LOCUS       NM_021224              10345 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens zinc finger protein 462 (ZNF462), transcript variant
            1, mRNA.
ACCESSION   NM_021224
VERSION     NM_021224.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10345)
  AUTHORS   van der Laan,L., Kleinendorst,L., van Hagen,J.M., Waisfisz,Q. and
            van Haelst,M.M.
  TITLE     Phenotypic spectrum in Weiss-Kruszka syndrome caused by ZNF462
            variants: Three new patients and literature review
  JOURNAL   Eur J Med Genet 71, 104964 (2024)
   PUBMED   39069253
  REMARK    GeneRIF: Phenotypic spectrum in Weiss-Kruszka syndrome caused by
            ZNF462 variants: Three new patients and literature review.
            Review article
REFERENCE   2  (bases 1 to 10345)
  AUTHORS   Brady,L., Ballantyne,M., Duck,J., Fisker,T., Kleefman,R., Li,C.,
            Nfonsam,L., Schultz,L.A., Tarnopolsky,M. and McCready,E.
  TITLE     Further characterization of the 9q31 microdeletion phenotype;
            delineation of a common region of overlap containing ZNF462
  JOURNAL   Mol Genet Genomic Med 11 (3), e2116 (2023)
   PUBMED   36461789
  REMARK    GeneRIF: Further characterization of the 9q31 microdeletion
            phenotype; delineation of a common region of overlap containing
            ZNF462.
REFERENCE   3  (bases 1 to 10345)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 10345)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 10345)
  AUTHORS   Kruszka,P., Hu,T., Hong,S., Signer,R., Cogne,B., Isidor,B.,
            Mazzola,S.E., Giltay,J.C., van Gassen,K.L.I., England,E.M.,
            Pais,L., Ockeloen,C.W., Sanchez-Lara,P.A., Kinning,E., Adams,D.J.,
            Treat,K., Torres-Martinez,W., Bedeschi,M.F., Iascone,M., Blaney,S.,
            Bell,O., Tan,T.Y., Delrue,M.A., Jurgens,J., Barry,B.J., Engle,E.C.,
            Savage,S.K., Fleischer,N., Martinez-Agosto,J.A., Boycott,K.,
            Zackai,E.H. and Muenke,M.
  TITLE     Phenotype delineation of ZNF462 related syndrome
  JOURNAL   Am J Med Genet A 179 (10), 2075-2082 (2019)
   PUBMED   31361404
  REMARK    GeneRIF: a multiple congenital anomaly syndrome associated with
            haploinsufficiency of ZNF462 that has distinct clinical
            characteristics and facial features, is reported.
REFERENCE   6  (bases 1 to 10345)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10345)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 10345)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   9  (bases 1 to 10345)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
REFERENCE   10 (bases 1 to 10345)
  AUTHORS   Kruszka,P.
  TITLE     Weiss-Kruszka Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   31670927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX648965.1, AL512593.9 and
            F13685.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021224.5.
            
            Summary: The protein encoded by this gene belongs to C2H2-type zinc
            finger family of proteins. It contains multiple C2H2-type zinc
