LOCUS       NM_181489              18314 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens zinc finger protein 445 (ZNF445), transcript variant
            1, mRNA.
ACCESSION   NM_181489 XM_498931
VERSION     NM_181489.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18314)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 18314)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 18314)
  AUTHORS   Takahashi,N., Coluccio,A., Thorball,C.W., Planet,E., Shi,H.,
            Offner,S., Turelli,P., Imbeault,M., Ferguson-Smith,A.C. and
            Trono,D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
REFERENCE   4  (bases 1 to 18314)
  AUTHORS   Luo,K., Yuan,J., Shan,Y., Li,J., Xu,M., Cui,Y., Tang,W., Wan,B.,
            Zhang,N., Wu,Y. and Yu,L.
  TITLE     Activation of transcriptional activities of AP1 and SRE by a novel
            zinc finger protein ZNF445
  JOURNAL   Gene 367, 89-100 (2006)
   PUBMED   16368201
REFERENCE   5  (bases 1 to 18314)
  AUTHORS   Calabro,V., Pengue,G., Bartoli,P.C., Pagliuca,A., Featherstone,T.
            and Lania,L.
  TITLE     Positional cloning of cDNAs from the human chromosome 3p21-22
            region identifies a clustered organization of zinc-finger genes
  JOURNAL   Hum Genet 95 (1), 18-21 (1995)
   PUBMED   7814019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY295873.2, AC134943.2 and BX108541.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181489.5.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY295873.2, SRR1660805.128566.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396077.8/ ENSP00000379387.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9105              AY295873.2         1-9105
            9106-9579           AC134943.2         33734-34207
            9580-10249          BX108541.1         1-670
            10250-18314         AC134943.2         34878-42942
FEATURES             Location/Qualifiers
     source          1..18314
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..18314
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="zinc finger protein 445"
                     /db_xref="GeneID:353274"
                     /db_xref="HGNC:HGNC:21018"
                     /db_xref="MIM:619508"
     exon            1..80
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            81..201
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            202..777
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..3444
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="isoform 1 is encoded by transcript variant 1; zinc
                     finger protein 168; zinc finger protein with KRAB and SCAN
                     domains 15"
                     /codon_start=1
                     /product="zinc finger protein 445 isoform 1"
                     /protein_id="NP_852466.1"
                     /db_xref="CCDS:CCDS2713.1"
                     /db_xref="GeneID:353274"
                     /db_xref="HGNC:HGNC:21018"
                     /db_xref="MIM:619508"
                     /translation="MPPGRWHAAYPAQAQSSRERGRLQTVKKEEEDESYTPVQAARPQ
                     TLNRPGQELFRQLFRQLRYHESSGPLETLSRLRELCRWWLRPDVLSKAQILELLVLEQ
                     FLSILPGELRVWVQLHNPESGEEAVALLEELQRDLDGTSWRDPGPAQSPDVHWMGTGA
                     LRSAQIWSLASPLRSSSALGDHLEPPYEIEARDFLAGQSDTPAAQMPALFPREGCPGD
                     QVTPTRSLTAQLQETMTFKDVEVTFSQDEWGWLDSAQRNLYRDVMLENYRNMASLVGP
                     FTKPALISWLEAREPWGLNMQAAQPKGNPVAAPTGDDLQSKTNKFILNQEPLEEAETL
                     AVSSGCPATSVSEGIGLRESFQQKSRQKDQCENPIQVRVKKEETNFSHRTGKDSEVSG
