LOCUS       NP_003416                682 aa            linear   PRI 27-APR-2025
DEFINITION  zinc finger protein 45 [Homo sapiens].
ACCESSION   NP_003416
VERSION     NP_003416.1
DBSOURCE    REFSEQ: accession NM_003425.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 682)
  AUTHORS   Lovering,R.C., Gaudet,P., Acencio,M.L., Ignatchenko,A., Jolma,A.,
            Fornes,O., Kuiper,M., Kulakovskiy,I.V., Laegreid,A., Martin,M.J.
            and Logie,C.
  TITLE     A GO catalogue of human DNA-binding transcription factors
  JOURNAL   Biochim Biophys Acta Gene Regul Mech 1864 (11-12), 194765 (2021)
   PUBMED   34673265
REFERENCE   2  (residues 1 to 682)
  AUTHORS   Giri,A.K., Prasad,G., Bandesh,K., Parekatt,V., Mahajan,A.,
            Banerjee,P., Kauser,Y., Chakraborty,S., Rajashekar,D., Sharma,A.,
            Mathur,S.K., Basu,A., McCarthy,M.I., Tandon,N. and Bharadwaj,D.
  CONSRTM   INDICO
  TITLE     Multifaceted genome-wide study identifies novel regulatory loci in
            SLC22A11 and ZNF45 for body mass index in Indians
  JOURNAL   Mol Genet Genomics 295 (4), 1013-1026 (2020)
   PUBMED   32363570
  REMARK    GeneRIF: our study discovered 3 novel population-specific
            functional genetic variants (rs6913677, rs2078267, rs8100011) in 2
            novel (SLC22A11 and ZNF45) and 1 earlier reported gene (BAI3) for
            BMI in Indians. Our study decodes key genomic loci underlying
            obesity phenotype in Indians that may serve as prospective drug
            targets in future
REFERENCE   3  (residues 1 to 682)
  AUTHORS   Davis,O.S., Band,G., Pirinen,M., Haworth,C.M., Meaburn,E.L.,
            Kovas,Y., Harlaar,N., Docherty,S.J., Hanscombe,K.B.,
            Trzaskowski,M., Curtis,C.J., Strange,A., Freeman,C., Bellenguez,C.,
            Su,Z., Pearson,R., Vukcevic,D., Langford,C., Deloukas,P., Hunt,S.,
            Gray,E., Dronov,S., Potter,S.C., Tashakkori-Ghanbaria,A.,
            Edkins,S., Bumpstead,S.J., Blackwell,J.M., Bramon,E., Brown,M.A.,
            Casas,J.P., Corvin,A., Duncanson,A., Jankowski,J.A., Markus,H.S.,
            Mathew,C.G., Palmer,C.N., Rautanen,A., Sawcer,S.J., Trembath,R.C.,
            Viswanathan,A.C., Wood,N.W., Barroso,I., Peltonen,L., Dale,P.S.,
            Petrill,S.A., Schalkwyk,L.S., Craig,I.W., Lewis,C.M., Price,T.S.,
            Donnelly,P., Plomin,R. and Spencer,C.C.
  CONSRTM   Wellcome Trust Case Control Consortium 2
  TITLE     The correlation between reading and mathematics ability at age
            twelve has a substantial genetic component
  JOURNAL   Nat Commun 5, 4204 (2014)
   PUBMED   25003214
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 682)
  AUTHORS   Bonetti,A., Koivisto,K., Pirttila,T., Elovaara,I., Reunanen,M.,
            Laaksonen,M., Ruutiainen,J., Peltonen,L., Rantamaki,T. and
            Tienari,P.J.
  TITLE     A follow-up study of chromosome 19q13 in multiple sclerosis
            susceptibility
  JOURNAL   J Neuroimmunol 208 (1-2), 119-124 (2009)
   PUBMED   19195718
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 682)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   6  (residues 1 to 682)
  AUTHORS   Shannon,M. and Stubbs,L.
  TITLE     Analysis of homologous XRCC1-linked zinc-finger gene families in
            human and mouse: evidence for orthologous genes
  JOURNAL   Genomics 49 (1), 112-121 (1998)
   PUBMED   9570955
REFERENCE   7  (residues 1 to 682)
  AUTHORS   Constantinou Deltas,C., Bashiardes,E., Patsalis,P.C.,
            Hadjimarcou,M., Kroisel,P.M., Ioannou,P.A., Roses,A.D. and Lee,J.E.
