LOCUS       NP_852466               1031 aa            linear   PRI 20-SEP-2024
DEFINITION  zinc finger protein 445 isoform 1 [Homo sapiens].
ACCESSION   NP_852466 XP_498931
VERSION     NP_852466.1
DBSOURCE    REFSEQ: accession NM_181489.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1031)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (residues 1 to 1031)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1031)
  AUTHORS   Takahashi,N., Coluccio,A., Thorball,C.W., Planet,E., Shi,H.,
            Offner,S., Turelli,P., Imbeault,M., Ferguson-Smith,A.C. and
            Trono,D.
  TITLE     ZNF445 is a primary regulator of genomic imprinting
  JOURNAL   Genes Dev 33 (1-2), 49-54 (2019)
   PUBMED   30602440
REFERENCE   4  (residues 1 to 1031)
  AUTHORS   Luo,K., Yuan,J., Shan,Y., Li,J., Xu,M., Cui,Y., Tang,W., Wan,B.,
            Zhang,N., Wu,Y. and Yu,L.
  TITLE     Activation of transcriptional activities of AP1 and SRE by a novel
            zinc finger protein ZNF445
  JOURNAL   Gene 367, 89-100 (2006)
   PUBMED   16368201
REFERENCE   5  (residues 1 to 1031)
  AUTHORS   Calabro,V., Pengue,G., Bartoli,P.C., Pagliuca,A., Featherstone,T.
            and Lania,L.
  TITLE     Positional cloning of cDNAs from the human chromosome 3p21-22
            region identifies a clustered organization of zinc-finger genes
  JOURNAL   Hum Genet 95 (1), 18-21 (1995)
   PUBMED   7814019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY295873.2, AC134943.2 and BX108541.1.
            
            On Jan 12, 2005 this sequence version replaced XP_498931.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY295873.2, SRR1660805.128566.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396077.8/ ENSP00000379387.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     Protein         1..1031
                     /product="zinc finger protein 445 isoform 1"
                     /note="zinc finger protein 168; zinc finger protein with
                     KRAB and SCAN domains 15"
                     /calculated_mol_wt=118832
     Region          1..43
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P59923.1)"
     Region          51..155
                     /region_name="SCAN"
                     /note="leucine rich region; smart00431"
                     /db_xref="CDD:128708"
     Region          234..292
                     /region_name="KRAB"
                     /note="krueppel associated box; smart00349"
                     /db_xref="CDD:214630"
     Region          415..451
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          <457..643
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          460..479
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          487..507
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(492,494,496,498..499,502..503,506,520,522,526..527,
                     530..531,534,548,550,552,554..555,558..559,562)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          515..535
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          543..563
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          595..1031
                     /region_name="COG5048"
                     /note="FOG: Zn-finger [General function prediction only]"
                     /db_xref="CDD:227381"
     Region          599..619
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          627..647
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          683..703
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          711..731
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          764..784
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(769,771,773,775..776,779..780,783,797,799,803..804,
                     807..808,811,847,849,851,853..854,857..858,861)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          792..812
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          842..862
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          870..890
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          898..918
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          911..939
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P59923.1)"
     Region          953..972
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Site            order(957,959,961,963..964,967..968,971,985,987,991..992,
                     995..996,999,1013,1015,1017,1019..1020,1023..1024,1027)
                     /site_type="other"
                     /note="putative nucleic acid binding site [nucleotide
                     binding]"
                     /db_xref="CDD:275368"
     Region          980..1000
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     Region          1008..1028
                     /region_name="C2H2 Zn finger"
                     /note="C2H2 Zn finger [structural motif]"
                     /db_xref="CDD:275368"
     CDS             1..1031
                     /gene="ZNF445"
                     /gene_synonym="ZFP445; ZKSCAN15; ZNF168; ZSCAN47"
                     /coded_by="NM_181489.6:349..3444"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS2713.1"
                     /db_xref="GeneID:353274"
                     /db_xref="HGNC:HGNC:21018"
                     /db_xref="MIM:619508"
ORIGIN      
        1 mppgrwhaay paqaqssrer grlqtvkkee edesytpvqa arpqtlnrpg qelfrqlfrq
       61 lryhessgpl etlsrlrelc rwwlrpdvls kaqilellvl eqflsilpge lrvwvqlhnp
      121 esgeeavall eelqrdldgt swrdpgpaqs pdvhwmgtga lrsaqiwsla splrsssalg
      181 dhleppyeie ardflagqsd tpaaqmpalf pregcpgdqv tptrsltaql qetmtfkdve
      241 vtfsqdewgw ldsaqrnlyr dvmlenyrnm aslvgpftkp aliswleare pwglnmqaaq
      301 pkgnpvaapt gddlqsktnk filnqeplee aetlavssgc patsvsegig lresfqqksr
      361 qkdqcenpiq vrvkkeetnf shrtgkdsev sgsnsldlkh vtylrvsgrk eslkhgcgkh
      421 frmsshhydy kkygkglrhm iggfslhqri hsglkgnkkd vcgkdfslss hhqrgqslht
      481 vgvsfkcsdc grtfshsshl ayhqrlhtqe kafkcrvcgk afrwssncar hekihtgvkp
      541 ykcdlcekaf rrlsayrlhr ethakkkfle lnqyraalty ssgfdhhlgd qsgeklfdcs
      601 qcrksfhcks yvlehqriht qekpykctkc rktfrwrsnf trhmrlheee kfykqdecre
      661 gfrqspdcsq pqgapavekt flcqqcgktf trkktlvdhq rihtgekpyq csdcgkdfay
      721 rsafivhkkk hamkrkpegg psfsqdtvfq vpqsshskee pykcsqcgka frnhsfllih
      781 qrvhtgekpy kcrecgkafr wssnlyrhqr ihslqkqydc hesektpnve pkiltgekrf
      841 wcqecgktft rkrtlldhkg ihsgekrykc nlcgksydrn yrlvnhqrih sterpfkcqw
      901 cgkefigrht lsshqrkhtr aaqaersppa rsssqdtklr lqklkpseem pledckeacs
      961 qssrltglqd isigkkchkc sicgktfnks sqlishkrfh trerpfkcsk cgktfrwssn
     1021 larhmknhir d
//
