LOCUS       NM_207336               2843 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 467 (ZNF467), transcript variant
            1, mRNA.
ACCESSION   NM_207336
VERSION     NM_207336.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2843)
  AUTHORS   Gluscevic,M., Paradise,C.R., Dudakovic,A., Karperien,M.,
            Dietz,A.B., van Wijnen,A.J. and Deyle,D.R.
  TITLE     Functional expression of ZNF467 and PCBP2 supports adipogenic
            lineage commitment in adipose-derived mesenchymal stem cells
  JOURNAL   Gene 737, 144437 (2020)
   PUBMED   32032745
  REMARK    GeneRIF: demonstrate that PCBP2 and ZNF467 impact adipogenic but
            not osteogenic differentiation, further supporting evidence that
            AMSCs and BMSCs appear to be adapted to their microenvironment
REFERENCE   2  (bases 1 to 2843)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2843)
  AUTHORS   Sanders,Y.Y., Ambalavanan,N., Halloran,B., Zhang,X., Liu,H.,
            Crossman,D.K., Bray,M., Zhang,K., Thannickal,V.J. and Hagood,J.S.
  TITLE     Altered DNA methylation profile in idiopathic pulmonary fibrosis
  JOURNAL   Am J Respir Crit Care Med 186 (6), 525-535 (2012)
   PUBMED   22700861
  REMARK    GeneRIF: ZNF467 gene DNA methylation is importants in the
            pathogenesis of idiopathic pulmonary fibrosis.
REFERENCE   4  (bases 1 to 2843)
  AUTHORS   Quach,J.M., Walker,E.C., Allan,E., Solano,M., Yokoyama,A., Kato,S.,
            Sims,N.A., Gillespie,M.T. and Martin,T.J.
  TITLE     Zinc finger protein 467 is a novel regulator of osteoblast and
            adipocyte commitment
  JOURNAL   J Biol Chem 286 (6), 4186-4198 (2011)
   PUBMED   21123171
REFERENCE   5  (bases 1 to 2843)
  AUTHORS   Saijou,E., Itoh,T., Kim,K.W., Iemura,S., Natsume,T. and Miyajima,A.
  TITLE     Nucleocytoplasmic shuttling of the zinc finger protein EZI Is
            mediated by importin-7-dependent nuclear import and
            CRM1-independent export mechanisms
  JOURNAL   J Biol Chem 282 (44), 32327-32337 (2007)
   PUBMED   17848547
  REMARK    GeneRIF: These results identify EZI as a novel cargo protein for
            importin-7 and demonstrate a nucleocytoplasmic shuttling mechanism
            that is mediated by importin-7-dependent nuclear localization and
            CRM1-independent nuclear export.
REFERENCE   6  (bases 1 to 2843)
  AUTHORS   Nakayama,K., Kim,K.W. and Miyajima,A.
  TITLE     A novel nuclear zinc finger protein EZI enhances nuclear retention
            and transactivation of STAT3
  JOURNAL   EMBO J 21 (22), 6174-6184 (2002)
   PUBMED   12426389
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004877.1, CV575107.1,
            BC052625.1 and BC038972.1.
            
            On Nov 22, 2018 this sequence version replaced NM_207336.2.