                     SNSLDLKHVTYLRVSGRKESLKHGCGKHFRMSSHHYDYKKYGKGLRHMIGGFSLHQRI
                     HSGLKGNKKDVCGKDFSLSSHHQRGQSLHTVGVSFKCSDCGRTFSHSSHLAYHQRLHT
                     QEKAFKCRVCGKAFRWSSNCARHEKIHTGVKPYKCDLCEKAFRRLSAYRLHRETHAKK
                     KFLELNQYRAALTYSSGFDHHLGDQSGEKLFDCSQCRKSFHCKSYVLEHQRIHTQEKP
                     YKCTKCRKTFRWRSNFTRHMRLHEEEKFYKQDECREGFRQSPDCSQPQGAPAVEKTFL
                     CQQCGKTFTRKKTLVDHQRIHTGEKPYQCSDCGKDFAYRSAFIVHKKKHAMKRKPEGG
                     PSFSQDTVFQVPQSSHSKEEPYKCSQCGKAFRNHSFLLIHQRVHTGEKPYKCRECGKA
                     FRWSSNLYRHQRIHSLQKQYDCHESEKTPNVEPKILTGEKRFWCQECGKTFTRKRTLL
                     DHKGIHSGEKRYKCNLCGKSYDRNYRLVNHQRIHSTERPFKCQWCGKEFIGRHTLSSH
                     QRKHTRAAQAERSPPARSSSQDTKLRLQKLKPSEEMPLEDCKEACSQSSRLTGLQDIS
                     IGKKCHKCSICGKTFNKSSQLISHKRFHTRERPFKCSKCGKTFRWSSNLARHMKNHIR
                     D"
     exon            778..946
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1041
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1168
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1279
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..18314
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8356..8361
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AGTAAA"
     polyA_site      8378
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="major polyA site"
     regulatory      10229..10234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AGTAAA"
     polyA_site      10249
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
     regulatory      12516..12521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AATAAA"
     polyA_site      12538
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
     regulatory      18278..18283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /note="hexamer: AATAAA"
     polyA_site      18314
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
ORIGIN      
        1 ggagccgccg ggaggtaggc gcgggacggg cggctgcggt ggcggcgggt ggaccgattg
       61 tcgctcggcg gcgggagtcg gtggagtctc gctctttcgc aaggctggag tgcaatggca
      121 tgatctcggc tcactgcagc ctccgcctcc tgggttcaag tgattcttct gcctcagcct
      181 cccgagtagc tgggactaca gaaatgctgg taatttcagt cacttgctga tgacttctga
      241 tgtcccagca aatgttggca ttgttgactg ctgagaagat acttctgagg acccacgtct
      301 aaggtggact tggttcgcac tcttctggtt agtccctgaa caggagtgat gcctccaggc
      361 aggtggcatg ctgcctatcc agctcaggcc cagtcttcga gggagcgagg gcggcttcag
      421 acagtaaaga aggaagaaga ggatgaaagc tatactccag tgcaggctgc caggccacag
      481 actctcaacc gccctggcca ggagctgttc cgccagctct tcagacagct tcgctaccat
      541 gagtcttcag ggcccctaga aactctgagc cggctccggg aactctgtcg ctggtggctg
      601 aggcctgacg ttctctccaa ggcacagatc ctagagctgc tggtgctgga acagttcctg
      661 agcatcctgc ctggggagct ccgggtttgg gtgcagcttc ataaccctga gagtggcgag
      721 gaggctgtgg ccttgctgga ggagctgcag agggaccttg atgggacatc ctggagggac
      781 ccgggccctg cccagagccc agatgtgcat tggatgggta caggagccct gcgatctgca
      841 cagatatggt cccttgcttc acctctcagg agcagctctg ctctggggga ccacctggag
      901 cctccctatg aaatagaagc acgtgacttc ctggctgggc aatccgatac tcctgctgcc
      961 cagatgcctg cccttttccc gagagagggg tgcccgggag accaggtaac accaaccagg
     1021 tccctgacag cccagctcca ggagaccatg actttcaagg atgtggaggt gaccttctcc
     1081 caggacgagt gggggtggct ggactctgct cagaggaacc tgtacaggga tgtgatgctg
     1141 gagaattata ggaacatggc ttccctggtg ggaccattca ccaaacctgc tctgatctcc
     1201 tggttggaag caagggagcc atggggcctg aacatgcagg cagctcagcc taaggggaat
     1261 ccagttgctg ctcctacagg agatgacctc cagagtaaaa caaacaaatt catcttaaat
