LOCUS       NM_006635               3850 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 460 (ZNF460), transcript variant
            1, mRNA.
ACCESSION   NM_006635 XM_371199
VERSION     NM_006635.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3850)
  AUTHORS   Shao,X., Zhong,L., Chu,X., Wan,P., Chen,S., Zhou,Z., Zhang,H.,
            Wang,M. and Liu,B.
  TITLE     ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia
            Proliferation Via the NF-kappaB Signaling Pathway
  JOURNAL   Int J Med Sci 20 (4), 520-529 (2023)
   PUBMED   37057209
  REMARK    GeneRIF: ZNF460-regulated COMMD7 Promotes Acute Myeloid Leukemia
            Proliferation Via the NF-kappaB Signaling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3850)
  AUTHORS   An,L. and Liu,Y.
  TITLE     ZNF460 mediates epithelial-mesenchymal transition to promote
            gastric cancer progression by transactivating APOC1 expression
  JOURNAL   Exp Cell Res 422 (2), 113452 (2023)
   PUBMED   36563923
  REMARK    GeneRIF: ZNF460 mediates epithelial-mesenchymal transition to
            promote gastric cancer progression by transactivating APOC1
            expression.
REFERENCE   3  (bases 1 to 3850)
  AUTHORS   Zou,C., Li,X., Lv,X., Wu,S., Song,J., Tang,Z., Luo,H., Wei,H. and
            Ai,Y.
  TITLE     Circular RNA mitochondrial translation optimization 1 homologue
            (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes
            oral squamous cell carcinoma progression through the microRNA
            miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX)
            axis
  JOURNAL   Bioengineered 12 (2), 9585-9597 (2021)
   PUBMED   34738503
  REMARK    GeneRIF: Circular RNA mitochondrial translation optimization 1
            homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460)
            promotes oral squamous cell carcinoma progression through the
            microRNA miR-320a / alpha thalassemia/mental retardation, X-linked
            (ATRX) axis.
REFERENCE   4  (bases 1 to 3850)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 3850)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 3850)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 3850)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   8  (bases 1 to 3850)
  AUTHORS   Dai,J., Li,Y., Ji,C., Jin,F., Zheng,Z., Wang,X., Sun,X., Xu,X.,
            Gu,S., Xie,Y. and Mao,Y.
  TITLE     Characterization of two novel KRAB-domain-containing zinc finger
            genes, ZNF460 and ZNF461, on human chromosome 19q13.1-->q13.4
  JOURNAL   Cytogenet Genome Res 103 (1-2), 74-78 (2003)
   PUBMED   15004467
  REMARK    GeneRIF: Molecular cloning and tissue distribution of ZNF460.
REFERENCE   9  (bases 1 to 3850)
  AUTHORS   Abrink,M., Aveskogh,M. and Hellman,L.
  TITLE     Isolation of cDNA clones for 42 different Kruppel-related zinc
            finger proteins expressed in the human monoblast cell line U-937
  JOURNAL   DNA Cell Biol 14 (2), 125-136 (1995)
   PUBMED   7865130
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA991801.1, BC118625.1, AC005261.2 and AK074582.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006635.3.
            
            Summary: Zinc finger proteins, such as ZNF272, interact with
            nucleic acids and have diverse functions. The zinc finger domain is
            a conserved amino acid sequence motif containing 2 specifically
            positioned cysteines and 2 histidines that are involved in
            coordinating zinc. Kruppel-related proteins form 1 family of zinc
            finger proteins. See ZFP93 (MIM 604749) for additional information
            on zinc finger proteins.[supplied by OMIM, May 2004].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292144.1, SRR1803612.162662.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360338.4/ ENSP00000353491.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               DA991801.1         1-322
