LOCUS       NM_152695               4034 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens zinc finger protein 449 (ZNF449), mRNA.
ACCESSION   NM_152695
VERSION     NM_152695.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4034)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4034)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 4034)
  AUTHORS   Okada,K., Fukai,A., Mori,D., Hosaka,Y., Yano,F., Chung,U.I.,
            Kawaguchi,H., Tanaka,S., Ikeda,T. and Saito,T.
  TITLE     Identification of SCAN domain zinc-finger gene ZNF449 as a novel
            factor of chondrogenesis
  JOURNAL   PLoS One 9 (12), e115169 (2014)
   PUBMED   25546433
  REMARK    GeneRIF: During chondrogenic differentiation of human mesenchymal
            stem cells, ZNF449 was increased at an early stage, and its
            overexpression enhanced SOX9 and SOX6 only at the initial stage of
            the differentiation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4034)
  AUTHORS   Luo,K., Li,J., Cui,Y., Xu,M., Yuan,J., Tang,W., Wan,B. and Yu,L.
  TITLE     Identification and characterization of the human SCAN domain
            zinc-finger gene ZNF449
  JOURNAL   Mol Biol Rep 33 (1), 51-57 (2006)
   PUBMED   16636917
  REMARK    GeneRIF: ZNF449 is a member of the zinc-finger family and it may
            function as a transcription factor
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA319333.1, BC060768.1,
            BX537604.1 and AY280801.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_152695.5.
            
            Summary: This gene encodes a nuclear protein that likely functions
            as a transcription factor. The protein includes an N-terminal SCAN
            domain, and seven C2H2-type zinc finger motifs. [provided by
            RefSeq, May 2010].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY280801.1, AL833407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339249.5/ ENSP00000339585.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               DA319333.1         26-577
            553-1824            BC060768.1         553-1824
            1825-3762           BX537604.1         2609-4546
            3763-4034           AY280801.1         3764-4035
FEATURES             Location/Qualifiers
     source          1..4034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.3"
     gene            1..4034
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /note="zinc finger protein 449"
                     /db_xref="GeneID:203523"
                     /db_xref="HGNC:HGNC:21039"
                     /db_xref="MIM:300627"
     exon            1..40
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /inference="alignment:Splign:2.1.0"
     exon            41..494
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1697
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /note="zinc finger and SCAN domain-containing protein 19"
                     /codon_start=1
                     /product="zinc finger protein 449"
                     /protein_id="NP_689908.3"
                     /db_xref="CCDS:CCDS14649.1"
                     /db_xref="GeneID:203523"
                     /db_xref="HGNC:HGNC:21039"