     1321 caggaacctt tggaagaagc agaaacctta gctgtgtcat caggatgtcc tgcgacaagt
     1381 gtttctgagg gaattgggct cagagaatct tttcaacaga agagcaggca gaaggatcaa
     1441 tgtgaaaatc ccatacaagt aagagttaag aaagaagaga ccaatttcag tcacaggaca
     1501 ggaaaagact ctgaagtatc aggaagtaat agtcttgact taaaacatgt tacatatttg
     1561 agagtttctg gaagaaagga atcccttaaa catggctgtg gcaaacactt cagaatgagt
     1621 tcacaccact atgactacaa gaaatatggg aaggggctca gacacatgat tgggggcttc
     1681 agcctacatc agagaattca tagtggactg aaagggaaca aaaaggacgt gtgtggaaaa
     1741 gacttcagcc ttagctctca tcaccaacgt gggcagagtc ttcacacagt gggagtgtca
     1801 tttaagtgca gtgactgtgg aaggactttc agtcatagct cccatcttgc gtatcatcag
     1861 agacttcaca ctcaagagaa agcatttaaa tgtagggtgt gtgggaaagc cttccggtgg
     1921 agttccaact gtgcgcggca tgagaaaatt cacactggag tgaagcctta taaatgcgat
     1981 ttatgtgaga aagctttccg acgcctgtca gcctaccgtc tgcaccgaga aacccatgct
     2041 aagaagaaat ttcttgaatt gaatcagtat agggcagctc tcacctacag ctcagggttt
     2101 gatcatcatt tgggagacca aagtggggag aaactctttg actgcagcca gtgcaggaaa
     2161 tccttccact gtaagtcata tgttcttgaa catcaaagga ttcacaccca ggagaagccc
     2221 tataaatgta ccaaatgtag gaaaaccttt agatggagat caaactttac tcgtcatatg
     2281 aggttgcatg aggaggaaaa attctacaaa caagatgaat gtcgtgaagg cttcaggcaa
     2341 tctcctgact gcagtcagcc ccagggtgct cccgctgtgg agaaaacatt tctgtgtcag
     2401 cagtgtggga aaacttttac tagaaagaaa actctcgttg accaccagag aattcacaca
     2461 ggtgagaaac cttaccagtg tagcgattgt gggaaggact ttgcctatag gtcagccttt
     2521 attgttcata agaagaagca tgccatgaaa agaaaacctg agggcgggcc atcttttagt
     2581 caggacacag tgttccaggt tcctcagagc agtcactcca aagaggagcc ctacaaatgc
     2641 agccagtgtg gcaaggcctt ccgcaatcac tcattcctcc tcatccatca gagagttcac
     2701 actggagaga agccatataa gtgcagggag tgtgggaaag ccttcagatg gagttccaat
     2761 ctctaccgac atcagaggat tcactctctt caaaaacagt atgattgcca tgaaagtgaa
     2821 aagactccaa atgtggagcc aaaaatcctc actggtgaga aacgtttttg gtgtcaagaa
     2881 tgtgggaaaa cctttacacg taaaagaacc cttttagatc ataagggaat acacagtgga
     2941 gagaagcgct ataaatgtaa tctatgtggg aaatcttatg atagaaacta tcgccttgtt
     3001 aaccatcaga ggatccactc tacagagaga cctttcaaat gtcagtggtg tgggaaagag
     3061 ttcattggga gacataccct ttccagtcac cagaggaaac acaccagagc agcacaggct
     3121 gaacgtagcc cgcctgcacg gtcttcctct caggacacaa agttgagatt acagaagcta
     3181 aaaccaagtg aagagatgcc cctcgaagac tgcaaagaag cttgcagcca gagctccagg
     3241 ctcactggac tccaggacat aagcattggg aaaaagtgcc acaaatgcag catatgtggg
     3301 aaaactttta acaagagttc acaactcatt agccacaaga gatttcatac tcgagagagg
     3361 cccttcaaat gcagcaagtg tggaaagacc ttcaggtggt cttcgaacct ggctcggcat
     3421 atgaaaaacc atattagaga ttagcctggg acctgacagt gacagtgggg gtgggttctc
     3481 agtcccctgc tagagaaccc ttaattatag gcattgtgga gtaactttga taaagggccc
     3541 agccctttct gttttggaag ctagtgacag aatcccaagg atttgaaagc tcggggagtc
     3601 cccagcctgc ctgctaggat gtgacgctgg ggaagtgcag caccatgtcc tttggagccc
     3661 ttctggagac tccggcccct aggagtggcc tctgcaccat agcctgcggc tcccctattc
     3721 aggtctcctt ccacaactct gaagagagag accactgccc tttgtggttg gacagaatat
     3781 ctgtggcatc atgggctatg gctgctggaa aggggccagt gggatcctag atttgtcttc
     3841 aagtttggcc tgtggccatg cctattctgt tgactttaaa agcagcagca tcaagaactc
     3901 ctagccttcc caaatgcccc ctggggagtt ctggctgggg cttcagcctt cctggctggc
     3961 ttttggatat ctgctagggg gttagagtgg tctcagcggc aggtggagga gagcaggatg
     4021 ctgggctcaa gcgcttggcg tgtggatctc taccagtacc ctgttgccat ccccatccca
     4081 caggcctgca taggcagcag cggtccatct gtttaacaga aatgtgctga gcactcccat