            323-2011            BC118625.1         1-1689
            2012-3494           AC005261.2         120007-121489
            3495-3849           AK074582.1         1463-1817
            3850-3850           AC005261.2         121845-121845
FEATURES             Location/Qualifiers
     source          1..3850
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.43"
     gene            1..3850
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /note="zinc finger protein 460"
                     /db_xref="GeneID:10794"
                     /db_xref="HGNC:HGNC:21628"
                     /db_xref="MIM:604755"
     exon            1..352
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /inference="alignment:Splign:2.1.0"
     CDS             323..2011
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 272; zinc finger protein HZF8"
                     /codon_start=1
                     /product="zinc finger protein 460 isoform 1"
                     /protein_id="NP_006626.3"
                     /db_xref="CCDS:CCDS12949.1"
                     /db_xref="GeneID:10794"
                     /db_xref="HGNC:HGNC:21628"
                     /db_xref="MIM:604755"
                     /translation="MAAAWMAPAQESVTFEDVAVTFTQEEWGQLDVTQRALYVEVMLE
                     TCGLLVALGDSTKPETVEPIPSHLALPEEVSLQEQLAQGVPRYSYLGQAMDQDGPSEM
                     QEYFLRPGTDPQSEKLHGKMSLEHEGLATADGICSMMIQNQVSPEDALYGFDSYGPVT
                     DSLIHEGENSYKFEEMFNENCFLVQHEQILPRVKPYDCPECGKAFGKSKHLLQHHIIH
                     TGEKPYKCLECGKDFNRRSHLTRHQRTHNGDKPFVCSECGRTFNRGSHLTRHQRVHSG
                     EKPFVCNECGKAFTYRSNFVLHNKSHNEKKPFACSECGKGFYESTALIQHFIIHTGER
                     PFKCLECGKAFNCRSHLKQHERIHTGEKPFVCSQCGKAFTHYSTYVLHERAHTGEKPF
                     ECKECGKAFSIRKDLIRHFNIHTGEKPYECLQCGKAFTRMSGLTRHQWIHTGEKPYVC
                     IQCGKAFCRTTNLIRHFSIHTGEKPYECVECGKAFNRRSPLTRHQRIHTAEKSHEPIQ
                     SGNVSCESTDLIQHSIIHTESSPVSAVNMETPSIAAHSSSLDINGFIVEETLPL"
     exon            353..479
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /inference="alignment:Splign:2.1.0"
     exon            480..3850
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3067..3072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /note="hexamer: AATAAA"
     polyA_site      3090
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
     polyA_site      3509
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /note="major polyA site"
     regulatory      3820..3825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
                     /note="hexamer: AATAAA"
     polyA_site      3850
                     /gene="ZNF460"
                     /gene_synonym="HZF8; ZNF272"
ORIGIN      
        1 gaaacagtgt ggggcctaga gcgctgggtg ggcgcgttct gcggcctgag cagggacggg
       61 tagtgaagcg gttacgcccc ttcttcgcgt cttggcggga gcctgacgcc ccgcttctcc
      121 cctaacgagg tgtcccaccg gcgcccgccg aggcctaggc ctccgcagcc gccctccgtc
      181 tcctcagccc cgacgctgcg ccttgggcct tgtgcgcatt tttttcgggg gaaaactgag
      241 gctcggagtg cgaaagtcag ccgaggtcgc cccgcccagg acagagaagg gctgtggtcg
      301 gctgatccgc ggcattcccg ggatggcggc ggcgtggatg gctccggcgc aggagtctgt
      361 gaccttcgag gatgtggctg tgacatttac ccaggaggag tgggggcagt tggacgtgac
      421 ccagagggcc ttgtacgtgg aggtgatgct ggagacctgt gggcttctgg tcgcactggg
      481 tgacagcaca aaacctgaga ccgtagagcc tatcccttct catctggcct tgcctgagga
      541 agtctcactc caggaacagc tggcacaggg agtcccaaga tactcctatt tggggcaggc
      601 catggatcaa gatgggccat ctgaaatgca ggaatacttt ttgagaccag ggacagaccc
      661 acagagtgag aaactccatg ggaaaatgag ccttgaacac gaaggtttgg cgacagctga
      721 tggtatttgt tcaatgatga tacagaacca agtctcacca gaagatgctc tctatggatt
      781 tgactcatat ggaccagtta cagattcctt gattcatgaa ggggaaaatt cctataaatt
