LOCUS       NM_153257               3955 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 461 (ZNF461), transcript variant
            1, mRNA.
ACCESSION   NM_153257
VERSION     NM_153257.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3955)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3955)
  AUTHORS   Dai,J., Li,Y., Ji,C., Jin,F., Zheng,Z., Wang,X., Sun,X., Xu,X.,
            Gu,S., Xie,Y. and Mao,Y.
  TITLE     Characterization of two novel KRAB-domain-containing zinc finger
            genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4
  JOURNAL   Cytogenet Genome Res 103 (1-2), 74-78 (2003)
   PUBMED   15004467
  REMARK    GeneRIF: Molecular cloning and tissue distribution of ZNF461.
REFERENCE   3  (bases 1 to 3955)
  AUTHORS   Mizutani,T., Yamada,K., Yazawa,T., Okada,T., Minegishi,T. and
            Miyamoto,K.
  TITLE     Cloning and characterization of gonadotropin-inducible ovarian
            transcription factors (GIOT1 and -2) that are novel members of the
            (Cys)(2)-(His)(2)-type zinc finger protein family
  JOURNAL   Mol Endocrinol 15 (10), 1693-1705 (2001)
   PUBMED   11579202
REFERENCE   4  (bases 1 to 3955)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK299370.1, AY329493.1, AB021641.1 and AC074138.5.
            
            On Nov 23, 2018 this sequence version replaced NM_153257.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY329493.1, SRR1803614.97950.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588268.6/ ENSP00000467931.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AK299370.1         5-143
            140-1709            AY329493.1         140-1709
            1710-2426           AK299370.1         1645-2361
            2427-2985           AB021641.1         1472-2030
            2986-3955           AC074138.5         88914-89883         c
FEATURES             Location/Qualifiers
     source          1..3955
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..3955
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /note="zinc finger protein 461"
                     /db_xref="GeneID:92283"
                     /db_xref="HGNC:HGNC:21629"
                     /db_xref="MIM:608640"
     exon            1..148
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     exon            149..237
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     CDS             229..1920
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     gonadotropin-inducible ovary transcription repressor 1;
                     zinc finger protein 28"
                     /codon_start=1
                     /product="zinc finger protein 461 isoform 1"
                     /protein_id="NP_694989.2"
                     /db_xref="CCDS:CCDS54257.1"
                     /db_xref="GeneID:92283"
                     /db_xref="HGNC:HGNC:21629"
                     /db_xref="MIM:608640"
                     /translation="MAHELVMFRDVAIDVSQEEWECLNPAQRNLYKEVMLENYSNLVS
                     LGLSVSKPAVISSLEQGKEPWMVVREETGRWCPGTWKTWGFHNNFLDNNEATDINADL
                     ASRDEPQKLSPKRDIYETELSQWVNMEEFKSHSPERSIFSAIWEGNCHFEQHQGQEEG