            fingers and may be involved in transcriptional regulation.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX648965.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277225.10/ ENSP00000277225.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               BX648965.1         70-509
            441-6067            AL512593.9         46007-51633
            6068-8185           BX648965.1         6137-8254
            8186-10207          AL512593.9         133349-135370
            10208-10345         F13685.1           11-148              c
FEATURES             Location/Qualifiers
     source          1..10345
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.2"
     gene            1..10345
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="zinc finger protein 462"
                     /db_xref="GeneID:58499"
                     /db_xref="HGNC:HGNC:21684"
                     /db_xref="MIM:617371"
     exon            1..190
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            191..440
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..7741
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger PBX1-interacting protein"
                     /codon_start=1
                     /product="zinc finger protein 462 isoform 1"
                     /protein_id="NP_067047.4"
                     /db_xref="CCDS:CCDS35096.1"
                     /db_xref="GeneID:58499"
                     /db_xref="HGNC:HGNC:21684"
                     /db_xref="MIM:617371"
                     /translation="MEVLQCDGCDFRAPSYEDLKAHIQDVHTAFLQPTDVAEDNVNEL
                     RCGSVNASNQTEVEFSSIKDEFAIAEDLSGQNATSLGTGGYYGHSPGYYGQHIAANPK
                     PTNKFFQCKFCVRYFRSKNLLIEHTRKVHGAQAEGSSSGPPVPGSLNYNIMMHEGFGK
                     VFSCQFCTYKSPRRARIIKHQKMYHKNNLKETTAPPPAPAPMPDPVVPPVSLQDPCKE
                     LPAEVVERSILESMVKPLTKSRGNFCCEWCSYQTPRRERWCDHMMKKHRSMVKILSSL
                     RQQQEGTNLPDVPNKSAPSPTSNSTYLTMNAASREIPNTTVSNFRGSMGNSIMRPNSS
                     ASKFSPMSYPQMKPKSPHNSGLVNLTERSRYGMTDMTNSSADLETNSMLNDSSSDEEL
                     NEIDSENGLSAMDHQTSGLSAEQLMGSDGNKLLETKGIPFRRFMNRFQCPFCPFLTMH
                     RRSISRHIENIHLSGKTAVYKCDECPFTCKSSLKLGAHKQCHTGTTSDWDAVNSQSES
                     ISSSLNEGVVSYESSSINGRKSGVMLDPLQQQQPPQPPPPPPPPPPSQPQPLQQPQPP
                     QLQPPHQVPPQPQTQPPPTQQPQPPTQAAPLHPYKCTMCNYSTTTLKGLRVHQQHKHS
                     FCDNLPKFEGQPSSLPLENETDSHPSSSNTVKKSQTSILGLSSKNNFVAKASRKLAND
                     FPLDLSPVKKRTRIDEIASNLQSKINQTKQQEDAVINVEDDEEEEEDNEVEIEVELDR
                     EEEPTEPIIEVPTSFSAQQIWVRDTSEPQKEPNFRNITHDYNATNGAEIELTLSEDEE
                     DYYGSSTNLKDHQVSNTALLNTQTPIYGTEHNSENTDFGDSGRLYYCKHCDFNNKSAR
                     SVSTHYQRMHPYIKFSFRYILDPNDHSAVYRCLECYIDYTNFEDLQQHYGEHHPEAMN
                     VLNFDHSDLIYRCRFCSYTSPNVRSLMPHYQRMHPTVKINNAMIFSSYVVEQQEGLNT
                     ESQTLREILNSAPKNMATSTPVARGGGLPATFNKNTPKTFTPECENQKDPLVNTVVVY
                     DCDVCSFASPNMHSVLVHYQKKHPEEKASYFRIQKTMRMVSVDRGSALSQLSFEVGAP
                     MSPKMSNMGSPPPPQPPPPDLSTELYYCKHCSYSNRSVVGVLVHYQKRHPEIKVTAKY
                     IRQAPPTAAMMRGVEGPQGSPRPPAPIQQLNRSSSERDGPPVENEMFFCQHCDYGNRT
                     VKGVLIHYQKKHRDFKANADVIRQHTATIRSLCDRNQKKPASCVLVSPSNLERDKTKL
                     RALKCRQCSYTSPYFYALRKHIKKDHPALKATVTSIMRWAFLDGLIEAGYHCEWCIYS
