt atttattgtt
     3721 aatgtatgga aattcaacta atttttggtg ctgttattct attctgcaaa taaactgaat
     3781 gtgtttgtta gttccagttg cattttggct gactctttgt gattttcttt acagaaggtc
     3841 atgtcatcta caaacaaata aaatttgact tctttctttc tgatttggat gagtttgatt
     3901 tcttttgcta tttcattgtt ctggctagga cagccagtat tgattgaata gaaggggtga
     3961 gagcattctt gcatcatgtg agatcctaca ggaaaagcat tccgttttcc ctgattggtt
     4021 atttctgctg tggtcatttc atggatggtc tttgtattgc tgaggtaaat tttcttctgt
     4081 atctattttg tgtgggattt ctatgatgac ttgatgttga cttttgtgaa atgctttttc
     4141 tccatgtatt gagatgatgt ggttttcatc tttcattgtg ttcaagtggt atatcacatt
     4201 gatttgcttg actatgttga accatccttg catcccagaa ataagtggca cttgcatatc
     4261 tacaatcctt ttaatatcct cttgaataca gttcgctagt acaaggggtc ttcaagaagt
     4321 tcatgaaaaa aatacatatt atgtgaaaat tgcacatgat gtcacatttt ctgcaccaaa
     4381 ataaactggc acaaatctgt tataa
//