     4141 acaccaggcg ctggtgtgtt tgccagagac ccagcaggga ccagaacaga tgaaaatcct
     4201 gccatcttgg atctttacag atgacaaaca aatgggatac gcagtattct ggatggtgat
     4261 gtgtgtagtg gacaaagtga atcagagaag agcagaggga gtgctggatt gggagatcag
     4321 tcgtgatttt agatagtctg gtcagggagg gcctcaactg agaaggtgaa atgtgagcaa
     4381 agacgtgaag gaagccaggg aggtagcagg tagctctcta gggagagttg caggcagagg
     4441 agattgggtc ttgactggtg tcctcaggaa ggaagcccct gggatggagt gcagggagcc
     4501 agctggaagg gaaggagagg ggccagggag gccacaggcc cggccatatg agcatcatgg
     4561 gtcattacgg gggcttgagc tggctcagag ggaggcaggg agcttttgga caattttgag
     4621 ttgaggagtg atgtggtttg aatctgaatt atattttata agggttaacc acagatccaa
     4681 ggactcagta aaagggtgaa aggcttctca tgcagttagc cttgctgcca gttcccataa
     4741 atcagactcc tccccactcc gtttctgaat tttctatagg atcctcggcc tcagcagata
     4801 taaacgctta ccattgttgt gttcatgtct ctagcccctg cacactgcag gcccctctca
     4861 gcttcacata cccctctcca tgtatgagat ctggtgctag caatcagatt caacccgaag
     4921 gaacaagtgc atgtgcctgc tgctctcagg agaaaaggca gcctgttctg ggaggagctc
     4981 cctcactggc ccacccactt gtgttgaagc aaaaagcaag aatcaattac ttaaaggcaa
     5041 aggagtgata ttgctaaagc atgtgagtaa tcattgcttc tgattattga agaggtcaga
     5101 ttatgaatga aaggataaaa tgttttaata gtagagcagt gtcctgacta taggggcccg
     5161 ttcatggagc tggtcatttc ttgaaatgag aagaaaccaa cctggaagat gtctttttca
     5221 gtagagtatg gaataatctt acctgctctg gattgccatg agcaggtgaa aatgaaggct
     5281 ctgatattgt gtggtggtgt cacaggatgg tgggggcggg gcagaagtct cctgttggtg
     5341 ttctgatgcc tgttcagctt tgtcctcagg aaggtttggt catcttggtt ctgccatcct
     5401 cttgccttcc tacggcagca gctgttcatg gcactgaaga tgtcccttca ctgtcccaaa
     5461 actggcacta gaagtggctg ggcagggggg ccagagtcat aggaagggtc ttggagtcat
     5521 cagatctggg ttccaggcat ggtgtgcctt ttcttggcag gattgatctt gagcaagtca
     5581 atgaacctct gcatcaattt ccttatgtgt gaagttagag tgcttggctg tgctacctga
     5641 ttcctgagat tggtgaaaga gggcttggtt taccaaggct ctccatcagg tggttgacct
     5701 ctaggaccag ggccctctca gaggtgcagc ttccatgtca gttggtgttg taaccatgga
     5761 aaagtccctt tccaatcaaa cttttagcac ccctttcccc ccatctctgc tccctttgcc
     5821 acaggatacc ttgtaaagtt cctgccccag tatagggata tttttactgt cttttttatt
     5881 ttttgagaca gggttgccca gggtggagtg cagtggcagg atcacagctt actgcagcct
     5941 tgacctccca ggctcaggtc ccatctgagc ctcccgagta gctggggcta caggtgtgtg
     6001 ccaccctgcc agctaatttt ttatattttt ttgtagagac aaaactttta tttttttttc
     6061 ccatgttgct catgctggtc tcaaactcct gggctcaagc aatccaccca cctctgcctc
     6121 ccaaagtgct gggattacag gcgtgagcca ctgtgcctga cctgtcattt ttatagaatg
     6181 aaatgtgctt atttctaaac attctaatca aattttaaaa tgtgcaaaga atgaagtgaa
     6241 aaactgaatt tttttttttt tttgatacgg agtctcactc tgttacccag gctagagtgc
     6301 agtggcgcga tctccgctca ctgcaagctc tgcctcctgg gctcacacca ttctcctgcc
     6361 tcagcctcct cagtagctgg gactacaagt gcctgccacc acgcctgggt tattttttat
     6421 atttttagta gagacggggt ttcactgtgt tagccaggat ggtctcgatc tccaggatgg
     6481 tctcgatctc caggatggtc tcgatctcct gacgtcgtga tccacccgcc tcggcctccc
     6541 aaaatgctgg gattacaggt gtgagccact gtgcccggcc aaaagaacag aaattatttt
     6601 atcctgaagt aagctgttta tatttgggat tatactgaac ctatttgtcc aataacctga
     6661 gttttcaaat aattttagtt ctataagtac tataattata taaatattaa tgaattcaga
     6721 ttagctgaaa ggaaaaaaag tagaagcctg actacttggt gctaactact aaagattttg
     6781 gcagaatcaa tgttggattt ggctttcctg tcccttcccc atgccagccc cccagagtgt
     6841 tctgccttgt gctgcctccc ttcacctgga gtgccacacc cctctctctg ccagttcagc
     6901 tcttcattct tcaaggcctg accttgtctg acccttgtgc ctctaaaccc gtggccccac