            
            Summary: The protein encoded by this gene is a zinc finger protein
            whose function has not yet been elucidated in humans. However, the
            mouse ortholog of this protein enhances adipocyte differentiation
            and suppresses osteoblast differentiation in bone marrow. The mouse
            protein also is a transcription factor for several genes and can
            help recruit histone deacetylase complexes. [provided by RefSeq,
            Aug 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052625.1, ERR279864.124.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302017.4/ ENSP00000304769.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AC004877.1         28775-28883         c
            110-382             CV575107.1         1-273
            383-2662            BC052625.1         1-2280
            2663-2843           BC038972.1         733-913
FEATURES             Location/Qualifiers
     source          1..2843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..2843
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /note="zinc finger protein 467"
                     /db_xref="GeneID:168544"
                     /db_xref="HGNC:HGNC:23154"
                     /db_xref="MIM:614040"
     exon            1..481
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /inference="alignment:Splign:2.1.0"
     exon            482..557
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /inference="alignment:Splign:2.1.0"
     CDS             524..2311
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein EZI"
                     /codon_start=1
                     /product="zinc finger protein 467 isoform 1"
                     /protein_id="NP_997219.1"
                     /db_xref="CCDS:CCDS5899.1"
                     /db_xref="GeneID:168544"
                     /db_xref="HGNC:HGNC:23154"
                     /db_xref="MIM:614040"
                     /translation="MRETLEALSSLGFSVGQPEMAPQSEPREGSHNAQEQMSSSREER
                     ALGVCSGHEAPTPEEGAHTEQAEAPCRGQACSAQKAQPVGTCPGEEWMIRKVKVEDED
                     QEAEEEVEWPQHLSLLPSPFPAPDLGHLAAAYKLEPGAPGALSGLALSGWGPMPEKPY
                     GCGECERRFRDQLTLRLHQRLHRGEGPCACPDCGRSFTQRAHMLLHQRSHRGERPFPC
                     SECDKRFSKKAHLTRHLRTHTGERPYPCAECGKRFSQKIHLGSHQKTHTGERPFPCTE
                     CEKRFRKKTHLIRHQRIHTGERPYQCAQCARSFTHKQHLVRHQRVHQTAGPARPSPDS
                     SASPHSTAPSPTPSFPGPKPFACSDCGLSFGWKKNLATHQCLHRSEGRPFGCDECALG
                     ATVDAPAAKPLASAPGGPGCGPGSDPVVPQRAPSGERSFFCPDCGRGFSHGQHLARHP
                     RVHTGERPFACTQCDRRFGSRPNLVAHSRAHSGARPFACAQCGRRFSRKSHLGRHQAV
                     HTGSRPHACAVCARSFSSKTNLVRHQAIHTGSRPFSCPQCGKSFSRKTHLVRHQLIHG
                     EAAHAAPDAALAAPAWSAPPEVAPPPLFF"
     exon            558..674
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /inference="alignment:Splign:2.1.0"
     exon            675..785
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /inference="alignment:Splign:2.1.0"
     exon            786..2843
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2643..2648
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /note="hexamer: ATTAAA"
     polyA_site      2662
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /note="major polyA site"
     regulatory      2826..2831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
                     /note="hexamer: AATATA"
     polyA_site      2843
                     /gene="ZNF467"
                     /gene_synonym="EZI; Zfp467"
ORIGIN      