  TITLE     Complete coding sequence, exon/intron arrangement and chromosome
            location of ZNF45, a KRAB-domain-containing gene
  JOURNAL   Cytogenet Cell Genet 75 (4), 230-233 (1996)
   PUBMED   9067431
REFERENCE   8  (residues 1 to 682)
  AUTHORS   Constantinou-Deltas,C.D., Gilbert,J., Bartlett,R.J.,
            Herbstreith,M., Roses,A.D. and Lee,J.E.
  TITLE     The identification and characterization of KRAB-domain-containing
            zinc finger proteins
  JOURNAL   Genomics 12 (3), 581-589 (1992)
   PUBMED   1559709
REFERENCE   9  (residues 1 to 682)
  AUTHORS   Thiesen,H.J.
  TITLE     Multiple genes encoding zinc finger domains are expressed in human
            T cells
  JOURNAL   New Biol 2 (4), 363-374 (1990)
   PUBMED   2288909
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006213.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.51680.1, AK127739.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269973.10/ ENSP00000269973.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..682
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.31"
     Protein         1..682
                     /product="zinc finger protein 45"
                     /note="zinc finger protein 45 (a Kruppel-associated box
                     (KRAB) domain polypeptide); zinc finger protein 13;
                     BRC1744; zinc finger protein KOX5"
                     /calculated_mol_wt=78111
     Region          8..67
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Site            order(148,150..151,154..155,157,171,173,177..178,181..182,
                     185,199,201,203,205..206,209..210,213)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          166..186
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          169..542
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          194..214
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          251..270
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          278..298
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          306..326
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(311,313,315,317..318,321..322,325,339,341,345..346,
                     349..350,353,367,369,371,373..374,377..378,381)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          334..354
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          362..382
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          390..410
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          418..438
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          446..466
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(451,453,455,457..458,461..462,465,479,481,485..486,
                     489..490,493,507,509,511,513..514,517..518,521)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          474..494
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <496..607
                     /region_name="SFP1"
                     /note="Putative transcriptional repressor regulating G2/M
                     transition [Transcription / Cell division and chromosome
                     partitioning]; COG5189"
                     /db_xref="CDD:227516"
     Region          502..522
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          530..550
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          558..578
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          586..606
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(591,593,595,597..598,601..602,605,619,621,625..626,
                     629..630,633,647,649,651,653..654,657..658,661)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          598..622
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          614..634
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          626..650
                     /region_name="zf-H2C2_2"
                     /note="Zinc-finger double domain; pfam13465"
                     /db_xref="CDD:463886"
     Region          642..662
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          662..682
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q02386.2)"
     CDS             1..682
                     /gene="ZNF45"
                     /gene_synonym="KOX5; ZNF13"
                     /coded_by="NM_003425.4:1115..3163"
                     /db_xref="CCDS:CCDS12632.1"
                     /db_xref="GeneID:7596"
                     /db_xref="HGNC:HGNC:13111"
                     /db_xref="MIM:194554"
ORIGIN      
        1 mtkskeavtf kdvavvfsee elqlldlaqr klyrdvmlen frnvvsvghq stpdglpqle
       61 reeklwmmkm atqrdnssga knlkemetlq evglrylphe elfcsqiwqq itrelikyqd
      121 svvniqrtgc qlekrddlhy kdegfsnqss hlqvhrvhtg ekpykgehcv ksfswsshlq
      181 inqrahagek pykcekcdna frrfsslqah qrvhsraksy tndasyrsfs qrshlphhqr
      241 vptgenpyky eecgrnvgks shcqaplivh tgekpykcee cgvgfsqrsy lqvhlkvhtg
      301 kkpykceecg ksfswrsrlq aherihtgek pykcnacgks fsysshlnih crihtgekpy
      361 kceecgkgfs vgshlqahqi shtgekpykc eecgkgfcra snlldhqrgh tgekpyqcda
      421 cgkgfsrssd fnihfrvhtg ekpykceecg kgfsqasnll ahqrghtgek pykcgtcgkg
      481 fsrssdlnvh crihtgekpy kcercgkafs qfsslqvhqr vhtgekpyqc aecgkgfsvg
      541 sqlqahqrch tgekpyqcee cgkgfcrasn flahrgvhtg ekpyrcdvcg krfrqrsylq
      601 ahqrvhtger pykceecgkv fswssylqah qrvhtgekpy kceecgkgfs wsssliihqr
      661 vhaddegdkd fpssedshrk tr
//