      841 cgaggaaatg tttaatgaga attgcttcct tgttcagcat gagcagattc tccctcgtgt
      901 gaagccctat gattgcccag aatgtgggaa agccttcggc aagagcaaac acctccttca
      961 gcatcacatc atccatactg gggagaagcc ctataaatgc ctggagtgtg ggaaagactt
     1021 caaccgcagg tcacacctca cacggcacca gcggactcac aatggagata agccctttgt
     1081 gtgcagtgaa tgtggaagga ccttcaatcg cgggtcgcac cttacacggc accagcgggt
     1141 tcacagtgga gagaagcctt ttgtgtgcaa tgaatgtgga aaggccttta cctaccgctc
     1201 caattttgtc ttgcataaca agagccacaa tgagaagaaa cccttcgcat gcagcgaatg
     1261 tggaaaaggc ttttatgaga gtacagccct cattcaacac ttcattatcc atactgggga
     1321 gaggcccttt aagtgccttg agtgtgggaa ggccttcaac tgcaggtcac acctcaagca
     1381 gcatgagcgg attcacactg gtgagaagcc ctttgtgtgc agtcaatgtg gaaaggcctt
     1441 cactcactat tccacctatg tcctgcatga aagagcccac actggagaaa agccttttga
     1501 gtgcaaagaa tgtgggaaag cctttagcat tcgaaaagac ctcattcgac acttcaacat
     1561 ccacactgga gagaagccct atgagtgttt acagtgtgga aaggctttta cccgcatgtc
     1621 agggctcaca aggcaccagt ggattcatac tggagagaag ccgtatgtat gcatccaatg
     1681 tgggaaagcc ttttgtcgga ccacaaacct gattcgacac tttagcatcc acactggaga
     1741 gaagccctat gaatgcgtgg agtgcgggaa ggccttcaac cgcaggtcac ccctcacaag
     1801 gcaccagcgg attcacactg cagagaagtc ccacgaaccc atccagagtg ggaacgtttc
     1861 ttgtgagagc acagatctca ttcaacactc catcatccac actgagagta gcccagtgag
     1921 tgcagtgaat atggaaacgc cttcaattgc cgctcattcc tcctcactcg acatcaacgg
     1981 attcatagtg gaagaaaccc taccattgta acagatgtgg aaagactttt tacgtacact
     2041 tcagtcaaca tccaagaatt cctattagcg aaatagtttt ttaatataac cactgaagaa
     2101 aatctgtggt gagaggaaac atcttaccat ctggtcattc atactgaaga gaaactccat
     2161 aagtatcatc tctgtgggaa aacctgtttt agatcatcat ttgtcatcta aacaattatg
     2221 ttagaaattg acacagccaa gagtcttatt ctacatctga taattcaccc atgaaagaga
     2281 cccagtggtt actgtgcact taggaaaacc ttcagccaca tctttcttat tagtttacag
     2341 tgaaatgtta tctcagggac attcaaacaa aggaggagga gtcataggga agagaaagaa
     2401 atggaagcac agcttctttc agacttccct gacaagccca tggcaatttg tcatcccctc
     2461 cttattttat ttgggagagg gaaatgtttc agaaacaaaa gggcctcatc ccctttattt
     2521 tccctgtgta tacattcact gctgtccagt gctgtagaca aacggtttgt ttgaaaacat
     2581 tttgtgaaag cctgctttgt tccacagcat tgtctccact cttgaggagc agaagcatat
     2641 atctttatga gaaagatgga ggcttgagtt atgaaatact tttacattta aggagataaa
     2701 ggatgtacat atgaatgggc acattttact gcacacttca gacgctttga cttttttaaa
     2761 aaaattgttt ctccgtgtgt ctttaaccac ccagtaccat acttttttct tgatctggat
     2821 ctacttgtca atttcttctt tatttttctg taggatggag atgatattgt agctgtttgt
     2881 acataatgta atccagggag tcctaattct tccctctgat tgtggtttct cagctttttt
     2941 actgctcttt agagagagta aatagttcaa aattcacctc aacaattttc tagaggtcaa
     3001 tttggaacca aaaatgaaat aagacatgta gctaaagtaa gttaaaagat tatgataaac
     3061 tcagaaaata aacacagaga aggaatctca tttttcagtc ttacagaaga ttgtgtgaag
     3121 gctgactata cataaagtga ctggaatttt aacaggtgaa cctgcatatg tatatgcagg
     3181 tagttgtcac catggattga gtccagtcgt agtaattaat atgtttaatc agaatatttt
     3241 ggaatttctc ttttggtatt ctttttgttt cttttattgt ttttaattga caatgtttat
     3301 ggggtttggt gtgatatttc aatacatgtg tgctaagagt aatgatcaaa tcagggtaat
     3361 tagcatatcc atctcaatca tttatcattt ctttgtgttt agaaacattc acagtctgct
     3421 tttctagcta tttgaaaata taaaatgtat tattgccaat tgtactcatt ctgcagtgcc
     3481 acagaacact acaacttatt caaatggaat cttacttgct gtaattttgt atttgttaac
     3541 caatctctat ctgcctctct gctgtccttc ccagcctctg gttaccacca ttctcaacct
     3601 tttatgcttg catatgagta gaaacatgga gtatttctct ttctgtgtct agcttatttc
     3661 acttaatgtc tttcaagctc attcatgttg ctgtgaatga caggtttatt tttcatggct
     3721 gagtagtatt ccattgtgta tatatgccat gttttctttc ttcattcatc tgataatgga
     3781 cacttagact gatttcttag ctattatgaa tagtgcttca ataaacatag gagtgtagat
     3841 ctctctttga
//