                     HTEPNGLLLHYQRRHPEHYVDYTYMATKLWAGPDPSPPSLTMPAEAKTYRCRDCVFEA
                     VSIWDITNHYQAFHPWAMNGDESVLLDIIKEKDAVEKPILSSEELAGPVNCENSIPTP
                     FPEQEAECPEDARLSPEKSLQLASANPAISSTPYQCTVCQSEYNNLHGLLTHYGKKHP
                     GMKVKAADFAQDIDINPGAVYKCRHCPYINTRIHGVLTHYQKRHPSIKVTAEDFVHDV
                     EQSADISQNDVEETSRIFKQGYGAYRCKLCPYTHGTLEKLKIHYEKYHNQPEFDVFSQ
                     SPPKLPVPLEPEMTTEVSPSQVSITEEEVGEEPVSTSHFSTSHLVSHTVFRCQLCKYF
                     CSTRKGIARHYRIKHNNVRAQPEGKNNLFKCALCAYTNPIRKGLAAHYQKRHDIDAYY
                     THCLAASRTISDKPNKVIIPSPPKDDSPQLSEELRRAVEKKKCSLCSFQSFSKKGIVS
                     HYMKRHPGVFPKKQHASKLGGYFTAVYADEHEKPTLMEEEERGNFEKAEVEGEAQEIE
                     WLPFRCIKCFKLSFSTAELLCMHYTDHHSRDLKRDFIILGNGPRLQNSTYQCKHCDSK
                     LQSTAELTSHLNIHNEEFQKRAKRQERRKQLLSKQKYADGAFADFKQERPFGHLEEVP
                     KIKERKVVGYKCKFCVEVHPTLRAICNHLRKHVQYGNVPAVSAAVKGLRSHERSHLAL
                     AMFTREDKYSCQYCSFVSAFRHNLDRHMQTHHGHHKPFRCKLCSFKSSYNSRLKTHIL
                     KAHAGEHAYKCSWCSFSTMTISQLKEHSLKVHGKALTLPRPRIVSLLSSHSHHSSQKA
                     TPAEEVEDSNDSSYSEPPDVQQQLNHYQSAALARNNSRVSPVPLSGAAAGTEQKTEAV
                     LHCEFCEFSSGYIQSIRRHYRDKHGGKKLFKCKDCSFYTGFKSAFTMHVEAGHSAVPE
                     EGPKDLRCPLCLYHTKYKRNMIDHIVLHREERVVPIEVCRSKLSKYLQGVVFRCDKCT
                     FTCSSDESLQQHIEKHNELKPYKCQLCYYETKHTEELDSHLRDEHKVSRNFELVGRVN
                     LDQLEQMKEKMESSSSDDEDKEEEMNSKAEDRELMRFSDHGAALNTEKRFPCEFCGRA
                     FSQGSEWERHVLRHGMALNDTKQVSREEIHPKEIMENSVKMPSIEEKEDDEAIGIDFS
                     LKNETVAICVVTADKSLLENAEAKKE"
     exon            441..6067
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6068..6232
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6233..6336
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6337..6455
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6456..6647
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6648..6915
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            6916..7052
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7053..7276
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7277..7409
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7410..7533
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     exon            7534..10345
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7912..7917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="hexamer: ATTAAA"
     polyA_site      7936
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="major polyA site"
     regulatory      9935..9940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="hexamer: AATAAA"
     polyA_site      9964
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="major polyA site"
     regulatory      10322..10327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="hexamer: AATAAA"
     polyA_site      10345
                     /gene="ZNF462"
                     /gene_synonym="WSKA; Zfp462; ZFPIP"
                     /note="major polyA site"
ORIGIN      
        1 gagtctgagg agccgaggaa ggcagggaag atggcgatcc tccattgctg agacccggca
       61 gaagcacatg agactcccaa acaacttcca caacaataac ccgagcagga agaggagaaa