        1 cttggcaccc ttccccgcag cccgagtgcc tgtcctcccc agcctcctcg ccctcctcca
       61 ccccctctcc catcaccctc ccctcccctc ccctcccctc ccccgtcctg agctcccact
      121 tccacaccta ctccaggctc ggagccttag gaccatcacc tgcccaccta agcccacggt
      181 gctccctcct gggaccccac tcctgaaacc ccctgcccct gcctccccca gcccggtgcg
      241 ccggggctct ccgcccgctc cctcggtccc tcctcccttg caggcgccgt ttcccggctt
      301 cgactccccg cgcgtctatc cctctcctcc ccgcgaagtt tcggggctgt cagtctgtca
      361 gtctttcagg ccgtcagcac ccgagctgca ggcggcgagc gccattgtga gcagagccgg
      421 cggggcagga ggcccgggcg cctgggtccc cgcggcgcgg gcggagcggc cggccagcca
      481 ggttctgtgg cctgatcccc aggaggagct actctgggtt accatgagag agaccttgga
      541 ggccctcagc tccctgggat tctctgtggg acagccagag atggcccccc aaagtgagcc
      601 cagggaagga tcccataatg cccaggagca gatgtcctct tctagggaag agagagcact
      661 gggggtgtgc tcagggcacg aggcccctac accggaggaa ggtgcccaca cagaacaagc
      721 cgaggctccc tgcagaggcc aggcgtgctc agcacagaag gctcagcctg tgggtacctg
      781 cccaggagag gagtggatga ttcggaaggt gaaggtggag gacgaagatc aggaggcaga
      841 agaggaggtc gaatggcccc agcatctatc gttacttccc agcccctttc ccgcgcctga
      901 cctggggcat ctggctgccg cgtacaaact ggagccaggg gccccggggg cactgagtgg
      961 gctcgcgctg tctgggtggg gtccgatgcc ggagaagccc tacggctgcg gggagtgtga
     1021 gcggcgcttc cgggaccagc tgacgttgcg actgcaccag cggctgcacc ggggcgaggg
     1081 cccctgcgcc tgcccggact gcggccgcag cttcacgcag cgcgcccaca tgctactgca
     1141 tcagcgcagc caccgcggcg agcggccttt cccgtgctcc gagtgcgaca agcgcttcag
     1201 caagaaggcc catctgaccc gccacctgcg cacgcacacg ggcgagcggc cctacccgtg
     1261 cgcggagtgc ggcaagcgct tcagccagaa gatccacctg ggctcgcacc aaaagaccca
     1321 caccggcgag cggcccttcc cctgcacgga atgcgagaag cgctttcgca agaagacgca
     1381 cttgattcgg caccagcgca tccatacggg cgagaggccc taccagtgcg cacagtgcgc
     1441 acgcagcttc acgcacaagc agcacttggt gcggcaccaa agggtgcacc agacggccgg
     1501 cccggccagg ccctctcccg actcgtccgc ttctcctcat tccactgccc cgtccccgac
     1561 cccatccttt cccgggccaa agcctttcgc gtgctccgac tgcggcttga gcttcggctg
     1621 gaaaaagaac ctcgccacgc accagtgtct gcaccgcagc gagggtcgcc cctttgggtg
     1681 cgatgagtgc gcactgggcg ccaccgtgga tgcccccgcc gccaagcccc tggccagcgc
     1741 gcctggcgga ccgggctgcg gcccaggatc cgatcccgtg gtgccccagc gcgccccctc
     1801 gggcgagcgg tccttcttct gcccggactg cgggcgcggc ttctcccatg ggcagcacct
     1861 ggcgcggcac ccgcgcgtgc acacgggcga acggcccttc gcctgcacgc agtgtgaccg
     1921 ccgcttcggc tcgcggccta atctggtcgc ccactccagg gcccacagcg gcgccaggcc
     1981 tttcgcctgc gctcagtgcg gccgccgctt cagccgcaag tcgcacctgg gccgccacca
     2041 ggcggtgcac actggcagcc gcccccacgc ctgcgccgtc tgcgcccgca gcttcagctc
     2101 caaaaccaac ctagtccgcc accaggcgat ccacacaggc tcccgcccct tctcctgccc
     2161 gcagtgcgga aagagcttca gccgcaagac ccacctggtg cggcaccagc tcattcacgg
     2221 cgaagccgcc cacgcggccc cggacgccgc ccttgcggcc ccagcctggt ccgctccccc
     2281 cgaggtggcg ccgcccccgc tcttcttctg agcctagttc tcacgaggac cctttcttgc
     2341 ccacagtttc gagaggcccg tgccatgaga ccgcctgggg tgagcaaggc gacctgggct
     2401 gctgcccgaa ggtttggccg ccgcgggaca cctgtttcct tcccgcagtg tctgcgtccg
     2461 cacagcatac ccagctcgga cctcctagga cagagactca gcgaaccctt gctgggaacc
     2521 gctgagctga agttcttgga aggctcccac ccaggtgccc cgttggaaag cagatatttc
     2581 ccggacccag cgcggcctca accagggcag gaaagagtgg ttatttatgt acttaaagtt
     2641 tcattaaagt taaaatcgga aagttctggg gctgctaaat gaattggggg agggaacacc
     2701 tgactctcct tagccactgt cccacctcca tccacacaca gaccaccccc ctccacttcc
     2761 ccttctgtcc tgggtgagtt acatttagcc agctgctgtt aattggttct cccaaataaa
     2821 aatgtaatat atttattcac taa
//