     6961 ctctcttggt tcctatgtca ggtgatgttt gtgtttttgg ttatgcccat ctccatagcc
     7021 agaccaagca ctctggaagc cagggttggg tgcttattta tctgtttgcc atgcagaaaa
     7081 tatcttgcac aaaattacct ctgttaagga atctgaagct gaatttagtt tggctgagtc
     7141 agggttgggt tttttttaag gggctgtggg gtgaaatgtt gactggaagc cacccacaaa
     7201 cacacacctg ctggttagga acccggctgt gggtggttct gagctgtttg gcttcagttg
     7261 acagtttctg attgccctga gcaccaggtc tcatcttgca tctcatcctg gcctggagaa
     7321 cattcagttt ccttccaacc cttcccacct ttcccccact cccttggagg aactgaagtt
     7381 ggggttgagg agagccagat ggctggagtg ggtatttgaa ggtctttctg tcacctgttc
     7441 agtgtggtct gccccacccc tgctgaccaa gactgactga aatgtaaaat aatacagacc
     7501 atctcacact cagaaagctg gcacattttt gaaagcccaa gtgtgggtaa gtgcgtggaa
     7561 caacgataat tcacactgct ttatgagtag aaattgtgag aaatattgtg ccaggcaatt
     7621 tgcaaaatct tggaaggttg tgtgcactta accacccagc aactactcct ggatgcatcc
     7681 tagagaagtg ccatgtgaac agagaatgat tttaagactt cactgaagta ttgtttaggt
     7741 agcaagattg ggaaaagcct gcatttcatc agcagaagaa tggataaata aatgggttgt
     7801 ttttggtcct tggaaagtga atatgaaaga gttacgtctc aacacagata gatgaaaaat
     7861 tatgctgaga aagttggtga agctacatac aaggtaccct tagtgtaaag ttaagcatac
     7921 tgtgtacctg tgggcacgtt acttcaactt gtttttcact ttttctgtaa aatgggatag
     7981 tagtggcaat ctcacagggt gattgtgggt gggggggtgg tcaatgaagt aatgcatgta
     8041 aaatgcttag aatagtgtct agcatgtaag ccttgtggac atatagaaag tgttattgtt
     8101 ttgcacagta atctattttc tgtggattca aataatatga aatgagtata aaatcatgta
     8161 ttggaacgat gtgtgcaagt caccattctg ccttcctaag gcaggagacc tgatggattt
     8221 ggggagggta catggggcct tcagttgtgt tttctttgtt tttttctaaa aattgatgca
     8281 gaggcatcac aatgttaaga tttttacagg gtagtgtggt gggtactttt taactgtttg
     8341 cttaaagtgt ttcaaagtaa aaatatttct taagcatagt ctctgacatc ttatgacttt
     8401 atagaaatcc ctgccaggta catgatgtta cttagagtga gccacctaat ctttcaaggc
     8461 ttccatttcc tcacctgcaa aaattgggag tgtcagaggc gtttgaacca gagtgactcc
     8521 atcttgaata gggaactggg taaaataagg ctgagaccta ctgggctgca ttcccaggag
     8581 gttaggcatt ccaagtcatg ggatgagata ggaggtcagc acaagataca gtcataaaga
     8641 ccttgccaat aaaacagcat gtggtaaaga agccggtcaa aaccaagatg gcaatgaaag
     8701 tgacctctgg ttgtcctcac tgctgtaatt atactgtaat tataatgcat tagcatgcta
     8761 acagacactc ccaccagtgc catgacagtt tacaaacgcc atggcaggcc tggcacgatg
     8821 gctcatgcct gtaatcccag cactttggga ggccaaggcg ggcggattat gaggtcagga
     8881 gattgagacc agcctggcca acatggtgaa accctgtctc tactaaaaaa tacaaaaatt
     8941 agctgggcat ggtggcacgt gcctgtaatc ccagctactt gagaggctga ggcaggagaa
     9001 tctctagatc ccgggagttg gaggttgcag tgagccaaga tggtgccact gcactccagc
     9061 ctgggtgaca gagcaagact ctgtctcaaa aaaaaaaaaa aaaaatgcca tggcaacatc
     9121 aggaagtaac actatatggt ctaaaaagga gaggaaccct cagttctggt aattgctcac
     9181 acctttcccg ggaaacttat gaataatcta ccccttgttt agcatataat caataaataa
     9241 ccataaaaat aggcaaccag cagcccttgg ggctactctt cctatggagt agccattctg
     9301 tatttcttta ctttcttaat attaactact ttcactttgt ggactcgccc gaattctttt
     9361 cttgagcaag gtccaagaac tctctcttgg ggactggatc acgaccgctt tctggtaaca
     9421 ggagcaatac aaatggctat tagtaaacga acgcttaagt aactctagta catctatgat
     9481 gaaataccag gccacagttt ttttaaaaat gaggatgttc tctatatact gacgcacagt
     9541 caccaagaca tgcactttat aggaaattat aagctcctcc ttgcctaaat ctccttaatt
     9601 ttgcttaata aataacaagt gaagccagaa gctgtaaact cataatttta atgaagaaat
     9661 gggatccaga agatggagat gtttttcatt ctactttatt agatgaggaa aaggagagta
     9721 aatacttgta tgccagctac cacacctttt aaagttaatg ttaaccctgc taagaacagc
     9781 aaggagattt tatatcagcc aggttttagt tgccagaaac cacaccagtt attttagcaa