                     /db_xref="MIM:300627"
                     /translation="MAVALGCAIQASLNQGSVFQEYDTDCEVFRQRFRQFQYREAAGP
                     HEAFNKLWELCCQWLKPKMRSKEQILELLVLEQFLTILPTEIETWVREHCPENRERVV
                     SLIEDLQRELEIPEQQVDMHDMLLEELAPVGTAHIPPTMHLESPALQVMGPAQEAPVA
                     EAWIPQAGPPELNYGATGECQNFLDPGYPLPKLDMNFSLENREEPWVKELQDSKEMKQ
                     LLDSKIGFEIGIENEEDTSKQKKMETMYPFIVTLEGNALQGPILQKDYVQLENQWETP
                     PEDLQTDLAKLVDQQNPTLGETPENSNLEEPLNPKPHKKKSPGEKPHRCPQCGKCFAR
                     KSQLTGHQRIHSGEEPHKCPECGKRFLRSSDLYRHQRLHTGERPYECTVCKKRFTRRS
                     HLIGHQRTHSEEETYKCLECGKSFCHGSSLKRHLKTHTGEKPHRCHNCGKSFSRLTAL
                     TLHQRTHTEERPFKCNYCGKSFRQRPSLVIHLRIHTGEKPYKCTHCSKSFRQRAGLIM
                     HQVTHFRGLI"
     exon            495..699
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /inference="alignment:Splign:2.1.0"
     exon            700..813
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /inference="alignment:Splign:2.1.0"
     exon            814..4034
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3743..3748
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /note="hexamer: AATAAA"
     polyA_site      3766
                     /gene="ZNF449"
                     /gene_synonym="ZSCAN19"
                     /note="major polyA site"
ORIGIN      
        1 agttgccggt gagcttggga gaaccgtggg cgctgaggcg ctgtaggtgg ctccctccca
       61 ccccaacgat ttcagagaga aacaagtcgg aatctgagaa gtgaggctcc agataaactg
      121 taaactgctg gaagggggcg atggctgtgg ccctgggttg tgcaatccag gcatccttga
      181 atcaaggctc tgtgtttcaa gaatatgata ctgactgtga agttttccgt cagcgcttca
      241 ggcagttcca gtacagagaa gcagctgggc ctcatgaagc atttaacaaa ctctgggagc
      301 tttgctgtca atggctgaag ccaaagatgc gctctaagga acaaatcctg gagctgctag
      361 tgttggagca attcctaact atcctgccca cagagataga gacctgggtg agggagcact
      421 gcccagagaa tagagaaaga gttgtgtcac tgatagaaga cttacagaga gaacttgaga
      481 taccagagca gcaggttgat atgcatgaca tgctcttgga agaactggca ccagtgggaa
      541 cggcacacat accaccaacc atgcacctag agtcacctgc actccaggta atgggacctg
      601 cccaggaggc cccagtagca gaggcatgga tcccacaggc agggccaccg gagctgaact
      661 atggtgctac tggagaatgt cagaactttc tggaccctgg atatccatta ccaaaacttg
      721 acatgaactt ctcattggag aatagagaag agccatgggt gaaggaatta caggattcta
      781 aagaaatgaa acaattactt gattccaaga taggttttga gatcgggata gaaaatgaag
      841 aagatacttc aaaacagaaa aaaatggaga ctatgtatcc atttattgta actttagagg
      901 ggaatgctct ccagggtccc attttgcaaa aagactatgt acagttagaa aatcaatggg
      961 aaaccccccc agaggattta cagacagatt tagcaaaact ggtagatcag cagaacccca
     1021 ctctgggaga gacacctgag aactccaact tggaagaacc tctcaaccct aaaccccaca
     1081 agaaaaagag tccaggagag aaacctcacc gatgtcctca gtgtggaaaa tgttttgctc
     1141 ggaagtcaca acttactggg catcagagaa ttcattcagg agaagaacct cacaaatgcc
     1201 ctgaatgtgg gaaaagattc cttcgtagtt cagaccttta tagacaccaa cgacttcata
     1261 caggggagag accctatgaa tgcactgtat gtaaaaagcg attcactcgg cggtcacatc
     1321 ttatagggca ccagagaacc cattctgaag aagaaacata taaatgtctt gagtgtggga
     1381 aaagtttttg tcatggatca agtcttaaaa gacatctgaa aactcataca ggtgaaaaac
     1441 ctcatagatg tcataattgt gggaaaagtt ttagtcgact gacagctctt actttgcacc