      121 gagaaagagg ataaggaggc ggtggggctg gagaacccga agcacctccc ggcgccggga
      181 cgcttcttct gttcctaatg tgagaggcta gacccagatc atggaggtgc ttcagtgtga
      241 tggctgtgat ttccgagccc cgtcttatga agatctcaag gcacacattc aggatgtcca
      301 cacggcattt ctgcagccaa ctgatgttgc tgaggacaat gtgaatgagc tacgatgtgg
      361 gtccgtgaat gccagtaatc agacagaggt ggagttttct tctataaagg atgaatttgc
      421 cattgcagaa gatttatcag gtcaaaatgc aacttcattg gggaccggag gttactatgg
      481 ccacagtcca ggatattatg gtcagcatat tgccgctaat cccaaaccaa caaacaagtt
      541 ttttcaatgc aagttctgtg tacgctactt caggtcaaaa aacctcctca tagaacacac
      601 tagaaaggtc catggagctc aagctgaagg gagttcatca ggaccccctg tcccgggatc
      661 cttaaattat aatatcatga tgcacgaggg atttggaaag gtcttctctt gccagttttg
      721 cacatacaag tcaccaagaa gggcaagaat aattaagcat cagaagatgt atcacaaaaa
      781 caatttgaag gagaccactg ctcccccacc tgctcctgct ccaatgccag accctgtggt
      841 tccgcccgta tcactgcagg acccctgcaa ggaactgcca gcagaggttg tggagcgcag
      901 catcttagag tctatggtca agcctttgac caaatctcga ggcaactttt gttgtgagtg
      961 gtgcagctac cagacccccc gccgagaacg ctggtgtgac cacatgatga agaaacaccg
     1021 cagtatggtc aagatccttt ccagtctcag acagcaacaa gaaggaacta atctacctga
     1081 tgtgccgaac aagagtgccc ccagccccac ttccaactcc acctatctga ccatgaatgc
     1141 tgcaagccgg gagataccca atactaccgt ctccaacttc aggggctcca tgggcaactc
     1201 catcatgaga cccaattctt cagcttccaa gttttcgccc atgtcttacc ctcagatgaa
     1261 gccgaagtca cctcacaatt ctggtctagt taacttgaca gagagatccc gttatggaat
     1321 gactgacatg accaattctt ctgctgacct ggaaactaac agcatgctaa atgactctag
     1381 ttctgatgaa gagttaaatg aaatagacag tgagaatggt ttaagtgcta tggatcacca
     1441 gacatcaggc ctgtctgcag agcagctgat gggctcagat ggcaacaaat tattggagac
     1501 caaggggatt ccatttagaa gattcatgaa taggttccag tgcccctttt gtcctttcct
     1561 caccatgcat cgacgtagca tctctcgtca catagaaaac atccacttat ctggaaagac
     1621 agctgtctac aaatgtgacg aatgtccgtt tacttgcaag agctcgttga aacttggggc
     1681 tcacaaacag tgtcacacgg gtacaacgtc agattgggat gctgtgaatt cccagagtga
     1741 aagcatttct tcctcactga atgaaggtgt ggtgtcttat gagagctcaa gcatcaatgg
     1801 tagaaagtca ggagtcatgt tggatccctt gcagcagcaa cagccaccgc agccaccacc
     1861 accgccgccg ccaccaccac catcacagcc acagccactg cagcagccac agccaccaca
     1921 gctgcagcca ccacatcagg tgccacccca gccacaaaca cagccaccac caacgcagca
     1981 gccacagcca cccacacaag ccgcacctct gcacccatac aaatgcacca tgtgtaatta
     2041 ctccaccaca actctgaaag ggctaagagt ccatcagcag cataaacatt cattctgtga
     2101 caacttgcca aaattcgagg ggcagccctc aagcctacca ttggaaaatg agacagacag
     2161 ccacccctct tccagcaaca ctgtgaagaa aagtcagacc tcaattcttg ggttgtcctc
     2221 caagaacaat tttgtagcta aagcctctag gaagctcgcc aatgactttc ctctagattt
     2281 gtcacccgtg aagaagagaa ccaggattga cgagatagca agcaaccttc agagcaaaat
     2341 taaccaaacc aaacagcagg aagatgcagt gatcaatgtt gaggatgatg aagaggaaga
     2401 ggaagacaac gaagtcgaga tagaggttga gttggacagg gaggaagaac cgacagaacc
     2461 catcatagag gttcccactt ccttttctgc ccaacagata tgggtaagag ataccagtga
     2521 gccccagaaa gagcccaact tcagaaacat cacccacgat tacaatgcca ccaatggggc
     2581 tgagattgag ctcacccttt ctgaagatga agaggattat tatggctcct caacaaactt
     2641 gaaagatcac caagtttcca atactgctct gctgaatacc caaactccca tctatgggac
