LOCUS       NM_003425               3926 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens zinc finger protein 45 (ZNF45), mRNA.
ACCESSION   NM_003425
VERSION     NM_003425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Giri,A.K., Prasad,G., Bandesh,K., Parekatt,V., Mahajan,A.,
            Banerjee,P., Kauser,Y., Chakraborty,S., Rajashekar,D., Sharma,A.,
            Mathur,S.K., Basu,A., McCarthy,M.I., Tandon,N. and Bharadwaj,D.
  CONSRTM   INDICO
  TITLE     Multifaceted genome-wide study identifies novel regulatory loci in
            SLC22A11 and ZNF45 for body mass index in Indians
  JOURNAL   Mol Genet Genomics 295 (4), 1013-1026 (2020)
   PUBMED   32363570
  REMARK    GeneRIF: our study discovered 3 novel population-specific
            functional genetic variants (rs6913677, rs2078267, rs8100011) in 2
            novel (SLC22A11 and ZNF45) and 1 earlier reported gene (BAI3) for
            BMI in Indians. Our study decodes key genomic loci underlying
            obesity phenotype in Indians that may serve as prospective drug
            targets in future
REFERENCE   3  (bases 1 to 3926)
  AUTHORS   Davis,O.S., Band,G., Pirinen,M., Haworth,C.M., Meaburn,E.L.,
            Kovas,Y., Harlaar,N., Docherty,S.J., Hanscombe,K.B.,
            Trzaskowski,M., Curtis,C.J., Strange,A., Freeman,C., Bellenguez,C.,
            Su,Z., Pearson,R., Vukcevic,D., Langford,C., Deloukas,P., Hunt,S.,
            Gray,E., Dronov,S., Potter,S.C., Tashakkori-Ghanbaria,A.,
            Edkins,S., Bumpstead,S.J., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A., Duncanson,A., Jankowski,J.A., Markus,H.S.,
            Mathew,C.G., Palmer,C.N., Rautanen,A., Sawcer,S.J., Trembath,R.C.,
            Viswanathan,A.C., Wood,N.W., Barroso,I., Peltonen,L., Dale,P.S.,
            Petrill,S.A., Schalkwyk,L.S., Craig,I.W., Lewis,C.M., Price,T.S.,
            Donnelly,P., Plomin,R. and Spencer,C.C.
  CONSRTM   Wellcome Trust Case Control Consortium 2
  TITLE     The correlation between reading and mathematics ability at age
            twelve has a substantial genetic component
  JOURNAL   Nat Commun 5, 4204 (2014)
   PUBMED   25003214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3926)
  AUTHORS   Bonetti,A., Koivisto,K., Pirttila,T., Elovaara,I., Reunanen,M.,
            Laaksonen,M., Ruutiainen,J., Peltonen,L., Rantamaki,T. and
            Tienari,P.J.
  TITLE     A follow-up study of chromosome 19q13 in multiple sclerosis
            susceptibility
  JOURNAL   J Neuroimmunol 208 (1-2), 119-124 (2009)
   PUBMED   19195718
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3926)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   6  (bases 1 to 3926)
  AUTHORS   Shannon,M. and Stubbs,L.
  TITLE     Analysis of homologous XRCC1-linked zinc-finger gene families in
            human and mouse: evidence for orthologous genes
  JOURNAL   Genomics 49 (1), 112-121 (1998)
   PUBMED   9570955
REFERENCE   7  (bases 1 to 3926)
  AUTHORS   Constantinou Deltas,C., Bashiardes,E., Patsalis,P.C.,
            Hadjimarcou,M., Kroisel,P.M., Ioannou,P.A., Roses,A.D. and Lee,J.E.
  TITLE     Complete coding sequence, exon/intron arrangement and chromosome
            location of ZNF45, a KRAB-domain-containing gene
  JOURNAL   Cytogenet Cell Genet 75 (4), 230-233 (1996)
   PUBMED   9067431
REFERENCE   8  (bases 1 to 3926)
  AUTHORS   Constantinou-Deltas,C.D., Gilbert,J., Bartlett,R.J.,
            Herbstreith,M., Roses,A.D. and Lee,J.E.