     9841 agaccttata aagaagtgta ctatatttaa gtagctaaaa aggcaagaag aaaatgccaa
     9901 ggtgtcttgg aggtagcaac tgctaagcag ctgccacccc aggactgggg gagctagaat
     9961 agagtctccc catgtttgac gtttgtctgc taatagcatt caagctctcc ccctcagttt
    10021 gcctggatct ggacaagctg ataagaaagc ccagccactt cctctttgcg tcagagggga
    10081 agttcaaact gtgcaaaccc tgactgtcaa atgcactgag ctctcataac cacaacaaaa
    10141 accagagcca cttgttcgtc ctttcactga agcccaacag actggcgtgg gtgcccgctt
    10201 tgctttccct agaaggcctc atgtgagtag taaacttttt cataacctct tggtgtctgc
    10261 agtgtcatca gtttcaacat ccgaaccagt tttgagtgat ggtagtttat tgatcccacc
    10321 tcatgtggag caaagtgcaa agcaggaaca aagagacgtg gctagaattg ttgaaaggtg
    10381 ggagattgga agagggacct tgtggagctg aactcagacc tatggtggag gagtggactg
    10441 ctgggctgac atagtgtctg tgctcaggga ggggccctgt ggcctttgga tctgtgcttc
    10501 tgtggagagg tcccagctac taatgctggg gcagggagca gaagggaggg tcacaatgag
    10561 actttgagtg ttagttaacc accttttgcc tgaagaacat gtaatggcct tccctgaggt
    10621 atatgtcttc caaaagtccg ctgacgttgc tcatgaccta tggtcaccac tgctttttgc
    10681 gttttgcttt tttttttttt ttttttttga gacaaggtct caccctgtca cccaggctgg
    10741 agtgcagtgg cacgatctca gctcactgca acctccactt tcccaggctc aagcgattct
    10801 ccagcctcag cctcctgact agctgggact acaagcgtgc accaccacac ccagctaatt
    10861 tttgtatttt tgtagagaca aggtttggcc atgttgccca agctggtctt gaactcctga
    10921 cctcaagtga cccacctgcc tcagcttgcc aaagtgctgg gattacaggt gtgagccacc
    10981 atgcctggag tccttgtttt tttttttttt atacttttag ggtacatgtg cacaatgtgc
    11041 aggttagtta catatgtata catgtgccat gctggtgcgc tgcacccact aactcatcat
    11101 ctagcattag gtatatctcc caatgctatc cctccccccc tccccccacc ccacaacagt
    11161 ccccagagtg tgatgttccc cttcctgtgt ccatgttttc tcattgttca attcccacct
    11221 atgagtgaga atatgcggtg tttggttttt tgttcttgcg atagtttact gagaatgatt
    11281 atttccacct tcatccatgt ccctacaaag gacatgaact catcattttt tatggctgca
    11341 tagtattcca tggtgtatgt gtgccacatt ttcttaatcc agtctatcat tgcctggagt
    11401 ccttttaaaa aaattatttt tttggccagg cacggtggct cacacctgta atcccagcac
    11461 tttgggaggc tgaggcgggc agatcacgag gtcaagagat cgagaccatg ctggctaacg
    11521 cggtgaaacc ccgtctctag taaaaataca aaaaattaac cgggcgtggc agcgggcgcc
    11581 tgtagtccca gctactcggg aggctgaggc gggcagatca cgagatcagg agattgagac
    11641 cagccagcct ggccaatatg gtgaaacccc atctctatta aaaatacaaa aattagccgg
    11701 gtgtggtggt gtgtgcctgt aatcctagct actggggagg ctgaggcagg agaatcactt
    11761 gaacccagga ggtggaagtt gcagtgagcc gagatcgcac aactgcactc cagcctgggc
    11821 gacagagtga aactttgtct caattaaaaa aaaaaaaaag tgaagtgcaa aatgtgactg
    11881 aggagataca gtactctcca aattgcataa ttttgccaat ttttatagaa acctggggaa
    11941 tctgtagaga tagcgtcaga agcattggaa cgagagcaac tccatgttga ataggggctg
    12001 ggtaaaagtg tcagaggtat ttgaaccaga gcgactccat tttgagtgag ggctgggaaa
    12061 atgaggctga gacttactgg cctgcattct cagaaagtta ggcattccta ccctctagga
    12121 ttgaattggg acccctttcc tgtaacatat ttctggtgac cacagaaggg actatagtgc
    12181 agaaacgttg acccaacggc tacctttgcg taagtgttgg ggtcctgtaa catatttctg
    12241 gcaaaccaca gaaaggatga tactgaagaa atccccccaa ccccaaagaa atagactgca
    12301 gcactgattg gacgactttg ggtaagtgat ggggtacccg agtaacaaat gggattgggt
    12361 tagaggccca acttagggga gttggagttt ctcctaagac agagtgagtt agaggcccct
    12421 cttaataaaa ggcaaggaca cttgactgac ctcaggttag aggttactcc atcctactct
    12481 atggagtagc tgtcctttca ccactttact ttcttaataa acttgttttt gctttgcact
    12541 gcggacttgc cctgaatcct ttcttgcacg agatccaaga actctcttaa gagtctggat
    12601 cgggacccct ttcctgtaac aaaatgaggc tgagacctac tgggctgcat tcccagacgg