     2701 tgagcacaat agtgaaaaca cagactttgg tgactctgga aggctttact attgtaaaca
     2761 ctgtgacttt aacaacaaat ctgcccggag tgttagcacc cactaccaac gaatgcaccc
     2821 atacattaaa ttcagcttta ggtacatctt ggaccccaat gatcacagtg cagtgtacag
     2881 gtgcctggaa tgctacatcg attacaccaa cttcgaagat ctccagcagc attatggcga
     2941 gcaccaccca gaagccatga atgtactcaa ctttgatcac tcggacctga tctaccggtg
     3001 tcggttttgt tcatacacga gcccgaatgt tagaagcctg atgccacatt accaaagaat
     3061 gcatcccacg gtgaagatca acaacgcgat gatattttca agctatgtcg tggagcagca
     3121 ggaagggctg aatacagaat cccagaccct gagggagatt ctgaattcgg ctcccaagaa
     3181 catggcgact tccacacctg tggctcgtgg tggtggtttg ccagctacgt tcaacaaaaa
     3241 cactcctaag acctttactc ctgaatgtga aaatcagaag gaccctttgg tcaacactgt
     3301 tgttgtttat gattgtgatg tttgttcgtt tgcaagcccc aacatgcatt ctgtcttggt
     3361 tcattatcag aagaaacacc ccgaagaaaa ggcttcctac tttaggatcc agaaaactat
     3421 gcgaatggtg tctgtggaca ggggctctgc cctttctcaa ttatcatttg aggtgggtgc
     3481 tccaatgtct cccaaaatgt ccaacatggg ttccccaccc cccccacaac ccccgccacc
     3541 agacctcagt actgagcttt actactgcaa acactgttcc tacagcaatc ggtcagttgt
     3601 gggagtgctt gtccactacc agaaaagaca cccagaaata aaggttactg ccaaatatat
     3661 cagacaggct cctcccacag ctgcaatgat gagaggggtc gaagggcccc aaggctcccc
     3721 ccggccaccc gcccccatac aacagctgaa ccgaagcagc tctgagagag atggccctcc
     3781 tgtggagaat gagatgttct tttgccagca ctgtgattat gggaaccgga cggtcaaagg
     3841 ggtactcatt cattatcaga agaagcaccg agacttcaag gccaatgcag atgtgatccg
     3901 gcagcatacg gccaccattc gaagcctctg cgaccgaaat cagaagaagc ctgccagctg
     3961 cgtgcttgtc tccccctcta atctggagcg ggacaaaacg aaactccgag cactcaaatg
     4021 taggcagtgc tcatatacct ccccctactt ctatgcactg aggaagcata tcaagaaaga
     4081 ccaccccgcc ctgaaagcca cagtcacgtc catcatgcga tgggcatttc tagatggctt
     4141 gatagaagct ggctaccact gcgagtggtg catctactcc catacggagc ccaacggttt
     4201 gctcctgcat taccaacgga ggcatccaga acactatgtt gattacacct acatggctac
     4261 taaactgtgg gctgggccag acccatcccc tccctctctc acaatgccag ccgaagccaa
     4321 aacctacaga tgcagggact gtgttttcga agctgtttcc atctgggaca tcactaatca
     4381 ctaccaagca ttccacccct gggccatgaa tggtgatgag tcagtgctac tggacatcat
     4441 caaggagaaa gatgctgtgg agaagcccat tctttcatcc gaagagttgg caggccctgt
     4501 gaattgtgaa aacagtatac ccaccccttt cccggagcag gaagctgaat gtccagagga
     4561 tgcaagactg tcccctgaga aaagcctgca gctagcttca gccaaccccg ccatatcctc
     4621 caccccatac cagtgcacgg tatgccaatc tgagtataac aacttgcacg gccttctcac
     4681 tcattatggg aagaagcacc ctggcatgaa agtgaaggct gctgactttg cccaggacat
     4741 tgacatcaac ccaggtgccg tctacaaatg caggcattgc ccatacatca acacccgcat
     4801 ccacggcgta ctgacccact accagaagcg acacccgtcc atcaaggtga ccgctgagga
     4861 ctttgtgcac gacgtagagc agtctgctga catatcccag aatgacgtgg aggagacgag
     4921 caggatcttc aagcaagggt atggcgccta ccggtgcaaa ctgtgtccgt acacacacgg
     4981 cactttggag aaactaaaaa tccactacga gaagtatcac aatcagcctg aatttgatgt
     5041 cttttcccag tcgcccccga agctgccagt ccccctcgag cccgagatga ccactgaagt
     5101 gagcccttcc caagtctcca tcactgagga ggaggtggga gaggagcccg tgtccacttc
     5161 tcacttctct acctcccacc tggtctccca cactgtgttc cggtgccagc tctgcaagta