     1501 agagaacgca tactgaagag agacctttta aatgtaatta ttgtgggaaa agttttagac
     1561 agagaccaag cctcgttatt catttaagaa tccacacagg ggagaagcca tacaagtgta
     1621 ctcattgttc taaaagcttc agacagagag ccggccttat tatgcaccag gtcactcact
     1681 ttagaggact tatttaagaa ttgctaaggg aaacaggtct tacacaaatt gacactaact
     1741 caaaaaaaat cttaacctgc agcaggctgt ttgtcttgga agcttttgtt tgagcttata
     1801 agaacataga cagctttttt ttttactagt tttaaaaccc atcttccaag gtatatgaat
     1861 tctagagtat ttatctactc ctgtgatttt cttagatttg atttcttctg tctgcacaac
     1921 tcttcttttt ttaattacaa tgaaaaattt tgtgttccaa ggcaactgta tcataggtgt
     1981 aaacataaag catataaatt atgacaatcc ttttagaggt agggtcaata tagtggataa
     2041 acctgtctat cagacgtatt gattatagca gtactatagt tattctgctg tcattattaa
     2101 agatgattat attcattcaa agctttagat gtgtcccatg tggcaagaaa ggagacagtg
     2161 aattttgtca aacaataaaa atgtgtcagg aacacaagga tgaaggggat gtcatttgcc
     2221 tggtaagaac tgggttattt ccactgaaat ttgttatgtt taaggaaatt aagattttaa
     2281 gcttgaaatt atacaagcag aatctaattt aattttgatt gactgaagaa ccagggtctt
     2341 ttgctctcct ttggtatttc actctccttt ggtattcaat catgtgtctt ttagtgcttt
     2401 ttaaaatttt acccattctt taattcagca tctccctatg tatgtgtcat agaatactta
     2461 gttctgctag atattctgca aatatatttg ggaattactt cctgctgttt cgccttctta
     2521 ggttcatagt acacatcagc atatgagaat ctctgagagg tcctctagaa aggagagaaa
     2581 aagcacctct tttggctcaa tgttttccaa acttatttga ccccaaaacc tttttcatat
     2641 acccaataat aagctacaga actaatattc tgcaaatgtc tcttggaaca cactgcctta
     2701 aacagatatt tctatagctg tcagtatagt tatgttgctc ccaagcctag ttatctccag
     2761 ttgttttaag ggtgttatga aaaattctta aaatatatat gaatttgtgt aacacacaca
     2821 gagacacaca cacatactac tttaaggggg tgaggatcat taattcagat aatttttaag
     2881 tttcctagtg attctcaatc tctttgaatt ttacttacat ttacacacac acgcacacac
     2941 atatgtatat acacatatca ttttaagaag ctgaggatca ctaattcaga taatgtataa
     3001 gtttcccagt gattctcaac ctctttgaat tttacttata attacataca cacacacact
     3061 gctacttata taaatgttct catgtaatca tggtaacagc tcaaattccc aaagcaaggg
     3121 aagacttctc attgtcagtt aaacctgtta aaacatgaaa atattcattg agcctagttc
     3181 cttgttataa aatacaagaa ataagacatt caggcatttt ccctttatga agatgttcag
     3241 tcatcctttc cttgaactac aattaggaaa agtatatgtc tttattccat tgaagttctc
     3301 gagagtgata taaatacttt ggggggtatc tactatgtgc ctaactagtc ctgttctagg
     3361 cttagtggaa gctagtaaag aaatataatt catggatcag gctcataaag attttataat
     3421 atttttagtt aaacaagagt tgggaaacag gtggagaata atgcaagaga gtttgtaatt
     3481 aagtgccaat tataccaatt gctagaccca ggatgtatct ttaattcttg tcatccaggt
     3541 caacatatga tgctgctata agtctggggc tcaaattgat atcccagtag caataaacat
     3601 ataatatagg aggagtctga atgtagagat gaaaaataca gaatgtaatg gcttctcttt
     3661 tctctcttgt ggaattgcat tcaaaccaga acagtgcctt agaatggatg tgcccaactg
     3721 ctctgtattt atgcaatatt tgaataaagc ggaaatgtat gtgctcttcc tgcttcactt
     3781 gcactaatta attatttgaa caacttagag cttcttccct gaacagtggc aacaagcatg
     3841 gcaattgact ctgtcctcat cccaagttgg aatcgctttt ctctctgcaa ccatggcact
     3901 gtgattatgc atcattttta gcatttaata cagtccattt ttggctagta gggttagttg
     3961 caatcataat atgagttgca tcctccctct catttatatc aaatatactt gactagattt
     4021 ttacaagtta gaga
//