                     YFRQLMINHENMPIFSQHTLLTQEFYDREKISECKKCRKIFSYHLFFSHHKRTHSKEL
                     SECKECTEIVNTPCLFKQQTIQNGDKCNECKECWKAFVHCSQLKHLRIHNGEKRYECN
                     ECGKAFNYGSELTLHQRIHTGEKPYECKECGKAFRQRSQLTQHQRLHTGEKPYECKQC
                     GKAFIRGFQLTEHLRLHTGEKPYECKECGKTFRHRSHLTIHQRIHTGEKPYECRECGK
                     AFSYHSSFSHHQKIHSGKKPYECHECGKAFCDGLQLTLHQRIHTGEKPYECKECGKTF
                     RQCSHLKRHQRIHTGEKPHECMICGKAFRLHSHLIQHQRIHTGEKPYECKECGKAFSY
                     HSSFSHHQRIHSGKKPYQCGKAFNHRLQLNLHQTLHTGEKPVRFPLLPPHPSLAS"
     exon            238..364
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     exon            365..460
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     exon            461..529
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     exon            530..3955
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2118..2123
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /note="hexamer: AATAAA"
     polyA_site      2142
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /note="major polyA site"
     polyA_site      3955
                     /gene="ZNF461"
                     /gene_synonym="GIOT-1; GIOT1; HZF28"
                     /note="major polyA site"
ORIGIN      
        1 acttccggta ggagcctcgc aggaatggtc tccgggtaga ggcaggtaag gatgtcccgg
       61 gccggtggag aaggaagagc tgggcgtgtg gcttcgcttg gaatccgaat cagagcttgg
      121 accagagcct tccctgagaa tgctgaagca acaccttctt tggattgagt ttcttccaga
      181 gggaacgaag aagaggatta aataatacat tcaattctaa aataagacat ggcccatgag
      241 ttggtgatgt tcagagatgt ggctatagat gtctctcagg aggaatggga atgcctgaac
      301 ccagcgcaga ggaatttgta caaggaggtg atgttggaga attatagcaa cttggtgtca
      361 cttggacttt ctgtttctaa gccagccgta atctcctcat tggagcaagg gaaggagccc
      421 tggatggttg tgagggaaga gacaggaaga tggtgcccag gtacatggaa aacttgggga
      481 tttcacaata atttcttgga caataatgag gctacagaca taaatgcaga cttggcatcc
      541 agagatgagc cccagaagtt atctccaaaa agggatattt atgaaacaga attatcccag
      601 tgggttaaca tggaagaatt taaaagccat agtcctgaga gatcaatttt cagcgctatc
      661 tgggaaggca actgtcattt tgagcaacat cagggacaag aggagggtta ttttagacaa
      721 cttatgatta accatgaaaa catgcccatt tttagccaac atactttact cactcaagaa
      781 ttttatgata gagagaaaat ctctgaatgt aaaaagtgta gaaaaatctt cagttaccat
      841 ttatttttta gtcaccacaa aagaactcat tctaaagaac tttctgaatg taaagaatgc
      901 acagaaattg ttaatacacc atgccttttt aaacaacaga caattcaaaa tggtgacaaa
      961 tgcaatgagt gtaaagaatg ttggaaggcc tttgttcatt gctcacaact taaacatcta
     1021 agaattcata atggtgaaaa acgctatgaa tgtaacgaat gtgggaaggc ctttaattat
     1081 ggctcagaac ttactctaca tcaaagaatt cacactggtg agaaacctta tgaatgtaaa
     1141 gaatgtggga aggcctttag acagcgatca cagcttactc aacatcagag acttcatact
     1201 ggtgaaaaac cctatgaatg taagcaatgt gggaaggctt ttattcgtgg ctttcaactt
     1261 actgaacacc tgcgactcca tactggagag aaaccttatg aatgtaaaga atgtggaaag
     1321 acttttaggc atcgctcaca tcttactata catcagagaa ttcatactgg tgagaaaccc
     1381 tatgaatgtc gggaatgtgg gaaggccttt agctatcact caagcttctc acaccatcag
     1441 aaaattcatt ctggcaagaa accttatgaa tgtcatgaat gtgggaaggc tttttgtgat