     5221 cttctgctcc acgaggaagg ggatcgccag gcactaccgc atcaagcaca ataatgtccg
     5281 agcccagcca gaaggcaaga acaacctctt caagtgtgcc ctgtgtgcct acaccaaccc
     5341 catccgcaaa ggtctggcag cccactacca gaagcgccac gacattgatg cgtattacac
     5401 tcactgcttg gcagcctcca ggaccatcag cgacaagccc aacaaagtga tcatcccatc
     5461 cccgcccaag gacgactccc ctcagctgag cgaggaactc cggcgggcag tggagaagaa
     5521 aaagtgctcc ttgtgctctt tccagtcgtt cagcaagaag ggcatcgtgt cccattacat
     5581 gaaacgccac ccaggggtgt tcccaaagaa gcagcacgcc agcaagttgg ggggctactt
     5641 cacggccgtc tatgcagatg agcatgagaa gcccacactg atggaagaag aggagagagg
     5701 caactttgag aaagccgagg tggagggtga agctcaggaa atcgagtggc tcccattccg
     5761 ctgcatcaaa tgcttcaagc tgtcctttag cactgcagag ctgctgtgca tgcattacac
     5821 tgaccaccac agtcgggacc taaagaggga cttcatcatt ctgggcaacg gcccccgctt
     5881 gcagaactcc acctaccagt gtaagcactg tgatagcaaa ctgcaaagca cagccgagct
     5941 gacctcacac ttgaacattc acaatgagga attccagaag cgtgccaaac gtcaggagag
     6001 gaggaaacag cttttgagca agcagaaata tgcagatggt gcttttgcag atttcaaaca
     6061 agagaggcct tttggtcact tagaagaggt gccaaagatc aaggagagga aagtggtggg
     6121 ctacaaatgt aaattctgtg tggaagtgca cccaacgctc cgagccatct gcaatcacct
     6181 ccgaaagcac gtccagtatg gcaatgtccc agctgtgtca gctgctgtga aggggctgcg
     6241 ttctcatgag aggagccacc tggccctggc catgtttacc cgcgaggaca agtacagctg
     6301 ccagtattgc tcgtttgttt ctgctttcag gcacaatttg gatcgccata tgcaaaccca
     6361 ccacggacac cataaaccat tccgatgcaa actctgctcc ttcaagtcct cctataacag
     6421 ccggctgaaa acacatatac tcaaagctca tgctggtgag catgcctaca agtgttcttg
     6481 gtgctcattc tccaccatga caatcagcca gctgaaggaa cactccctca aggtccacgg
     6541 aaaagccctg accctcccca ggccacggat cgtcagtctc ctctcctcac actcccacca
     6601 ctcctcccaa aaagctaccc cggctgaaga agtggaagac tccaatgact catcatattc
     6661 agagccccca gatgttcagc agcagttgaa ccactatcag tcagctgccc tggcaaggaa
     6721 caacagccgt gttagccctg tgcctctttc tggggctgct gctggcactg agcagaaaac
     6781 tgaagccgtg cttcactgcg aattctgtga attctcctcc ggctacatcc agagcatcag
     6841 gcgtcattac cgggacaagc atggtgggaa gaagcttttc aagtgcaaag actgctcctt
     6901 ttacacaggc tttaaatctg cttttactat gcacgtggaa gctgggcact cagcagttcc
     6961 cgaggagggc cccaaagatc ttcgctgtcc tctctgcctc tatcacacca aatacaagcg
     7021 caacatgatt gaccacatcg tgctgcaccg agaagagcgt gttgtcccca ttgaagtttg
     7081 ccggtccaaa ctgtccaaat acttgcaggg agtagttttc cgctgtgata agtgtacctt
     7141 cacctgctcc agtgatgaga gcctccagca acatatagaa aagcacaatg aactgaaacc
     7201 ttacaaatgc cagctctgct actatgagac caagcacacg gaggaactgg acagccacct
     7261 tcgggatgag cataaggtaa gccgtaactt tgagctggtt ggacgggtta acttggatca
     7321 gctggaacag atgaaggaga aaatggagag ctccagcagc gatgatgagg acaaggaaga
     7381 agaaatgaac agcaaggctg aagacagaga gctgatgaga ttttctgacc acggggctgc
     7441 tcttaacact gagaagcgtt ttccatgtga attttgtgga cgggcgtttt cacagggctc
     7501 tgagtgggaa agacatgtgc tgagacacgg catggcattg aatgacacca agcaggtgag
     7561 cagagaagaa atccacccaa aagagatcat ggagaacagt gttaaaatgc cctccataga
     7621 ggaaaaggaa gatgacgagg ccattgggat agacttttcc ctaaagaatg aaacagtagc
     7681 catctgtgta gtaactgccg acaaatctct cctggagaat gcagaggcca aaaaagaatg
     7741 agcgtttggt gaaattctta atcaaacctt acttgaacag tgatgaaaaa gtgggagggc