    12661 ttaaggcatt ctaagtcacg ggatgagata ggagattggc acaagatcca ggccacaaag
    12721 accttgctga taaagcaggt tgcagtaaag aagccagcta aaacccacca aaaccaagac
    12781 ggtgatgaga atgacctctg gtcatcctca ctgctaccct cccaccagtg ccatgacagt
    12841 ttacagttgc catggcaaca tcaggaagtt accctatatg gcctggagag gggaggcatg
    12901 aataatccac cccttgttta gcatatcatc aagaaaccat aaaatagaca accagcagcc
    12961 ctcggggctg ctctgtctat ggagtagcca ttcttttatt cctttactta ataaacttgc
    13021 tttctcttta cggactcgcc ctgaattctt tcttgtgcga gatccaagaa ccctctcttg
    13081 gggtctggat tgggaacctt ttgcggtaac aagggtgcag gatcatcgtg gaaggaatat
    13141 aaagtcagat caagctgaat tattcgatat gggataatta agcagagatt tgtggttcat
    13201 tgttttaact tgagaagctg agaatggctg tcttcatttg ctttgagttg ttgagatatg
    13261 gactcactgt aatcccagct tgggaggctg aggtgggagg attgcttgag gccaggagtt
    13321 tgagactggc ttgggcaata tagtgagaac tcatctccaa aagaaaaaaa aaacacgaat
    13381 gcaaacataa cctgcactga atgagttgaa atgcgagaac ttcgttggta tactgtagag
    13441 gaagatatgt aaatgcttaa ggagataaaa atgcttgagt atttatcatg taaatacctg
    13501 ctcacccacc cagggagggt ccagaggaca cttcattatg agaaataaat tcatgtagag
    13561 agtgccagat attctataca ggccacatta cagtgggaaa tgctccctga agtgcagtgg
    13621 ggctgatgga atcctgagga ggcagggacc atatggtaac acttagtcac caaaaacaca
    13681 attggtgtgg tgactgccat ggacagtgca gccaaagcag gatcctgaat ggtctgaccc
    13741 acagagatct gtgatgtctg cctgctgatc atagtgtcct gagaactgaa atggatgggc
    13801 tgcctactaa agttttactt gatccgagta agtaggaaag ctccagatct ggtgaataaa
    13861 gtctgaccta aattaccaac acagagttac aatcactcag tcaattccaa gtcttgatct
    13921 agttcacaaa cccacagctt cttgaataaa ggataggcca ggtccctttg aagtaggacc
    13981 ctgctgcact gacaataatt tatacttttt atcttcctag gcctccccaa aggcacccaa
    14041 ggccatttat cagagtgatt gtgcattggg aagggcaaat aattagactt ttctgggata
    14101 accagcctct agttctgaac tagcagtaat tacaggagac tcaaaatgcc accatggttc
    14161 ctcagagtaa gagtgtatgg aggtcaggtg atcaatgggc tttttggctc agattcatct
    14221 cacagtagat ctagtagatt cctgaaccca tcctatggtt atttccctgg ttctagaatg
    14281 cgtaattaga atagacatag tcaacaatgg gcagaatccc acactagttc cctgatccat
    14341 acagtaaaag taattctggt agaaaaggcc aagtagaagc cactagagct gcctcattca
    14401 caaaaatatt aaagcaaact aataccacat tcctggagag attgttgaga ttagtgccac
    14461 catcaaagac gggaacacat ctccacttag ctcacctact cagcctgtgc agaagacaga
    14521 tggatcttgg agaatgacaa ttggattaat tgtaaactta attaactagt gattccaagt
    14581 gcaggtgctg tttccacatg tggtttcagt gctgagcaaa cgatacgtct gacaactggt
    14641 ttgcagttgt tactgagcca ggcccaggtt tgttctgttc tcacacagta aatcaatcac
    14701 tgtgacatgg gttttgcaaa agagagaaga attattcaca aggctgtcca gtgaggagat
    14761 gggagaatgg ctctcaaatt cacctcccca aagatgaggc ttagagagat ttataggtta
    14821 gagaagtagg gtggtctgag gcatggggaa aggtgattgg cagtggggaa aaatgcagtc
    14881 ataattgggg ttcatatgac atatgtgcag aaaatggtgg cgttaacatg atctgagggt
    14941 ggagtttttg gccctctgat gtcaaaaggc cacctcttgg gcatgtgtac aggcccagtt
    15001 gaagggttgg cagtctcaac tggtttgaac tggacaggat ctgccccaag ttcctgaaaa
    15061 ataagtggtt gttatggtga cttataaatg ttatctataa ggtagcacgt aaaagttgag
    15121 ttacagtgtt caatagcata gccttcagct atcgtggcct tcagcttcat gggggaaaaa
    15181 ataacaaaga gcaagcaacc aaaagcaagc ggggcaggcg aagtgtggca cacccgatcc
    15241 gattatcccc ttggctgccc agttacccat ctggtgaatg tttctctata cctgtgagta
    15301 aagaccatca ggaacagttt gctttcagct agatacacct tcaccaccct atctcaaggc
    15361 tgcctcaact ctgccgccca gctcatgatc tagttcccag gtcctttgag aaccttttca
    15421 ccctcaggac gacacactgg tccattatat tgatgacatt atagtcactg gacctggtgt
