LOCUS       NM_001178089            2383 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens zinc finger protein 454 (ZNF454), transcript variant
            1, mRNA.
ACCESSION   NM_001178089
VERSION     NM_001178089.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Zhu,Q., Wang,J., Zhang,Q., Wang,F., Fang,L., Song,B., Xie,C. and
            Liu,J.
  TITLE     Methylation-driven genes PMPCAP1, SOWAHC and ZNF454 as potential
            prognostic biomarkers in lung squamous cell carcinoma
  JOURNAL   Mol Med Rep 21 (3), 1285-1295 (2020)
   PUBMED   32016477
  REMARK    GeneRIF: Methylationdriven genes PMPCAP1, SOWAHC and ZNF454 as
            potential prognostic biomarkers in lung squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA081954.1, AK292317.1, AK094763.1 and AC104117.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001178089.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.262019.1,
                                           SRR1660805.242661.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000519564.2/ ENSP00000430354.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                DA081954.1         8-32
            26-850              AK292317.1         1-825
            851-2108            AK094763.1         768-2025
            2109-2383           AC104117.2         82168-82442
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..2383
                     /gene="ZNF454"
                     /note="zinc finger protein 454"
                     /db_xref="GeneID:285676"
                     /db_xref="HGNC:HGNC:21200"
     exon            1..247
                     /gene="ZNF454"
                     /inference="alignment:Splign:2.1.0"
     exon            248..387
                     /gene="ZNF454"
                     /inference="alignment:Splign:2.1.0"
     CDS             355..1923
                     /gene="ZNF454"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="zinc finger protein 454 isoform 1"
                     /protein_id="NP_001171560.1"
                     /db_xref="CCDS:CCDS4441.1"
                     /db_xref="GeneID:285676"
                     /db_xref="HGNC:HGNC:21200"
                     /translation="MAVSHLPTMVQESVTFKDVAILFTQEEWGQLSPAQRALYRDVML
                     ENYSNLVSLGLLGPKPDTFSQLEKREVWMPEDTPGGFCLDWMTMPASKKSTVKAEIPE
                     EELDQWTIKERFSSSSHWKCASLLEWQCGGQEISLQRVVLTHPNTPSQECDESGSTMS
                     SSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIKEKRYEC
                     RECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFECNL
                     CGKAFIRNIHLAHHHRIHTGEKPFKCNICEKAFVCRAHLTKHQNIHSGEKPYKCNECG
                     KAFNQSTSFLQHQRIHTGEKPFECNECGKAFRVNSSLTEHQRIHTGEKPYKCNECGKA
                     FRDNSSFARHRKIHTGEKPYRCGLCEKAFRDQSALAQHQRIHTGEKPYTCNICEKAFS
                     DHSALTQHKRIHTREKPYKCKICEKAFIRSTHLTQHQRIHTGEKPYKCNKCGKAFNQT
                     ANLIQHQRHHIGEK"
     exon            388..514
                     /gene="ZNF454"
                     /inference="alignment:Splign:2.1.0"
     exon            515..604
                     /gene="ZNF454"
                     /inference="alignment:Splign:2.1.0"
     exon            605..2383
                     /gene="ZNF454"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggctcccggc tgcagactcc agctcattgt gttctgactg cgatgtggcg cttgcgatct
       61 ctcgccgccg gcagaggctc ctcgaagagc gacacggggc tgaccaggca cggtggtcaa
      121 agccgcagag ggagagcggg agcggtcgtg aggtcgtctg gggagaaggg cggaggcaaa
      181 gccgaggagg tgcgggttgt ggtccattct ggaggacgct gatcgaatgc cccaaacttc
      241 ccggaatcag gtgtgtggac ccttctagcc tgaggagtcc tgcaggtgtg aagctccaca
      301 cctgcctcca tagcactttg cctgtcccta agagggctca tcggagaaga aagaatggct
      361 gtcagccacc tgccaaccat ggtccaggaa tcggtgacct tcaaggatgt ggctatactg
      421 ttcacccagg aagagtgggg gcagctgagc cccgcccaga gggccctgta cagggacgtg
      481 atgctggaga actacagcaa cctggtctca ctgggactct taggacccaa accagatacg
      541 ttttcccagc tagaaaaaag ggaagtgtgg atgccagagg acacccctgg aggcttctgt
      601 cttgactgga tgactatgcc tgccagtaag aaatctactg tcaaggcaga gattcctgaa
      661 gaagaattgg atcaatggac aataaaggaa agattcagta gcagtagtca ctggaagtgt
      721 gctagcctgc tggagtggca atgtggaggc caggagatca gtttgcagcg agtggtactc
      781 actcacccca acaccccatc acaggaatgt gatgaatccg ggagcactat gagctcatct
      841 cttcacagtg atcaaagtca gggatttcaa cctagcaaaa atgcctttga gtgtagtgag
      901 tgtggaaaag tcttctctaa gagttcaact cttaataaac atcagaaaat tcataatgaa
      961 aaaaatgcaa atcagaaaat tcatattaag gagaaaagat atgaatgtag agaatgtggg
     1021 aaagcctttc accagagtac gcaccttatc catcaccaaa gaattcacac tggcgagaaa
     1081 ccctatgaat gtaaggaatg tggcaaggcc ttctcagtga gctcctcact tacgtaccat
     1141 cagaaaattc atactggaga gaagcctttt gaatgcaact tatgtggaaa agcttttatc
     1201 cgaaatatac accttgccca tcatcataga atacatactg gagagaaacc ttttaaatgt
     1261 aacatttgtg aaaaagcctt tgtgtgcagg gcacacctta ccaaacacca gaatatccac
     1321 agtggagaga aaccctataa atgcaatgaa tgtggaaaag cctttaatca gagtacaagt
     1381 ttccttcagc atcagagaat tcacactgga gagaaaccct ttgaatgtaa tgaatgtggg
     1441 aaggccttca gggtgaactc ttcccttact gaacatcaga gaattcatac tggagagaaa
     1501 ccttataaat gtaatgaatg tgggaaagct ttcagggata attcatcctt tgcacgacat
     1561 cggaaaattc acactggaga gaaaccttac agatgtggct tgtgtgagaa agcctttcgg
     1621 gaccaatcag cactagccca acatcagaga attcatactg gggaaaaacc ttatacatgt
     1681 aacatatgtg aaaaagcctt cagtgaccat tcagccctta cccaacataa gagaattcat
     1741 actagggaaa aaccttacaa atgtaaaatc tgtgagaaag cctttatccg aagcactcac
     1801 ctgactcaac atcagaggat tcacacagga gagaaaccct ataaatgtaa taaatgtggg
     1861 aaagctttta accagactgc aaacctcatt cagcatcaga gacatcatat tggagagaag
     1921 tgatatgaat gcagtttgta tggaagacct ttgagactga gtagatgaat tattgaatgt
     1981 gagataatcc gttctagaga ataactatga aagcttgcat caagatagtc actttattta
     2041 ctgagggtca ggtttcacag tgtcatgggg tttgggcatt taagaatggc aaacactcgg
     2101 ctgggcacag tggctcacgt ctgtaatctt tgggagcact ttgggaggcc gaggtgggcg
     2161 gatcacgagg tcaggagatc gagaccatcc tggctaacag ggtgaaaccc catcgctact
     2221 aaaaatataa aaaattaccc gggcatggtg gtgggcgcct gtagtcccag ctactcggga
     2281 ggctgaggca ggagaatggc atgaacccgg gaggcagagg ttgcagtgag ccgagatcgt
     2341 gccactgcac tccagcctgg gcgacagagc aagactcagt ctc
//