     7801 tggcttgggc tgagaaggga gggacagaaa agagaagaca gaacaaagct gctttttagg
     7861 actgaacaat ctattttcaa agcactggta cctgtgtgag tgagtatgta aattaaagtt
     7921 atttaaatgg ttggaatatg tggctccttt tccatcacta catcttttct tccggatctt
     7981 catcatggaa gtttcatttg ttgcggaata tggaagcacc tcccaatggt acggtgcacc
     8041 ctgtggtggt cttggacagt atgtggaaac agaagctcca tgacggtaga agacttctca
     8101 ttggggagca actttttgac gcacaacttt tggtgcgttt ttctagtttt aataccttaa
     8161 gctttttcaa gacctaactg cagccgcttt gggaaaaaaa aacaaaaaac aaaaaacaga
     8221 aaacaaaaaa aaaaaaactg ctttgcataa aacagtcacc tgtttcctag tacctcaaac
     8281 ttaaccaagg gaactctctg catttgtcag tactacctgt cgtcgttgtg gttaaatgta
     8341 gagagaactg ctgggcaaga tggtgaatgg agaaaaaaaa agagttttaa agaaaggaac
     8401 acaaattgtg cttaaaatcc ccatgtgggt tttatttctt aaaatactgt gattttttta
     8461 attattttag taaaaaacaa aacaaaaaaa agaaacagac tttaattatt agataactgt
     8521 ttgtgaattg tcatccttta ttccaggtaa gctgtttatt agtgttcaac tataatttag
     8581 aatttggtag attcatgtga gctaatttta aggtgattgt ggagttttgt ttgccacatg
     8641 tttattttct atcaatttga gtgttacaaa cacagcacaa ttcagttttt catatgaatt
     8701 gtttttcgtg tgtgtgttgt tattgttgtt ttaatttcgg ggcaagggag atttagtttt
     8761 ttgtgaatag gaatgttttt attttaaaca tggaaataac aaagaagtta actttctttt
     8821 tttttttttt tttttttttt aatttaacta aagaaccaaa ctttcggcac agctatgcag
     8881 cttgtgggcc agacgaggag gtcctcctca cccttttgtt gcctgtcaaa ttcacgcatt
     8941 atccgtctca taaataattt ctgttaggat tggctggctt ttgtgtgtga ttttaaaatc
     9001 tgtgttttgt ttctgctggc attgtgtttt gttgggggtt ttcatttatt taggggacga
     9061 ggggatgtac tagaatccca tccctttcgt gagagtggac aagaaataac atatcctaca
     9121 aggagcctgg agaactactt tctttctttc tttttttttt tttttttttt tttttaaatc
     9181 tagctgccag ctgctctgtc ccccatatca gctttttcag gagggagcag cttagactaa
     9241 atctaagcct acatttataa tatgttctga ttgtgaacaa agggtttcgt tccaaaaaat
     9301 agaaaagaac ttttcttgaa gcctaggttt tagaagcccg tgtgtgtgtg tgcttggatg
     9361 tgtgtgtgcg tgtatgagtg tgtgtgtgca tgtgtgcacg tgtgaatcct ttggttttca
     9421 tgtttttttt tttttttttt tacttggaag ggttgtggga gggtgggagg gaagaaaggg
     9481 aaggggaatt gctgagatga cagtgtccca cacagcttca aataaaatcc atggaaagat
     9541 gttgcatttg tggaataagt gcttacttga aaagcatgtt cttcttttat tttcttactg
     9601 ttaagaattt ttatttgtag gatgtttgtt ttaatttaat ttttttaagg gatgggggcc
     9661 atcatgtgga aaccagaaaa tggggaaagt gtgaactatc cagacaaaga ttcattttgt
     9721 gtctatattt gtttttaatt ggcctcattt caaatgtatt aaacagttcc atacctggat
     9781 tgggtgtttg taatggttac caaaaaacaa acaaaaaaag aaagaaaaag gaaaaaaaaa
     9841 aagaaaataa ttgtgacatg cttttatcac tactttattt ttcaaataac atgtaaatat
     9901 tgtaatccat tggattttgt tttgctaacc tgttaataaa aatatgggac cattatcctt
     9961 ttaacaaggc tagaatgtca tttttttctt tttcaaacat atacctgata ttttgtggcc
    10021 gcacattttg gatgcattat tataattctg ttgactgtaa tgacatagaa tttacaacat
    10081 tttttgttgt tgtttaattt atacagagga catttttttc agagcttgag agaagaaaat
    10141 aaatagcaaa atgataacct attgactcca gtaatcagtg tttcccaata cttcataaga
    10201 gatagggaga ccctgagtcc ttgaagccaa gggtttaaaa acaaaacaaa aacaaaaaaa
    10261 accacaagta ggttattcaa gttgtttgca acatacattt tgtaatgaaa tgtgagaaat
    10321 taataaagaa tttttttcac atgtg
//