     1501 ggcttacaac taaccctaca tcagaggatt catactggtg agaaacccta tgagtgtaag
     1561 gaatgtggga agacttttag acagtgttca cacctcaaaa gacatcagag aattcatact
     1621 ggtgagaaac ctcatgaatg catgatatgt ggtaaggcct ttagacttca ttcacacctt
     1681 attcaacatc aaagaattca tactggtgag aaaccctatg aatgtaagga atgtgggaag
     1741 gcctttagct atcattcaag cttctcacac catcagagaa ttcattctgg aaagaaacct
     1801 tatcaatgcg ggaaggcgtt taatcataga ttacaactta acttacatca gactcttcat
     1861 actggcgaga agccagtcag gtttcctctc ctccctcccc atcctagtct agcatcatga
     1921 aatttgttga tggaaatata cattgtcttt gttttattta aggaaaaagt tggtaagcca
     1981 ccagtttcat tagtatttat ttatttaaat aatccttgaa aatcaaatgt ttttaagtga
     2041 gaaagtggat aactaaagtg taaattttgg tctcatttta atgctgtttc tgagttattg
     2101 tattaaccat tattgagaat aaattttttt attgagaata aattttctaa aattacatgt
     2161 ttcactgaaa ccagtgaaat atttcactga aacagtgaaa taaaatgaaa acaatttcct
     2221 cccttccctc aaatctctga gataaccagt atgtgtattt cttcttcctt tatgctcaaa
     2281 caacctgtac acagaaagca ttttttgcat gtgtttggag gagcttttac ccccatacag
     2341 acatttgaca gcgtcttgtc cttttcataa taatcatgaa tacttttcca ggtcagtacg
     2401 taaagatgta acccattctt tgtaaggttc agaatatttc tagaatggaa tgtatgtccg
     2461 tattttgggc cattacctac tacagacatt gaagttgttt ctaatgttca cctagaactc
     2521 taattttacc ttcttttgtt tctattgtgc agattcccaa cagtgggatt aaagagtatc
     2581 tggcgtatat attttgacat tacatttatt ttttaaaatc ttctaaattt tttgtttaat
     2641 aaaagcacac attataaaaa ttcaaaaatt accaaaaatg tgaaaattaa ttctccccta
     2701 acatccagtt ctgtagccac tcactttcca cagatgcaac aactgctatc agtttccttt
     2761 tattctaacg ggaatatttc atgtaaattt cataaattct ttggacaaaa gtaggttatt
     2821 cataatatgt gatttattac acattctcat tattagtcca catttggcct acttcatttt
     2881 tttttttttt gagacacacc caggctggag tccagtggtg caatcttggc tcactgcaac
     2941 ctccgccacc caggttaaaa attctcctgc ctcagcctcc tgagtagctg ggactacagg
     3001 catgcgcagc cactatgccc ggccaataag ctatatttat tcttatttga tgtggatgaa
     3061 aattatcaaa attggccagg cttggtggct catgcctgta atcccagcac tttgggaggc
     3121 cgaggcgggc ggatcacgag gtcaggagat cgagaccatc ctggctaaca tggtgaaacc
     3181 ccgtctctac taaaaaaaaa atacaaaaat tagctgggcg tggtggtggg tgcctgtagt
     3241 cccagctact cgggaggctg aggcagaaga atggcgtgaa cctgggagat ggatcttgca
     3301 gtaagctgag atcgcgccac tgcactccag cgtgggcaac acagtgagac tctgtctcaa
     3361 aaagaaaaaa aaaaaagaaa attgtcaaaa cacaaccaat agataatgtt aacatgcatt
     3421 ctaacatgca atttattgga tttagcgaat agaatgtgag tggaagttac ttttggtaga
     3481 actgttggga aaagggcttg tggagtgcct gcataaactg gccataaaaa tatgggacaa
     3541 taagttgtgg aaagccacaa gaggcctctg aggaggaaag cctcctaatt gccatcacgt
     3601 tcctatgacc agagtgtgac ctgctctctt atctataaac actgtgctca aggagaaaga
     3661 cactcctttg aagcattgga atgtggccag atatgctggc ttctagttag gcccactccc
     3721 cacagctgct ctctgataag taaaagaata aatcagtagt taagtttatg ctgcttcagc
     3781 acaaagaaaa tgtacctaaa ctgccattgc ccccctttca ctgtttcacc cctgaacatc
     3841 tgcttcttag atctaagtga ttgtactcaa taaatagtgt ggagaccaga gcttggcgcc
     3901 tttgcagctt ttgatttgct ctggcccctt ggctcccacc tttatgaact cttaa
//