    15481 acagggagta gcaactgctc cagacatgtt ggaagacaca taatatgact cagtgtagga
    15541 aataaaccca caacatggct aagggcaaat aatgtttcca aaacttcttt ctctcttttt
    15601 tttttctttt ttgagacaga gtctcactct gtagctcgag ctggagtgga ggcaatcttg
    15661 gctcactgca acctgcacct cctgggtaca agtgaagctg cttcctcagc ctgttgggac
    15721 tacaggtgtg cgccaccacg cccggctaat tttttttttt ttttttttgg taaaggcagg
    15781 gtttcaccat gttagccagc ttggtcttga actcttgacc tcaagtgatc tgcccacctc
    15841 agcctcccaa agtgctggga ttacagaagt gagccaccaa gccaggccct ttttctctct
    15901 ctttccaata gttacattct atatgtttaa aagggacacg agacaatttt gtatgtgatt
    15961 ttctgaatca cataattcca catttaacat tttggggaaa tgccaaactg ttttccaaag
    16021 gggctgcctg ggagtctcag ctctagttct cagtcctcag cagccattcc tttcctcagt
    16081 ggggcgtcag tgctgccttc caaagtccag ggctgccttg agacctgatc aggaccggct
    16141 attttgccag gtgcagtgca tgatgttcaa gaccattcag aatttcaaga ccctgacagc
    16201 agagcaagat agcaggcgga ggccattcta agtgtggggc cccgcagggc tgcccaggct
    16261 gcctgcctgt gaagccagtc ctgcctgatg gagatgcttt tgccatggcg tgagggaaag
    16321 tgagctgatg gttctccact ttcccactct ctctctgcag gtccggctcc tctaagggca
    16381 gaagccagaa cttggtccct gaaccttctc cagtctccct ccctgggcat ttctctcata
    16441 accccatcag accccccagt aatggcctga cgtgggttct ggaaatagaa catgggttct
    16501 tagaatggct ctctgagact tcattgagtt gtctgtccta tttctttcct caacaaaatg
    16561 tccacatcct caatctcctg tctcagcagg aaagatgaaa agaacagtga ggcttaggcc
    16621 aggcacggtg gctcacacct gtaatcccaa cactttggga ggctgaggtg ggcagatcac
    16681 ctgagaacgg gagttcgaga ccagtctgaa ctccctgtct ctactaaaaa tacaaaagta
    16741 gccaggcgtg gtagcgggca cctgtaaatc ccagctactg gggaggctga gacaggagaa
    16801 tcgtttgaac ctgggaggcg gacgttgtgg tgagccgaga tagtgccact gcactccagc
    16861 ctggacaaca gagcgggaaa aaaaaaaaaa aagaacgatg acccttagca tcccaggaag
    16921 ctttgggtgg tgagagatgg agagtatctc cttcctgtgg tacttcagtt tcccgtctcc
    16981 ttgttaggat gttgcaaagc tggcctgctg aggtcttctg tgatctcctg tgcttcctac
    17041 acttccacct gaaaatgaac ctactgcagg gatgaatcca tgagcagaat tttaatgaaa
    17101 aggaagcaga cacaaaggaa tccatgggtt gtaactccac cgacttaaaa tgaaaaacac
    17161 aggcaacaaa gaacaggcac gatgctgctt cgccagctgg ttccttgttg ggttctgcca
    17221 ttcagggatg taagagggaa gctgggatgt tggaggactg gagtgtgagg gtaaatttta
    17281 ggtgtcaact tggctgagcc acaaggtccc caggtatttg atcaaacatt atgctgggtg
    17341 tttctgtgag gttgctttgg atgagattaa cgtttaaatt tgtggacttt gaggaaagca
    17401 gattgccctc tatctgtggg tgggcttcat ccaatcacct gaagacctga ggagaacata
    17461 aagtctggct gccccagact ctctctcagg caagagagaa ttcttccgca gactgccttc
    17521 agagttcatg cacaccatct actaatcctg ctccacagca ggtgccactg ggctctcact
    17581 ggaatatgta ttctcctggt tctccagcct gctcatccac cctgaagatt tgggacttgc
    17641 cagcctcctt aattctataa gccaattcct tatcataaat tcataaatcc ctctctctct
    17701 atctccatcc acacacacac acacacacac acacacacac acacagacac acacacacaa
    17761 atgagtgtag atgtgttcca ataaaacttc atttagagac attgaaattt aaatttcaag
    17821 ggctgggcat ggtggctcaa cgcctgtaat ctcagcactt tgggaggctg aggcaggtgg
    17881 atcacttgag gtcaggagtt cgagaccagc ctggccaaca tggtgaaacc ccgtctctac
    17941 taaaaataca aaacatgtag ccacgtgcag tggctcatgc ctgtaatccc agctgggagg
    18001 ctaagatggg agaatagctt gaacacagga ggcagaggtt gctgtgagct gaaatggtgc
    18061 ccagaagaca gagcgaccct gtctcaaaaa aataaaaaat aaaaaataaa tttcatataa
    18121 tcttcagata tattcattca tttacatatt gtctgtggtt gttttcaccc tttaggtcag
    18181 aagtagccga caacctttac acagtattta ccactgttat agacatcttt aaatatggtt
    18241 tacttttgcc tgtttttgta ctttatagaa atgaagtaat aaagtattgt ctgtcttgca
    18301 ttttttgctc aaaa
//