  TITLE     The identification and characterization of KRAB-domain-containing
            zinc finger proteins
  JOURNAL   Genomics 12 (3), 581-589 (1992)
   PUBMED   1559709
REFERENCE   9  (bases 1 to 3926)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006213.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003425.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.51680.1, AK127739.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269973.10/ ENSP00000269973.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-359               AC006213.1         75373-75731
            360-628             AC006213.1         75961-76229
            629-715             AC006213.1         77965-78051
            716-849             AC006213.1         85197-85330
            850-1009            AC006213.1         86094-86253
            1010-1082           AC006213.1         86345-86417
            1083-1129           AC006213.1         88438-88484
            1130-1256           AC006213.1         90956-91082
            1257-1349           AC006213.1         91693-91785
            1350-3926           AC006213.1         95455-98031
FEATURES             Location/Qualifiers
     source          1..3926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     gene            1..3926
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /note="zinc finger protein 45"
                     /db_xref="GeneID:7596"
                     /db_xref="HGNC:HGNC:13111"
                     /db_xref="MIM:194554"
     exon            1..359
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            360..628
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            629..715
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            716..849
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1009
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1082
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1129
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     CDS             1115..3163
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /note="zinc finger protein 45 (a Kruppel-associated box
                     (KRAB) domain polypeptide); zinc finger protein 13;
                     BRC1744; zinc finger protein KOX5"
                     /codon_start=1
                     /product="zinc finger protein 45"
                     /protein_id="NP_003416.1"
                     /db_xref="CCDS:CCDS12632.1"
                     /db_xref="GeneID:7596"
                     /db_xref="HGNC:HGNC:13111"
                     /db_xref="MIM:194554"
                     /translation="MTKSKEAVTFKDVAVVFSEEELQLLDLAQRKLYRDVMLENFRNV
                     VSVGHQSTPDGLPQLEREEKLWMMKMATQRDNSSGAKNLKEMETLQEVGLRYLPHEEL
                     FCSQIWQQITRELIKYQDSVVNIQRTGCQLEKRDDLHYKDEGFSNQSSHLQVHRVHTG
                     EKPYKGEHCVKSFSWSSHLQINQRAHAGEKPYKCEKCDNAFRRFSSLQAHQRVHSRAK
                     SYTNDASYRSFSQRSHLPHHQRVPTGENPYKYEECGRNVGKSSHCQAPLIVHTGEKPY
                     KCEECGVGFSQRSYLQVHLKVHTGKKPYKCEECGKSFSWRSRLQAHERIHTGEKPYKC
                     NACGKSFSYSSHLNIHCRIHTGEKPYKCEECGKGFSVGSHLQAHQISHTGEKPYKCEE
                     CGKGFCRASNLLDHQRGHTGEKPYQCDACGKGFSRSSDFNIHFRVHTGEKPYKCEECG
                     KGFSQASNLLAHQRGHTGEKPYKCGTCGKGFSRSSDLNVHCRIHTGEKPYKCERCGKA
                     FSQFSSLQVHQRVHTGEKPYQCAECGKGFSVGSQLQAHQRCHTGEKPYQCEECGKGFC
                     RASNFLAHRGVHTGEKPYRCDVCGKRFRQRSYLQAHQRVHTGERPYKCEECGKVFSWS
                     SYLQAHQRVHTGEKPYKCEECGKGFSWSSSLIIHQRVHADDEGDKDFPSSEDSHRKTR
                     "
     exon            1130..1256
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1349
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..3926
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3883..3888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /note="hexamer: ATTAAA"
     polyA_site      3926
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /note="major polyA site"
ORIGIN      
        1 gggcacttcc gcggcaagag gttgagagcg cggccttcat tcctctcgtg gaagtgagtg
       61 agtcctggga ccccgcgacc tgttttaact tttatggttt ggtcgtagga tcagcagggc
      121 tcgcacttcg gtcagcagga aaagacgctg cggcgagcag cggagggcgg agttgaatgg
      181 ctgggcagct gattgcctta ctgtatccgg agctgctgcg ttcggggcgg ttcgggagtc
      241 ccctggttgg aagtggacct gaatggggag gcgtctgagg atctcctggg ctctcagcgg
      301 cccgacccgc cttcccccac ctcccacagc tctgtagctt cctagcggtg taacgttggg
      361 aaaggaggct gttcttggac tatgcctgac ccgtttttta agaaagagtg catcactcaa
      421 caggtggcgt ctggagttat cctctgtgga ttttccagga tctcagacaa gatcgtgcaa
      481 tctcccagcc tcctttcctt cccctgccct gacttctgaa agaatgctgc gggagaggag
      541 gaaggagagc atcctggctt ctggcagcag agccccactg tgacaggacc tagcattcac
      601 cttcctcttc tgttccgagt gcgagaagac ttcagggacc tctgtttcat ggacattatc
      661 atattcttct caagagtacc cagcaagagg tttgcaaaga ggagttattc agtgaaatca
      721 gaatcatacc ctgagagcta caagaactcc atttttcact gtgcagaggc tctctgctga
      781 agggtcaagt ggaatctgga atccagccca tgtttcccca tcatcaagcc atgtgaagct
      841 gcagactcca agcaacagag agacaagatt tagaatactg gctctggtat gaaagctgga
      901 ttcaggtact gttcctgcct cttgacctca ccaagcctca gcttcctcgc ctgttaaatg
      961 gatacaattg tcgtcattat catctgttga gaactcccta aaatgccagc tgagcatagg
     1021 cacagaagtt taggtgtttg gaccaaggtc acacaactga tacaacagta gcttcttcac
     1081 agacttggca cttctccaga aggaggagga caaaatgacg aagtctaagg aggcagtgac
     1141 attcaaggac gtggctgtgg tcttctctga ggaggagctg caactgctgg accttgccca
     1201 gaggaagctg taccgagatg tgatgctgga gaacttcagg aatgtggtct cagtggggca
     1261 tcagtccaca ccagatggcc taccacagtt agagagagaa gaaaagctgt ggatgatgaa
     1321 gatggcaacc cagagagata actcctcagg agccaagaat ctaaaagaga tggagactct
     1381 tcaagaagta ggattaaggt acctgcctca tgaagagctt ttctgctccc agatctggca
     1441 acagattaca agagagttaa tcaagtatca agattctgtg gtaaatattc aaagaacagg
     1501 ctgccagttg gaaaaacgag atgatttgca ctataaagat gagggattca gtaatcagag
     1561 ttcccatctt caagttcaca gagtccacac tggtgaaaaa ccctacaaag gagaacattg
     1621 tgtgaaaagt ttcagctgga gctctcatct tcaaattaac caaagggctc atgcaggaga
     1681 gaagccctac aaatgtgaaa aatgtgataa tgccttccgt cggttttcaa gtcttcaagc
     1741 ccatcagaga gtccacagta gagcaaaatc atacacaaat gatgcaagtt acaggagttt
     1801 tagtcagagg tcacatcttc cccatcatca gagagttccc actggagaga atccatacaa
     1861 atatgaagag tgtgggagga atgttgggaa aagctcacat tgtcaagctc ctctgatagt
     1921 tcatacggga gagaaaccct ataaatgtga ggagtgtggg gtgggcttca gtcagagatc
     1981 atatcttcaa gttcatctga aagttcacac tggaaagaaa ccatataagt gtgaagagtg
     2041 tgggaagagc ttcagttggc gttcacgact gcaggctcat gagcgaatcc acactggcga
     2101 gaaaccatac aaatgcaatg catgtggcaa gagctttagt tacagctcac accttaatat
     2161 tcattgtaga atccacacag gagagaaacc ctataagtgt gaggagtgtg ggaaaggttt
     2221 cagtgtgggt tcacaccttc aggcccatca gataagccac actggagaga agccatacaa
     2281 atgtgaggag tgtgggaaag gcttctgccg ggcctcaaat ctgctggacc atcaaagagg
     2341 ccatactgga gagaaaccgt atcagtgtga tgcatgtggt aagggcttca gtcgtagctc
     2401 agattttaac attcatttta gagtccatac aggggaaaaa ccctataaat gtgaggagtg
     2461 tggcaagggc ttcagccagg cctcaaatct tctggcccat caaagaggcc acactggaga
     2521 gaaaccctac aaatgtggta catgtgggaa gggcttcagt cggagctcag atcttaatgt
     2581 acactgtaga atccacacag gagagaaacc ctataaatgc gagaggtgtg gtaaggcctt
     2641 cagtcagttc tccagccttc aggtgcatca gagagttcac actggagaga aaccatatca
     2701 gtgtgcagag tgtgggaagg gcttcagtgt aggttcacag cttcaagccc atcagaggtg
     2761 ccacactgga gagaaaccct atcaatgtga ggagtgtggg aagggcttct gtcgggcctc
     2821 caattttctg gcacatcgtg gagtccacac aggagaaaaa ccataccgat gtgatgtgtg
     2881 tggtaagcgc ttcagacaga gatcctacct tcaagcccac cagagggtcc acacaggaga
     2941 gagaccatac aaatgtgagg aatgtgggaa agtcttcagc tggagctcat accttcaagc
     3001 ccatcaaaga gttcacaccg gagaaaaacc atacaaatgt gaggagtgtg ggaagggctt
     3061 cagttggagc tcaagtctta tcattcatca gcgagtccat gctgatgatg agggtgacaa
     3121 ggactttcct tcatcagagg attcacacag gaaaactcga taaaatatgt tttactatct
     3181 cagatgggtg ctgaaatatt ttaataatca gagctatcat agacaaaaca tttgttttat
     3241 agagtcagta gttcagccaa gtgattggga gaccacacag cagagaagcc tcacaagagt
     3301 ggagacatat ggactgcatt cagaacattg accattagct gatacatgca gacaagagga
     3361 tcaggaagga tgagtctgat ctggagtaaa tcagaagtac taagatagaa atgctgaatt
     3421 ctgttccact agaatataag atccaagagg gcagggactt tgttgactgc caaatctact
     3481 ctgccttttc agtgcctaat acgttgtaat ttttcagtag tatttgaaat tactgtcata
     3541 tttgaaattc agtaatattt gacattttta tttatctcta gaagtttctc taaaattgta
     3601 ctcagaagaa ttctgcaagg cttggaggat atataagtta gtcatatggc ctgattttcc
     3661 catttttgca gatctcgtgg acaagtgttt atcaaactga aggttgcagc ttgttagtgg
     3721 gttcagaaat cagtttctgg ctagcaacta gaagttttgt atgttaacag tactttattg
     3781 aggtgtaatc tgcatgcagt aacatgcaca agtctcaagt tcatggcttt ctgaattttg
     3841 acaaatgtaa tcatcaccaa gatcaatgta tacaatatgt ctattaaacc aaaaagtttt
     3901 cttgtgccca tttccagtca atccca
//
